EP0652765A4 - Des-tyr dynorphinanaloge. - Google Patents
Des-tyr dynorphinanaloge.Info
- Publication number
- EP0652765A4 EP0652765A4 EP93914274A EP93914274A EP0652765A4 EP 0652765 A4 EP0652765 A4 EP 0652765A4 EP 93914274 A EP93914274 A EP 93914274A EP 93914274 A EP93914274 A EP 93914274A EP 0652765 A4 EP0652765 A4 EP 0652765A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- des
- analogues
- tyr
- tyr dynorphin
- dynorphin analogues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Addiction (AREA)
- Toxicology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89792092A | 1992-06-12 | 1992-06-12 | |
US897920 | 1992-06-12 | ||
PCT/US1993/005161 WO1993025217A1 (en) | 1992-06-12 | 1993-06-01 | Des-tyr dynorphin analogues |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0652765A1 EP0652765A1 (de) | 1995-05-17 |
EP0652765A4 true EP0652765A4 (de) | 1997-04-09 |
Family
ID=25408662
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP93914274A Withdrawn EP0652765A4 (de) | 1992-06-12 | 1993-06-01 | Des-tyr dynorphinanaloge. |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0652765A4 (de) |
JP (1) | JPH08501075A (de) |
KR (1) | KR950701818A (de) |
AU (1) | AU4399093A (de) |
CA (1) | CA2137916A1 (de) |
CZ (1) | CZ281630B6 (de) |
FI (1) | FI945811A (de) |
HU (1) | HUT70160A (de) |
NO (1) | NO944778L (de) |
RU (1) | RU95106651A (de) |
WO (1) | WO1993025217A1 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5482930A (en) * | 1993-06-09 | 1996-01-09 | The Regents Of The University Of California | Anti-inflammatory composition and method with des-Tyr dynorphin and analogues |
US7220737B1 (en) | 1997-09-04 | 2007-05-22 | Novoneuron, Inc | Noribogaine in the treatment of pain and drug addiction |
ATE265213T1 (de) | 1997-09-04 | 2004-05-15 | Novoneuron Inc | Noribogain zur behandlung von schmerzen und drogenabhängigkeit |
US6437092B1 (en) | 1998-11-06 | 2002-08-20 | Conjuchem, Inc. | Conjugates of opioids and endogenous carriers |
US6887470B1 (en) | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
US7601691B2 (en) | 1999-05-17 | 2009-10-13 | Conjuchem Biotechnologies Inc. | Anti-obesity agents |
US6849714B1 (en) | 1999-05-17 | 2005-02-01 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
EP1591453A1 (de) | 1999-05-17 | 2005-11-02 | ConjuChem Inc. | Modifizierte YY-Peptide und ihre Konjugate |
US6706892B1 (en) | 1999-09-07 | 2004-03-16 | Conjuchem, Inc. | Pulmonary delivery for bioconjugation |
CN1491233A (zh) | 2001-02-02 | 2004-04-21 | 康久化学公司 | 长效生长激素释放因子衍生物 |
JP4280070B2 (ja) | 2001-02-16 | 2009-06-17 | コンジュケム バイオテクノロジーズ インコーポレイテッド | 胃腸疾患および胃腸障害の処置のための長期持続性グルカゴン様ペプチド2(glp−2) |
US9394294B2 (en) | 2010-05-11 | 2016-07-19 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
US8765737B1 (en) | 2010-05-11 | 2014-07-01 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
US8362007B1 (en) | 2010-05-11 | 2013-01-29 | Demerx, Inc. | Substituted noribogaine |
US9586954B2 (en) | 2010-06-22 | 2017-03-07 | Demerx, Inc. | N-substituted noribogaine prodrugs |
US8637648B1 (en) | 2010-06-22 | 2014-01-28 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
US8741891B1 (en) | 2010-06-22 | 2014-06-03 | Demerx, Inc. | N-substituted noribogaine prodrugs |
US8802832B2 (en) | 2010-06-22 | 2014-08-12 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
RU2586296C2 (ru) | 2010-07-23 | 2016-06-10 | Демеркс, Инк. | Композиции норибогаина |
EP2481740B1 (de) | 2011-01-26 | 2015-11-04 | DemeRx, Inc. | Verfahren und Zusammensetzungen zur Herstellung von Noribogain aus Voacangin |
US9617274B1 (en) | 2011-08-26 | 2017-04-11 | Demerx, Inc. | Synthetic noribogaine |
EP2788003A4 (de) | 2011-12-09 | 2015-05-27 | Demerx Inc | Phosphatester von noribogain |
US9150584B2 (en) | 2012-01-25 | 2015-10-06 | Demerx, Inc. | Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them |
US8877921B2 (en) | 2012-01-25 | 2014-11-04 | Demerx, Inc. | Synthetic voacangine |
US8940728B2 (en) | 2012-12-20 | 2015-01-27 | Demerx, Inc. | Substituted noribogaine |
US9045481B2 (en) | 2012-12-20 | 2015-06-02 | Demerx, Inc. | Substituted noribogaine |
US9783535B2 (en) | 2012-12-20 | 2017-10-10 | Demerx, Inc. | Substituted noribogaine |
US10428115B2 (en) | 2013-05-24 | 2019-10-01 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Dynorphin A analogs with bradykinin receptors specificity for modulation of neuropathic pain |
US9550789B2 (en) | 2014-06-18 | 2017-01-24 | Demerx, Inc. | Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996006626A1 (en) * | 1994-08-26 | 1996-03-07 | Lee Nancy M | Analgesic method with dynorphin analogues truncated at the n-terminus |
-
1993
- 1993-06-01 AU AU43990/93A patent/AU4399093A/en not_active Abandoned
- 1993-06-01 CZ CZ943131A patent/CZ281630B6/cs unknown
- 1993-06-01 CA CA002137916A patent/CA2137916A1/en not_active Abandoned
- 1993-06-01 EP EP93914274A patent/EP0652765A4/de not_active Withdrawn
- 1993-06-01 KR KR1019940704525A patent/KR950701818A/ko not_active Application Discontinuation
- 1993-06-01 WO PCT/US1993/005161 patent/WO1993025217A1/en not_active Application Discontinuation
- 1993-06-01 JP JP6501537A patent/JPH08501075A/ja active Pending
- 1993-06-01 HU HU9403563A patent/HUT70160A/hu unknown
- 1993-06-01 RU RU95106651/14A patent/RU95106651A/ru unknown
-
1994
- 1994-12-09 FI FI945811A patent/FI945811A/fi not_active Application Discontinuation
- 1994-12-09 NO NO944778A patent/NO944778L/no unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996006626A1 (en) * | 1994-08-26 | 1996-03-07 | Lee Nancy M | Analgesic method with dynorphin analogues truncated at the n-terminus |
Non-Patent Citations (7)
Also Published As
Publication number | Publication date |
---|---|
JPH08501075A (ja) | 1996-02-06 |
HU9403563D0 (en) | 1995-02-28 |
FI945811A0 (fi) | 1994-12-09 |
HUT70160A (en) | 1995-09-28 |
EP0652765A1 (de) | 1995-05-17 |
CZ281630B6 (cs) | 1996-11-13 |
FI945811A (fi) | 1995-02-06 |
CA2137916A1 (en) | 1993-12-23 |
WO1993025217A1 (en) | 1993-12-23 |
AU4399093A (en) | 1994-01-04 |
NO944778L (no) | 1995-02-10 |
NO944778D0 (no) | 1994-12-09 |
CZ313194A3 (en) | 1995-08-16 |
RU95106651A (ru) | 1996-12-27 |
KR950701818A (ko) | 1995-05-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19950109 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
|
RHK1 | Main classification (correction) |
Ipc: A61K 38/00 |
|
RHK1 | Main classification (correction) |
Ipc: C07K 5/00 |
|
A4 | Supplementary search report drawn up and despatched | ||
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
|
17Q | First examination report despatched |
Effective date: 19980113 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19990416 |