CA2137916A1 - Analogues de peptides dynorphine des-tyr - Google Patents

Analogues de peptides dynorphine des-tyr

Info

Publication number
CA2137916A1
CA2137916A1 CA002137916A CA2137916A CA2137916A1 CA 2137916 A1 CA2137916 A1 CA 2137916A1 CA 002137916 A CA002137916 A CA 002137916A CA 2137916 A CA2137916 A CA 2137916A CA 2137916 A1 CA2137916 A1 CA 2137916A1
Authority
CA
Canada
Prior art keywords
dynorphin
dose
narcotic analgesic
arg
therapeutic method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002137916A
Other languages
English (en)
Inventor
Nancy M. Lee
Horace H. Loh
Akira E. Takemori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Des Tyr Dynorphin Partnership
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2137916A1 publication Critical patent/CA2137916A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Addiction (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA002137916A 1992-06-12 1993-06-01 Analogues de peptides dynorphine des-tyr Abandoned CA2137916A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89792092A 1992-06-12 1992-06-12
US07/897,920 1992-06-12

Publications (1)

Publication Number Publication Date
CA2137916A1 true CA2137916A1 (fr) 1993-12-23

Family

ID=25408662

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002137916A Abandoned CA2137916A1 (fr) 1992-06-12 1993-06-01 Analogues de peptides dynorphine des-tyr

Country Status (11)

Country Link
EP (1) EP0652765A4 (fr)
JP (1) JPH08501075A (fr)
KR (1) KR950701818A (fr)
AU (1) AU4399093A (fr)
CA (1) CA2137916A1 (fr)
CZ (1) CZ281630B6 (fr)
FI (1) FI945811A (fr)
HU (1) HUT70160A (fr)
NO (1) NO944778L (fr)
RU (1) RU95106651A (fr)
WO (1) WO1993025217A1 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5482930A (en) * 1993-06-09 1996-01-09 The Regents Of The University Of California Anti-inflammatory composition and method with des-Tyr dynorphin and analogues
US7220737B1 (en) 1997-09-04 2007-05-22 Novoneuron, Inc Noribogaine in the treatment of pain and drug addiction
ATE265213T1 (de) 1997-09-04 2004-05-15 Novoneuron Inc Noribogain zur behandlung von schmerzen und drogenabhängigkeit
US6437092B1 (en) 1998-11-06 2002-08-20 Conjuchem, Inc. Conjugates of opioids and endogenous carriers
DE60026300T2 (de) 1999-05-17 2006-11-16 Conjuchem, Inc., Montreal Schutz endogener, therapeutisch aktiver peptide vor peptidaseaktivität durch konjugation an blutbestandteile
US7601691B2 (en) 1999-05-17 2009-10-13 Conjuchem Biotechnologies Inc. Anti-obesity agents
US6849714B1 (en) 1999-05-17 2005-02-01 Conjuchem, Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
US6887470B1 (en) 1999-09-10 2005-05-03 Conjuchem, Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
US6706892B1 (en) 1999-09-07 2004-03-16 Conjuchem, Inc. Pulmonary delivery for bioconjugation
CA2435563A1 (fr) 2001-02-02 2002-08-15 Conjuchem Inc. Derives du facteur de liberation de l'hormone de croissance de longue duree
EP1360202B1 (fr) 2001-02-16 2008-05-21 ConjuChem Biotechnologies Inc. Peptide 2 de type glucagon (glp-2) de longue duree utilise dans le traitement des maladies et troubles gastro-intestinaux
US9394294B2 (en) 2010-05-11 2016-07-19 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US8362007B1 (en) 2010-05-11 2013-01-29 Demerx, Inc. Substituted noribogaine
US8765737B1 (en) 2010-05-11 2014-07-01 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US8637648B1 (en) 2010-06-22 2014-01-28 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
US8802832B2 (en) 2010-06-22 2014-08-12 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US8741891B1 (en) 2010-06-22 2014-06-03 Demerx, Inc. N-substituted noribogaine prodrugs
MX2013000733A (es) 2010-07-23 2013-05-30 Demerx Inc Composiciones de noribogaina.
EP2481740B1 (fr) 2011-01-26 2015-11-04 DemeRx, Inc. Procédés et compositions pour préparer de la noribogaïne à partir de voacangine
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
WO2013085922A1 (fr) 2011-12-09 2013-06-13 Demerx, Inc. Esters phosphoriques de noribogaïne
WO2013112673A1 (fr) 2012-01-25 2013-08-01 Demerx, Inc. Voacangine synthétique
US9150584B2 (en) 2012-01-25 2015-10-06 Demerx, Inc. Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
US8940728B2 (en) 2012-12-20 2015-01-27 Demerx, Inc. Substituted noribogaine
US9045481B2 (en) 2012-12-20 2015-06-02 Demerx, Inc. Substituted noribogaine
US9783535B2 (en) 2012-12-20 2017-10-10 Demerx, Inc. Substituted noribogaine
WO2014190313A2 (fr) 2013-05-24 2014-11-27 The Arizona Board Of Regents On Behalf Of The University Of Arizona Analogues de dynorphine a à spécificité de récepteurs de la bradykinine pour moduler une douleur neuropathique
WO2015195673A2 (fr) 2014-06-18 2015-12-23 Demerx, Inc. Dérivés d'indole et de benzofurane halogénés d'isoquinuclidène et procédés pour leur préparation.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7637394A (en) * 1994-08-26 1996-03-22 Avram Goldstein Analgesic method with dynorphin analogues truncated at the n-terminus

Also Published As

Publication number Publication date
WO1993025217A1 (fr) 1993-12-23
NO944778L (no) 1995-02-10
HUT70160A (en) 1995-09-28
AU4399093A (en) 1994-01-04
FI945811A (fi) 1995-02-06
CZ313194A3 (en) 1995-08-16
KR950701818A (ko) 1995-05-17
NO944778D0 (no) 1994-12-09
JPH08501075A (ja) 1996-02-06
CZ281630B6 (cs) 1996-11-13
RU95106651A (ru) 1996-12-27
FI945811A0 (fi) 1994-12-09
EP0652765A1 (fr) 1995-05-17
EP0652765A4 (fr) 1997-04-09
HU9403563D0 (en) 1995-02-28

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Legal Events

Date Code Title Description
FZDE Discontinued