DE69737290T2 - Substrat fangende protein tyrosin phosphatase - Google Patents

Substrat fangende protein tyrosin phosphatase Download PDF

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Publication number
DE69737290T2
DE69737290T2 DE69737290T DE69737290T DE69737290T2 DE 69737290 T2 DE69737290 T2 DE 69737290T2 DE 69737290 T DE69737290 T DE 69737290T DE 69737290 T DE69737290 T DE 69737290T DE 69737290 T2 DE69737290 T2 DE 69737290T2
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DE
Germany
Prior art keywords
protein
ptp
tyrosine
tyrosine phosphatase
cas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69737290T
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German (de)
English (en)
Other versions
DE69737290D1 (en
Inventor
Nicholas Huntington TONKS
J. Andrew Bothell FLINT
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Cold Spring Harbor Laboratory
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Cold Spring Harbor Laboratory
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Publication of DE69737290D1 publication Critical patent/DE69737290D1/de
Application granted granted Critical
Publication of DE69737290T2 publication Critical patent/DE69737290T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Alcoholic Beverages (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69737290T 1996-07-25 1997-07-24 Substrat fangende protein tyrosin phosphatase Expired - Fee Related DE69737290T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US685992 1996-07-25
US08/685,992 US5912138A (en) 1996-07-25 1996-07-25 Substrate trapping protein tyrosine phosphatases
PCT/US1997/013016 WO1998004712A2 (en) 1996-07-25 1997-07-24 Substrate trapping protein tyrosine phosphatases

Publications (2)

Publication Number Publication Date
DE69737290D1 DE69737290D1 (en) 2007-03-15
DE69737290T2 true DE69737290T2 (de) 2007-11-08

Family

ID=24754471

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69737290T Expired - Fee Related DE69737290T2 (de) 1996-07-25 1997-07-24 Substrat fangende protein tyrosin phosphatase

Country Status (9)

Country Link
US (2) US5912138A (cg-RX-API-DMAC7.html)
EP (1) EP0918867B1 (cg-RX-API-DMAC7.html)
JP (1) JP2000515760A (cg-RX-API-DMAC7.html)
AT (1) ATE352625T1 (cg-RX-API-DMAC7.html)
AU (1) AU728405B2 (cg-RX-API-DMAC7.html)
CA (1) CA2262440A1 (cg-RX-API-DMAC7.html)
DE (1) DE69737290T2 (cg-RX-API-DMAC7.html)
ES (1) ES2281915T3 (cg-RX-API-DMAC7.html)
WO (1) WO1998004712A2 (cg-RX-API-DMAC7.html)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6528271B1 (en) * 1997-06-05 2003-03-04 Duke University Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
US7541151B2 (en) 1997-06-05 2009-06-02 Duke University Single-cell biosensor for the measurement of GPCR ligands in a test sample
US5891646A (en) * 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods
AU3922999A (en) * 1998-05-21 1999-12-13 Mcgill University Agents interfering with the binding of protein tyrosine phosphatase pest to domains of signalling proteins as inhibitors of cell migration and/or of focal adhesion
US6156551A (en) * 1998-06-05 2000-12-05 Beth Israel Deaconess Medical Center Activated mutants of SH2-domain-containing protein tyrosine phosphatases and methods of use thereof
US6248327B1 (en) 1998-09-11 2001-06-19 Vanderbilt University Modulation of endothelial cell surface receptor activity in the regulation of angiogenesis
US7176289B1 (en) 1998-09-11 2007-02-13 Vanderbilt University Modulation of endothelial cell surface receptor activity in the regulation of angiogenesis
US6355786B1 (en) 1998-10-30 2002-03-12 Vanderbilt University Purified and isolated protein zero related (PZR) and therapeutic and screening methods using same
JP2002537854A (ja) 1999-03-08 2002-11-12 メルク フロスト カナダ アンド カンパニー タンパク質チロシンホスファターゼの無傷細胞アッセイ
US6852520B1 (en) 1999-03-24 2005-02-08 Ceptyr, Inc. DSP-2 dual-specificity phosphatase
US6492157B1 (en) 1999-04-07 2002-12-10 Ceptyr, Inc. DSP-9 dual-specificity phosphatase
US6841369B1 (en) 1999-04-07 2005-01-11 Ceptyr, Inc. DSP-4 dual specificity phosphatase
JP2002542785A (ja) 1999-04-23 2002-12-17 セプティア, インコーポレイテッド Dsp−10二重特異性mapキナーゼホスファターゼ
US6645753B1 (en) 1999-04-27 2003-11-11 Ceptyr, Inc. DSP-5 dual-specificity phosphatase
WO2000075339A1 (en) * 1999-06-03 2000-12-14 Cold Spring Harbor Laboratory Substrate trapping protein tyrosine phosphatases
US7078210B2 (en) 1999-07-02 2006-07-18 Ceptyr, Inc. DSP-3 dual-specificity phosphatase
US6649391B1 (en) 1999-07-20 2003-11-18 Ceptyr, Inc. DSP-11 dual-specificity phosphatase
WO2001057221A2 (en) 2000-02-02 2001-08-09 Ceptyr, Inc. Dsp-12 and dsp-13 dual-specificity phosphatases
US20020009762A1 (en) * 2000-02-14 2002-01-24 Flint Andrew J. Assay for protein tyrosine phosphatases
US6825021B2 (en) 2000-09-19 2004-11-30 Ceptyr, Inc. DSP-15 dual-specificity phosphatase
US8071348B2 (en) * 2002-01-14 2011-12-06 Albert Einstein College Of Medicine Of Yeshiva University Protein tyrosine phosphatase substrate-trapping double mutant and uses thereof
US20030215899A1 (en) * 2002-02-13 2003-11-20 Ceptyr, Inc. Reversible oxidation of protein tyrosine phosphatases
US20030182669A1 (en) * 2002-03-19 2003-09-25 Rockman Howard A. Phosphoinositide 3-kinase mediated inhibition of GPCRs
US20040009946A1 (en) * 2002-05-23 2004-01-15 Ceptyr, Inc. Modulation of PTP1B expression and signal transduction by RNA interference
US7290215B2 (en) * 2002-06-03 2007-10-30 Microsoft Corporation Dynamic wizard interface system and method
PL377714A1 (pl) * 2002-11-26 2006-02-06 Cold Spring Harbor Laboratory Białka oddziałujące z receptorową tyrozynową fosfatazą białkową DEP-1 oraz sposoby ich wykorzystania
US20070238129A1 (en) * 2006-03-29 2007-10-11 Moyer Susanne C Catalytically inactive enzymes for affinity binding
AU2010319531A1 (en) * 2009-11-10 2012-05-24 Amgen Inc. Anti-c-MPL antibodies
CN113899902B (zh) * 2020-06-22 2024-10-29 上海科技大学 一种酪氨酸磷酸酶底物鉴定方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2054602C (en) * 1991-10-31 2003-04-22 Anthony Pawson Method for assaying for a substance that affects an sh2-phosphorylated ligand regulatory system
US5589375A (en) * 1992-10-06 1996-12-31 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E. V. PTP 1D: a novel protein tyrosine phosphatase
US5585233A (en) * 1993-03-23 1996-12-17 Max-Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. PTP-S31: A novel protein tyrosine phosphatase
EP0789771A2 (en) * 1993-09-01 1997-08-20 Ludwig Institute For Cancer Research Primary structure and functional expression of nucleotide sequences for novel protein tyrosine phosphatases
US5744313A (en) * 1994-12-09 1998-04-28 The Regents Of The University Of California Assay employing novel protein domain which binds tyrosine phosphorylated proteins

Also Published As

Publication number Publication date
EP0918867A2 (en) 1999-06-02
JP2000515760A (ja) 2000-11-28
US5912138A (en) 1999-06-15
AU728405B2 (en) 2001-01-11
DE69737290D1 (en) 2007-03-15
CA2262440A1 (en) 1998-02-05
EP0918867B1 (en) 2007-01-24
WO1998004712A3 (en) 1998-03-12
AU5939598A (en) 1999-02-16
ATE352625T1 (de) 2007-02-15
WO1998004712A2 (en) 1998-02-05
US5951979A (en) 1999-09-14
ES2281915T3 (es) 2007-10-01

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