DE69826124D1 - Verabreichung der nukleinsäure in den quergestreiften muskel - Google Patents
Verabreichung der nukleinsäure in den quergestreiften muskelInfo
- Publication number
- DE69826124D1 DE69826124D1 DE69826124T DE69826124T DE69826124D1 DE 69826124 D1 DE69826124 D1 DE 69826124D1 DE 69826124 T DE69826124 T DE 69826124T DE 69826124 T DE69826124 T DE 69826124T DE 69826124 D1 DE69826124 D1 DE 69826124D1
- Authority
- DE
- Germany
- Prior art keywords
- nucleic acid
- molecule
- administration
- muscle cell
- sup
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
- A61N1/0416—Anode and cathode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9708233 | 1997-06-30 | ||
FR9708233A FR2765242B1 (fr) | 1997-06-30 | 1997-06-30 | Amelioration du transfert d'acide nucleique dans le muscle strie et combinaison permettant la mise en oeuvre du procede |
US6748897P | 1997-12-01 | 1997-12-01 | |
US67488P | 1997-12-01 | ||
PCT/FR1998/001400 WO1999001158A1 (fr) | 1997-06-30 | 1998-06-30 | Amelioration du transfert d'acide nucleique dans le muscle strie et combinaison permettant la mise en oeuvre du procede |
Publications (3)
Publication Number | Publication Date |
---|---|
DE69826124D1 true DE69826124D1 (de) | 2004-10-14 |
DE69826124T2 DE69826124T2 (de) | 2005-09-15 |
DE69826124T3 DE69826124T3 (de) | 2007-10-11 |
Family
ID=26233648
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69826124T Expired - Lifetime DE69826124T3 (de) | 1997-06-30 | 1998-06-30 | Verabreichung der nukleinsäure in den quergestreiften muskel |
Country Status (16)
Country | Link |
---|---|
US (1) | US6939862B2 (de) |
EP (1) | EP0991426B2 (de) |
JP (1) | JP2002507985A (de) |
KR (1) | KR20010020571A (de) |
CN (1) | CN1261807A (de) |
AT (1) | ATE275423T1 (de) |
AU (1) | AU8444798A (de) |
BR (1) | BR9810369A (de) |
CA (1) | CA2294793A1 (de) |
CZ (1) | CZ299473B6 (de) |
DE (1) | DE69826124T3 (de) |
HU (1) | HUP0004589A3 (de) |
IL (1) | IL133710A0 (de) |
NO (1) | NO328102B1 (de) |
PL (1) | PL337583A1 (de) |
WO (1) | WO1999001158A1 (de) |
Families Citing this family (131)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9810372A (pt) * | 1997-06-30 | 2000-09-05 | Rhone Poulenc Rorer Sa | Processo de transferência de ácido nucléico para o interior de células de organismos eucarióticos pluricelulares in vivo, composição, ácido nucléico e campo elétrico, e, produto de combinação |
US20090239940A1 (en) * | 1997-07-22 | 2009-09-24 | Del Monte Federica | Treating heart failure and ventricular arrhythmias |
US6800484B2 (en) | 1998-06-24 | 2004-10-05 | Genetronics, Inc. | High efficiency transfection based on low electric field strength, long pulse length |
WO2001000856A1 (en) * | 1999-06-25 | 2001-01-04 | Genetronics, Inc. | High efficiency transfection based on low electric field strength, long pulse length |
US7922709B2 (en) | 1998-07-13 | 2011-04-12 | Genetronics, Inc. | Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation |
US6678556B1 (en) * | 1998-07-13 | 2004-01-13 | Genetronics, Inc. | Electrical field therapy with reduced histopathological change in muscle |
WO2001068131A1 (en) | 2000-03-13 | 2001-09-20 | Cornell Research Foundation, Inc. | Blocking leukocyte emigration and inflammation by interfering with cd99/hec2 |
US7416726B2 (en) | 2000-04-13 | 2008-08-26 | The Rockefeller University | Enhancement of antibody-mediated immune responses |
AU6475901A (en) | 2000-05-22 | 2001-12-03 | Merck And Company Inc | System and method for assessing the performance of a pharmaceutical agent delivery system |
WO2002040093A2 (en) | 2000-11-17 | 2002-05-23 | Gendel Limited | Ablation of cells using combined electric field and ultrasound therapy |
US6821274B2 (en) | 2001-03-07 | 2004-11-23 | Gendel Ltd. | Ultrasound therapy for selective cell ablation |
AU2002227450B2 (en) | 2000-12-28 | 2008-02-28 | Wyeth | Recombinant protective protein from $I(streptococcus pneumoniae) |
DK1499349T3 (da) | 2001-03-02 | 2010-04-06 | Univ Rockefeller | Rekombinante hybrid-allergenkonstrukter med reduceret allergenitet, der bibeholder det naterulige allergens immunogenitet |
US20040023910A1 (en) * | 2001-09-28 | 2004-02-05 | Zhiming Zhang | Use of cyr61 in the treatment and diagnosis of human uterine leiomyomas |
MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
JP2005518904A (ja) | 2002-03-07 | 2005-06-30 | マーク アンド カンパニー インコーポレイテッド | 電気的刺激の側面を備えた臨床用注射器 |
JP2005526579A (ja) | 2002-05-23 | 2005-09-08 | ジェンデル・リミテッド | 焼灼デバイス |
CA2484000A1 (en) | 2002-05-24 | 2003-12-04 | Schering Corporation | Neutralizing human anti-igfr antibody |
US7785608B2 (en) | 2002-08-30 | 2010-08-31 | Wyeth Holdings Corporation | Immunogenic compositions for the prevention and treatment of meningococcal disease |
US7468273B2 (en) | 2003-05-01 | 2008-12-23 | Meial Limited | Canine GHRH gene, polypeptides and methods of use |
WO2005023292A1 (en) | 2003-09-03 | 2005-03-17 | The General Hospital Corporation | Methods of treating restenosis |
CA2562699C (en) | 2004-04-16 | 2015-07-21 | Critical Care Innovations, Inc. | Systems and methods for improving image-guided tissue ablation |
FR2880808A1 (fr) * | 2005-01-20 | 2006-07-21 | Yves Scherman | Dispositif pour l'administration de principe actif aux cellules et tissus a l'aide d'electrodes de surface non invasives |
US7923251B2 (en) * | 2005-02-23 | 2011-04-12 | The Board Of Trustees Of The Leland Stanford Junior University | Method and apparatus for avalanche-mediated transfer of agents into cells |
US8101169B2 (en) * | 2005-02-23 | 2012-01-24 | The Board Of Trustees Of The Leland Stanford Junior University | Ocular gene therapy using avalanche-mediated transfection |
ES2343270T3 (es) | 2005-04-25 | 2010-07-27 | Merial Ltd. | Vacunas contra el virus nipah. |
CN101437539B (zh) | 2005-07-05 | 2013-10-02 | 康奈尔研究基金会(有限公司) | 通过干扰cd99l2阻断白细胞迁出和炎症 |
FR2889066B1 (fr) * | 2005-07-28 | 2007-11-09 | Centre Nat Rech Scient | Procede d'immunisation genetique par electrotransfert contre une toxine et antiserum susceptible d'etre obtenu par ledit procede |
US20080241184A1 (en) | 2005-08-25 | 2008-10-02 | Jules Maarten Minke | Canine influenza vaccines |
US7771995B2 (en) | 2005-11-14 | 2010-08-10 | Merial Limited | Plasmid encoding human BMP-7 |
CA2629522A1 (en) | 2005-11-14 | 2007-05-18 | Merial Limited | Gene therapy for renal failure |
JP5238710B2 (ja) | 2006-10-19 | 2013-07-17 | シーエスエル、リミテッド | インターロイキン−13レセプターアルファ1の高親和性抗体アンタゴニスト |
US8613925B2 (en) | 2006-10-19 | 2013-12-24 | Csl Limited | Anti-IL-13Rα1 antibodies and their uses thereof |
AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
AU2007352618B2 (en) | 2007-05-02 | 2013-07-18 | Boehringer Ingelheim Animal Health USA Inc. | DNA plasmids having improved expression and stability |
CN102016023A (zh) | 2008-04-04 | 2011-04-13 | 宾夕法尼亚州立大学托管会 | 使用il-28和组合物的疫苗和免疫治疗及其使用方法 |
US8093043B2 (en) | 2008-06-04 | 2012-01-10 | New York University | β-TrCP1, β-TrCP2 and RSK1 or RSK2 inhibitors and methods for sensitizing target cells to apoptosis |
EP2147697A1 (de) | 2008-07-21 | 2010-01-27 | Centre National De La Recherche Scientifique-CNRS | Verfahren und Vorrichtung zur Anwendung elektrischer Felder in leitfähiges Material |
EP2156860A1 (de) | 2008-08-20 | 2010-02-24 | Centre National De La Recherche Scientifique-CNRS | Verfahren zur Herstellung isolierter Elektroden zum Einfügen elektrischer Felder in ein leitfähiges Material |
BRPI0921286B8 (pt) | 2008-11-05 | 2022-10-25 | Wyeth Llc | Composição imunogênica com múltiplos componentes para a prevenção de doença por estreptococos beta-hemolíticos (bhs). |
MY159543A (en) | 2008-11-28 | 2017-01-13 | Merial Inc | Recombinant avian influenza vaccine and uses thereof |
AU2010291900A1 (en) | 2009-09-14 | 2012-03-22 | The Trustees Of The University Of Pennsylvania | Vaccines and immunotherapeutics comprising IL-15 receptor alpha and/or nucleic acid molecules encoding the same, and methods for using the same |
CN102712931A (zh) | 2009-11-02 | 2012-10-03 | 宾夕法尼亚大学托管会 | 口蹄疫病毒病毒(fmdv)共有蛋白质、其编码序列及由其制备的疫苗 |
CN103260643A (zh) | 2009-12-28 | 2013-08-21 | 梅里亚有限公司 | 重组ndv抗原及其用途 |
US8298820B2 (en) | 2010-01-26 | 2012-10-30 | The Trustees Of The University Of Pennsylvania | Influenza nucleic acid molecules and vaccines made therefrom |
CN102781952B (zh) | 2010-02-08 | 2015-09-02 | 宾夕法尼亚大学托管会 | 编码rantes的核酸分子、包含其的组合物以及其使用方法 |
US20130197612A1 (en) | 2010-02-26 | 2013-08-01 | Jack W. Lasersohn | Electromagnetic Radiation Therapy |
CN103492410A (zh) | 2010-03-12 | 2014-01-01 | 梅里亚有限公司 | 蓝舌病毒重组疫苗和其使用 |
PL3246044T3 (pl) | 2010-08-23 | 2021-08-23 | Wyeth Llc | Stabilne preparaty antygenów rLP2086 Neisseria meningitidis |
ES2728282T3 (es) | 2010-09-10 | 2019-10-23 | Wyeth Llc | Variantes no lipidadas de antígenos ORF2086 de Neisseria meningitidis |
KR20180096814A (ko) | 2010-09-27 | 2018-08-29 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 공통 항원 구성체 및 이것으로부터 만들어진 백신 및 말라리아를 치료하기 위한 이것의 사용방법 |
BR112013011705B1 (pt) | 2010-11-12 | 2022-04-05 | The Trustees Of The University Of Pennsylvania | Antígenos de próstata de consenso, molécula de ácido nucleico quecodifica os mesmos e vacina e usos compreendendo os mesmos |
US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
CA2821515A1 (en) | 2010-12-01 | 2012-06-07 | Alder Biopharmaceuticals, Inc. | Anti-ngf compositions and use thereof |
US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
CA2826199A1 (en) | 2011-01-31 | 2012-08-09 | The Trustees Of The University Of Pennsylvania | Nucleic acid molecules encoding novel herpes antigens, vaccine comprising the same, and methods of use thereof |
EA037377B1 (ru) | 2011-02-11 | 2021-03-22 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Вакцина для индукции иммунного ответа на hbv |
US9238679B2 (en) | 2011-02-11 | 2016-01-19 | The Trustees Of The University Of Pennslyvania | Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same |
US20120301479A1 (en) | 2011-05-27 | 2012-11-29 | Jean-Christophe Audonnet | Hendra virus recombinant compositions and uses thereof |
CA2837375C (en) | 2011-06-01 | 2019-07-16 | Merial Limited | Needle-free administration of prrsv vaccines |
CN103687625B (zh) | 2011-07-11 | 2017-06-13 | 艾诺奥医药品有限公司 | 交叉保护性沙粒病毒疫苗及其使用方法 |
JP6333730B2 (ja) | 2011-12-12 | 2018-05-30 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 改善されたil−12遺伝子構築物を含む組成物、及びそれを用いたワクチン、免疫治療剤及び方法 |
US9750795B2 (en) | 2011-12-12 | 2017-09-05 | The Trustees Of The University Of Pennsylvania | Proteins comprising MRSA PBP2a and fragments thereof, nucleic acids encoding the same, and compositions and their use to prevent and treat MRSA infections |
CN104203274B (zh) | 2012-02-14 | 2017-09-08 | 梅里亚股份有限公司 | 轮状病毒亚单位疫苗及其制备和使用的方法 |
WO2013123242A1 (en) | 2012-02-14 | 2013-08-22 | Merial Limited | Recombinant poxviral vectors expressing both rabies and ox40 proteins, and vaccines made therefrom |
EP3485906A1 (de) | 2012-03-09 | 2019-05-22 | Pfizer Inc | Neisseria meningitidis-zusammensetzungen und verfahren dafür |
SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
KR20190100431A (ko) | 2012-03-22 | 2019-08-28 | 메리얼 인코포레이티드 | 개질된 마렉병 바이러스, 및 이로부터 제조된 백신 |
US10040828B2 (en) | 2012-04-10 | 2018-08-07 | The Trustees Of The University Of Pennsylvania | Human respiratory syncytial virus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same |
JP6389163B2 (ja) | 2012-04-12 | 2018-09-12 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | フィロウイルスコンセンサス抗原、核酸構築物、およびそれから作製されるワクチン、ならびにその使用方法 |
CA2876196C (en) | 2012-06-13 | 2021-09-21 | Merial Limited | Reassortant btv vaccines |
JP6523174B2 (ja) | 2012-12-13 | 2019-05-29 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | Wt1ワクチン |
WO2014107739A1 (en) | 2013-01-07 | 2014-07-10 | Eleven Biotherapeutics, Inc. | Antibodies against pcsk9 |
WO2014136064A2 (en) | 2013-03-08 | 2014-09-12 | Pfizer Inc. | Immunogenic fusion polypeptides |
US9993545B2 (en) | 2013-03-15 | 2018-06-12 | The Trustees Of The University Of Pennsylvania | Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom |
EA034110B1 (ru) | 2013-03-15 | 2019-12-27 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Противораковые вакцины и способы лечения с их применением |
DK3028048T3 (en) | 2013-07-31 | 2019-01-21 | Bioventures Llc | COMPOSITIONS FOR TREATMENT AND PREVENTION OF CANCER TARGETING AGAINST TUMOR-ASSOCIATED CARBOHYDRATE ANTIGEN |
KR20210002757A (ko) | 2013-09-08 | 2021-01-08 | 화이자 인코포레이티드 | 나이세리아 메닌지티디스 조성물 및 그의 방법 |
SG11201604719WA (en) | 2013-12-13 | 2016-07-28 | Univ Pennsylvania | Dna antibody constructs and method of using same |
BR112017011556A2 (pt) | 2014-12-01 | 2018-03-06 | Inovio Pharmaceuticals Inc | métodos para gerar um anticorpo sintético, prevenir ou tratar uma doença, tratar um sujeito de infecção por um patógeno e um sujeito com câncer, produto, molécula de ácido nucleico, e, composição. |
MX2017010705A (es) | 2015-02-19 | 2017-12-04 | Pfizer | Composiciones de neisseria meningitidis y metodos de la misma. |
KR20180041724A (ko) | 2015-08-20 | 2018-04-24 | 메리얼 인코포레이티드 | Fcv 재조합 백신 및 그의 용도 |
FI3355915T3 (fi) | 2015-09-29 | 2024-01-12 | Boehringer Ingelheim Animal Health Usa Inc | Koirien parvoviruksen (CPV) viruksen kaltaisten hiukkasten (VLP) rokotteet ja niiden käytöt |
RU2714428C2 (ru) | 2015-11-23 | 2020-02-14 | Мериал, Инк. | Слитые белки fmdv-e2 и их применение |
TWI760322B (zh) | 2016-01-29 | 2022-04-11 | 美商百靈佳殷格翰動物保健美國有限公司 | 重組腺病毒載體裝載之fmdv疫苗及其用途 |
WO2017136758A1 (en) | 2016-02-05 | 2017-08-10 | Inovio Pharmaceuticals, Inc. | Cancer vaccines and methods of treatment using the same |
WO2017180770A1 (en) | 2016-04-13 | 2017-10-19 | Synthetic Genomics, Inc. | Recombinant arterivirus replicon systems and uses thereof |
EP3526332A1 (de) | 2016-10-17 | 2019-08-21 | Synthetic Genomics, Inc. | Rekombinante virus-replikon-systeme und verwendungen davon |
BR112019011661A2 (pt) | 2016-12-05 | 2020-01-07 | Synthetic Genomics, Inc. | Composições e métodos para aumentar expressão de gene |
IL303108B1 (en) | 2017-01-31 | 2024-03-01 | Pfizer | NEISSERIA MENINGITIDIS preparations and methods therefor |
US11235044B2 (en) | 2017-12-13 | 2022-02-01 | Inovio Pharmaceuticals, Inc. | Cancer vaccines targeting MUC16 and uses thereof |
HUE061198T2 (hu) | 2017-12-13 | 2023-05-28 | Inovio Pharmaceuticals Inc | A PRAME-t célzó rákvakcinák és alkalmazásaik |
EP3723810A4 (de) | 2017-12-13 | 2022-02-23 | Inovio Pharmaceuticals, Inc. | Gegen mesothelin gerichtete krebsvakzine und deren verwendungen |
EA202091516A1 (ru) | 2017-12-19 | 2020-11-03 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Способы и композиции для индукции иммунного ответа против вируса гепатита b (hbv) |
US11389531B2 (en) | 2017-12-19 | 2022-07-19 | Janssen Sciences Ireland Unlimited Company | Methods and apparatus for the delivery of hepatitis B virus (HBV) vaccines |
ES2963179T3 (es) | 2017-12-19 | 2024-03-25 | Janssen Sciences Ireland Unlimited Co | Vacunas contra el virus de la hepatitis b (VHB) y usos de las mismas |
MA51312A (fr) | 2017-12-19 | 2020-10-28 | Bavarian Nordic As | Méthodes et compositions permettant d'induire une réponse immunitaire contre le virus de l'hépatite b (vhb) |
EA202091513A1 (ru) | 2017-12-19 | 2020-09-09 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Вакцины против вируса гепатита b (hbv) и их применение |
AU2019210189A1 (en) | 2018-01-19 | 2020-08-06 | Janssen Pharmaceuticals, Inc. | Induce and enhance immune responses using recombinant replicon systems |
WO2020255038A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and pyridopyrimidine derivatives |
CA3143634A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and anti-pd-1 antibody |
CA3141238A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Hepatitis b virus (hbv) vaccines and uses thereof |
WO2020255042A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and a pyrimidine derivative |
WO2020255019A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and a quinazoline derivative |
WO2020254876A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Virus-like particle delivery of hepatitis b virus (hbv) vaccines |
WO2020255021A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and small molecule pdl1 or pd1 inhibitor |
CA3143680A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and anti-pd-1 or anti-pd-l1 antibody |
CA3141003A1 (en) | 2019-06-18 | 2020-12-24 | Helen Horton | Combination of hepatitis b virus (hbv) vaccines and pd-l1 inhibitors |
WO2020255013A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and capsid assembly modulators being amide derivatives |
WO2020255016A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators |
US20220305107A1 (en) | 2019-06-18 | 2022-09-29 | Janssen Sciences Ireland Unlimited Company | COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND HBV-TARGETING RNAi |
US20220233526A1 (en) | 2019-06-18 | 2022-07-28 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators |
CN114340664A (zh) | 2019-06-18 | 2022-04-12 | 爱尔兰詹森科学公司 | 乙型肝炎病毒(HBV)疫苗和靶向HBV的RNAi的组合 |
WO2020255010A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of recombinant interleukin 12 construct and hepatitis b virus (hbv) vaccines |
CA3140707A1 (en) | 2019-06-18 | 2020-12-24 | Helen Horton | Combination of hepatitis b virus (hbv) vaccines and quinazoline derivatives |
EP3986915A1 (de) | 2019-06-18 | 2022-04-27 | Janssen Sciences Ireland Unlimited Company | Konstrukt aus rekombinantem interleukin 12 und verwendungen davon |
TWI772823B (zh) | 2019-06-18 | 2022-08-01 | 愛爾蘭商健生科學愛爾蘭無限公司 | B型肝炎病毒(hbv)疫苗與蛋白殼組裝調節劑之組合 |
US20220249647A1 (en) | 2019-06-18 | 2022-08-11 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators |
WO2020255035A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and pyrimidine derivatives |
WO2020255022A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and aminopyridine derivatives as hpk1 inhibitors |
CA3143627A1 (en) | 2019-06-20 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Carbohydrate nanocarrier delivery of hepatitis b virus (hbv) vaccines |
US20220305108A1 (en) | 2019-06-20 | 2022-09-29 | Janssen Sciences Ireland Unlimited Company | Lipid nanoparticle or liposome delivery of hepatitis b virus (hbv) vaccines |
JP2023533174A (ja) | 2020-06-12 | 2023-08-02 | ユニバーシティ オブ ロチェスター | ACE-tRNAのコード化及び発現 |
CA3188801A1 (en) | 2020-07-08 | 2022-01-13 | Janssen Sciences Ireland Unlimited Company | Rna replicon vaccines against hbv |
TW202245809A (zh) | 2020-12-18 | 2022-12-01 | 美商詹森藥物公司 | 用於治療b型肝炎病毒感染之組合療法 |
WO2022146654A1 (en) | 2020-12-28 | 2022-07-07 | Janssen Pharmaceuticals, Inc. | Transcription activator-like effector nucleases (talens) targeting hbv |
WO2023150753A1 (en) | 2022-02-07 | 2023-08-10 | University Of Rochester | Optimized sequences for enhanced trna expression or/and nonsense mutation suppression |
WO2023233290A1 (en) | 2022-05-31 | 2023-12-07 | Janssen Sciences Ireland Unlimited Company | Rnai agents targeting pd-l1 |
Family Cites Families (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4301794A (en) | 1978-10-18 | 1981-11-24 | Robert Tapper | Method for iontophoretic treatment |
US4411657A (en) | 1980-05-19 | 1983-10-25 | Anibal Galindo | Hypodermic needle |
JPS5810066A (ja) | 1981-07-10 | 1983-01-20 | 株式会社アドバンス | イオントフオレ−ゼ用プラスタ−構造体 |
US4476004A (en) | 1983-04-08 | 1984-10-09 | D.E.P. Systems, Inc. | Apparatus for electrofusion of biological particles |
US4441972A (en) | 1983-04-08 | 1984-04-10 | D.E.P. Systems, Inc. | Apparatus for electrofusion of biological particles |
US4639244A (en) | 1983-05-03 | 1987-01-27 | Nabil I. Rizk | Implantable electrophoretic pump for ionic drugs and associated methods |
DE3317415A1 (de) | 1983-05-13 | 1984-11-15 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Kammer zur behandlung von zellen im elektrischen feld |
US4557723A (en) | 1983-08-18 | 1985-12-10 | Drug Delivery Systems Inc. | Applicator for the non-invasive transcutaneous delivery of medicament |
US4622031A (en) | 1983-08-18 | 1986-11-11 | Drug Delivery Systems Inc. | Indicator for electrophoretic transcutaneous drug delivery device |
ATE198350T1 (de) | 1983-10-20 | 2001-01-15 | Univ New York State Res Found | Regulierung der genexpression durch translationshemmung unter verwendung einer m-rns behindernden komplementären rns |
US4578168A (en) | 1984-07-27 | 1986-03-25 | Biotronics | Apparatus for fusing live cells with electric fields |
FR2573436B1 (fr) | 1984-11-20 | 1989-02-17 | Pasteur Institut | Adn recombinant comportant une sequence nucleotidique codant pour un polypeptide determine sous le controle d'un promoteur d'adenovirus, vecteurs contenant cet adn recombinant, cellules eucaryotes transformees par cet adn recombinant, produits d'excretion de ces cellules transformees et leurs applications, notamment a la constitution de vaccins |
US6696420B1 (en) | 1984-11-20 | 2004-02-24 | Institut Pasteur | Adenoviral vector with a deletion in the E1A coding region expressing a hetorologous protein |
US4663292A (en) | 1984-12-21 | 1987-05-05 | Wong Daniel T | High-voltage biological macromolecule transfer and cell fusion system |
US4702732A (en) | 1984-12-24 | 1987-10-27 | Trustees Of Boston University | Electrodes, electrode assemblies, methods, and systems for tissue stimulation and transdermal delivery of pharmacologically active ligands |
AT385894B (de) | 1985-10-04 | 1988-05-25 | Basem Dr Nashef | Schlauchfoermige sonde |
US5049488A (en) | 1985-11-08 | 1991-09-17 | Genentech, Inc. | Method and nucleic acid for the preparation of lecithin:cholesterol acyltransferase |
US4695547A (en) | 1986-04-02 | 1987-09-22 | Jeffrey L. Hilliard | Probe for electrofusion, electroporation, or like procedure |
FR2602790B1 (fr) | 1986-08-13 | 1990-06-01 | Transgene Sa | Expression d'un antigene specifique de tumeur par un virus vecteur recombinant et utilisation de celui-ci pour le traitement preventif ou curatif de la tumeur correspondante |
US5744133A (en) | 1986-08-13 | 1998-04-28 | Transgene S.A. | Expression of a tumor-specific antigen by a recombinant vector virus and use thereof in preventitive or curative treatment of the corresponding tumor |
US6007806A (en) | 1986-08-13 | 1999-12-28 | Transgene S.A. | Expression of a tumor-specific antigen by a recombinant vector virus and use thereof in preventive or curative treatment of the corresponding tumor |
US4786277A (en) | 1986-11-21 | 1988-11-22 | Trustees Of Boston University | Electrodes, electrode assemblies, methods, and systems for tissue stimulation |
US5371003A (en) | 1987-05-05 | 1994-12-06 | Sandoz Ltd. | Electrotransformation process |
US5128257A (en) | 1987-08-31 | 1992-07-07 | Baer Bradford W | Electroporation apparatus and process |
US4970154A (en) | 1987-10-09 | 1990-11-13 | Baylor College Of Medicine | Method for inserting foreign genes into cells using pulsed radiofrequency |
EP0640688A1 (de) | 1987-12-15 | 1995-03-01 | Gene Shears Pty. Limited | Ribozyme |
US5389069A (en) | 1988-01-21 | 1995-02-14 | Massachusetts Institute Of Technology | Method and apparatus for in vivo electroporation of remote cells and tissue |
US5749847A (en) | 1988-01-21 | 1998-05-12 | Massachusetts Institute Of Technology | Delivery of nucleotides into organisms by electroporation |
US5547467A (en) | 1988-01-21 | 1996-08-20 | Massachusettes Institute Of Technology | Method for rapid temporal control of molecular transport across tissue |
JP2798459B2 (ja) | 1988-01-21 | 1998-09-17 | マサチユセツツ・インスチチユート・オブ・テクノロジー | エレクトロポレーションを利用した診断装置及び分子の組織内移動装置 |
US5693622A (en) * | 1989-03-21 | 1997-12-02 | Vical Incorporated | Expression of exogenous polynucleotide sequences cardiac muscle of a mammal |
US5119832A (en) | 1989-07-11 | 1992-06-09 | Ravi Xavier | Epidural catheter with nerve stimulators |
US5124259A (en) | 1989-08-23 | 1992-06-23 | Mitsui Toatsu Chemicals, Inc. | Method for electroporation |
US6228844B1 (en) * | 1991-11-12 | 2001-05-08 | Vical Incorporated | Stimulating vascular growth by administration of DNA sequences encoding VEGF |
US5236413B1 (en) | 1990-05-07 | 1996-06-18 | Andrew J Feiring | Method and apparatus for inducing the permeation of medication into internal tissue |
US5081990A (en) | 1990-05-11 | 1992-01-21 | New York University | Catheter for spinal epidural injection of drugs and measurement of evoked potentials |
US5499971A (en) | 1990-06-15 | 1996-03-19 | Cortrak Medical, Inc. | Method for iontophoretically delivering drug adjacent to a heart |
DE69110467T2 (de) | 1990-06-15 | 1996-02-01 | Cortrak Medical Inc | Vorrichtung zur abgabe von medikamenten. |
FR2681786A1 (fr) | 1991-09-27 | 1993-04-02 | Centre Nat Rech Scient | Vecteurs recombinants d'origine virale, leur procede d'obtention et leur utilisation pour l'expression de polypeptides dans des cellules musculaires. |
FR2688514A1 (fr) | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant. |
US5501662A (en) | 1992-05-22 | 1996-03-26 | Genetronics, Inc. | Implantable electroporation method and apparatus for drug and gene delivery |
US5814603A (en) | 1992-06-12 | 1998-09-29 | Affymax Technologies N.V. | Compounds with PTH activity |
US5607691A (en) | 1992-06-12 | 1997-03-04 | Affymax Technologies N.V. | Compositions and methods for enhanced drug delivery |
JPH063783A (ja) | 1992-06-19 | 1994-01-14 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
US5304120A (en) | 1992-07-01 | 1994-04-19 | Btx Inc. | Electroporation method and apparatus for insertion of drugs and genes into endothelial cells |
JP3099049B2 (ja) * | 1992-07-29 | 2000-10-16 | 農林水産省果樹試験場長 | 電気的細胞融合及び電気的核酸導入のための大量処理用電極 |
US5273525A (en) * | 1992-08-13 | 1993-12-28 | Btx Inc. | Injection and electroporation apparatus for drug and gene delivery |
US5462520A (en) | 1992-08-17 | 1995-10-31 | Genetronics, Inc. | Transsurface drug delivery by electrofusion of microbubbles to the tissue surface |
US5318514A (en) | 1992-08-17 | 1994-06-07 | Btx, Inc. | Applicator for the electroporation of drugs and genes into surface cells |
US5464386A (en) | 1992-08-17 | 1995-11-07 | Genetronics, Inc. | Transdermal drug delivery by electroincorporation of vesicles |
US5688233A (en) | 1992-08-17 | 1997-11-18 | Genetronics, Inc. | Electronincorporation enhanced transdermal delivery of molecules |
JP3351572B2 (ja) | 1992-10-05 | 2002-11-25 | 井上 聰一 | イオンクロマトグラフィーによる分析体の分離・分析方法、イオンクロマトグラフィー用両荷電具備固定相及び多機能液体クロマトグラフィーによる分析体の分離・分析方法 |
US5468223A (en) | 1992-11-30 | 1995-11-21 | C.N.R.S. Paris | Electrochemotherapy |
FR2703253B1 (fr) | 1993-03-30 | 1995-06-23 | Centre Nat Rech Scient | Applicateur d'impulsions electriques pour traitement de tissus biologiques. |
US5439440A (en) | 1993-04-01 | 1995-08-08 | Genetronics, Inc. | Electroporation system with voltage control feedback for clinical applications |
US5993434A (en) * | 1993-04-01 | 1999-11-30 | Genetronics, Inc. | Method of treatment using electroporation mediated delivery of drugs and genes |
US5702359A (en) | 1995-06-06 | 1997-12-30 | Genetronics, Inc. | Needle electrodes for mediated delivery of drugs and genes |
GB9317380D0 (en) * | 1993-08-20 | 1993-10-06 | Therexsys Ltd | Transfection process |
US5804566A (en) | 1993-08-26 | 1998-09-08 | The Regents Of The University Of California | Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides |
US5679647A (en) | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
US5849719A (en) | 1993-08-26 | 1998-12-15 | The Regents Of The University Of California | Method for treating allergic lung disease |
DE4341424A1 (de) | 1993-12-04 | 1995-06-08 | Bosch Gmbh Robert | Kraftstoffeinspritzpumpe |
IL108775A (en) | 1994-02-25 | 2003-09-17 | Univ Ramot | Method for efficient incorporation of molecules into cells |
AU2947795A (en) | 1994-06-24 | 1996-01-19 | Cygnus, Inc. | Pulsatile delivery systems of biologically active agents using electro voltage pulsing for controlling membrane permeability |
US5471884A (en) | 1994-07-05 | 1995-12-05 | Motorola, Inc. | Gain-adjusting circuitry for combining two sensors to form a media isolated differential pressure sensor |
IT235163Y1 (it) | 1994-10-10 | 2000-03-31 | Ideal Standard Spa | Gruppo di tenuta per elementi maschio di stampi per la colatura di apparecchiature igienico-sanitarie |
US5641680A (en) * | 1994-11-14 | 1997-06-24 | Zhao; Xi | Gene transfer apparatus and method for using the same |
US5810762A (en) | 1995-04-10 | 1998-09-22 | Genetronics, Inc. | Electroporation system with voltage control feedback for clinical applications |
WO1997007826A1 (en) * | 1995-08-29 | 1997-03-06 | Cbr Laboratories, Inc. | In vivo electroporation of cells |
FR2738842B1 (fr) | 1995-09-15 | 1997-10-31 | Rhone Poulenc Rorer Sa | Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique |
US5944710A (en) | 1996-06-24 | 1999-08-31 | Genetronics, Inc. | Electroporation-mediated intravascular delivery |
US5944726A (en) | 1996-08-23 | 1999-08-31 | Scimed Life Systems, Inc. | Stent delivery system having stent securement means |
US5960974A (en) | 1996-10-03 | 1999-10-05 | Advance Engineered Products Ltd. | Intermodal bulk container |
JPH10234366A (ja) | 1997-02-26 | 1998-09-08 | Hisamitsu Pharmaceut Co Inc | エレクトロポレーション用電極及びその製法、それを用いた製剤 |
DK1023107T3 (da) | 1997-04-03 | 2006-12-27 | Electrofect As | Fremgangsmåde til indgivelse af farmaceutiske præparater og nucleinsyrer i skeletmuskulaturen |
US6055453A (en) | 1997-08-01 | 2000-04-25 | Genetronics, Inc. | Apparatus for addressing needle array electrodes for electroporation therapy |
US6241701B1 (en) * | 1997-08-01 | 2001-06-05 | Genetronics, Inc. | Apparatus for electroporation mediated delivery of drugs and genes |
WO1999036563A1 (en) | 1998-01-14 | 1999-07-22 | Emed Corporation | Electrically mediated cellular expression |
EP2428249B1 (de) | 1998-07-13 | 2015-10-07 | Inovio Pharmaceuticals, Inc. | Haut- und muskelgerichtete Gentherapie mithilfe eines gepulsten elektrischen Felds |
US6678556B1 (en) | 1998-07-13 | 2004-01-13 | Genetronics, Inc. | Electrical field therapy with reduced histopathological change in muscle |
-
1998
- 1998-06-30 HU HU0004589A patent/HUP0004589A3/hu unknown
- 1998-06-30 CN CN98806671A patent/CN1261807A/zh active Pending
- 1998-06-30 JP JP50653099A patent/JP2002507985A/ja active Pending
- 1998-06-30 PL PL98337583A patent/PL337583A1/xx not_active Application Discontinuation
- 1998-06-30 CA CA002294793A patent/CA2294793A1/fr not_active Abandoned
- 1998-06-30 DE DE69826124T patent/DE69826124T3/de not_active Expired - Lifetime
- 1998-06-30 EP EP98935067A patent/EP0991426B2/de not_active Expired - Lifetime
- 1998-06-30 AT AT98935067T patent/ATE275423T1/de not_active IP Right Cessation
- 1998-06-30 CZ CZ0475599A patent/CZ299473B6/cs not_active IP Right Cessation
- 1998-06-30 BR BR9810369-5A patent/BR9810369A/pt not_active IP Right Cessation
- 1998-06-30 AU AU84447/98A patent/AU8444798A/en not_active Abandoned
- 1998-06-30 IL IL13371098A patent/IL133710A0/xx unknown
- 1998-06-30 WO PCT/FR1998/001400 patent/WO1999001158A1/fr active IP Right Grant
- 1998-06-30 KR KR1019997012481A patent/KR20010020571A/ko not_active Application Discontinuation
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Also Published As
Publication number | Publication date |
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CN1261807A (zh) | 2000-08-02 |
NO996542L (no) | 2000-02-17 |
HUP0004589A1 (hu) | 2001-04-28 |
DE69826124T2 (de) | 2005-09-15 |
KR20010020571A (ko) | 2001-03-15 |
HUP0004589A3 (en) | 2003-08-28 |
WO1999001158A1 (fr) | 1999-01-14 |
NO328102B1 (no) | 2009-12-07 |
JP2002507985A (ja) | 2002-03-12 |
IL133710A0 (en) | 2001-04-30 |
DE69826124T3 (de) | 2007-10-11 |
NO996542D0 (no) | 1999-12-29 |
AU8444798A (en) | 1999-01-25 |
US20030073653A1 (en) | 2003-04-17 |
BR9810369A (pt) | 2000-09-05 |
EP0991426B1 (de) | 2004-09-08 |
ATE275423T1 (de) | 2004-09-15 |
PL337583A1 (en) | 2000-08-28 |
EP0991426A1 (de) | 2000-04-12 |
CA2294793A1 (fr) | 1999-01-14 |
CZ475599A3 (cs) | 2000-07-12 |
US6939862B2 (en) | 2005-09-06 |
CZ299473B6 (cs) | 2008-08-06 |
EP0991426B2 (de) | 2007-03-28 |
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