DE69735643T2 - IL12 zur Gentherapie der Tumoren - Google Patents
IL12 zur Gentherapie der Tumoren Download PDFInfo
- Publication number
- DE69735643T2 DE69735643T2 DE69735643T DE69735643T DE69735643T2 DE 69735643 T2 DE69735643 T2 DE 69735643T2 DE 69735643 T DE69735643 T DE 69735643T DE 69735643 T DE69735643 T DE 69735643T DE 69735643 T2 DE69735643 T2 DE 69735643T2
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- Germany
- Prior art keywords
- construct
- tumor
- tumors
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US659206 | 1996-06-05 | ||
| US08/659,206 US5922685A (en) | 1996-06-05 | 1996-06-05 | IL-12 gene therapy of tumors |
| PCT/US1997/009591 WO1997046263A1 (en) | 1996-06-05 | 1997-06-04 | Il-12 gene therapy of tumors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69735643D1 DE69735643D1 (de) | 2006-05-18 |
| DE69735643T2 true DE69735643T2 (de) | 2006-12-14 |
Family
ID=24644498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69735643T Expired - Fee Related DE69735643T2 (de) | 1996-06-05 | 1997-06-04 | IL12 zur Gentherapie der Tumoren |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5922685A (2) |
| EP (1) | EP0963207B1 (2) |
| JP (1) | JP2000512980A (2) |
| DE (1) | DE69735643T2 (2) |
| ES (1) | ES2262180T3 (2) |
| WO (1) | WO1997046263A1 (2) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998041229A1 (en) * | 1997-03-19 | 1998-09-24 | F. Hoffmann-La Roche Ag | USE OF IL-12p40 AS IMMUNOSTIMULANT |
| EP1489100B1 (en) | 1997-12-08 | 2016-06-15 | Merck Patent GmbH | Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation |
| US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
| RU2229305C2 (ru) * | 1998-04-15 | 2004-05-27 | Лексиген Фармасьютикэлс Корпорейшн | Усиление иммунных ответов, опосредованных белками, слитыми из антитела и цитокина, посредством совместного введения ингибитора ангиогенеза |
| AU761520B2 (en) * | 1998-09-15 | 2003-06-05 | Genetics Institute, Llc | Treatment of Kaposi's Sarcoma with IL-12 |
| SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| JP4793971B2 (ja) | 1999-08-09 | 2011-10-12 | メルク パテント ゲーエムベーハー | 複合サイトカイン−抗体複合体 |
| US20030190305A1 (en) * | 1999-09-15 | 2003-10-09 | Wyeth And National Institutes Of Health | Treatment of Kaposi's sarcoma with IL-12 |
| US6802826B1 (en) | 1999-10-11 | 2004-10-12 | Felton International, Inc. | Universal anti-infectious protector for needleless injectors |
| US7074210B2 (en) * | 1999-10-11 | 2006-07-11 | Felton International, Inc. | Universal protector cap with auto-disable features for needle-free injectors |
| EP1142590B8 (en) * | 1999-10-29 | 2008-11-26 | AnGes MG, Inc. | Gene therapy for diabetic ischemic disease |
| EP1228214A2 (en) | 1999-11-12 | 2002-08-07 | MERCK PATENT GmbH | Erythropoietin forms with improved properties |
| US6770054B1 (en) | 1999-11-23 | 2004-08-03 | Felton International, Inc. | Injector assembly with driving means and locking means |
| US7887506B1 (en) | 1999-11-23 | 2011-02-15 | Pulse Needlefree Systems, Inc. | Safety mechanism to prevent accidental patient injection and methods of same |
| US7115712B1 (en) | 1999-12-02 | 2006-10-03 | Maxygen, Inc. | Cytokine polypeptides |
| HUP0204475A2 (en) | 2000-02-11 | 2003-04-28 | Merck Patent Gmbh | Enhancing the circulating half-life of antibody-based fusion proteins |
| US20040213798A1 (en) * | 2000-06-08 | 2004-10-28 | Powderject Vaccines, Inc. | Spray-dried alum compositions |
| US20020120228A1 (en) * | 2000-06-08 | 2002-08-29 | Yuh-Fun Maa | Powder compositions |
| DE60129695T2 (de) * | 2000-06-29 | 2008-06-05 | Merck Patent Gmbh | Steigerung von durch antikörper-zytokin-fusionsproteine mediierten immunantworten durch eine kombinierte behandlung mit mitteln zur erhöhung der immunzytokinaufnahme |
| US20020086036A1 (en) | 2000-12-05 | 2002-07-04 | Allergan Sales, Inc. | Methods for treating hyperhidrosis |
| US7255865B2 (en) * | 2000-12-05 | 2007-08-14 | Allergan, Inc. | Methods of administering botulinum toxin |
| AU2002248571B2 (en) * | 2001-03-07 | 2007-01-18 | Merck Patent Gmbh | Expression technology for proteins containing a hybrid isotype antibody moiety |
| WO2002079415A2 (en) * | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| PT1383785E (pt) * | 2001-05-03 | 2011-06-28 | Merck Patent Gmbh | Anticorpo recombinante específico de tumores e utilização deste |
| CA2349506C (en) * | 2001-06-14 | 2009-12-08 | Duke University | A method for selective expression of therapeutic genes by hyperthermia |
| PT1454138E (pt) | 2001-12-04 | 2012-03-28 | Merck Patent Gmbh | Imunocitoquinas com seletividade modulada |
| CN100432105C (zh) * | 2002-12-17 | 2008-11-12 | 默克专利有限公司 | 与gd2结合的小鼠14.18抗体的人源化抗体(h14.18)以及其与il-2的融合 |
| AU2005203962C1 (en) * | 2004-01-05 | 2012-11-08 | Antisoma Research Limited | Interleukin-12 targeted to oncofoetal fibronectin |
| BRPI0620648B1 (pt) * | 2005-12-30 | 2022-12-20 | Merck Patent Gesellschaft Mit Beschrãnkter Haftung | Variante de il-12 p40, proteínas il-12, il-23 e de fusão, composição farmacêutica e uso da mesma |
| WO2007084364A2 (en) * | 2006-01-13 | 2007-07-26 | The Government Of The United States, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health | Improved il-12 for expression in mammalian cells |
| HUE035406T2 (en) * | 2007-10-08 | 2018-05-02 | Intrexon Corp | Engineered dendritic cells and uses for the treatment of cancer |
| CN102575227A (zh) | 2008-10-08 | 2012-07-11 | 英特瑞克斯顿股份有限公司 | 表达多种免疫调节剂的工程改造细胞及其应用 |
| AU2010241864B2 (en) * | 2009-04-30 | 2014-02-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inducible interleukin-12 |
| US20110014228A1 (en) * | 2009-06-15 | 2011-01-20 | New York University | Il23 modified viral vector for recombinant vaccines and tumor treatment |
| KR102469450B1 (ko) | 2016-05-18 | 2022-11-22 | 모더나티엑스, 인크. | 인터류킨-12 (il12)를 코딩하는 폴리뉴클레오티드 및 그의 용도 |
| JP7285220B2 (ja) | 2017-05-18 | 2023-06-01 | モデルナティエックス インコーポレイテッド | 連結したインターロイキン－１２（ｉｌ１２）ポリペプチドをコードするポリヌクレオチドを含む脂質ナノ粒子 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5833975A (en) * | 1989-03-08 | 1998-11-10 | Virogenetics Corporation | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
| US4945050A (en) * | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5015580A (en) * | 1987-07-29 | 1991-05-14 | Agracetus | Particle-mediated transformation of soybean plants and lines |
| US5149655A (en) * | 1990-06-21 | 1992-09-22 | Agracetus, Inc. | Apparatus for genetic transformation |
| CA2158733C (en) * | 1994-01-21 | 2007-01-16 | Dennis E. Mccabe | Gas driven gene delivery instrument |
| WO1998017814A2 (en) * | 1996-10-18 | 1998-04-30 | Valentis Inc. | Gene expression and delivery systems and uses |
-
1996
- 1996-06-05 US US08/659,206 patent/US5922685A/en not_active Expired - Fee Related
-
1997
- 1997-06-04 WO PCT/US1997/009591 patent/WO1997046263A1/en not_active Ceased
- 1997-06-04 EP EP97927949A patent/EP0963207B1/en not_active Expired - Lifetime
- 1997-06-04 DE DE69735643T patent/DE69735643T2/de not_active Expired - Fee Related
- 1997-06-04 ES ES97927949T patent/ES2262180T3/es not_active Expired - Lifetime
- 1997-06-04 JP JP10500803A patent/JP2000512980A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000512980A (ja) | 2000-10-03 |
| WO1997046263A1 (en) | 1997-12-11 |
| EP0963207A4 (en) | 2003-01-22 |
| EP0963207A1 (en) | 1999-12-15 |
| HK1024622A1 (en) | 2000-10-20 |
| US5922685A (en) | 1999-07-13 |
| ES2262180T3 (es) | 2006-11-16 |
| DE69735643D1 (de) | 2006-05-18 |
| EP0963207B1 (en) | 2006-04-05 |
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