DE69823520D1 - Noribogain zur behandlung von schmerzen und drogenabhängigkeit - Google Patents
Noribogain zur behandlung von schmerzen und drogenabhängigkeitInfo
- Publication number
- DE69823520D1 DE69823520D1 DE69823520T DE69823520T DE69823520D1 DE 69823520 D1 DE69823520 D1 DE 69823520D1 DE 69823520 T DE69823520 T DE 69823520T DE 69823520 T DE69823520 T DE 69823520T DE 69823520 D1 DE69823520 D1 DE 69823520D1
- Authority
- DE
- Germany
- Prior art keywords
- pain
- treatment
- noribogain
- drug addiction
- noribogaine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Addiction (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5792197P | 1997-09-04 | 1997-09-04 | |
US57921P | 1997-09-04 | ||
PCT/US1998/018284 WO1999011250A2 (en) | 1997-09-04 | 1998-09-03 | Noribogaine in the treatment of pain and drug addiction |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69823520D1 true DE69823520D1 (de) | 2004-06-03 |
DE69823520T2 DE69823520T2 (de) | 2005-05-12 |
Family
ID=22013572
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69823520T Expired - Lifetime DE69823520T2 (de) | 1997-09-04 | 1998-09-03 | Noribogain zur behandlung von schmerzen und drogenabhängigkeit |
Country Status (9)
Country | Link |
---|---|
US (6) | US7754710B2 (de) |
EP (4) | EP2246058A1 (de) |
AT (2) | ATE265213T1 (de) |
AU (1) | AU754088B2 (de) |
CA (1) | CA2302754C (de) |
DE (1) | DE69823520T2 (de) |
ES (3) | ES2224430T3 (de) |
IL (2) | IL134796A0 (de) |
WO (1) | WO1999011250A2 (de) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001052851A1 (en) * | 2000-01-22 | 2001-07-26 | Albert Shulman | Methods for the treatment of substance abuse |
CN1525851A (zh) | 2001-05-11 | 2004-09-01 | ������ҩ������˾ | 抗滥用阿片样物质控释剂型 |
AU2002303718B2 (en) * | 2001-05-11 | 2008-02-28 | Endo Pharmaceuticals, Inc. | Abuse-resistant opioid dosage form |
DK2425824T5 (en) | 2002-04-05 | 2018-02-12 | Mundipharma As | Pharmaceutical preparation containing oxycodone and naloxone |
EP1702558A1 (de) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Verfahren und Vorrichtung zur Darmtätigkeitserfassung |
WO2010103039A1 (en) | 2009-03-10 | 2010-09-16 | Euro-Celtique S.A. | Immediate release pharmaceutical compositions comprising oxycodone and naloxone |
US8362007B1 (en) * | 2010-05-11 | 2013-01-29 | Demerx, Inc. | Substituted noribogaine |
US9394294B2 (en) | 2010-05-11 | 2016-07-19 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
US8765737B1 (en) | 2010-05-11 | 2014-07-01 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
US9586954B2 (en) | 2010-06-22 | 2017-03-07 | Demerx, Inc. | N-substituted noribogaine prodrugs |
US8741891B1 (en) | 2010-06-22 | 2014-06-03 | Demerx, Inc. | N-substituted noribogaine prodrugs |
US8802832B2 (en) | 2010-06-22 | 2014-08-12 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
US8637648B1 (en) | 2010-06-22 | 2014-01-28 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
US9358237B2 (en) | 2010-07-23 | 2016-06-07 | Demerx, Inc. | Noribogaine compositions |
EP2481740B1 (de) * | 2011-01-26 | 2015-11-04 | DemeRx, Inc. | Verfahren und Zusammensetzungen zur Herstellung von Noribogain aus Voacangin |
US8742096B2 (en) * | 2011-03-28 | 2014-06-03 | Demerx, Inc. | Methods and compositions for preparing noribogaine from voacangine |
US9617274B1 (en) | 2011-08-26 | 2017-04-11 | Demerx, Inc. | Synthetic noribogaine |
US9040520B2 (en) | 2011-09-15 | 2015-05-26 | Demerx, Inc. | Noribogaine salt ansolvates |
IN2014CN04160A (de) * | 2011-12-08 | 2015-07-17 | Demerx Inc | |
WO2013085849A2 (en) * | 2011-12-09 | 2013-06-13 | Demerx, Inc. | Sulfate esters of noribogaine |
WO2013085922A1 (en) * | 2011-12-09 | 2013-06-13 | Demerx, Inc. | Phosphate esters of noribogaine |
US8877921B2 (en) | 2012-01-25 | 2014-11-04 | Demerx, Inc. | Synthetic voacangine |
US9150584B2 (en) | 2012-01-25 | 2015-10-06 | Demerx, Inc. | Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them |
JP2016508979A (ja) * | 2012-12-20 | 2016-03-24 | デメレックス, インコーポレイテッド | 置換ノルイボガイン |
US9045481B2 (en) | 2012-12-20 | 2015-06-02 | Demerx, Inc. | Substituted noribogaine |
US8940728B2 (en) | 2012-12-20 | 2015-01-27 | Demerx, Inc. | Substituted noribogaine |
WO2014143201A1 (en) * | 2013-03-15 | 2014-09-18 | Demerx, Inc. | Method for noribogaine treatment of addiction in patients on methadone |
AU2014295042B2 (en) | 2013-07-23 | 2017-03-30 | Mundipharma Pty Limited | A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation |
CA2875384A1 (en) | 2013-12-20 | 2015-06-20 | AntiOP, Inc. | Intranasal naloxone compositions and methods of making and using same |
AU2014383143A1 (en) * | 2014-02-18 | 2016-09-29 | Demerx, Inc. | Methods for acute and long-term treatment of drug addiction |
CA3221251A1 (en) * | 2014-02-18 | 2015-08-27 | Demerx, Inc. | Therapeutic methods employing noribogaine and related compounds |
US9345711B2 (en) * | 2014-02-18 | 2016-05-24 | Demerx, Inc. | Methods for acute and long-term treatment of drug addiction |
US9561232B2 (en) | 2014-02-18 | 2017-02-07 | Demerx, Inc. | Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use |
US20150246055A1 (en) * | 2014-03-03 | 2015-09-03 | Demerx, Inc. | Methods for acute and long-term treatment of opioid and opioid-like drug addiction |
US20150258111A1 (en) * | 2014-03-13 | 2015-09-17 | Demerx, Inc. | Methods and compositions for reducing tolerance to opioid analgesics using ibogaine and derivatives thereof |
US9591978B2 (en) | 2014-03-13 | 2017-03-14 | Demerx, Inc. | Methods and compositions for pre-screening patients for treatment with noribogaine |
WO2015142346A1 (en) * | 2014-03-20 | 2015-09-24 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
WO2015195673A2 (en) | 2014-06-18 | 2015-12-23 | Demerx, Inc. | Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them |
US9549935B2 (en) | 2014-07-14 | 2017-01-24 | Demerx, Inc. | Methods and compositions for treating migraines using noribogaine |
US9592239B2 (en) | 2014-09-12 | 2017-03-14 | Demerx, Inc. | Methods and compositions for ibogaine treatment of impulse control disorder, anxiety-related disorders, violence and/or anger, or regulating food intake |
PT3223906T (pt) * | 2014-11-26 | 2021-05-05 | Demerx Inc | Métodos e composições para potencializar a ação de analgésicos de opioides usando alcaloides de iboga |
WO2016183244A1 (en) * | 2015-05-11 | 2016-11-17 | Demerx, Inc. | Methods for treatment of opioid dependency and withdrawal using noribogaine |
GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
EP3955936A1 (de) | 2019-04-17 | 2022-02-23 | COMPASS Pathfinder Limited | Behandlung von depression und anderen verschiedenen störungen mit psilocybin |
Family Cites Families (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB841697A (en) * | 1956-03-22 | 1960-07-20 | Ciba Ltd | Analgesic compositions |
GB924042A (en) | 1959-03-05 | 1963-04-18 | Geigy Ag J R | Process for the decarboxylation of alkyl esters of unsaturated, nitrogen-containing carboxylic acids |
US3639408A (en) | 1967-06-03 | 1972-02-01 | Shionogi & Co | Process for the preparation of isoquinuclidine derivatives |
US3516989A (en) | 1967-10-02 | 1970-06-23 | American Home Prod | Intermediates for total synthesis of iboga alkaloids and means of preparation |
FR7131M (de) | 1968-01-31 | 1969-07-21 | ||
US3557126A (en) | 1969-08-14 | 1971-01-19 | American Home Prod | Derivatives of iboga alkaloids |
US3574220A (en) | 1969-08-14 | 1971-04-06 | American Home Prod | 1,7-methano-1h-1-benzazepin-5(4h)-ones |
CA982478A (en) | 1971-04-12 | 1976-01-27 | Jerome Berk | Orally administered drug composition for therapy in the treatment of narcotic drug addiction |
US4375414A (en) | 1971-05-20 | 1983-03-01 | Meir Strahilevitz | Immunological methods for removing species from the blood circulatory system and devices therefor |
US3715361A (en) * | 1971-10-08 | 1973-02-06 | American Cyanamid Co | Acyl derivatives of 10-methoxyibogamine |
US3875011A (en) | 1972-11-06 | 1975-04-01 | Syva Co | Enzyme immunoassays with glucose-6-phosphate dehydrogenase |
US4272541A (en) | 1978-06-02 | 1981-06-09 | Miles Laboratories, Inc. | 7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them |
US4464378A (en) | 1981-04-28 | 1984-08-07 | University Of Kentucky Research Foundation | Method of administering narcotic antagonists and analgesics and novel dosage forms containing same |
CA1188989A (en) | 1981-05-21 | 1985-06-18 | Richard R. Scherschlicht | Nonapeptide for the treatment of drug withdrawal symptoms |
US4604365A (en) | 1981-06-02 | 1986-08-05 | Electro-Nucleonics, Inc. | Immunoprecipitation assay |
US4462941A (en) | 1982-06-10 | 1984-07-31 | The Regents Of The University Of California | Dynorphin amide analogs |
JPS59208119A (ja) * | 1983-05-13 | 1984-11-26 | Sankei Giken Kogyo Kk | 触媒コンバ−タ |
US4499096A (en) | 1983-11-18 | 1985-02-12 | Lotsof Howard S | Rapid method for interrupting the narcotic addiction syndrome |
US5266574A (en) * | 1984-04-09 | 1993-11-30 | Ian S. Zagon | Growth regulation and related applications of opioid antagonists |
US4626539A (en) | 1984-08-10 | 1986-12-02 | E. I. Dupont De Nemours And Company | Trandermal delivery of opioids |
US4573995A (en) * | 1984-10-09 | 1986-03-04 | Alza Corporation | Transdermal therapeutic systems for the administration of naloxone, naltrexone and nalbuphine |
GB8430346D0 (en) | 1984-11-30 | 1985-01-09 | Reckitt & Colmann Prod Ltd | Analgesic compositions |
ATE95430T1 (de) * | 1984-12-22 | 1993-10-15 | Sanol Arznei Schwarz Gmbh | Wirkstoffpflaster. |
US4806341A (en) | 1985-02-25 | 1989-02-21 | Rutgers, The State University Of New Jersey | Transdermal absorption dosage unit for narcotic analgesics and antagonists and process for administration |
US4587243A (en) | 1985-07-15 | 1986-05-06 | Lotsof Howard S | Rapid method for interrupting the cocaine and amphetamine abuse syndrome |
US5316759A (en) | 1986-03-17 | 1994-05-31 | Robert J. Schaap | Agonist-antagonist combination to reduce the use of nicotine and other drugs |
GB8625941D0 (en) * | 1986-10-30 | 1986-12-03 | Sandoz Ltd | Substituted alpha-amino acids |
US4857523A (en) | 1988-07-18 | 1989-08-15 | Nda International, Inc. | Rapid method for attenuating the alcohol dependency syndrome |
US5629307A (en) | 1989-10-20 | 1997-05-13 | Olney; John W. | Use of ibogaine in reducing excitotoxic brain damage |
US5075341A (en) | 1989-12-01 | 1991-12-24 | The Mclean Hospital Corporation | Treatment for cocaine abuse |
DE4010079A1 (de) | 1990-03-29 | 1991-10-02 | Lohmann Therapie Syst Lts | Pharmazeutische formulierung zur behandlung des alkoholismus |
US5026697A (en) | 1990-05-30 | 1991-06-25 | Nda International, Inc. | Rapid method for interrupting or attenuating the nicotine/tobacco dependency syndrome |
US5152994A (en) | 1990-05-31 | 1992-10-06 | Lotsof Howard S | Rapid method for interrupting or attenuating poly-drug dependency syndromes |
US5283247A (en) | 1991-02-06 | 1994-02-01 | Research Corporation Technologies, Inc. | Anticonvulsant substituted quinazolones |
US5149538A (en) | 1991-06-14 | 1992-09-22 | Warner-Lambert Company | Misuse-resistive transdermal opioid dosage form |
US5290784A (en) | 1991-07-18 | 1994-03-01 | Yueqian Qu | Aconitane derivatives used as a medication to treat addiction |
HU219476B (hu) | 1992-04-10 | 2001-04-28 | Merrell Dow Pharmaceuticals Inc. | Eljárás valamely 2'-halo-metilidén-származékot és S-fázisú vagy M-fázisú specifikus daganatellenes szert tartalmazó gyógyszerkészítmények előállítására |
EP0652765A4 (de) | 1992-06-12 | 1997-04-09 | Des Tyr Dynorphin Partnership | Des-tyr dynorphinanaloge. |
US5256669A (en) * | 1992-08-07 | 1993-10-26 | Aminotek Sciences, Inc. | Methods and compositions for treating acute or chronic pain and drug addiction |
US5580876A (en) | 1992-09-21 | 1996-12-03 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists |
CA2145207A1 (en) | 1992-09-21 | 1994-03-22 | Bo-Yi Qin | Methods for identifying and using low/non-addictive opioid analgesics |
CN1042895C (zh) | 1992-09-23 | 1999-04-14 | 曲曰谦 | 治疗吸毒者戒断综合症及脱瘾的药物组合物 |
AU4066693A (en) | 1992-12-23 | 1994-07-19 | Bernhard Hugemann | Compacted drug body for use in the mechanical generation of inhalable active-substance particles |
US5865444A (en) * | 1994-03-21 | 1999-02-02 | Deere & Company | Body leveling suspension including a pivoting arrangement |
JP2819236B2 (ja) | 1994-05-06 | 1998-10-30 | 日東電工株式会社 | 経皮吸収製剤 |
US5552406A (en) | 1994-06-17 | 1996-09-03 | The Mclean Hospital Corporation | Method for treating pain and brain perfusion abnormalities using mixed opioid agonist-antagonists |
FR2721945B1 (fr) | 1994-07-04 | 1996-10-18 | David Fabrice | Accroissement genique, un procede d'amplicication genique isotherme et ses applications |
MX9701430A (es) | 1994-07-25 | 1997-12-31 | Nda Int Inc | Un metodo de tratamiento de dependencia quimica en mamiferos y una composicion para el mismo. |
US5591738A (en) * | 1994-10-14 | 1997-01-07 | Nda International, Inc. | Method of treating chemical dependency using β-carboline alkaloids, derivatives and salts thereof |
US5760044A (en) | 1996-05-16 | 1998-06-02 | Archer; Sydney | Method for treating cocaine and amphetamine dependency |
US6451806B2 (en) * | 1999-09-29 | 2002-09-17 | Adolor Corporation | Methods and compositions involving opioids and antagonists thereof |
US6864271B2 (en) * | 2002-11-12 | 2005-03-08 | The Foundation For The Lsu Health Sciences Center | Synergistic combinations including N-acylated 4-hydroxyphenylamine derivatives |
AU2004200486B2 (en) | 2003-02-12 | 2007-06-07 | Samsung Electronics Co., Ltd. | Complex wireless service apparatus using wired and wireless communication systems and method thereof |
US6806291B1 (en) * | 2003-10-09 | 2004-10-19 | The Foundation For The Lsu Health Sciences Center | Analgesic compounds, their synthesis and pharmaceutical compositions containing them |
-
1998
- 1998-09-03 EP EP10170898A patent/EP2246058A1/de not_active Withdrawn
- 1998-09-03 CA CA2302754A patent/CA2302754C/en not_active Expired - Fee Related
- 1998-09-03 DE DE69823520T patent/DE69823520T2/de not_active Expired - Lifetime
- 1998-09-03 AU AU92174/98A patent/AU754088B2/en not_active Ceased
- 1998-09-03 ES ES98944698T patent/ES2224430T3/es not_active Expired - Lifetime
- 1998-09-03 WO PCT/US1998/018284 patent/WO1999011250A2/en active IP Right Grant
- 1998-09-03 EP EP10180121.5A patent/EP2338494B1/de not_active Expired - Lifetime
- 1998-09-03 AT AT98944698T patent/ATE265213T1/de active
- 1998-09-03 EP EP98944698A patent/EP1009407B1/de not_active Expired - Lifetime
- 1998-09-03 AT AT03075683T patent/ATE510542T1/de active
- 1998-09-03 IL IL13479698A patent/IL134796A0/xx active IP Right Grant
- 1998-09-03 ES ES10180121T patent/ES2435722T3/es not_active Expired - Lifetime
- 1998-09-03 ES ES03075683T patent/ES2395268T3/es not_active Expired - Lifetime
- 1998-09-03 EP EP03075683A patent/EP1327447B1/de not_active Expired - Lifetime
-
2000
- 2000-02-29 IL IL134796A patent/IL134796A/en not_active IP Right Cessation
-
2007
- 2007-04-06 US US11/784,343 patent/US7754710B2/en not_active Expired - Fee Related
-
2010
- 2010-06-08 US US12/796,247 patent/US20100311723A1/en not_active Abandoned
- 2010-06-08 US US12/796,241 patent/US20100311722A1/en not_active Abandoned
- 2010-06-08 US US12/796,249 patent/US8178524B2/en not_active Expired - Fee Related
- 2010-06-15 US US12/815,908 patent/US20100311725A1/en not_active Abandoned
-
2011
- 2011-12-08 US US13/315,127 patent/US20120083485A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20100311725A1 (en) | 2010-12-09 |
CA2302754C (en) | 2011-11-08 |
CA2302754A1 (en) | 1999-03-11 |
ES2395268T3 (es) | 2013-02-11 |
ES2435722T3 (es) | 2013-12-23 |
EP2338494B1 (de) | 2013-07-10 |
US20100311722A1 (en) | 2010-12-09 |
ES2224430T3 (es) | 2005-03-01 |
IL134796A0 (en) | 2001-04-30 |
US20100311724A1 (en) | 2010-12-09 |
US20100311723A1 (en) | 2010-12-09 |
AU9217498A (en) | 1999-03-22 |
WO1999011250A3 (en) | 1999-08-05 |
EP2338494A1 (de) | 2011-06-29 |
ATE510542T1 (de) | 2011-06-15 |
EP1327447B1 (de) | 2011-05-25 |
WO1999011250A2 (en) | 1999-03-11 |
US20120083485A1 (en) | 2012-04-05 |
ATE265213T1 (de) | 2004-05-15 |
EP1009407B1 (de) | 2004-04-28 |
AU754088B2 (en) | 2002-11-07 |
US7754710B2 (en) | 2010-07-13 |
EP2246058A1 (de) | 2010-11-03 |
US20070185085A1 (en) | 2007-08-09 |
EP1327447A1 (de) | 2003-07-16 |
EP1009407A2 (de) | 2000-06-21 |
US8178524B2 (en) | 2012-05-15 |
IL134796A (en) | 2008-11-26 |
DE69823520T2 (de) | 2005-05-12 |
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