DE69737415D1 - Gespannte, helixformende peptide und verfahren um sie herzustellen - Google Patents
Gespannte, helixformende peptide und verfahren um sie herzustellenInfo
- Publication number
- DE69737415D1 DE69737415D1 DE69737415T DE69737415T DE69737415D1 DE 69737415 D1 DE69737415 D1 DE 69737415D1 DE 69737415 T DE69737415 T DE 69737415T DE 69737415 T DE69737415 T DE 69737415T DE 69737415 D1 DE69737415 D1 DE 69737415D1
- Authority
- DE
- Germany
- Prior art keywords
- methods
- helix
- tightened
- create
- peptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 208000011616 HELIX syndrome Diseases 0.000 title 1
- 101800001690 Transmembrane protein gp41 Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000034217 membrane fusion Effects 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- AIDS & HIV (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74369896A | 1996-11-06 | 1996-11-06 | |
US743698 | 1996-11-06 | ||
US87669897A | 1997-06-16 | 1997-06-16 | |
US876698 | 1997-06-16 | ||
PCT/US1997/020069 WO1998020036A1 (en) | 1996-11-06 | 1997-11-05 | Constrained helical peptides and methods of making same |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69737415D1 true DE69737415D1 (de) | 2007-04-12 |
DE69737415T2 DE69737415T2 (de) | 2007-10-31 |
Family
ID=27114189
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69737415T Expired - Fee Related DE69737415T2 (de) | 1996-11-06 | 1997-11-05 | Gespannte, helixformende peptide und verfahren um sie herzustellen |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0938497B1 (de) |
JP (1) | JP2001503064A (de) |
AT (1) | ATE355300T1 (de) |
AU (1) | AU745101B2 (de) |
CA (1) | CA2270869A1 (de) |
DE (1) | DE69737415T2 (de) |
IL (1) | IL129772A0 (de) |
WO (1) | WO1998020036A1 (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
JP2002522029A (ja) | 1998-07-27 | 2002-07-23 | ジェネンテック・インコーポレーテッド | コートタンパク質の改変によるファージ提示における改良した形質転換効率 |
JP3971108B2 (ja) | 1999-01-06 | 2007-09-05 | ジェネンテック・インコーポレーテッド | インシュリン様成長因子(igf)i突然変異体 |
EP1282437B1 (de) | 2000-05-16 | 2008-03-19 | Genentech, Inc. | Behandlung von knorpelerkrankungen |
US20070160576A1 (en) | 2001-06-05 | 2007-07-12 | Genentech, Inc. | IL-17A/F heterologous polypeptides and therapeutic uses thereof |
MXPA03011985A (es) | 2001-06-20 | 2004-03-26 | Genentech Inc | Composiciones y metodos para el diagnostico y tratamiento de tumores. |
KR101008758B1 (ko) | 2001-09-18 | 2011-01-14 | 제넨테크, 인크. | 종양의 진단 및 치료를 위한 방법 및 이를 위한 조성물 |
EP2067472A1 (de) | 2002-01-02 | 2009-06-10 | Genentech, Inc. | Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Tumoren |
NZ535925A (en) | 2002-04-16 | 2008-06-30 | Genentech Inc | An isolated antibody that binds to a particular polypeptide |
JP4667868B2 (ja) * | 2002-08-06 | 2011-04-13 | アプラーゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング | 結合分子 |
ATE401345T1 (de) * | 2002-08-06 | 2008-08-15 | Aplagen Gmbh | Synthetische mimetika von physiologischen bindungsmolekülen |
EP1445614A1 (de) * | 2003-02-06 | 2004-08-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Verfahren zur in vitro Überwachung der Entwicklung von HIV Virus eines Individuums |
FR2851165A1 (fr) * | 2003-02-19 | 2004-08-20 | Aventis Pasteur | Antigene derivant de l'helice c de la proteine gp41 |
SI2784084T2 (sl) | 2003-07-08 | 2024-02-29 | Novartis Pharma Ag | Antagonistična protitelesa proti IL-17 A/F heterolognim polipeptidom |
CA2548483A1 (en) * | 2003-08-26 | 2005-03-10 | Uwe Fiebig | Induction of antiviral neutralizing antibodies in humans and animals |
US7329725B1 (en) | 2003-10-29 | 2008-02-12 | Nastech Pharmaceutical Company Inc. | Phage displayed Trp cage ligands |
EP2161283B1 (de) | 2003-11-17 | 2014-06-04 | Genentech, Inc. | Zusammensetzungen, die Antikörper gegen CD79b enthalten, die an Wachstumshemmer oder an zytotoxische Subtanzen gekoppelt sind und Verfahren zur Behandlung von Tumoren hämatopoetischen Ursprungs |
BRPI0607985A2 (pt) | 2005-03-10 | 2009-10-27 | Genentech Inc | modulador da dscr1, métodos de tratamento, método de melhoria de efeitos colaterais e método de inibição do crescimento de tumores |
CA2647277A1 (en) | 2006-04-05 | 2007-11-08 | Genentech, Inc. | Method for using boc/cdo to modulate hedgehog signaling |
EP2057465A4 (de) | 2006-08-09 | 2010-04-21 | Homestead Clinical Corp | Organspezifische proteine und anwendungsverfahren dafür |
JPWO2008032833A1 (ja) | 2006-09-14 | 2010-01-28 | 株式会社医学生物学研究所 | Adcc活性を増強させた抗体及びその製造方法 |
ES2379413T3 (es) | 2007-02-22 | 2012-04-25 | Genentech, Inc. | Procedimientos para detectar la enfermedad inflamatoria del intestino |
CA2713089C (en) | 2008-01-23 | 2017-11-21 | Dana Farber Cancer Institute | Compositions and methods for the treatment of viral infections |
EP2319869B1 (de) | 2008-06-20 | 2016-08-17 | National University Corporation Okayama University | ANTIKÖRPER GEGEN DEN OXIDIERTES LDL/ß²GPI-KOMPLEX UND ANWENDUNG DAVON |
EP2324049B1 (de) * | 2008-08-04 | 2016-05-25 | The Government of the U.S.A. as represented by The Secretary of the dept. of Health & Human Services | In der lipidschicht eines virusähnlichen partikelimpfstoffes verankerte proximale membranregion von hiv gp41 |
US9182406B2 (en) | 2008-08-04 | 2015-11-10 | Biodesy, Inc. | Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability |
EP2442829B1 (de) * | 2009-06-18 | 2021-02-24 | Dana-Farber Cancer Institute, Inc. | Strukturierte viralpeptidzusammensetzungen und verwendungsverfahren dafür |
WO2011050194A1 (en) | 2009-10-22 | 2011-04-28 | Genentech, Inc. | Methods and compositions for modulating hepsin activation of macrophage-stimulating protein |
CA2781887C (en) | 2009-11-30 | 2018-03-27 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
CA2787657A1 (en) | 2010-02-23 | 2011-09-01 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
BR112012028010A2 (pt) | 2010-05-03 | 2017-09-26 | Genentech Inc | anticorpo isolado, célula, ácido nucleíco isolado, método de identificação de um primeiro anticorpo que se liga a um epítopo antigênico tat425 ligado or um anticorpo, métodos de inibir o crescimento de uma célula, de tratamento terapêutico de determinação da presença de uma proteína de tat425 e de diagnóstico da presença de um tumor em um mamífero |
AU2012230899A1 (en) | 2011-03-21 | 2013-10-10 | Biodesy, Llc | Classification of kinase inhibitors using nonlinear optical techniques |
CA2846083A1 (en) | 2011-09-15 | 2013-03-21 | Genentech, Inc. | Methods of promoting differentiation |
JP6254087B2 (ja) | 2011-10-15 | 2017-12-27 | ジェネンテック, インコーポレイテッド | 癌を治療するためのscd1アンタゴニスト |
WO2013109856A2 (en) | 2012-01-18 | 2013-07-25 | Genentech, Inc. | Methods of using fgf19 modulators |
RU2014133069A (ru) | 2012-02-11 | 2016-04-10 | Дженентек, Инк. | Транслокации r-спондина и способы с их использованием |
US9139863B2 (en) | 2012-03-16 | 2015-09-22 | Genentech, Inc. | Engineered conformationally-stabilized proteins |
MX2014010943A (es) | 2012-03-16 | 2014-11-26 | Genentech Inc | Proteinas estabilizadas conformacionalmente de ingenieria. |
MX2014010953A (es) | 2012-03-16 | 2014-10-13 | Hoffmann La Roche | Metodos para tratamiento de melanoma con inhibidores pak1. |
GB2517857A (en) | 2012-04-25 | 2015-03-04 | Biodesy Inc | Methods for detecting allosteric modulators of proteins |
WO2013170191A1 (en) | 2012-05-11 | 2013-11-14 | Genentech, Inc. | Methods of using antagonists of nad biosynthesis from nicotinamide |
EP3633377A1 (de) | 2013-03-15 | 2020-04-08 | F. Hoffmann-La Roche AG | Biomarker und verfahren zur behandlung von pd-1 und pd-l1-verwandten leiden |
WO2015116902A1 (en) | 2014-01-31 | 2015-08-06 | Genentech, Inc. | G-protein coupled receptors in hedgehog signaling |
CA2944717A1 (en) | 2014-05-23 | 2015-11-26 | Genentech, Inc. | Mit biomarkers and methods using the same |
US10562946B2 (en) | 2014-06-20 | 2020-02-18 | Genentech, Inc. | Chagasin-based scaffold compositions, methods, and uses |
WO2016106286A1 (en) | 2014-12-23 | 2016-06-30 | Biodesy, Inc. | Attachment of proteins to interfaces for use in nonlinear optical detection |
JP6952605B2 (ja) | 2015-04-24 | 2021-10-20 | ジェネンテック, インコーポレイテッド | 多特異性抗原結合タンパク質 |
WO2017196891A1 (en) | 2016-05-09 | 2017-11-16 | Biodesy, Inc. | Methods and devices for detection of peripheral membrane protein interactions using nonlinear optical techniques |
JP2019534858A (ja) | 2016-09-09 | 2019-12-05 | ジェネンテック, インコーポレイテッド | Frizzledの選択的ペプチド阻害剤 |
WO2018152496A1 (en) | 2017-02-17 | 2018-08-23 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Compositions and methods for the diagnosis and treatment of zika virus infection |
US11236151B2 (en) | 2017-04-25 | 2022-02-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibodies and methods for the diagnosis and treatment of Epstein Barr virus infection |
US11827669B2 (en) | 2017-07-19 | 2023-11-28 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Antibodies and methods for the diagnosis and treatment of hepatitis b virus infection |
JP7397884B2 (ja) | 2019-05-09 | 2023-12-13 | ジェネンテック, インコーポレイテッド | 抗体の作製方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0527789A1 (de) * | 1990-04-03 | 1993-02-24 | Genentech, Inc. | Hiv-hüllpolypeptide |
AU9118891A (en) * | 1990-11-29 | 1992-06-25 | Smithkline Beecham Corporation | Conformationally constrained peptides i |
US6100377A (en) * | 1994-06-10 | 2000-08-08 | The Trustees Of The University Of Pennsylvania | Constrained peptides |
-
1997
- 1997-11-05 JP JP10521703A patent/JP2001503064A/ja not_active Ceased
- 1997-11-05 CA CA002270869A patent/CA2270869A1/en not_active Abandoned
- 1997-11-05 AU AU54287/98A patent/AU745101B2/en not_active Ceased
- 1997-11-05 DE DE69737415T patent/DE69737415T2/de not_active Expired - Fee Related
- 1997-11-05 IL IL12977297A patent/IL129772A0/xx unknown
- 1997-11-05 WO PCT/US1997/020069 patent/WO1998020036A1/en active IP Right Grant
- 1997-11-05 EP EP97948165A patent/EP0938497B1/de not_active Expired - Lifetime
- 1997-11-05 AT AT97948165T patent/ATE355300T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0938497A1 (de) | 1999-09-01 |
IL129772A0 (en) | 2000-02-29 |
EP0938497B1 (de) | 2007-02-28 |
DE69737415T2 (de) | 2007-10-31 |
CA2270869A1 (en) | 1998-05-14 |
ATE355300T1 (de) | 2006-03-15 |
AU745101B2 (en) | 2002-03-14 |
AU5428798A (en) | 1998-05-29 |
WO1998020036A1 (en) | 1998-05-14 |
JP2001503064A (ja) | 2001-03-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |