KR950701818A - 탈-tyr 다이놀핀 동족체(des-tyr dynorphin analogues) - Google Patents

탈-tyr 다이놀핀 동족체(des-tyr dynorphin analogues)

Info

Publication number
KR950701818A
KR950701818A KR1019940704525A KR19940704525A KR950701818A KR 950701818 A KR950701818 A KR 950701818A KR 1019940704525 A KR1019940704525 A KR 1019940704525A KR 19940704525 A KR19940704525 A KR 19940704525A KR 950701818 A KR950701818 A KR 950701818A
Authority
KR
South Korea
Prior art keywords
arg
leu
gly
lys
ile
Prior art date
Application number
KR1019940704525A
Other languages
English (en)
Inventor
낸시 엠. 리
호레이스 엠. 로
아키라 이. 다께모리
Original Assignee
원본미기재
데스-티 아이알 다이놀핀 파트너쉽
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 원본미기재, 데스-티 아이알 다이놀핀 파트너쉽 filed Critical 원본미기재
Publication of KR950701818A publication Critical patent/KR950701818A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

본 발명의 신규한 펩타이드는 다이놀핀 동족체로서 내인성 다이놀핀과 유사한 활성을 갖지만 내인성 다이놀핀과 관련하여 탈-Try 또는 탈-Try-Gly된 것이다. 이 펩타이드는 마약성 진통제의 활성에 상승작용을 하도록 하고 및/또는 금단증상을 차단하도록 마약성 진통제에 내성을 갖는 숙주에서 투여하는 치료적인 용도를 갖는다.

Description

탈-TYR 다이놀핀 동족체(DES-TYR DYNORPHIN ANALOGUES)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 하기 서열을 갖는 펩타이드 :
    Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn (SEQ IN NO :4) ;Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp (SEQ IN NO: 5) ;Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp(SEQ IN NO:6) ;Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys (SEQ IN NO:7);Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu(SEQ IN NO:8);Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys(SEQ IN NO:9);Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro(SEQ IN NO:10);Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg(SEQ IN NO:11); 여기서, C-말단은 산 또는 아미드형태이다.
  2. 하기 서열을 갖는 펩타이드;
    Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln (SEQ IN NO :13);Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn (SEQ IN NO :14);Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp(SEQ IN NO :15);Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp(SEQ IN NO :16);Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys(SEQ IN NO :17);Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu(SEQ IN NO :18);
  3. 마약성 진통제 금단증상을 차단하고 및/또는 마약성 진통제와 함께 투여되어 상승작용을 일으키도록 하는 데 효과적인 양의 다이놀핀 동족체를 투여하는데 투여된 다이놀핀 동족체가 N-말단에서 탈-Tyr또는 탈-Tyr-Gly인 것을 포함하는, 마약성 진통제가 내성을 갖는 환자의 치료방법.
  4. 제10항에 있어서, 다이놀핀 동족제가 약제학적으로 수용가능한 용액에 투여되는 치료방법.
  5. 제10항에 있어서, 다이놀핀 동족제가 최소한 6아미노산 잔기를 갖는 치료방법.
  6. 제10항에 있어서, 다인놀핀, 다이놀핀 동족제가 C-말단에서 아미드화 되는 치료방법.
  7. 제10항에 있어서, 다이놀핀 동족제가 내인성 다이놀핀의 아미노산 서열에 비하여 증가된 생체내 안정성 또는 배좌안정성을 치료방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940704525A 1992-06-12 1993-06-01 탈-tyr 다이놀핀 동족체(des-tyr dynorphin analogues) KR950701818A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89792092A 1992-06-12 1992-06-12
US07/897,920 1992-06-12
PCT/US1993/005161 WO1993025217A1 (en) 1992-06-12 1993-06-01 Des-tyr dynorphin analogues

Publications (1)

Publication Number Publication Date
KR950701818A true KR950701818A (ko) 1995-05-17

Family

ID=25408662

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940704525A KR950701818A (ko) 1992-06-12 1993-06-01 탈-tyr 다이놀핀 동족체(des-tyr dynorphin analogues)

Country Status (11)

Country Link
EP (1) EP0652765A4 (ko)
JP (1) JPH08501075A (ko)
KR (1) KR950701818A (ko)
AU (1) AU4399093A (ko)
CA (1) CA2137916A1 (ko)
CZ (1) CZ281630B6 (ko)
FI (1) FI945811A (ko)
HU (1) HUT70160A (ko)
NO (1) NO944778L (ko)
RU (1) RU95106651A (ko)
WO (1) WO1993025217A1 (ko)

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US5482930A (en) * 1993-06-09 1996-01-09 The Regents Of The University Of California Anti-inflammatory composition and method with des-Tyr dynorphin and analogues
US7220737B1 (en) 1997-09-04 2007-05-22 Novoneuron, Inc Noribogaine in the treatment of pain and drug addiction
EP1009407B1 (en) 1997-09-04 2004-04-28 Novoneuron, Inc. Noribogaine in the treatment of pain and drug addiction
US6437092B1 (en) 1998-11-06 2002-08-20 Conjuchem, Inc. Conjugates of opioids and endogenous carriers
US7601691B2 (en) 1999-05-17 2009-10-13 Conjuchem Biotechnologies Inc. Anti-obesity agents
EP1591453A1 (en) 1999-05-17 2005-11-02 ConjuChem Inc. Modified peptides yy and conjugates thereof
US6849714B1 (en) 1999-05-17 2005-02-01 Conjuchem, Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
US6887470B1 (en) 1999-09-10 2005-05-03 Conjuchem, Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
US6706892B1 (en) 1999-09-07 2004-03-16 Conjuchem, Inc. Pulmonary delivery for bioconjugation
JP2004520395A (ja) 2001-02-02 2004-07-08 コンジュケム，インコーポレーテッド 長期持続性成長ホルモン放出因子誘導体
EP1360202B1 (en) 2001-02-16 2008-05-21 ConjuChem Biotechnologies Inc. Long lasting glucagon-like peptide 2 (glp-2) for the treatment of gastrointestinal diseases and disorders
US8765737B1 (en) 2010-05-11 2014-07-01 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US8362007B1 (en) 2010-05-11 2013-01-29 Demerx, Inc. Substituted noribogaine
US9394294B2 (en) 2010-05-11 2016-07-19 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US8741891B1 (en) 2010-06-22 2014-06-03 Demerx, Inc. N-substituted noribogaine prodrugs
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
US8637648B1 (en) 2010-06-22 2014-01-28 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US8802832B2 (en) 2010-06-22 2014-08-12 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
MX2013000733A (es) 2010-07-23 2013-05-30 Demerx Inc Composiciones de noribogaina.
EP2481740B1 (en) 2011-01-26 2015-11-04 DemeRx, Inc. Methods and compositions for preparing noribogaine from voacangine
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
EP2788003A4 (en) 2011-12-09 2015-05-27 Demerx Inc PHOSPHATESTER OF NORIBOGAIN
EP2807168A4 (en) 2012-01-25 2015-10-14 Demerx Inc SYNTHETIC VOACANGINE
US9150584B2 (en) 2012-01-25 2015-10-06 Demerx, Inc. Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
EP2934541A4 (en) 2012-12-20 2016-08-03 Demerx Inc NORIBOGAINE SUBSTITUTE
US8940728B2 (en) 2012-12-20 2015-01-27 Demerx, Inc. Substituted noribogaine
US9045481B2 (en) 2012-12-20 2015-06-02 Demerx, Inc. Substituted noribogaine
US10428115B2 (en) 2013-05-24 2019-10-01 Arizona Board Of Regents On Behalf Of The University Of Arizona Dynorphin A analogs with bradykinin receptors specificity for modulation of neuropathic pain
US9550789B2 (en) 2014-06-18 2017-01-24 Demerx, Inc. Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them

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JPH10511077A (ja) * 1994-08-26 1998-10-27 ナンシー、 エム． リー、 Ｎ末端基で切断されたダイノルフィン類似体を用いた鎮痛方法

Also Published As

Publication number Publication date
WO1993025217A1 (en) 1993-12-23
CA2137916A1 (en) 1993-12-23
HUT70160A (en) 1995-09-28
NO944778L (no) 1995-02-10
CZ281630B6 (cs) 1996-11-13
JPH08501075A (ja) 1996-02-06
EP0652765A1 (en) 1995-05-17
NO944778D0 (no) 1994-12-09
FI945811A (fi) 1995-02-06
FI945811A0 (fi) 1994-12-09
CZ313194A3 (en) 1995-08-16
RU95106651A (ru) 1996-12-27
EP0652765A4 (en) 1997-04-09
HU9403563D0 (en) 1995-02-28
AU4399093A (en) 1994-01-04

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