DE69804964D1 - Neue verbindungen - Google Patents

Neue verbindungen

Info

Publication number
DE69804964D1
DE69804964D1 DE69804964T DE69804964T DE69804964D1 DE 69804964 D1 DE69804964 D1 DE 69804964D1 DE 69804964 T DE69804964 T DE 69804964T DE 69804964 T DE69804964 T DE 69804964T DE 69804964 D1 DE69804964 D1 DE 69804964D1
Authority
DE
Germany
Prior art keywords
pct
new connections
sec
date
pub
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69804964T
Other languages
English (en)
Other versions
DE69804964T2 (de
Inventor
David Hardern
Brian Springthorpe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WEY HANS HEINRICH
Original Assignee
WEY HANS HEINRICH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WEY HANS HEINRICH filed Critical WEY HANS HEINRICH
Publication of DE69804964D1 publication Critical patent/DE69804964D1/de
Application granted granted Critical
Publication of DE69804964T2 publication Critical patent/DE69804964T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
DE69804964T 1997-07-22 1998-07-15 Neue verbindungen Expired - Fee Related DE69804964T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9702772A SE9702772D0 (sv) 1997-07-22 1997-07-22 Novel compounds
PCT/SE1998/001392 WO1999005142A1 (en) 1997-07-22 1998-07-15 Novel compounds

Publications (2)

Publication Number Publication Date
DE69804964D1 true DE69804964D1 (de) 2002-05-23
DE69804964T2 DE69804964T2 (de) 2002-11-07

Family

ID=20407803

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69804964T Expired - Fee Related DE69804964T2 (de) 1997-07-22 1998-07-15 Neue verbindungen

Country Status (21)

Country Link
US (1) US6156756A (de)
EP (1) EP0996620B1 (de)
JP (1) JP2001510841A (de)
KR (1) KR20010022082A (de)
CN (1) CN1271359A (de)
AT (1) ATE216389T1 (de)
AU (1) AU8370598A (de)
BR (1) BR9811022A (de)
CA (1) CA2296648A1 (de)
DE (1) DE69804964T2 (de)
EE (1) EE200000042A (de)
HU (1) HUP0100202A3 (de)
ID (1) ID24837A (de)
IL (1) IL134112A0 (de)
IS (1) IS5351A (de)
NO (1) NO20000311L (de)
PL (1) PL338518A1 (de)
SE (1) SE9702772D0 (de)
SK (1) SK188099A3 (de)
TR (1) TR200000151T2 (de)
WO (1) WO1999005142A1 (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9702773D0 (sv) * 1997-07-22 1997-07-22 Astra Pharma Prod Novel compounds
DE69905451T2 (de) * 1998-02-17 2003-11-20 Astrazeneca Uk Ltd., London Neue triazolo(4,5d) pyrimidinverbindungen
SE9802574D0 (sv) * 1998-07-17 1998-07-17 Astra Pharma Prod Novel compounds
TWI229674B (en) * 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
SE9904129D0 (sv) * 1999-11-15 1999-11-15 Astra Pharma Prod Novel compounds
SE9904128D0 (sv) * 1999-11-15 1999-11-15 Astra Pharma Prod Novel compounds
US6867199B2 (en) 2000-08-21 2005-03-15 Inspire Pharmaceuticals, Inc. Dinucleoside polyphosphate compositions and their therapeutic use
US7504497B2 (en) 2003-10-21 2009-03-17 Inspire Pharmaceuticals, Inc. Orally bioavailable compounds and methods for inhibiting platelet aggregation
JP2007514647A (ja) 2003-10-21 2007-06-07 インスパイアー ファーマシューティカルズ，インコーポレイティド テトラヒドロ−フロ［３，４−ｄ］ジオキソール化合物並びに血小板凝集を阻害する組成物及び方法
US7335648B2 (en) 2003-10-21 2008-02-26 Inspire Pharmaceuticals, Inc. Non-nucleotide composition and method for inhibiting platelet aggregation
US7749981B2 (en) 2003-10-21 2010-07-06 Inspire Pharmaceuticals, Inc. Drug-eluting stents coated with non-nucleotide P2Y12 receptor antagonist compound
US7932376B2 (en) 2005-05-05 2011-04-26 Inspire Pharmaceuticals, Inc. Pyrimidine-based non-nucleotide composition and method for inhibiting platelet aggregation
US8148385B2 (en) 2006-10-31 2012-04-03 Janssen Pharmaceutica N.V. Substituted [1,2,3] triazolo[4,5-d]pyrimidine derivatives as ADP P2Y12 receptor antagonists
CA2668180A1 (en) * 2006-10-31 2008-05-08 Janssen Pharmaceutica N.V. Triazolopyrimidine derivatives as adp p2y12 receptor antagonists
TWI496776B (zh) * 2007-11-15 2015-08-21 Astrazeneca Ab 製備(3aR,4S,6R,6aS)-6-胺基-2,2-二甲基四氫-3aH-環戊并[d][1,3]二氧雜環戊烯-4-醇之純非對映異構性之二苯甲醯-L-酒石酸鹽之方法
WO2010043721A1 (en) 2008-10-17 2010-04-22 Oryzon Genomics, S.A. Oxidase inhibitors and their use
WO2010084160A1 (en) 2009-01-21 2010-07-29 Oryzon Genomics S.A. Phenylcyclopropylamine derivatives and their medical use
WO2011017108A2 (en) 2009-07-27 2011-02-10 Auspex Pharmaceuticals, Inc. Cyclopropyl modulators of p2y12 receptor
WO2011035941A1 (en) 2009-09-25 2011-03-31 Oryzon Genomics S.A. Lysine specific demethylase-1 inhibitors and their use
WO2011042217A1 (en) 2009-10-09 2011-04-14 Oryzon Genomics S.A. Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use
AU2011216991A1 (en) 2010-02-16 2012-08-30 Actavis Group Ptc Ehf Improved processes for preparing ticagrelor intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine
US9186337B2 (en) 2010-02-24 2015-11-17 Oryzon Genomics S.A. Lysine demethylase inhibitors for diseases and disorders associated with Hepadnaviridae
US9616058B2 (en) 2010-02-24 2017-04-11 Oryzon Genomics, S.A. Potent selective LSD1 inhibitors and dual LSD1/MAO-B inhibitors for antiviral use
KR101794020B1 (ko) 2010-04-19 2017-11-06 오리존 지노믹스 에스.에이. 라이신 특이적 디메틸라아제-1 억제제 및 이의 용도
WO2012013727A1 (en) 2010-07-29 2012-02-02 Oryzon Genomics S.A. Cyclopropylamine derivatives useful as lsd1 inhibitors
RU2611437C2 (ru) 2010-07-29 2017-02-22 Оризон Дженомикс С.А. Ингибиторы деметилазы lsd1 на основе арилциклопропиламина и их применение в медицине
WO2012045883A1 (en) 2010-10-08 2012-04-12 Oryzon Genomics S.A. Cyclopropylamine inhibitors of oxidases
WO2012063126A2 (en) 2010-11-09 2012-05-18 Actavis Group Ptc Ehf Improved processes for preparing pure (3ar,4s,6r,6as)-6-amino-2,2-dimethyltetrahdro-3ah-cyclopenta[d] [1,3]-dioxol-4-ol and its key starting material
WO2012072713A2 (en) 2010-11-30 2012-06-07 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
RU2013133879A (ru) 2010-12-20 2015-01-27 Актавис Груп Птс Ехф НОВЫЕ СПОСОБЫ ПОЛУЧЕНИЯ ТРИАЗОЛО[4, 5-d]ПИРИМИДИНА, ЕГО ПРОИЗВОДНЫЕ И ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ
EP3981395A1 (de) 2011-02-08 2022-04-13 Oryzon Genomics, S.A. Lysindemethylase-hemmer für myeloproliferative erkrankungen
CZ2011229A3 (cs) 2011-04-19 2012-08-15 Zentiva, K.S. Opticky aktivní soli (3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyklopenta-[d][1,3]dioxol-4-olu a zpusob jejich prípravy
SI2707363T1 (sl) * 2011-05-13 2016-01-29 Astrazeneca Ab Postopek za pripravo benzil ((3as,4r,6s,6ar)-6-hidroksi-2,2- dimetiltetrahidro-3ah-ciklopenta(d)(1,3)dioksol)-4-il)karbamatq in vmesne spojine v postopku
WO2012172426A1 (en) 2011-06-15 2012-12-20 Actavis Group Ptc Ehf Improved process for preparing cyclopentylamine derivatives and intermediates thereof
CN102924457A (zh) * 2011-08-12 2013-02-13 上海恒瑞医药有限公司 三唑并嘧啶类衍生物、其制备方法及其用途
BR112014009306B1 (pt) 2011-10-20 2021-07-20 Oryzon Genomics S.A. Compostos de (hetero)aril ciclopropilamina como inibidores de lsd1
CN107417549A (zh) 2011-10-20 2017-12-01 奥莱松基因组股份有限公司 作为lsd1抑制剂的（杂）芳基环丙基胺化合物
CN102659691B (zh) * 2012-05-23 2014-04-02 山东诚创医药技术开发有限公司 一种4,6-二氯-5-氨基-2-丙硫基嘧啶的制备方法
PL2822954T3 (pl) 2012-12-21 2016-09-30 Policykliczne związki karbamoilopirydonu i ich farmaceutyczne zastosowanie
WO2014206187A1 (zh) 2013-06-24 2014-12-31 苏州明锐医药科技有限公司 替卡格雷及其中间体的制备方法
SI3252058T1 (sl) 2013-07-12 2021-03-31 Gilead Sciences, Inc. Policiklične karbamoilpiridonske spojine in njihova uporaba za zdravljenje okužb s HIV
NO2865735T3 (de) 2013-07-12 2018-07-21
WO2015162630A1 (en) 2014-04-25 2015-10-29 Anlon Chemical Research Organization Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis.
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
NO2717902T3 (de) 2014-06-20 2018-06-23
TWI744723B (zh) 2014-06-20 2021-11-01 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
WO2018183965A1 (en) * 2017-03-30 2018-10-04 Corvus Pharmaceuticals, Inc. Processes for making triazolo[4,5d] pyramidine derivatives and intermediates thereof
JP6722365B1 (ja) * 2017-07-18 2020-07-15 ロンザ リミテッドＬｏｎｚａ Ｌｉｍｉｔｅｄ 塩素化ｓ−プロピル−チオバルビツル酸の製造方法
WO2020068583A1 (en) * 2018-09-27 2020-04-02 Corvus Pharmaceuticals, Inc. Processes for making triazolo [4,5d] pyramidine derivatives and intermediates thereof
CN111116592A (zh) * 2019-11-27 2020-05-08 杭州沧海帆医药科技有限公司 嘧啶并三氮唑类化合物及其医药用途
CN115710275B (zh) * 2022-11-21 2024-02-02 河南中医药大学 一种嘧啶-tcp类化合物、制备方法和医药用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4742064A (en) * 1985-09-10 1988-05-03 Regents Of The University Of Minnesota Antiviral carbocyclic analogs of xylofuranosylpurines
GB8826205D0 (en) * 1988-11-09 1988-12-14 Wellcome Found Heterocyclic compounds
AU699034B2 (en) * 1995-07-11 1998-11-19 Astrazeneca Ab New inhibitors of platelet aggregation
WO1998028300A1 (en) * 1996-12-20 1998-07-02 Astra Pharmaceuticals Ltd. Triazolo[4,5-d]pyrimidinyl derivatives and their use as medicaments

Also Published As

Publication number Publication date
HUP0100202A2 (hu) 2001-08-28
ID24837A (id) 2000-08-24
BR9811022A (pt) 2000-09-12
SE9702772D0 (sv) 1997-07-22
CN1271359A (zh) 2000-10-25
ATE216389T1 (de) 2002-05-15
EP0996620A1 (de) 2000-05-03
IL134112A0 (en) 2001-07-24
TR200000151T2 (tr) 2000-09-21
CA2296648A1 (en) 1999-02-04
DE69804964T2 (de) 2002-11-07
KR20010022082A (ko) 2001-03-15
US6156756A (en) 2000-12-05
PL338518A1 (en) 2000-11-06
NO20000311L (no) 2000-03-21
IS5351A (is) 2000-01-19
EP0996620B1 (de) 2002-04-17
SK188099A3 (en) 2000-08-14
JP2001510841A (ja) 2001-08-07
EE200000042A (et) 2000-10-16
WO1999005142A1 (en) 1999-02-04
NO20000311D0 (no) 2000-01-21
AU8370598A (en) 1999-02-16
HUP0100202A3 (en) 2001-10-29

Similar Documents

Publication Publication Date Title
ATE216389T1 (de) Neue verbindungen
TR200000197T2 (tr) Yeni bileşimler
MY121867A (en) Novel triazolo(4,5-d)pyrimidine compounds.
AU2002305143A1 (en) Pyrazolo'1,5-a!pyridine derivatives
DE69804966D1 (de) Neue verbindungen
PL336230A1 (en) Novel chemical compounds
DE69807741D1 (de) Neuartige verbindungen
IL133825A0 (en) Substituted 6-phenylphenanthridines, medicaments containing same and use thereof
EE9900315A (et) Pürrolo[3,4-d]pürimidinooni derivaadid ja nende kasutamine ravimitena
GEP20033081B (en) Pharmaceutical Agents for Treatment of Parkinson's Disease, ADFD and Microadenomas
DE69911785D1 (de) Triazolo[4,5-d]pyrimidin-verbindungen
DE60123103D1 (de) Neue verbindungen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee