DE69813536D1 - 7a-substituierte hexahydro-1h-pyrrolizinverbindungen verwendbar zur kontrolle von chemische synaptische übertragung - Google Patents

7a-substituierte hexahydro-1h-pyrrolizinverbindungen verwendbar zur kontrolle von chemische synaptische übertragung

Info

Publication number
DE69813536D1
DE69813536D1 DE69813536T DE69813536T DE69813536D1 DE 69813536 D1 DE69813536 D1 DE 69813536D1 DE 69813536 T DE69813536 T DE 69813536T DE 69813536 T DE69813536 T DE 69813536T DE 69813536 D1 DE69813536 D1 DE 69813536D1
Authority
DE
Germany
Prior art keywords
pyrrolizin
compounds used
synaptic transmission
controlling chemical
chemical synaptic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69813536T
Other languages
English (en)
Other versions
DE69813536T2 (de
Inventor
T Wasicak
S Garvey
W Holladay
Nan-Horng Lin
B Ryther
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of DE69813536D1 publication Critical patent/DE69813536D1/de
Publication of DE69813536T2 publication Critical patent/DE69813536T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69813536T 1997-02-19 1998-02-05 7a-substituierte hexahydro-1h-pyrrolizinverbindungen verwendbar zur kontrolle von chemische synaptische übertragung Expired - Fee Related DE69813536T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US802978 1991-12-06
US08/802,978 US5733912A (en) 1997-02-19 1997-02-19 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
PCT/US1998/002032 WO1998037082A1 (en) 1997-02-19 1998-02-05 7a-HETEROCYCLE-SUBSTITUTED HEXAHYDRO-1H-PYRROLIZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION

Publications (2)

Publication Number Publication Date
DE69813536D1 true DE69813536D1 (de) 2003-05-22
DE69813536T2 DE69813536T2 (de) 2004-02-19

Family

ID=25185234

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69813536T Expired - Fee Related DE69813536T2 (de) 1997-02-19 1998-02-05 7a-substituierte hexahydro-1h-pyrrolizinverbindungen verwendbar zur kontrolle von chemische synaptische übertragung

Country Status (16)

Country Link
US (1) US5733912A (de)
EP (1) EP0970083B1 (de)
JP (1) JP2001512479A (de)
AR (1) AR011148A1 (de)
AT (1) ATE237618T1 (de)
AU (1) AU6318898A (de)
CA (1) CA2281800A1 (de)
CO (1) CO4920251A1 (de)
DE (1) DE69813536T2 (de)
DK (1) DK0970083T3 (de)
ES (1) ES2196548T3 (de)
HK (1) HK1026416A1 (de)
PT (1) PT970083E (de)
TW (1) TW513425B (de)
WO (1) WO1998037082A1 (de)
ZA (1) ZA981301B (de)

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MY145722A (en) 2000-04-27 2012-03-30 Abbott Lab Diazabicyclic central nervous system active agents
US20030162770A1 (en) 2002-02-22 2003-08-28 Davis Bonnie M. Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
US7432009B2 (en) * 2002-04-03 2008-10-07 3M Innovative Properties Company Lamination apparatus and methods
MXPA05000370A (es) * 2002-07-05 2005-04-19 Targacept Inc Compuestos n-aril diazaespiraciclicos y metodos de preparacion y usos de los mismos.
BRPI0514509A (pt) * 2004-08-20 2008-06-10 Targacept Inc uso de composto n-aril diazaespiracìclicos no tratamento de dependência
CN101044134A (zh) * 2004-09-20 2007-09-26 塔加西普特公司 具有烟碱性胆碱能受体活性的氮杂螺烯和氮杂螺烷化合物
WO2006086068A1 (en) * 2004-12-07 2006-08-17 The Regents Of The University Of California Labeled alpha-4-beta-2 ligands and methods therefor
US9029557B2 (en) 2004-12-07 2015-05-12 The Regents Of The University Of California Labeled A4B2 ligands and methods therefor
DE102006050794A1 (de) * 2006-10-27 2008-04-30 Bayer Cropscience Ag Verwendung 7A-substituierter Hexahydro-1H-pyrrolizinverbindungen zur Bekämpfung tierischer Schädlinge
WO2014097150A1 (en) 2012-12-17 2014-06-26 Ranbaxy Laboratories Limited Process for the preparation of tofacitinib and intermediates thereof
US9006462B2 (en) 2013-02-28 2015-04-14 Dermira, Inc. Glycopyrrolate salts
JP6114841B2 (ja) 2013-02-28 2017-04-12 ダーミラ， インク．Ｄｅｒｍｉｒａ， Ｉｎｃ． グリコピロレート塩
CN111788204B (zh) 2018-02-26 2023-05-05 吉利德科学公司 作为hbv复制抑制剂的取代吡咯嗪化合物

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JPS56156283A (en) * 1980-05-07 1981-12-02 Suntory Ltd 8-substituted pyrrolitidine and its quaternary ammonium salt
US4582836A (en) * 1985-01-09 1986-04-15 Mcneilab, Inc. Octahydroindolizine compounds useful as analgesics
US4689329A (en) * 1986-02-04 1987-08-25 Mcneilab, Inc. 5-substituted octahydroindolizine analgesics compounds and 7-keto intermediates
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
DE3789039T2 (de) * 1986-06-27 1994-06-09 Beecham Group Plc Verbrückte bicyclische N-heterocyclische Verbindungen.
DE3854932T2 (de) * 1987-04-15 1996-06-13 Beecham Group Plc Am Brückenkopf substituierte Azabicyclenderivate
GB8714789D0 (en) * 1987-06-24 1987-07-29 Lundbeck & Co As H Heterocyclic compounds
GB8717446D0 (en) * 1987-07-23 1987-08-26 Merck Sharp & Dohme Chemical compounds
ES2053748T3 (es) * 1987-09-10 1994-08-01 Merck Sharp & Dohme Oxazoles y tiazoles para el tratamiento de la demencia senil.
NZ225999A (en) * 1987-09-10 1992-04-28 Merck Sharp & Dohme Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
NZ226000A (en) * 1987-09-10 1991-06-25 Merck Sharp & Dohme Oxadiazolyl-azabicycloheptanes and pharmaceutical compositions
US4800207A (en) * 1987-11-02 1989-01-24 Mcneilab, Inc. Hexahydropyrrolizine compounds useful as analgesics
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
EP0322182A3 (de) * 1987-12-22 1992-01-02 Beecham Group Plc Azabicyclische-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
IL88846A0 (en) * 1988-01-08 1989-07-31 Merck Sharp & Dohme Lipophilic oxadiazoles,their preparation and pharmaceutical compositions containing them
NZ227684A (en) * 1988-01-30 1991-07-26 Merck Sharp & Dohme Pyrazine, pyridazine, and pyrimidine derivatives and pharmaceutical compositions
US5260293A (en) * 1988-01-30 1993-11-09 Merck Sharp & Dohme Limited Pyrazines, pyrimidines and pyridazines useful in the treatment of senile dementia
NZ227841A (en) * 1988-02-12 1991-08-27 Merck Sharp & Dohme Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
GB8808926D0 (en) * 1988-04-15 1988-05-18 Beecham Group Plc Novel compounds
EP0363085A3 (de) * 1988-10-03 1991-03-27 Beecham Group Plc Chemische Verbindungen
CA2000041A1 (en) * 1988-10-13 1990-04-13 Barry S. Orlek Compounds
EP0402056A3 (de) * 1989-06-06 1991-09-04 Beecham Group p.l.c. Azabicyclische Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
CA2022886A1 (en) * 1989-08-08 1991-02-09 Raymond Baker Substituted pyridines, their preparation, formulations and use in dementia
US5177084A (en) * 1989-08-08 1993-01-05 Merck Sharp & Dohme Ltd. Therapeutic use of substituted benzenes, formulations thereof and novel substituted benzenes
EP0413545B1 (de) * 1989-08-16 1997-05-14 Beecham Group Plc Azabicyclische Verbindungen
DE69026197T2 (de) * 1989-10-07 1997-01-09 Beecham Group Plc Azabizyklische Verbindungen, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
IL97266A0 (en) * 1990-03-06 1992-05-25 Warner Lambert Co Azabicyclo and azacyclo oximes and amines,their preparation and pharmaceutical compositions containing them
GB9005737D0 (en) * 1990-03-14 1990-05-09 Beecham Group Plc Novel compounds
EP0459568A3 (en) * 1990-05-31 1992-09-30 Merck Sharp & Dohme Ltd. Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5418240A (en) * 1990-08-21 1995-05-23 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
JPH06501933A (ja) * 1990-10-12 1994-03-03 ビーチャム・グループ・パブリック・リミテッド・カンパニー １，２，５，６−テトラヒドロピリジン・オキシム誘導体
IE922270A1 (en) * 1991-07-26 1993-01-27 Akzo Nv Pyrazole derivatives
WO1993014089A1 (en) * 1992-01-13 1993-07-22 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
SE9201478D0 (sv) * 1992-05-11 1992-05-11 Kabi Pharmacia Ab Heteroaromatic quinuclidinenes, their use and preparation
US5472958A (en) * 1994-08-29 1995-12-05 Abbott Laboratories 2-((nitro)phenoxymethyl) heterocyclic compounds that enhance cognitive function
US5567710A (en) * 1994-10-13 1996-10-22 Sibia Neurosciences, Inc. Polycyclic fused ring modulators of acetylcholine receptors
US5629325A (en) * 1996-06-06 1997-05-13 Abbott Laboratories 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission

Also Published As

Publication number Publication date
JP2001512479A (ja) 2001-08-21
CA2281800A1 (en) 1998-08-27
TW513425B (en) 2002-12-11
EP0970083B1 (de) 2003-04-16
HK1026416A1 (en) 2000-12-15
WO1998037082A1 (en) 1998-08-27
DK0970083T3 (da) 2003-08-11
ES2196548T3 (es) 2003-12-16
DE69813536T2 (de) 2004-02-19
AU6318898A (en) 1998-09-09
US5733912A (en) 1998-03-31
ATE237618T1 (de) 2003-05-15
EP0970083A1 (de) 2000-01-12
PT970083E (pt) 2003-09-30
AR011148A1 (es) 2000-08-02
ZA981301B (en) 1998-08-28
CO4920251A1 (es) 2000-05-29

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Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee