EP0652765A4 - Analogues de dynophine des-tyr. - Google Patents

Analogues de dynophine des-tyr.

Info

Publication number
EP0652765A4
EP0652765A4 EP93914274A EP93914274A EP0652765A4 EP 0652765 A4 EP0652765 A4 EP 0652765A4 EP 93914274 A EP93914274 A EP 93914274A EP 93914274 A EP93914274 A EP 93914274A EP 0652765 A4 EP0652765 A4 EP 0652765A4
Authority
EP
European Patent Office
Prior art keywords
des
analogues
tyr
tyr dynorphin
dynorphin analogues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93914274A
Other languages
German (de)
English (en)
Other versions
EP0652765A1 (fr
Inventor
Nancy M Lee
Horace H Loh
Akira E Takemori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Des Tyr Dynorphin Partnership
Original Assignee
Des Tyr Dynorphin Partnership
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Des Tyr Dynorphin Partnership filed Critical Des Tyr Dynorphin Partnership
Publication of EP0652765A1 publication Critical patent/EP0652765A1/fr
Publication of EP0652765A4 publication Critical patent/EP0652765A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Addiction (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP93914274A 1992-06-12 1993-06-01 Analogues de dynophine des-tyr. Withdrawn EP0652765A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89792092A 1992-06-12 1992-06-12
US897920 1992-06-12
PCT/US1993/005161 WO1993025217A1 (fr) 1992-06-12 1993-06-01 Analogues de dynophine des-tyr

Publications (2)

Publication Number Publication Date
EP0652765A1 EP0652765A1 (fr) 1995-05-17
EP0652765A4 true EP0652765A4 (fr) 1997-04-09

Family

ID=25408662

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93914274A Withdrawn EP0652765A4 (fr) 1992-06-12 1993-06-01 Analogues de dynophine des-tyr.

Country Status (11)

Country Link
EP (1) EP0652765A4 (fr)
JP (1) JPH08501075A (fr)
KR (1) KR950701818A (fr)
AU (1) AU4399093A (fr)
CA (1) CA2137916A1 (fr)
CZ (1) CZ281630B6 (fr)
FI (1) FI945811A (fr)
HU (1) HUT70160A (fr)
NO (1) NO944778L (fr)
RU (1) RU95106651A (fr)
WO (1) WO1993025217A1 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5482930A (en) * 1993-06-09 1996-01-09 The Regents Of The University Of California Anti-inflammatory composition and method with des-Tyr dynorphin and analogues
US7220737B1 (en) 1997-09-04 2007-05-22 Novoneuron, Inc Noribogaine in the treatment of pain and drug addiction
EP2246058A1 (fr) 1997-09-04 2010-11-03 Novoneuron, Inc. Noribogain utilisée pour le traitement de la douleur et de la toxicomanie
US6437092B1 (en) 1998-11-06 2002-08-20 Conjuchem, Inc. Conjugates of opioids and endogenous carriers
US6887470B1 (en) 1999-09-10 2005-05-03 Conjuchem, Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
AU765753B2 (en) 1999-05-17 2003-09-25 Conjuchem Biotechnologies Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
US6849714B1 (en) 1999-05-17 2005-02-01 Conjuchem, Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
US7601691B2 (en) 1999-05-17 2009-10-13 Conjuchem Biotechnologies Inc. Anti-obesity agents
US6706892B1 (en) 1999-09-07 2004-03-16 Conjuchem, Inc. Pulmonary delivery for bioconjugation
EP1355941A2 (fr) 2001-02-02 2003-10-29 ConjuChem, Inc. Derives du facteur de liberation de l'hormone de croissance de longue duree
CA2436399A1 (fr) 2001-02-16 2002-08-29 Conjuchem Inc. Peptide 2 de type glucagon (glp-2) de longue duree utilise dans le traitement des maladies et troubles gastro-intestinaux
US8362007B1 (en) 2010-05-11 2013-01-29 Demerx, Inc. Substituted noribogaine
US8765737B1 (en) 2010-05-11 2014-07-01 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US9394294B2 (en) 2010-05-11 2016-07-19 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
US8741891B1 (en) 2010-06-22 2014-06-03 Demerx, Inc. N-substituted noribogaine prodrugs
US8802832B2 (en) 2010-06-22 2014-08-12 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US8637648B1 (en) 2010-06-22 2014-01-28 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US9358237B2 (en) 2010-07-23 2016-06-07 Demerx, Inc. Noribogaine compositions
EP2481740B1 (fr) 2011-01-26 2015-11-04 DemeRx, Inc. Procédés et compositions pour préparer de la noribogaïne à partir de voacangine
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
WO2013085922A1 (fr) 2011-12-09 2013-06-13 Demerx, Inc. Esters phosphoriques de noribogaïne
US9150584B2 (en) 2012-01-25 2015-10-06 Demerx, Inc. Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
US8877921B2 (en) 2012-01-25 2014-11-04 Demerx, Inc. Synthetic voacangine
JP2016508979A (ja) 2012-12-20 2016-03-24 デメレックス， インコーポレイテッド 置換ノルイボガイン
US9045481B2 (en) 2012-12-20 2015-06-02 Demerx, Inc. Substituted noribogaine
US8940728B2 (en) 2012-12-20 2015-01-27 Demerx, Inc. Substituted noribogaine
US10428115B2 (en) 2013-05-24 2019-10-01 Arizona Board Of Regents On Behalf Of The University Of Arizona Dynorphin A analogs with bradykinin receptors specificity for modulation of neuropathic pain
WO2015195673A2 (fr) 2014-06-18 2015-12-23 Demerx, Inc. Dérivés d'indole et de benzofurane halogénés d'isoquinuclidène et procédés pour leur préparation.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996006626A1 (fr) * 1994-08-26 1996-03-07 Lee Nancy M Procede analgesique utilisant des analogues de dynorphine tronques au niveau de la terminaison n

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996006626A1 (fr) * 1994-08-26 1996-03-07 Lee Nancy M Procede analgesique utilisant des analogues de dynorphine tronques au niveau de la terminaison n

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BAKSHI R. & FADEN A.I.: "Compeptitive and non-compeptitive NMDA antagonists limit dynorphin A-induced rat hindlimb paralysis", BRAIN RESEARCH, vol. 507, 1990, pages 1 - 5, XP000612654 *
CODD E.E. ET AL.: "A non-opoid pattern characterizes inhibition of growth hormone releasing peptide binding by Dynorphin-related peptides", NEUROPEPTIDES (EDINBOURGH), vol. 15, no. 3, 1990, pages 133 - 137, XP000612963 *
MWYER M.E.: "Intrastrial injections of Dynorphin A fragments potentiate the dorsal immobility response in rats", PHARMACOL.BIOCHEM.BEHAV., vol. 44, no. 2, 1993, pages 329 - 332, XP000613059 *
ROCHFORD J. ET AL.: "Intrathecal administation of dynorphin A and its fragments increase heart rate and arteria pressure in the urethane anesthetized rat: mediation by a nonopioid mechanism", BRAIN RESEARCH, vol. 565, no. 1, 1991, pages 67 - 77, XP000612957 *
See also references of WO9325217A1 *
TAKEMORI A. ET AL.: "Suppression by Dynorphin A and des-Tyr-Dynorphin A peptides of the expression of opiate withdrawl and tolerance in morphine-depedent mice", J.PHARMACOL.EXP.THER., vol. 266, no. 1, 1993, pages 121 - 124, XP000612554 *
XIE, GUO-XI ET AL.: "Expression of cDNA encoding a seven-helix receptor from human placenta with affinity for opioid ligands", PROC.NATL.ACAD.SCI., vol. 89, 1992, USA, pages 4124 - 4128, XP002022035 *

Also Published As

Publication number Publication date
RU95106651A (ru) 1996-12-27
FI945811A0 (fi) 1994-12-09
WO1993025217A1 (fr) 1993-12-23
KR950701818A (ko) 1995-05-17
NO944778L (no) 1995-02-10
CZ313194A3 (en) 1995-08-16
AU4399093A (en) 1994-01-04
CZ281630B6 (cs) 1996-11-13
HUT70160A (en) 1995-09-28
NO944778D0 (no) 1994-12-09
FI945811A (fi) 1995-02-06
HU9403563D0 (en) 1995-02-28
EP0652765A1 (fr) 1995-05-17
JPH08501075A (ja) 1996-02-06
CA2137916A1 (fr) 1993-12-23

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19950109

AK Designated contracting states

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RHK1 Main classification (correction)

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RHK1 Main classification (correction)

Ipc: C07K 5/00

A4 Supplementary search report drawn up and despatched
AK Designated contracting states

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18D Application deemed to be withdrawn

Effective date: 19990416