AU745409B2 - Multiple site delivery of adenoviral vector for the induction of angiogenesis - Google Patents
Multiple site delivery of adenoviral vector for the induction of angiogenesis Download PDFInfo
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- AU745409B2 AU745409B2 AU62530/98A AU6253098A AU745409B2 AU 745409 B2 AU745409 B2 AU 745409B2 AU 62530/98 A AU62530/98 A AU 62530/98A AU 6253098 A AU6253098 A AU 6253098A AU 745409 B2 AU745409 B2 AU 745409B2
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
- A61K38/1866—Vascular endothelial growth factor [VEGF]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (7)
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| US3660197P | 1997-01-29 | 1997-01-29 | |
| US60/036601 | 1997-01-29 | ||
| US08/801,352 US5846225A (en) | 1997-02-19 | 1997-02-19 | Gene transfer therapy delivery device and method |
| US08/801352 | 1997-02-19 | ||
| US7115698P | 1998-01-13 | 1998-01-13 | |
| US60/071156 | 1998-01-13 | ||
| PCT/US1998/001638 WO1998032859A1 (en) | 1997-01-29 | 1998-01-29 | Multiple site delivery of adenoviral vector for the induction of angiogenesis |
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| AU6253098A AU6253098A (en) | 1998-08-18 |
| AU745409B2 true AU745409B2 (en) | 2002-03-21 |
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| AU62530/98A Ceased AU745409B2 (en) | 1997-01-29 | 1998-01-29 | Multiple site delivery of adenoviral vector for the induction of angiogenesis |
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| JP (1) | JP2001509168A (enExample) |
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| AT (1) | ATE279518T1 (enExample) |
| AU (1) | AU745409B2 (enExample) |
| BR (1) | BR9806819A (enExample) |
| CA (1) | CA2278621A1 (enExample) |
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| HU (1) | HUP0001964A3 (enExample) |
| IL (1) | IL131021A0 (enExample) |
| MX (1) | MXPA99006993A (enExample) |
| NO (1) | NO993669L (enExample) |
| NZ (1) | NZ336838A (enExample) |
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| US7238673B2 (en) | 1989-03-31 | 2007-07-03 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| ATE279518T1 (de) * | 1997-01-29 | 2004-10-15 | Cornell Res Foundation Inc | An verschiedenen orten verabreichung von adenoviren-vektor zur induzierung von angiogenese |
| US6775574B1 (en) * | 1997-11-07 | 2004-08-10 | Medtronic, Inc. | Method and system for myocardial infarction repair |
| US6458092B1 (en) | 1998-09-30 | 2002-10-01 | C. R. Bard, Inc. | Vascular inducing implants |
| US6251079B1 (en) | 1998-09-30 | 2001-06-26 | C. R. Bard, Inc. | Transthoracic drug delivery device |
| WO2000024415A2 (en) | 1998-10-28 | 2000-05-04 | Cornell Research Foundation, Inc. | Methods for regulating angiogenesis and vascular integrity using trk receptor ligands |
| WO2000047235A2 (en) * | 1999-02-10 | 2000-08-17 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of stimulating angiogenesis |
| US6986784B1 (en) | 1999-05-14 | 2006-01-17 | C. R. Bard, Inc. | Implant anchor systems |
| US6440945B1 (en) * | 1999-05-27 | 2002-08-27 | Instituto Dermopatico Dell'immacolata | Method of inducing angiogenesis in nonis chemic skeletal muscle |
| AU5624500A (en) * | 1999-06-18 | 2001-01-09 | Collaborative Group, Ltd., The | Hyaluronic acid microspheres for sustained gene transfer |
| EP1067190A1 (en) * | 1999-07-09 | 2001-01-10 | Introgene B.V. | Gene therapy for enhancing and/or inducing angiogenesis |
| US6855160B1 (en) | 1999-08-04 | 2005-02-15 | C. R. Bard, Inc. | Implant and agent delivery device |
| AU6521500A (en) | 1999-08-05 | 2001-03-05 | Cornell Research Foundation Inc. | Gene therapy platformed needle and method of administering therapeutic solution to a heart |
| FR2799465B1 (fr) * | 1999-10-12 | 2004-02-13 | Centre Nat Rech Scient | Peptides ayant une activite de stimulation de la reponse immunitaire et de regeneration tissulaire |
| KR20020049031A (ko) * | 1999-11-05 | 2002-06-24 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 생체내 유전자 송달에 의하여 심혈관 질환을 치료하기위한 기술 및 조성물 |
| US6329348B1 (en) * | 1999-11-08 | 2001-12-11 | Cornell Research Foundation, Inc. | Method of inducing angiogenesis |
| US7232421B1 (en) | 2000-05-12 | 2007-06-19 | C. R. Bard, Inc. | Agent delivery systems |
| US6508802B1 (en) | 2000-05-23 | 2003-01-21 | Cornell Research Foundation, Inc. | Remote sensing gene therapy delivery device and method of administering a therapeutic solution to a heart |
| US7204847B1 (en) | 2000-07-28 | 2007-04-17 | C. R. Bard, Inc. | Implant anchor systems |
| US6939540B1 (en) | 2000-07-31 | 2005-09-06 | Cornell Research Foundation, Inc. | Method of enhancing bone density |
| JP2004505619A (ja) * | 2000-08-04 | 2004-02-26 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | 血管内皮増殖因子２ |
| US20040009940A1 (en) * | 2000-10-20 | 2004-01-15 | Coleman Michael E. | Gene delivery formulations and methods for treatment of ischemic conditions |
| EP1330252A4 (en) * | 2000-11-01 | 2007-12-26 | Ludwig Inst Cancer Res | IN VIVO STIMULATION OF ANGIOGENIC ACTIVITY |
| EP1361896A2 (en) * | 2001-01-23 | 2003-11-19 | Boston Scientific Corporation | Localized myocardial injection method for treating ischemic myocardium |
| AR027161A1 (es) | 2001-05-15 | 2003-03-19 | Bio Sidus S A | Metodo para inducir la proliferacion neovascular y regeneracion tisular |
| US20030157064A1 (en) * | 2001-11-09 | 2003-08-21 | Pascal Neuville | Chimeric promoters for controlling expression in muscle cells |
| JP2006514929A (ja) * | 2002-11-15 | 2006-05-18 | ジェンベク、インコーポレイティッド | 冠動脈疾患の治療 |
| JP4667451B2 (ja) | 2004-04-05 | 2011-04-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Ｎｋｇ２ｄの調節 |
| JP5855326B2 (ja) | 2005-01-06 | 2016-02-09 | ノヴォ ノルディスク アー／エス | 抗ｋｉｒ組み合わせ治療および方法 |
| RU2321631C2 (ru) * | 2005-06-24 | 2008-04-10 | Государственное учреждение Российский научный центр хирургии РАМН | Неинфекционный для человека аденовирус как вектор для заместительной генной терапии нарушений ангиогенеза, обеспечивающий эффективный синтез ангиогенина человека в трансфецированных клетках млекопитающих, способ индукции ангиогенеза, способ лечения ишемической болезни, композиция для индукции ангиогенеза и лечения ишемической болезни |
| US7751883B2 (en) | 2006-04-25 | 2010-07-06 | Eugenio Picano | System and method for promoting coronary angiogenesis |
| US9598673B2 (en) * | 2006-05-19 | 2017-03-21 | Creative Medical Health | Treatment of disc degenerative disease |
| US8983570B2 (en) * | 2007-03-27 | 2015-03-17 | Cardiovascular Biotherapeutics, Inc. | Therapeutic angiogenesis for treatment of the spine |
| US11224635B2 (en) | 2007-03-27 | 2022-01-18 | Venturis Thereuptics, Inc. | Therapeutic angiogenesis for treatment of the spine and other tissues |
| AU2008319053B2 (en) | 2007-11-01 | 2012-04-26 | Astellas Pharma Inc. | Immunosuppressive polypeptides and nucleic acids |
| US8088108B2 (en) * | 2009-08-22 | 2012-01-03 | Joseph Wayne Kraft | Rapid local anesthesia injection cone |
| US8409147B2 (en) * | 2009-08-22 | 2013-04-02 | Joseph Wayne Kraft | Rapid local anesthesia linear injection device |
| CN102740894B (zh) * | 2009-08-28 | 2015-07-15 | 克利夫兰临床医学基金会 | 用于治疗缺血组织的sdf-1递送 |
| US20150206302A1 (en) * | 2012-08-30 | 2015-07-23 | Emory University | Systems, methods and computer readable storage media storing instructions for integrating fluoroscopy venogram and myocardial images |
| HRP20240623T1 (hr) * | 2013-01-17 | 2024-08-02 | Medizinische Hochschule Hannover | Faktor 1 protein za uporabu u liječenju ili prevenciji bolesti |
| US11421229B2 (en) | 2015-02-20 | 2022-08-23 | Baylor College Of Medicine | p63 inactivation for the treatment of heart failure |
| CN110381976A (zh) | 2016-12-05 | 2019-10-25 | 努里塔斯有限公司 | 包括肽wkdeagkplvk的组合物 |
| EP3329930A1 (en) | 2016-12-05 | 2018-06-06 | Nuritas Limited | Pharmaceuctical compositions |
| US20240115732A1 (en) * | 2019-10-09 | 2024-04-11 | Xylocor Therapeutics, Inc. | Epicardial Delivery of Gene Therapy |
| WO2024233783A1 (en) | 2023-05-09 | 2024-11-14 | Cornell University | Expression cassette coding for vascular endothelial growth factor |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US510413A (en) | 1893-12-12 | Drainage-tube | ||
| US2551902A (en) | 1948-09-10 | 1951-05-08 | Arthur Schaffer | Dehorning fluid ejector |
| US2670673A (en) | 1950-07-17 | 1954-03-02 | Joyce A Gordon | Fluid injecting device |
| US3467096A (en) | 1966-04-12 | 1969-09-16 | Ferrell S Horn | Multiple hypodermic syringe arrangement |
| FR1584474A (enExample) | 1968-02-20 | 1969-12-26 | ||
| US3572336A (en) | 1968-04-30 | 1971-03-23 | Daniel R Hershberg | Syringe |
| US4150669A (en) | 1977-03-16 | 1979-04-24 | Alvaro Latorre | Apparatus for effecting and enhancing an erection |
| US4167179A (en) | 1977-10-17 | 1979-09-11 | Mark Kirsch | Planar radioactive seed implanter |
| US5335670A (en) | 1986-04-18 | 1994-08-09 | Henry Fishman | Allergy testing method and apparatus |
| JPS6438100A (en) | 1987-07-31 | 1989-02-08 | Toray Industries | Vascular endothelial cell growth factor |
| JPH02117698A (ja) | 1988-10-27 | 1990-05-02 | Toray Ind Inc | 血管内皮細胞成長因子 |
| US5240848A (en) | 1988-11-21 | 1993-08-31 | Monsanto Company | Dna sequences encoding human vascular permeability factor having 189 amino acids |
| JPH02279698A (ja) | 1989-04-20 | 1990-11-15 | M K Medical:Kk | 血管内皮細胞成長因子及びその製造方法 |
| US5332671A (en) | 1989-05-12 | 1994-07-26 | Genetech, Inc. | Production of vascular endothelial cell growth factor and DNA encoding same |
| DE69024261T2 (de) | 1989-05-24 | 1996-07-18 | Merck & Co Inc | Reinigung und Charakterisierung eines von einem Glioma abstammenden Wachstumsfaktors |
| US5219739A (en) * | 1989-07-27 | 1993-06-15 | Scios Nova Inc. | DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121 |
| JPH03178996A (ja) | 1989-12-06 | 1991-08-02 | Makoto Goto | 成長因子 |
| US6228844B1 (en) * | 1991-11-12 | 2001-05-08 | Vical Incorporated | Stimulating vascular growth by administration of DNA sequences encoding VEGF |
| EP0476983B1 (en) | 1990-09-21 | 2000-03-15 | Merck & Co. Inc. | Vascular endothelial cell growth factor II |
| EP0506477B1 (en) | 1991-03-28 | 1999-06-23 | Merck & Co. Inc. | Vascular endothelial cell growth factor C subunit |
| US5244460A (en) | 1991-11-27 | 1993-09-14 | The United States Of America As Represented By The Department Of Health And Human Services | Method to foster myocardial blood vessel growth and improve blood flow to the heart |
| EP0550296A3 (en) | 1991-11-28 | 1993-12-29 | Terumo Corp | Vascular endothelial cells growth factor |
| US5290258A (en) | 1992-07-27 | 1994-03-01 | Genesis Industries, Inc. | Syringe for administering sequentially multiple doses of a medicament |
| US5273525A (en) | 1992-08-13 | 1993-12-28 | Btx Inc. | Injection and electroporation apparatus for drug and gene delivery |
| US6177401B1 (en) * | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
| DK0751992T3 (da) | 1994-03-08 | 2006-03-06 | Human Genome Sciences Inc | Karendotelvækstfaktor 2 |
| US5851806A (en) * | 1994-06-10 | 1998-12-22 | Genvec, Inc. | Complementary adenoviral systems and cell lines |
| US5417683A (en) | 1994-07-13 | 1995-05-23 | Shiao; I-Shen | Mini-graft hair implanting device for implanting multiple clumps of hair follicles at one time |
| EP0804076A4 (en) * | 1994-10-19 | 1998-10-21 | Genetic Therapy Inc | GENTHERAPY THROUGH SIMULTANEOUS AND REPEATED ADMINISTRATION OF ADENOVIRUS AND IMMUNE SUPPRESSIVES |
| US5792453A (en) * | 1995-02-28 | 1998-08-11 | The Regents Of The University Of California | Gene transfer-mediated angiogenesis therapy |
| JP3178996B2 (ja) | 1995-08-24 | 2001-06-25 | 沖電気工業株式会社 | カード処理装置及びカード送り速度の制御方法 |
| US6121246A (en) | 1995-10-20 | 2000-09-19 | St. Elizabeth's Medical Center Of Boston, Inc. | Method for treating ischemic tissue |
| ATE279518T1 (de) * | 1997-01-29 | 2004-10-15 | Cornell Res Foundation Inc | An verschiedenen orten verabreichung von adenoviren-vektor zur induzierung von angiogenese |
| US5846225A (en) | 1997-02-19 | 1998-12-08 | Cornell Research Foundation, Inc. | Gene transfer therapy delivery device and method |
| JP3371331B2 (ja) * | 1998-12-14 | 2003-01-27 | セイコーエプソン株式会社 | インクジェット式記録ヘッドおよびその製造方法 |
-
1998
- 1998-01-29 AT AT98904730T patent/ATE279518T1/de not_active IP Right Cessation
- 1998-01-29 DE DE69827021T patent/DE69827021T2/de not_active Expired - Fee Related
- 1998-01-29 WO PCT/US1998/001638 patent/WO1998032859A1/en not_active Ceased
- 1998-01-29 CA CA002278621A patent/CA2278621A1/en not_active Abandoned
- 1998-01-29 NZ NZ336838A patent/NZ336838A/en unknown
- 1998-01-29 KR KR1019997006818A patent/KR20000070572A/ko not_active Withdrawn
- 1998-01-29 JP JP53224998A patent/JP2001509168A/ja not_active Ceased
- 1998-01-29 MX MXPA99006993A patent/MXPA99006993A/es unknown
- 1998-01-29 HU HU0001964A patent/HUP0001964A3/hu unknown
- 1998-01-29 PL PL98334902A patent/PL334902A1/xx unknown
- 1998-01-29 IL IL13102198A patent/IL131021A0/xx unknown
- 1998-01-29 AU AU62530/98A patent/AU745409B2/en not_active Ceased
- 1998-01-29 EP EP98904730A patent/EP1012291B1/en not_active Expired - Lifetime
- 1998-01-29 BR BR9806819-9A patent/BR9806819A/pt not_active IP Right Cessation
-
1999
- 1999-07-19 US US09/357,010 patent/US6518255B2/en not_active Expired - Lifetime
- 1999-07-28 NO NO993669A patent/NO993669L/no not_active Application Discontinuation
-
2003
- 2003-01-14 US US10/341,679 patent/US20030103943A1/en not_active Abandoned
Non-Patent Citations (3)
| Title |
|---|
| MAGOVERN C.J. ET AL 1997 HUMAN GENE THERAPY.8:215-227 * |
| MAGOVERN ET AL 1996. THE ANNALS OF THORACIC SURG.62:425-434 * |
| MUHLHAUSER ET AL 1995. CIRCULATION RESEARCH.77(1):1077-1086 * |
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| EP1012291A1 (en) | 2000-06-28 |
| KR20000070572A (ko) | 2000-11-25 |
| US6518255B2 (en) | 2003-02-11 |
| HUP0001964A2 (hu) | 2000-10-28 |
| AU6253098A (en) | 1998-08-18 |
| BR9806819A (pt) | 2000-05-09 |
| DE69827021D1 (de) | 2004-11-18 |
| EP1012291B1 (en) | 2004-10-13 |
| WO1998032859A1 (en) | 1998-07-30 |
| PL334902A1 (en) | 2000-03-27 |
| US20030103943A1 (en) | 2003-06-05 |
| NZ336838A (en) | 2002-04-26 |
| NO993669D0 (no) | 1999-07-28 |
| CA2278621A1 (en) | 1998-07-30 |
| MXPA99006993A (es) | 2005-06-01 |
| IL131021A0 (en) | 2001-01-28 |
| HUP0001964A3 (en) | 2002-01-28 |
| ATE279518T1 (de) | 2004-10-15 |
| NO993669L (no) | 1999-09-27 |
| US20010041679A1 (en) | 2001-11-15 |
| DE69827021T2 (de) | 2005-02-24 |
| JP2001509168A (ja) | 2001-07-10 |
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