DE69809561T2 - Zusammensetzung und verfahren zur regulierung von zellproliferation und zelltod - Google Patents

Zusammensetzung und verfahren zur regulierung von zellproliferation und zelltod

Info

Publication number
DE69809561T2
DE69809561T2 DE69809561T DE69809561T DE69809561T2 DE 69809561 T2 DE69809561 T2 DE 69809561T2 DE 69809561 T DE69809561 T DE 69809561T DE 69809561 T DE69809561 T DE 69809561T DE 69809561 T2 DE69809561 T2 DE 69809561T2
Authority
DE
Germany
Prior art keywords
dna
mcc
phlei
cells
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69809561T
Other languages
German (de)
English (en)
Other versions
DE69809561D1 (de
Inventor
C Filion
C Phillips
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Telesta Therapeutics Inc
Original Assignee
Bioniche Life Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioniche Life Sciences Inc filed Critical Bioniche Life Sciences Inc
Application granted granted Critical
Publication of DE69809561D1 publication Critical patent/DE69809561D1/de
Publication of DE69809561T2 publication Critical patent/DE69809561T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/711Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69809561T 1997-08-05 1998-08-05 Zusammensetzung und verfahren zur regulierung von zellproliferation und zelltod Expired - Lifetime DE69809561T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5477797P 1997-08-05 1997-08-05
US7506798P 1998-02-18 1998-02-18
US7511198P 1998-02-18 1998-02-18
US8631798P 1998-05-21 1998-05-21
PCT/CA1998/000744 WO1999007383A1 (en) 1997-08-05 1998-08-05 Composition and method for regulating cell proliferation and cell death

Publications (2)

Publication Number Publication Date
DE69809561D1 DE69809561D1 (de) 2003-01-02
DE69809561T2 true DE69809561T2 (de) 2003-09-25

Family

ID=27489673

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69809561T Expired - Lifetime DE69809561T2 (de) 1997-08-05 1998-08-05 Zusammensetzung und verfahren zur regulierung von zellproliferation und zelltod

Country Status (17)

Country Link
US (2) US6326357B1 (enExample)
EP (1) EP1003525B1 (enExample)
JP (2) JP4335435B2 (enExample)
KR (1) KR100533576B1 (enExample)
AT (1) ATE227996T1 (enExample)
AU (1) AU736450B2 (enExample)
BR (1) BR9815602A (enExample)
CA (1) CA2299548C (enExample)
DE (1) DE69809561T2 (enExample)
DK (1) DK1003525T3 (enExample)
ES (1) ES2187047T3 (enExample)
HU (1) HU227921B1 (enExample)
IL (3) IL134371A0 (enExample)
NO (1) NO322450B1 (enExample)
NZ (1) NZ502674A (enExample)
PT (1) PT1003525E (enExample)
WO (1) WO1999007383A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2299548C (en) 1997-08-05 2009-12-29 Bioniche Inc. Composition and method for regulating cell proliferation and cell death
PT1054680E (pt) * 1998-02-18 2005-06-30 Bioniche Life Sciences Inc Tratamento do cancro da bexiga pela parede celular de mycobacterium phlei
US6809081B1 (en) 1998-12-04 2004-10-26 Bioniche Life Sciences, Inc. Chemotherapeutic composition and method
PT1135164E (pt) * 1998-12-04 2004-11-30 Bioniche Life Sciences Inc Metodo para o tratamento de inflamacao
PT1135161E (pt) * 1998-12-04 2005-01-31 Bioniche Life Sciences Inc Composicao e metodo terapeutico
US6794368B1 (en) * 1999-04-01 2004-09-21 Bioniche Life Sciences Inc. Composition and method for inducing apoptosis in prostate cancer cells
PT1165106E (pt) * 1999-04-01 2005-10-31 Bioniche Life Sciences Inc Composicoes e metodo para induzir apoptose em celulas de cancro da prostata, por m-adn e mcc
JP2002541264A (ja) 1999-04-08 2002-12-03 ユーエイビー・リサーチ・ファウンデーション 冨gオリゴヌクレオチドの抗増殖活性およびヌクレオリンに結合するためのその使用方法
WO2001022979A1 (en) * 1999-09-29 2001-04-05 Bioniche Life Sciences Inc. Method to disrupt mitochondrial function
ATE455851T1 (de) * 1999-12-13 2010-02-15 Bioniche Life Sciences Inc Therapeutisch nützliche synthetische oligonukleotide
DK1250152T3 (da) 1999-12-28 2013-08-26 Bioniche Urology Ip Inc Synergistisk sammensætning indeholdende hyaluronsyre til behandling af cancer
US20030044352A1 (en) * 2001-04-24 2003-03-06 Phillips Nigel C. Method for evaluating the efficacy of treatment with bacterial DNA and bacterial cell walls
US6673566B1 (en) 2002-01-10 2004-01-06 The United States Of America As Represented By The Secretary Of Agriculture Diagnosis of pathogen infections through analysis of nitrite production by antigen stimulated leukocytes
JP2009544680A (ja) 2006-07-25 2009-12-17 リポクセン テクノロジーズ リミテッド ポリサッカライドによるタンパク質のn末端誘導体化
AR083443A1 (es) 2010-10-13 2013-02-27 Bioniche Life Sciences Inc Una composicion que comprende arn bacteriano y paredes celulares bacterianas, metodo para elaborar dicha composicion y sus usos

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3172815A (en) 1962-04-24 1965-03-09 Warner Lambert Pharmaceutical Method for preparing reticulo-endo-thelial system stimulant and stimulant thereof
FR2160326B1 (enExample) 1971-11-19 1975-02-07 Anvar
US4152423A (en) 1971-11-19 1979-05-01 Agence Nationale De Valorisation De La Recherche (Anvar) Immunological agents
US4010257A (en) 1973-02-23 1977-03-01 Burroughs Wellcome Co. Biological extracts
US3976544A (en) 1973-06-19 1976-08-24 The Agence Nationale De Valorisation De Le Recherche Water-soluble immunological adjuvants, in particular for vaccines, obtained from mycobacteria and related microorganisms and process for their extraction
FR2374042A1 (fr) 1976-06-04 1978-07-13 Merieux Inst Nouveau medicament immunostimulant et son procede de preparation
JPS54140710A (en) 1978-03-10 1979-11-01 Mitsui Toatsu Chem Inc Anti-tumor substance and its preparation
DE3011461C2 (de) 1980-03-25 1986-10-30 Dr. Madaus & Co, 5000 Köln Verwendung von Propionibakterien
US4520019A (en) 1982-04-29 1985-05-28 Ribi Immunochem Research, Inc. Stable composition and preparation thereof
US4579941A (en) 1982-08-13 1986-04-01 Mitsuitoatsu Chemicals, Inc. Thermally-denatured deoxyribonucleic acid MD-011 and antitumor agent
US4663306A (en) 1983-09-23 1987-05-05 Ribi Immunochem Research, Inc. Pyridine-soluble extract-refined detoxified endotoxin composition and use
GB8404280D0 (en) 1984-02-17 1984-03-21 Stanford J L Biological preparations
US4744984A (en) 1985-10-08 1988-05-17 Vetrepharm Research, Inc. Antiviral immunotherapeutic agent and preparation thereof
US4877611A (en) 1986-04-15 1989-10-31 Ribi Immunochem Research Inc. Vaccine containing tumor antigens and adjuvants
ATE179333T1 (de) 1993-01-29 1999-05-15 Vetrepharm Inc Immunotherapeutische zubereitung
CA2299548C (en) 1997-08-05 2009-12-29 Bioniche Inc. Composition and method for regulating cell proliferation and cell death

Also Published As

Publication number Publication date
IL134371A (en) 2007-07-24
KR20010022643A (ko) 2001-03-26
AU8723698A (en) 1999-03-01
EP1003525B1 (en) 2002-11-20
NZ502674A (en) 2002-06-28
NO20000576L (no) 2000-04-04
PT1003525E (pt) 2003-03-31
US6326357B1 (en) 2001-12-04
JP2001513504A (ja) 2001-09-04
IL180924A0 (en) 2007-07-04
CA2299548A1 (en) 1999-02-18
ATE227996T1 (de) 2002-12-15
ES2187047T3 (es) 2003-05-16
WO1999007383B1 (en) 1999-03-25
KR100533576B1 (ko) 2005-12-05
NO322450B1 (no) 2006-10-09
EP1003525A1 (en) 2000-05-31
AU736450B2 (en) 2001-07-26
DE69809561D1 (de) 2003-01-02
US6329347B1 (en) 2001-12-11
JP2008208140A (ja) 2008-09-11
CA2299548C (en) 2009-12-29
BR9815602A (pt) 2001-12-11
DK1003525T3 (da) 2003-03-24
IL134371A0 (en) 2001-04-30
NO20000576D0 (no) 2000-02-04
WO1999007383A1 (en) 1999-02-18
HU227921B1 (hu) 2012-06-28
HUP0003012A3 (en) 2004-03-29
IL180924A (en) 2010-11-30
HUP0003012A2 (hu) 2000-12-28
JP4335435B2 (ja) 2009-09-30

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Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: PHILLIPS, C., NIGEL, POINTE-CLAIRE, CA

Inventor name: FLLION, C., MARIO, LAVAL, CA

8381 Inventor (new situation)

Inventor name: PHILLIPS, C., NIGEL, POINTE-CLAIRE, CA

Inventor name: FILION, C., MARIO, LAVAL, CA

8364 No opposition during term of opposition
R082 Change of representative

Ref document number: 1003525

Country of ref document: EP

Representative=s name: VIERING, JENTSCHURA & PARTNER, DE