DE69802832D1 - Gepresste nitroglycerintablette und verfahren zu ihrer herstellung - Google Patents

Gepresste nitroglycerintablette und verfahren zu ihrer herstellung

Info

Publication number
DE69802832D1
DE69802832D1 DE69802832T DE69802832T DE69802832D1 DE 69802832 D1 DE69802832 D1 DE 69802832D1 DE 69802832 T DE69802832 T DE 69802832T DE 69802832 T DE69802832 T DE 69802832T DE 69802832 D1 DE69802832 D1 DE 69802832D1
Authority
DE
Germany
Prior art keywords
nitroglycerin
tablets
stable
direct compression
compression technology
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69802832T
Other languages
English (en)
Other versions
DE69802832T2 (de
Inventor
L Capella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of DE69802832D1 publication Critical patent/DE69802832D1/de
Application granted granted Critical
Publication of DE69802832T2 publication Critical patent/DE69802832T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69802832T 1997-10-03 1998-09-16 Gepresste nitroglycerintablette und verfahren zu ihrer herstellung Expired - Fee Related DE69802832T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6110597P 1997-10-03 1997-10-03
PCT/US1998/019356 WO1999017766A1 (en) 1997-10-03 1998-09-16 Compressed nitroglycerin tablet and its method of manufacture

Publications (2)

Publication Number Publication Date
DE69802832D1 true DE69802832D1 (de) 2002-01-17
DE69802832T2 DE69802832T2 (de) 2002-06-20

Family

ID=22033623

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69802832T Expired - Fee Related DE69802832T2 (de) 1997-10-03 1998-09-16 Gepresste nitroglycerintablette und verfahren zu ihrer herstellung

Country Status (16)

Country Link
US (1) US6500456B1 (de)
EP (1) EP1019039B1 (de)
JP (1) JP2001518500A (de)
KR (1) KR100569763B1 (de)
AT (1) ATE209911T1 (de)
AU (1) AU759018B2 (de)
BR (1) BR9812605B1 (de)
CA (1) CA2299231C (de)
DE (1) DE69802832T2 (de)
DK (1) DK1019039T3 (de)
ES (1) ES2169558T3 (de)
IL (1) IL134395A (de)
NZ (1) NZ502878A (de)
PT (1) PT1019039E (de)
TW (1) TWI228989B (de)
WO (1) WO1999017766A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7815937B2 (en) * 1998-10-27 2010-10-19 Biovail Laboratories International Srl Quick dissolve compositions and tablets based thereon
AU1323400A (en) * 1998-10-27 2000-05-15 Fuisz Technologies Ltd. Microparticles containing peg and/or peg glyceryl esters
US7815936B2 (en) 2001-10-30 2010-10-19 Evonik Degussa Gmbh Use of granular materials based on pyrogenically produced silicon dioxide in pharmaceutical compositions
US20040109889A1 (en) 2002-12-04 2004-06-10 Bunick Frank J. Surface treatment composition for soft substrates
US9254294B2 (en) 2003-02-24 2016-02-09 Pharmaceutical Productions Inc. Transmucosal hormone delivery system
JP5475215B2 (ja) * 2003-02-24 2014-04-16 ファーマシューティカル プロダクションズ， インコーポレイテッド 経粘膜薬物送達システム
US9358296B2 (en) 2003-02-24 2016-06-07 Pharmaceutical Productions Inc. Transmucosal drug delivery system
US9498454B2 (en) 2003-02-24 2016-11-22 Pharmaceutical Productions Inc. Transmucosal drug delivery system
US10172810B2 (en) 2003-02-24 2019-01-08 Pharmaceutical Productions, Inc. Transmucosal ketamine delivery composition
WO2005004989A2 (en) * 2003-07-01 2005-01-20 Todd Maibach Film comprising therapeutic agents
US7999003B2 (en) * 2003-08-26 2011-08-16 Mannatech, Incorporated Antioxidant compositions and methods thereto
US20060134202A1 (en) * 2004-12-22 2006-06-22 Hack Jacob C Homeopathic sublingual dosage forms and methods thereof
US8535714B2 (en) 2006-01-06 2013-09-17 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US9289583B2 (en) 2006-01-06 2016-03-22 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8252329B2 (en) 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8753308B2 (en) 2006-01-06 2014-06-17 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US9066847B2 (en) 2007-01-05 2015-06-30 Aceirx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
US8252328B2 (en) * 2006-01-06 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8357114B2 (en) 2006-01-06 2013-01-22 Acelrx Pharmaceuticals, Inc. Drug dispensing device with flexible push rod
US8865743B2 (en) 2006-01-06 2014-10-21 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8202535B2 (en) 2006-01-06 2012-06-19 Acelrx Pharmaceuticals, Inc. Small-volume oral transmucosal dosage forms
US20100215774A1 (en) * 2007-02-09 2010-08-26 Todd Maibach Film comprising nitroglycerin
US20090004254A1 (en) * 2007-06-19 2009-01-01 Todd Maibach Film comprising active drugs
ES2534433T3 (es) * 2007-08-07 2015-04-22 Acelrx Pharmaceuticals, Inc. Composiciones que comprenden sufentanilo y triazolam para sedación y analgesia operatorias utilizando formas farmacéuticas transmucosas orales
US8945592B2 (en) * 2008-11-21 2015-02-03 Acelrx Pharmaceuticals, Inc. Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
US20110091544A1 (en) * 2009-10-16 2011-04-21 Acelrx Pharmaceuticals, Inc. Compositions and Methods for Mild Sedation, Anxiolysis and Analgesia in the Procedural Setting
AU2011287948B2 (en) 2010-08-03 2014-11-06 G. Pohl-Boskamp Gmbh & Co. Kg Use of glyceryl trinitrate for treating traumatic edema
EP2678000B1 (de) * 2011-02-25 2018-03-07 G. Pohl-Boskamp GmbH & Co. KG Stabilisiertes granulat mit glyceryltrinitrat
US9248099B2 (en) 2012-05-31 2016-02-02 Desmoid Aktiengesellschaft Use of stabilized granules containing glyceryl trinitrate for arteriogenesis
PL2668947T3 (pl) 2012-05-31 2017-06-30 G. Pohl-Boskamp Gmbh & Co. Kg Indukcja arteriogenezy donorem NO, takim jak nitrogliceryna
EP2668948A1 (de) * 2012-05-31 2013-12-04 G. Pohl-Boskamp GmbH & Co. KG Verwendung von stabilisierten Körnchen mit Glyceryltrinitrat für Arteriogenese
CN104602693A (zh) * 2012-08-31 2015-05-06 安斯泰来制药株式会社 口服给药用药物组合物
CN105050708A (zh) 2012-11-14 2015-11-11 格雷斯公司 含有生物活性材料与无序无机氧化物的组合物
US20140303227A1 (en) * 2013-03-14 2014-10-09 Pharmaceutical Productions Inc. Transmucosal hormone delivery system
EP2878310B1 (de) 2013-11-29 2017-01-11 G. Pohl-Boskamp GmbH & Co. KG Sprühbare wässrige Zusammensetzung mit Nitroglycerin
JP2016510345A (ja) * 2014-02-07 2016-04-07 サイラブス， ファーマシューティカルズ 全自然非毒性舌下薬剤の送達システム
CN113679682A (zh) * 2020-05-19 2021-11-23 珠海润都制药股份有限公司 一种硝酸甘油舌下片及其制备方法
CN114469881A (zh) * 2022-03-14 2022-05-13 河北坤安药业有限公司 一种硝酸甘油片及其制备方法
CN115154431B (zh) * 2022-07-21 2024-03-12 南京卓康医药科技有限公司 一种硝酸甘油片剂及其制备方法
CN117653610A (zh) * 2023-09-28 2024-03-08 海南卓科制药有限公司 一种硝酸甘油片及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2357503A1 (de) * 1973-11-17 1975-05-28 Cassella Farbwerke Mainkur Ag Verfahren zur herstellung von festen carbocromen-hydrochlorid enthaltenden praeparaten
US4389393A (en) * 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
WO1996036330A2 (en) * 1995-05-17 1996-11-21 Cedars-Sinai Medical Center Compositions containing fatty acids for improving digestion and absorption in the small intestine
US5874418A (en) * 1997-05-05 1999-02-23 Cydex, Inc. Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use

Also Published As

Publication number Publication date
WO1999017766A1 (en) 1999-04-15
IL134395A0 (en) 2001-04-30
KR20010030839A (ko) 2001-04-16
EP1019039B1 (de) 2001-12-05
AU759018B2 (en) 2003-04-03
ATE209911T1 (de) 2001-12-15
AU9489398A (en) 1999-04-27
CA2299231C (en) 2003-03-18
DE69802832T2 (de) 2002-06-20
DK1019039T3 (da) 2002-03-25
TWI228989B (en) 2005-03-11
US6500456B1 (en) 2002-12-31
BR9812605A (pt) 2000-08-01
JP2001518500A (ja) 2001-10-16
NZ502878A (en) 2002-03-01
KR100569763B1 (ko) 2006-04-11
IL134395A (en) 2005-08-31
CA2299231A1 (en) 1999-04-15
BR9812605B1 (pt) 2009-01-13
EP1019039A1 (de) 2000-07-19
ES2169558T3 (es) 2002-07-01
PT1019039E (pt) 2002-04-29

Similar Documents

Publication Publication Date Title
ATE209911T1 (de) Gepresste nitroglycerintablette und verfahren zu ihrer herstellung
EP0151344A3 (de) Kaugummizusammensetzung, Herstellungsverfahren von Kaugummi und Kaugummi
CA2311734A1 (en) Flash-melt oral dosage formulation
NZ336789A (en) Use of methacrylic acid copolymer type C in the manufacture of tablets
EA199700110A1 (ru) Композиция с высоким содержанием ацетаминофена для прямого прессования
ATE100708T1 (de) Unbeschichtete pharmazeutische reaktionstablette.
ZA957670B (en) Pharmaceutical preparation containing metformin and processes for the production thereof
NO975320L (no) Kontinuerlige, fluorkjemiske mikrodispersjoner for avlevering av farmasöytiske midler
KR900012606A (ko) 이중 정제
ATE68346T1 (de) Feuchtigkeitsstabile feste valproinsaeurezubereitung und verfahren zu ihrer herstellung.
DE69513254T2 (de) Gepirone enthaltende Zusammensetzungen
ATE207739T1 (de) Enzymtablette und verfahren zu deren herstellung
MY120570A (en) Pharmaceutical preparation containing levothyroxine sodium
RU2002123182A (ru) Содержащая ибупрофен композиция
WO2003033808A3 (en) Composition and method for treating diabetes
IL78017A0 (en) Sustained release tablets of theophylline
ATE441410T1 (de) Fenofibrattabletten
KR910011241A (ko) 정제로 직접 압착 가능한 약제학적 분말 조성물을 제조하기 위한 분무 건조법
CA2185242C (en) Sustained release tablet containing diclofenac-na
ATE294580T1 (de) Nasses granulationsverfahren zur herstellung von pharmazeutischen tabletten mit paroxetinhydrochlorid anhydrat
ATE72118T1 (de) Pharmazeutische zusammensetzung und verfahren zu ihrer herstellung.
HU9602470D0 (en) Tablets containing captopril and process for producing them
CA2343949A1 (en) Benazepril hydrochloride tablet formulations
KR840001829A (ko) 새로운 이펜프로딜을 함유하는 정제의 제조방법
SU1155268A1 (ru) Способ получени шипучих таблеток

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee