DE69807748T2 - Membranen zur steuerung des durchflusses in vorrichtungen mit kontrollierter wirkstoffabgabe - Google Patents

Membranen zur steuerung des durchflusses in vorrichtungen mit kontrollierter wirkstoffabgabe

Info

Publication number
DE69807748T2
DE69807748T2 DE69807748T DE69807748T DE69807748T2 DE 69807748 T2 DE69807748 T2 DE 69807748T2 DE 69807748 T DE69807748 T DE 69807748T DE 69807748 T DE69807748 T DE 69807748T DE 69807748 T2 DE69807748 T2 DE 69807748T2
Authority
DE
Germany
Prior art keywords
membranes
controlling
devices
flow
active ingredients
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69807748T
Other languages
English (en)
Other versions
DE69807748D1 (de
Inventor
W Kleiner
M Gale
G Berggren
T Tong
Guohua Chen
E Dionne
R Houston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intarcia Therapeutics Inc
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of DE69807748D1 publication Critical patent/DE69807748D1/de
Publication of DE69807748T2 publication Critical patent/DE69807748T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
DE69807748T 1997-12-22 1998-12-03 Membranen zur steuerung des durchflusses in vorrichtungen mit kontrollierter wirkstoffabgabe Expired - Lifetime DE69807748T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6837797P 1997-12-22 1997-12-22
PCT/US1998/025646 WO1999032095A1 (en) 1997-12-22 1998-12-03 Rate controlling membranes for controlled drug delivery devices

Publications (2)

Publication Number Publication Date
DE69807748D1 DE69807748D1 (de) 2002-10-10
DE69807748T2 true DE69807748T2 (de) 2003-01-02

Family

ID=22082181

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69807748T Expired - Lifetime DE69807748T2 (de) 1997-12-22 1998-12-03 Membranen zur steuerung des durchflusses in vorrichtungen mit kontrollierter wirkstoffabgabe

Country Status (17)

Country Link
US (2) US6375978B1 (de)
EP (1) EP1041975B1 (de)
JP (1) JP4215188B2 (de)
KR (1) KR100576583B1 (de)
CN (1) CN100388916C (de)
AR (1) AR014065A1 (de)
AT (1) ATE223208T1 (de)
AU (1) AU1623099A (de)
CA (1) CA2315890C (de)
DE (1) DE69807748T2 (de)
DK (1) DK1041975T3 (de)
ES (1) ES2182379T3 (de)
HK (1) HK1029923A1 (de)
PT (1) PT1041975E (de)
TW (1) TW575438B (de)
WO (1) WO1999032095A1 (de)
ZA (1) ZA9811716B (de)

Families Citing this family (158)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6440457B1 (en) * 1993-05-27 2002-08-27 Alza Corporation Method of administering antidepressant dosage form
US7833543B2 (en) * 1995-06-07 2010-11-16 Durect Corporation High viscosity liquid controlled delivery system and medical or surgical device
MY125870A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
AU1623099A (en) * 1997-12-22 1999-07-12 Alza Corporation Rate controlling membranes for controlled drug delivery devices
ES2378675T3 (es) * 1997-12-30 2012-04-16 Intarcia Therapeutics, Inc Sistema de suministro de un agente beneficioso con una membrana obturadora
US7919109B2 (en) 1999-02-08 2011-04-05 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
US7258869B1 (en) * 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
US6835194B2 (en) * 1999-03-18 2004-12-28 Durect Corporation Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7108681B2 (en) * 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
US20100311701A1 (en) * 2002-02-15 2010-12-09 Transform Pharmaceuticals, Inc Pharmaceutical Co-Crystal Compositions
US7927613B2 (en) * 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US7790905B2 (en) * 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
CA2477923C (en) * 2002-03-01 2021-02-23 University Of South Florida Multiple-component solid phases containing at least one active pharmaceutical ingredient
JP2005533782A (ja) * 2002-06-17 2005-11-10 アルザ コーポレイション 流体ビヒクル中に分散した浸透剤を含む、押出し力が早く零次になる機関を有する浸透送出システム
MXPA05000232A (es) * 2002-06-21 2005-06-17 Transform Pharmaceuticals Inc Composiciones farmaceuticas con disolucion mejorada.
CN100435880C (zh) * 2003-02-28 2008-11-26 微创医疗器械(上海)有限公司 一种药物洗脱介入医疗器械及其制备方法
WO2004098472A1 (en) * 2002-08-30 2004-11-18 Watson Pharmaceuticals, Inc. Transdermal delivery systems and methods
US20060198894A1 (en) * 2002-10-29 2006-09-07 Johanna Bentz Stabilized, solid-state polypeptide particles
KR20050088196A (ko) * 2002-12-19 2005-09-02 알자 코포레이션 안정한 비수성 단일 상 겔 및 이식가능한 장치로부터전달하기 위한 이의 제형
US7731947B2 (en) * 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
US8183290B2 (en) * 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
EP2339328A3 (de) 2002-12-30 2011-07-13 Transform Pharmaceuticals, Inc. Pharmazeutische kokristallisierte Celecoxib-Zusammensetzungen
AU2003272270A1 (en) 2003-02-28 2004-09-28 The Regents Of The University Of Michigan Pharmaceutical co-crystal compositions of drugs such as carbamazeptine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
CN1767815A (zh) * 2003-03-31 2006-05-03 阿尔萨公司 非水单相载体和使用这类载体的制剂
KR20060017749A (ko) * 2003-03-31 2006-02-27 알자 코포레이션 내압 소멸 수단을 갖는 삼투성 펌프
CA2520766A1 (en) * 2003-03-31 2004-10-21 Alza Corporation Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems
US20040214893A1 (en) * 2003-04-11 2004-10-28 Matthew Peterson Gabapentin compositions
JP2007502329A (ja) 2003-05-23 2007-02-08 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド セルトラリン組成物
WO2005007020A2 (en) * 2003-07-03 2005-01-27 Corium International, Inc. Wound dressing, ingredient delivery device and iv hold-down, and method relating to same
US20090208540A1 (en) * 2003-08-11 2009-08-20 Indevus Pharmaceuticals, Inc. Implantable device for the delivery of naltrexone and methods of use thereof
AU2013200837B2 (en) * 2003-08-11 2015-08-27 Braeburn Pharmaceuticals, Inc. Manufacture of long term drug delivery devices with polyurethane based polymers
US7858110B2 (en) * 2003-08-11 2010-12-28 Endo Pharmaceuticals Solutions, Inc. Long term drug delivery devices with polyurethane based polymers and their manufacture
CA2437639C (en) * 2003-08-11 2016-07-05 Valera Pharmaceuticals, Inc. Long term drug delivery devices with polyurethane based polymers and their manufacture
US7470266B2 (en) * 2003-09-16 2008-12-30 I-Flow Corporation Fluid medication delivery device
AU2004314693B2 (en) 2003-09-26 2011-04-07 Alza Corporation Drug coating providing high drug loading and methods for providing the same
CA2540056C (en) * 2003-09-26 2015-03-24 Alza Corporation Controlled release formulations of opioid and nonopioid analgesics
CA2540059C (en) 2003-09-26 2013-08-06 Alza Corporation Controlled release formulations exhibiting an ascending rate of release
JP5670609B2 (ja) * 2003-09-26 2015-02-18 アルザ・コーポレーシヨン 有効成分の制御送達のためのｏｒｏｓプッシュ−スティック
EP1682099A2 (de) 2003-09-30 2006-07-26 ALZA Corporation Ein aufsteigendes freisetzungsprofil liefernde osmotisch angetriebene wirkstoffabgabevorrichtung
US20050113410A1 (en) * 2003-11-03 2005-05-26 Mark Tawa Pharmaceutical salts of zafirlukast
CN1874763A (zh) * 2003-11-06 2006-12-06 阿尔扎公司 与可植入渗透泵一起使用的模块化吸入速率减小器
EP2428516A1 (de) 2003-11-19 2012-03-14 Metabasis Therapeutics, Inc. Neue Phosphor enthaltende Thyromimetika
EP2292213A1 (de) 2004-02-06 2011-03-09 Cephalon, Inc. Armodafinil Polymorph enthaltende Zusammensetzungen
WO2005094526A2 (en) * 2004-03-24 2005-10-13 Corium International, Inc. Transdermal delivery device
WO2005092065A2 (en) * 2004-03-25 2005-10-06 Transform Pharmaceuticals, Inc. Novel tricyclic compounds and related methods of treatment
US20050266087A1 (en) * 2004-05-25 2005-12-01 Gunjan Junnarkar Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
JP5017103B2 (ja) * 2004-06-17 2012-09-05 トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド 薬剤共結晶組成物および関連した使用方法
WO2006015325A1 (en) * 2004-07-30 2006-02-09 Bay Materials, Llc Method of reducing stress relaxation in polymer articles and articles formed thereby
US7780981B2 (en) 2004-09-13 2010-08-24 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery
US8541026B2 (en) * 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US8252320B2 (en) 2004-10-21 2012-08-28 Durect Corporation Transdermal delivery system for sufentanil
ATE471146T1 (de) 2004-10-21 2010-07-15 Durect Corp Transdermale verabreichungssysteme
US8779175B2 (en) 2004-10-25 2014-07-15 Synthonics, Inc. Coordination complexes, pharmaceutical solutions comprising coordination complexes, and methods of treating patients
US20060160783A1 (en) * 2004-12-30 2006-07-20 Transform Pharmaceuticals, Inc. Novel omeprazole forms and related methods
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
EP2361630A1 (de) * 2005-02-03 2011-08-31 Intarcia Therapeutics, Inc Implantierbares Arzneimittelfreigabesystem Partikel und eine osmotische Pumpe enthaltend
US20060188558A1 (en) * 2005-02-18 2006-08-24 Mylan Technologies, Inc. Transdermal systems having control delivery system
US7959938B2 (en) 2005-03-15 2011-06-14 Intarcia Therapeutics, Inc. Polyoxaester suspending vehicles for use with implantable delivery systems
US20060223786A1 (en) * 2005-04-01 2006-10-05 Smith David J Transdermal pain control method and device
US20070026047A1 (en) * 2005-06-21 2007-02-01 Li-Chun Tsou Thermal effect on crystalinity for drug delivery devices
US20070027105A1 (en) * 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US20110086086A1 (en) * 2005-07-26 2011-04-14 Pfizer Inc Transdermal system for varenicline
US7790671B2 (en) * 2005-10-07 2010-09-07 Codman & Shurtleff, Inc. Implantable pump for protein delivery for obesity control by drug infusion into the brain
US20090022798A1 (en) * 2007-07-20 2009-01-22 Abbott Gmbh & Co. Kg Formulations of nonopioid and confined opioid analgesics
US20100172989A1 (en) * 2006-01-21 2010-07-08 Abbott Laboratories Abuse resistant melt extruded formulation having reduced alcohol interaction
US20090317355A1 (en) * 2006-01-21 2009-12-24 Abbott Gmbh & Co. Kg, Abuse resistant melt extruded formulation having reduced alcohol interaction
US20070248657A1 (en) * 2006-04-25 2007-10-25 Smith David J Multi-compartment transdermal pain control device
JP5143131B2 (ja) 2006-05-30 2013-02-13 インターシア セラピューティクス，インコーポレイティド 浸透圧送出システムの二片構成内部チャネル型の流れモジュレータ
US7659344B2 (en) * 2006-06-08 2010-02-09 E. I. Du Pont De Nemours And Company Shaped articles containing poly(vinylpyrrolidone)-iodine complex
PL2359808T3 (pl) * 2006-08-09 2013-10-31 Intarcia Therapeutics Inc Osmotyczne systemy dostawcze i zespoły tłokowe
US9114133B2 (en) 2006-08-25 2015-08-25 U.S. Dept. Of Veterans Affairs Method of improving diastolic dysfunction
US7538652B2 (en) * 2006-08-29 2009-05-26 International Business Machines Corporation Electrical component tuned by conductive layer deletion
PT2117521E (pt) 2006-11-03 2012-09-10 Durect Corp Sistemas de administração transdérmica que compreendem bupivacaína
EP2121111B1 (de) * 2007-01-22 2018-03-14 Corium International, Inc. Applikator für mikronadelanordnung
KR20180099916A (ko) 2007-02-09 2018-09-05 메타베이시스 테라퓨틱스, 인크. 글루카곤 수용체의 길항제
US8911749B2 (en) * 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
EP2146689B1 (de) 2007-04-16 2020-08-12 Corium, Inc. Einen wirkstoff enthaltende lösungsmittel-gegossene mikronadelanordnungen
MX2009011123A (es) * 2007-04-23 2009-11-02 Intarcia Therapeutics Inc Formulaciones de suspensiones de peptidos insulinotropicos y sus usos.
CA2692364C (en) 2007-07-04 2015-05-19 Acino Ag Reservoir system comprising a closed membrane
CA2695583A1 (en) 2007-08-13 2009-02-19 Metabasis Therapeutics, Inc. Novel activators of glucokinase
JP5178132B2 (ja) * 2007-10-11 2013-04-10 キヤノン株式会社 画像処理システム並びに画像処理方法
US9226907B2 (en) 2008-02-01 2016-01-05 Abbvie Inc. Extended release hydrocodone acetaminophen and related methods and uses thereof
EP2240155B1 (de) 2008-02-13 2012-06-06 Intarcia Therapeutics, Inc Vorrichtungen, formulierungen und verfahren zur freisetzung mehrerer wirkstoffe
EP3153501B1 (de) 2008-08-13 2018-11-28 Metabasis Therapeutics, Inc. Glucagon-antagonisten
BRPI0919465A2 (pt) * 2008-09-30 2015-12-01 Endo Pharmaceuticals Solutions dispositivo implantável para a liberação de risperidona e métodos de uso do mesmo
JP2012504139A (ja) * 2008-09-30 2012-02-16 エンド ファーマスーティカルズ ソリューションズ インコーポレイテッド． ヒストレリン送達用埋め込み可能型装置およびその使用方法
CN106880596A (zh) * 2008-10-15 2017-06-23 精达制药公司 高浓缩药物颗粒、制剂、混悬剂及其应用
US20100221313A1 (en) * 2008-12-01 2010-09-02 Innovative Pharmaceuticals, Llc Transdermal reservoir patch
KR100911753B1 (ko) * 2009-02-04 2009-08-10 (주)씨에스텍 경피투여형 패치제 및 이의 제조방법
HUP0900073A2 (en) * 2009-02-06 2010-11-29 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process and equipment for inquiry medical product on dermal surface
EP2429627B1 (de) * 2009-04-24 2017-06-14 Corium International, Inc. Verfahren zur herstellung von mikroprojektionsarrays
NZ598686A (en) 2009-09-28 2014-05-30 Intarcia Therapeutics Inc Rapid establishment and/or termination of substantial steady-state drug delivery
AU2010313456A1 (en) 2009-10-30 2012-05-17 Ntf Therapeutics, Inc. Improved neurturin molecules
AU2011237592B2 (en) 2010-04-08 2016-10-27 Emory University Substituted androst-4-ene diones
KR20130073893A (ko) 2010-04-13 2013-07-03 나지브 바불 1-메틸-2''-6''-피페콜옥실리디드의 피부 약제학적 조성물 및 사용 방법
EP2563380B1 (de) 2010-04-26 2018-05-30 aTyr Pharma, Inc. Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten der cysteinyl-trna-synthetase
AU2011248614B2 (en) 2010-04-27 2017-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases
AU2011288209C1 (en) 2010-04-28 2016-03-24 Kimberly-Clark Worldwide, Inc. Injection molded microneedle array and method for forming the microneedle array
AU2011311255B2 (en) 2010-04-28 2015-10-08 Sorrento Therapeutics, Inc. Method for increasing permeability of an epithelial barrier
US8993723B2 (en) 2010-04-28 2015-03-31 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl-tRNA synthetases
AU2011246879C1 (en) 2010-04-28 2016-03-24 Sorrento Therapeutics, Inc. Device for delivery of rheumatoid arthritis medication
CN102985131B (zh) 2010-04-28 2016-06-29 金伯利-克拉克环球有限公司 用于递送siRNA的医疗装置
EP2563383B1 (de) 2010-04-29 2017-03-01 Atyr Pharma, Inc. Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten von valyl-trna-synthetasen
CA2797374C (en) 2010-04-29 2021-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases
WO2011139986A2 (en) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases
CN103140233B (zh) 2010-05-03 2017-04-05 Atyr 医药公司 与甲硫氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现
ES2623805T3 (es) 2010-05-03 2017-07-12 Atyr Pharma, Inc. Descubrimiento innovador de composiciones terapéuticas, de diagnóstico y de anticuerpos relacionadas con fragmentos de proteínas de fenilalanil-alfa-ARNt sintetasas
JP6008844B2 (ja) 2010-05-04 2016-10-19 エータイアー ファーマ， インコーポレイテッド ｐ３８ＭＵＬＴＩ−ｔＲＮＡ合成酵素複合体のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
ES2719595T3 (es) 2010-05-04 2019-07-11 Corium Int Inc Método y dispositivo para la administración transdérmica de la hormona paratiroidea usando una matriz de microproyección
AU2011252990B2 (en) 2010-05-14 2017-04-20 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases
CA2799480C (en) 2010-05-17 2020-12-15 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-trna synthetases
EP2575856B1 (de) 2010-05-27 2017-08-16 aTyr Pharma, Inc. Therapeutische, diagnostische und antikörperhaltige zusammensetzungen in zusammenhang mit proteinfragmenten von glutaminyl-trna-synthetasen
WO2011153277A2 (en) 2010-06-01 2011-12-08 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases
WO2012021247A2 (en) 2010-07-12 2012-02-16 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases
AU2011293294B2 (en) 2010-08-25 2016-03-24 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Tyrosyl-tRNA synthetases
US8919385B2 (en) 2010-11-24 2014-12-30 Pall Corporation Manifold plates and fluid treatment arrangements including manifold plates
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
WO2012129237A2 (en) 2011-03-20 2012-09-27 Trustees Of Boston University Therapeutic agent for emphysema and copd
US8636696B2 (en) 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
US20140227293A1 (en) 2011-06-30 2014-08-14 Trustees Of Boston University Method for controlling tumor growth, angiogenesis and metastasis using immunoglobulin containing and proline rich receptor-1 (igpr-1)
WO2013061208A1 (en) 2011-10-27 2013-05-02 Kimberly-Clark Worldwide, Inc. Transdermal delivery of high viscosity bioactive agents
US20150196515A1 (en) * 2012-08-15 2015-07-16 Dow Coming Corporation Multi-Layer Drug Delivery System
US11052231B2 (en) 2012-12-21 2021-07-06 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
WO2014132239A1 (en) 2013-02-28 2014-09-04 Kimberly-Clark Worldwide, Inc. Drug delivery device
CN109621083B (zh) 2013-02-28 2022-03-22 索伦托治疗有限公司 药物递送装置
RU2674083C2 (ru) 2013-03-12 2018-12-04 Кориум Интернэшнл, Инк. Аппликаторы с микровыступами
EP2968116A1 (de) 2013-03-15 2016-01-20 Corium International, Inc. Mikroarray mit polymerfreien mikrostrukturen, verfahren zur herstellung und verfahren zur verwendung
WO2014150285A2 (en) 2013-03-15 2014-09-25 Corium International, Inc. Multiple impact microprojection applicators and methods of use
ES2761580T3 (es) 2013-03-15 2020-05-20 Corium Inc Micromatrices para suministro de agente terapéutico, métodos de uso y métodos de fabricación
US20140272220A1 (en) * 2013-03-15 2014-09-18 Monosol Rx, Llc Reduction in stress cracking of films
AU2014233695A1 (en) 2013-03-15 2015-10-01 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
DK2983750T3 (da) 2013-04-10 2019-01-02 Sanofi Sa Dispenseringshastighedsstyremekanisme og indsprøjtningsindretning
WO2015027146A1 (en) 2013-08-22 2015-02-26 The General Hospital Corporation Inhibitors of human 12/15-lipoxygenase
WO2015191900A1 (en) 2014-06-12 2015-12-17 Ligand Pharmaceuticals, Inc. Glucagon antagonists
WO2016036866A1 (en) 2014-09-04 2016-03-10 Corium International, Inc. Microstructure array, methods of making, and methods of use
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US10213586B2 (en) 2015-01-28 2019-02-26 Chrono Therapeutics Inc. Drug delivery methods and systems
AU2016270984B2 (en) 2015-06-03 2021-02-25 Intarcia Therapeutics, Inc. Implant placement and removal systems
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
PL3370705T3 (pl) 2015-11-05 2022-08-01 The General Hospital Corporation Dooponowe dostarczanie sekwencji kwasów nukleinowych do kodowania abcd1 w leczeniu adrenomieloneuropatii
CN109310743A (zh) 2016-05-16 2019-02-05 因塔西亚制药公司 胰高血糖素受体选择性多肽及其使用方法
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
US10869842B1 (en) * 2016-09-07 2020-12-22 David P Summers Transdermal delivery of pharmaceutical agents
CA3040906A1 (en) 2016-10-20 2018-04-26 Peptron, Inc. Methods of delivering a neuroprotective polypeptide to the central nervous system
EP3565580B1 (de) 2017-01-03 2024-03-06 i2o Therapeutics, Inc. Kontinuierlicher verabreichung von exenatid und co-verabreichung von acetaminophen, ethinylestradiol oder levonorgestrel
AU2018205529B2 (en) 2017-01-06 2023-08-10 Morningside Venture Investments Limited Transdermal drug delivery devices and methods
US20200188479A1 (en) 2017-03-08 2020-06-18 Intarcia Therapeutics, Inc. Apparatus and methods for administration of a nauseogenic compound from a drug delivery device
CA3101966A1 (en) 2018-05-29 2019-12-05 Morningside Venture Investments Limited Drug delivery methods and systems
USD933219S1 (en) 2018-07-13 2021-10-12 Intarcia Therapeutics, Inc. Implant removal tool and assembly
AU2019357621A1 (en) 2018-10-11 2021-05-27 Intarcia Therapeutics, Inc. Human amylin analog polypeptides and methods of use
AU2019381810A1 (en) * 2018-11-16 2021-06-03 Morningside Venture Investments Limited Thermally regulated transdermal drug delivery system
KR20220140711A (ko) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법
CN112472688A (zh) * 2020-11-09 2021-03-12 黄家辉 一种控释膜及其制备方法

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3797494A (en) 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3788322A (en) * 1972-12-27 1974-01-29 Alza Corp Drug delivery device with means for maintaining device in environment of use
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US3987790A (en) 1975-10-01 1976-10-26 Alza Corporation Osmotically driven fluid dispenser
US4077407A (en) * 1975-11-24 1978-03-07 Alza Corporation Osmotic devices having composite walls
US4436741A (en) 1975-12-08 1984-03-13 Alza Corporation Method for administering scopolamine transdermally
US4031894A (en) 1975-12-08 1977-06-28 Alza Corporation Bandage for transdermally administering scopolamine to prevent nausea
US4203439A (en) 1976-11-22 1980-05-20 Alza Corporation Osmotic system with volume amplifier for increasing amount of agent delivered therefrom
US4111203A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system with means for improving delivery kinetics of system
US4111202A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system for the controlled and delivery of agent over time
US4201211A (en) 1977-07-12 1980-05-06 Alza Corporation Therapeutic system for administering clonidine transdermally
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US4379454A (en) 1981-02-17 1983-04-12 Alza Corporation Dosage for coadministering drug and percutaneous absorption enhancer
US4661105A (en) 1981-06-29 1987-04-28 Alza Corporation Medical bandage for administering vasodilator drug
US4725272A (en) 1981-06-29 1988-02-16 Alza Corporation Novel bandage for administering beneficial drug
US5310559A (en) 1982-09-01 1994-05-10 Hercon Laboratories Corporation Device for controlled release and delivery to mammalian tissue of pharmacologically active agents incorporating a rate controlling member which comprises an alkylene-alkyl acrylate copolymer
US4612008A (en) 1983-05-11 1986-09-16 Alza Corporation Osmotic device with dual thermodynamic activity
US4588580B2 (en) * 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
US4681584A (en) 1985-05-03 1987-07-21 Alza Corporation Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes
US4615699A (en) 1985-05-03 1986-10-07 Alza Corporation Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes
US4698062A (en) 1985-10-30 1987-10-06 Alza Corporation Medical device for pulsatile transdermal delivery of biologically active agents
US4865845A (en) 1986-03-21 1989-09-12 Alza Corporation Release rate adjustment of osmotic or diffusional delivery devices
US4908027A (en) 1986-09-12 1990-03-13 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US5344656A (en) 1986-09-12 1994-09-06 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4832953A (en) 1987-08-13 1989-05-23 Alza Corporation Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix
US5024842A (en) * 1988-04-28 1991-06-18 Alza Corporation Annealed coats
US5160743A (en) 1988-04-28 1992-11-03 Alza Corporation Annealed composition for pharmaceutically acceptable drug
US4931285A (en) 1988-04-28 1990-06-05 Alza Corporation Aqueous based pharmaceutical coating composition for dosage forms
US5364630A (en) 1988-06-14 1994-11-15 Alza Corporation Subsaturated nicotine transdermal therapeutic system
US5004610A (en) 1988-06-14 1991-04-02 Alza Corporation Subsaturated nicotine transdermal therapeutic system
US5110596A (en) 1988-12-13 1992-05-05 Alza Corporation Delivery system comprising means for delivering agent to livestock
US5059423A (en) 1988-12-13 1991-10-22 Alza Corporation Delivery system comprising biocompatible beneficial agent formulation
US5057318A (en) 1988-12-13 1991-10-15 Alza Corporation Delivery system for beneficial agent over a broad range of rates
US5034229A (en) 1988-12-13 1991-07-23 Alza Corporation Dispenser for increasing feed conversion of hog
US5112614A (en) 1989-09-14 1992-05-12 Alza Corporation Implantable delivery dispenser
US5324280A (en) * 1990-04-02 1994-06-28 Alza Corporation Osmotic dosage system for delivering a formulation comprising liquid carrier and drug
US5234693A (en) 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5234692A (en) 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
AU651654B2 (en) * 1992-01-14 1994-07-28 Endo Pharmaceuticals Solutions Inc. Manufacture of water-swellable hydrophilic articles and drug delivery devices
US5137727A (en) 1991-06-12 1992-08-11 Alza Corporation Delivery device providing beneficial agent stability
EP0863751B1 (de) * 1995-12-01 2001-10-24 Alza Corporation Verbessertes verfahren zur verhinderung der kristallbildung in einer dispersion eines flüssigen stoffes in einer matrix
CZ293808B6 (cs) * 1996-02-02 2004-08-18 Alzaácorporation Implantabilní zařízení k dodávání leuprolidu do okolního tekutinového prostředí
AU1623099A (en) * 1997-12-22 1999-07-12 Alza Corporation Rate controlling membranes for controlled drug delivery devices

Also Published As

Publication number Publication date
CA2315890C (en) 2009-08-11
HK1029923A1 (en) 2001-04-20
JP4215188B2 (ja) 2009-01-28
TW575438B (en) 2004-02-11
CN1282240A (zh) 2001-01-31
ATE223208T1 (de) 2002-09-15
ES2182379T3 (es) 2003-03-01
JP2001526214A (ja) 2001-12-18
KR20010033412A (ko) 2001-04-25
EP1041975B1 (de) 2002-09-04
EP1041975A1 (de) 2000-10-11
KR100576583B1 (ko) 2006-05-04
DK1041975T3 (da) 2002-11-04
AU1623099A (en) 1999-07-12
CN100388916C (zh) 2008-05-21
DE69807748D1 (de) 2002-10-10
ZA9811716B (en) 1999-06-24
US6375978B1 (en) 2002-04-23
AR014065A1 (es) 2001-01-31
WO1999032095A1 (en) 1999-07-01
CA2315890A1 (en) 1999-07-01
US20020034535A1 (en) 2002-03-21
PT1041975E (pt) 2003-01-31

Similar Documents

Publication Publication Date Title
DE69807748T2 (de) Membranen zur steuerung des durchflusses in vorrichtungen mit kontrollierter wirkstoffabgabe
DE69838955D1 (de) Implantat mit durchflussregelung
DE69719394D1 (de) Durchflusskontrollvorrichtung mit Dreiwegehahn
DE69817034D1 (de) Verteilersystem mit durchflusssteuerung
DE69907704D1 (de) Speichersteuerungsvorrichtung mit programmierbarem verzögerungszähler zur leistungsabstimmung in abhängigkeit von zeitparametern des gesteuerten speichergeräts
DE69841253D1 (de) Medizinisches durchflussregelventil
DE69517216T2 (de) Absorbierender Artikel mit verbesserter Durchflusskontrolle
DE69811663D1 (de) Ventil zur anwendung im bohrloch
DE69110209D1 (de) Ventil zur Regelung des Flüssigkeitsdurchflusses.
ID28232A (id) Formulasi farmasi dengan pelepasan terkontrol
DE69531837D1 (de) Flüssigheitsverteiler und Wasserreiniger mit diesem Verteiler
EE200000788A (et) Ravimi läbimiskiirust kontrolliv membraan või maatriks
IT1306203B1 (it) Uso di insetticidi nel controllo di organismi nocivi.
DE69114344D1 (de) Schalter zur Kontrolle des Stromflusses in Supraleitern.
DK0740808T3 (da) Termostatreguleret blandeventil
DE69426027D1 (de) Thermisch gesteuertes Ventil
DE69837538D1 (de) Motorisierte durchflussregelventil
DE69713619D1 (de) Flüssigkeitsmengenregelventil
DE69828283D1 (de) System zur steuerung von transaktionen in kommunikationsnetzwerken
ATA35199A (de) Steuereinrichtung zur steuerung des stromflusswinkels
DE69111167T2 (de) Vorrichtung zur steuerung des flüssigkeitszulaufs.
DE69805524D1 (de) Flüssigkeitverteilendes leistungsventil
EP1232356A4 (de) Durchflussregelventil
DE29609979U1 (de) Ventil, insbesondere zur Flüssigkeitsregelung in Dosiergeräten
DE29520455U1 (de) Zahnärztliches Spritzhandstück mit Mitteln zur Steuerung des Medienflusses

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: INTARCIA THERAPEUTICS, INC., HAYWARD, CA, US