DE69827021T2 - An verschiedenen orten verabreichung von adenoviren-vektor zur induzierung von angiogenese - Google Patents

An verschiedenen orten verabreichung von adenoviren-vektor zur induzierung von angiogenese Download PDF

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Publication number
DE69827021T2
DE69827021T2 DE69827021T DE69827021T DE69827021T2 DE 69827021 T2 DE69827021 T2 DE 69827021T2 DE 69827021 T DE69827021 T DE 69827021T DE 69827021 T DE69827021 T DE 69827021T DE 69827021 T2 DE69827021 T2 DE 69827021T2
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DE
Germany
Prior art keywords
vector
target tissue
vegf
tissue
region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69827021T
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German (de)
English (en)
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DE69827021D1 (de
Inventor
K. Todd ROSENGART
G. Ronald CRYSTAL
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Cornell Research Foundation Inc
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Cornell Research Foundation Inc
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Priority claimed from US08/801,352 external-priority patent/US5846225A/en
Application filed by Cornell Research Foundation Inc filed Critical Cornell Research Foundation Inc
Publication of DE69827021D1 publication Critical patent/DE69827021D1/de
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Publication of DE69827021T2 publication Critical patent/DE69827021T2/de
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Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Plant Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69827021T 1997-01-29 1998-01-29 An verschiedenen orten verabreichung von adenoviren-vektor zur induzierung von angiogenese Expired - Fee Related DE69827021T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US3660197P 1997-01-29 1997-01-29
US36601P 1997-01-29
US08/801,352 US5846225A (en) 1997-02-19 1997-02-19 Gene transfer therapy delivery device and method
US801352 1997-02-19
US7115698P 1998-01-13 1998-01-13
US71156P 1998-01-13
PCT/US1998/001638 WO1998032859A1 (en) 1997-01-29 1998-01-29 Multiple site delivery of adenoviral vector for the induction of angiogenesis

Publications (2)

Publication Number Publication Date
DE69827021D1 DE69827021D1 (de) 2004-11-18
DE69827021T2 true DE69827021T2 (de) 2005-02-24

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE69827021T Expired - Fee Related DE69827021T2 (de) 1997-01-29 1998-01-29 An verschiedenen orten verabreichung von adenoviren-vektor zur induzierung von angiogenese

Country Status (16)

Country Link
US (2) US6518255B2 (enExample)
EP (1) EP1012291B1 (enExample)
JP (1) JP2001509168A (enExample)
KR (1) KR20000070572A (enExample)
AT (1) ATE279518T1 (enExample)
AU (1) AU745409B2 (enExample)
BR (1) BR9806819A (enExample)
CA (1) CA2278621A1 (enExample)
DE (1) DE69827021T2 (enExample)
HU (1) HUP0001964A3 (enExample)
IL (1) IL131021A0 (enExample)
MX (1) MXPA99006993A (enExample)
NO (1) NO993669L (enExample)
NZ (1) NZ336838A (enExample)
PL (1) PL334902A1 (enExample)
WO (1) WO1998032859A1 (enExample)

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US11421229B2 (en) 2015-02-20 2022-08-23 Baylor College Of Medicine p63 inactivation for the treatment of heart failure
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Also Published As

Publication number Publication date
EP1012291A1 (en) 2000-06-28
KR20000070572A (ko) 2000-11-25
US6518255B2 (en) 2003-02-11
HUP0001964A2 (hu) 2000-10-28
AU6253098A (en) 1998-08-18
BR9806819A (pt) 2000-05-09
DE69827021D1 (de) 2004-11-18
EP1012291B1 (en) 2004-10-13
WO1998032859A1 (en) 1998-07-30
PL334902A1 (en) 2000-03-27
AU745409B2 (en) 2002-03-21
US20030103943A1 (en) 2003-06-05
NZ336838A (en) 2002-04-26
NO993669D0 (no) 1999-07-28
CA2278621A1 (en) 1998-07-30
MXPA99006993A (es) 2005-06-01
IL131021A0 (en) 2001-01-28
HUP0001964A3 (en) 2002-01-28
ATE279518T1 (de) 2004-10-15
NO993669L (no) 1999-09-27
US20010041679A1 (en) 2001-11-15
JP2001509168A (ja) 2001-07-10

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