DE69735532D1 - Bestimmung von antigenen mittels oligonukleotid-antikörper-konjugaten - Google Patents

Bestimmung von antigenen mittels oligonukleotid-antikörper-konjugaten

Info

Publication number
DE69735532D1
DE69735532D1 DE69735532T DE69735532T DE69735532D1 DE 69735532 D1 DE69735532 D1 DE 69735532D1 DE 69735532 T DE69735532 T DE 69735532T DE 69735532 T DE69735532 T DE 69735532T DE 69735532 D1 DE69735532 D1 DE 69735532D1
Authority
DE
Germany
Prior art keywords
oligonucleotide
labeled
dendrimer
antigen
antigens
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69735532T
Other languages
English (en)
Other versions
DE69735532T2 (de
Inventor
Thor W Nilsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genisphere LLC
Original Assignee
Polyprobe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polyprobe Inc filed Critical Polyprobe Inc
Publication of DE69735532D1 publication Critical patent/DE69735532D1/de
Application granted granted Critical
Publication of DE69735532T2 publication Critical patent/DE69735532T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
DE69735532T 1996-10-29 1997-10-22 Bestimmung von antigenen mittels oligonukleotid-antikörper-konjugaten Expired - Lifetime DE69735532T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/738,641 US6117631A (en) 1996-10-29 1996-10-29 Detection of antigens via oligonucleotide antibody conjugates
US738641 1996-10-29
PCT/US1997/019093 WO1998018488A1 (en) 1996-10-29 1997-10-22 Detection of antigens via oligonucleotide antibody conjugates

Publications (2)

Publication Number Publication Date
DE69735532D1 true DE69735532D1 (de) 2006-05-11
DE69735532T2 DE69735532T2 (de) 2006-11-23

Family

ID=24968855

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69735532T Expired - Lifetime DE69735532T2 (de) 1996-10-29 1997-10-22 Bestimmung von antigenen mittels oligonukleotid-antikörper-konjugaten

Country Status (9)

Country Link
US (2) US6117631A (de)
EP (1) EP0951297B1 (de)
JP (1) JP3786970B2 (de)
AT (1) ATE320819T1 (de)
AU (1) AU718804B2 (de)
CA (1) CA2270227C (de)
DE (1) DE69735532T2 (de)
ES (1) ES2260787T3 (de)
WO (1) WO1998018488A1 (de)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6203989B1 (en) * 1998-09-30 2001-03-20 Affymetrix, Inc. Methods and compositions for amplifying detectable signals in specific binding assays
GB9924351D0 (en) 1999-10-14 1999-12-15 Brennan Frank Immunomodulation methods and compositions
DE10013993A1 (de) * 2000-03-22 2001-10-25 Ruediger Benters Verfahren zur Erzeugung von aktivierten Sensoroberflächen zur hocheffizienten kovalenten Immobilisierung bioorganischer Makromoleküle
WO2001086296A2 (en) * 2000-05-05 2001-11-15 Agilix Corporation Highly multiplexed reporter carrier systems
US6511809B2 (en) * 2000-06-13 2003-01-28 E. I. Du Pont De Nemours And Company Method for the detection of an analyte by means of a nucleic acid reporter
US7439016B1 (en) 2000-06-15 2008-10-21 Digene Corporation Detection of nucleic acids by type-specific hybrid capture method
US7601497B2 (en) 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
AU8356201A (en) * 2000-08-11 2002-02-25 Agilix Corp Ultra-sensitive detection systems
EP1978110B1 (de) * 2000-09-06 2010-05-26 Transnetyx, Inc. Computer-basiertes Verfahren und System zum Screenen von genomischer DNS
US6803196B1 (en) 2000-10-13 2004-10-12 Affymetrix, Inc. Methods and compositions for detecting signals in binding assays using microparticles
EP1348034B1 (de) * 2000-11-15 2016-07-20 Minerva Biotechnologies Corporation Oligonukleotididentifikatoren
GB0029154D0 (en) 2000-11-30 2001-01-17 Lee Helen Signal enhancement with multiple labelled-antibodies
GB0029617D0 (en) * 2000-12-05 2001-01-17 Norchip As Ligand detection method
DE10106654A1 (de) * 2001-02-12 2002-09-05 November Ag Molekulare Medizin Verfahren zum Nachweis und/oder zur Quantifizierung eines Analyten
WO2003012147A1 (en) * 2001-02-20 2003-02-13 Datascope Investment Corp. Method for reusing standard blots and microarrays utilizing dna dendrimer technology
US20020146745A1 (en) * 2001-04-03 2002-10-10 Surromed, Inc. Methods and reagents for multiplexed analyte capture, surface array self-assembly, and analysis of complex biological samples
KR100436554B1 (ko) * 2001-04-17 2004-06-18 삼성전자주식회사 혼성화된 핵산의 검출감도를 증가시키는 방법
US20020197694A1 (en) * 2001-06-20 2002-12-26 Weiping Shao Conjugates of reduced antibodies and biomolecules
CA2453434C (en) * 2001-07-16 2009-04-14 Hk Pharmaceuticals, Inc. Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
DE60144014D1 (de) * 2001-07-19 2011-03-24 Max Planck Gesellschaft Chemische Sensoren aus Nanopartikel-Dendrimer-Komposit-Materialen
US9201067B2 (en) * 2003-03-05 2015-12-01 Posco Size-controlled macromolecule
WO2003031591A2 (en) * 2001-10-10 2003-04-17 Superarray Bioscience Corporation Detecting targets by unique identifier nucleotide tags
CA2466861A1 (en) * 2001-11-06 2003-07-10 Agilix Corporation Sensitive coded detection systems
US20040023248A1 (en) * 2001-12-07 2004-02-05 Whitehead Institiute For Biomedical Research Methods and reagents for improving nucleic acid detection
US20040009495A1 (en) * 2001-12-07 2004-01-15 Whitehead Institute For Biomedical Research Methods and products related to drug screening using gene expression patterns
JP3897285B2 (ja) * 2002-02-05 2007-03-22 日立ソフトウエアエンジニアリング株式会社 生体高分子検出用試薬及び生体高分子検出方法
ATE421088T1 (de) * 2002-03-11 2009-01-15 Caprotec Bioanalytics Gmbh Verbindungen und verfahren für die analyse des proteoms
US20030175828A1 (en) * 2002-03-15 2003-09-18 Lazar James G. Signal amplification by Hybrid Capture
US20040022731A1 (en) * 2002-04-26 2004-02-05 Alexei Bogdanov In vivo imaging of apoptosis
AU2003267960A1 (en) * 2002-05-22 2004-01-06 Marshall University Methods, probes, and accessory molecules for detecting single nucleotide polymorphisms
WO2004064972A2 (en) * 2003-01-16 2004-08-05 Hk Pharmaceuticals, Inc. Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
CA2514841A1 (en) * 2003-02-02 2004-08-19 Palo Alto Institute Of Molecular Medicine Cell-killing molecules and methods of use thereof
US9696298B2 (en) * 2003-04-03 2017-07-04 Enzo Life Sciences, Inc. Multisignal reagents for labeling analytes
US7229763B2 (en) * 2003-04-07 2007-06-12 Beckman Coulter, Inc. Assay system using labeled oligonucleotides
KR100571808B1 (ko) * 2003-04-16 2006-04-17 삼성전자주식회사 다층 박막 구조를 가진 ｄｎａ 칩
AU2003260457A1 (en) * 2003-08-25 2005-03-10 Marc Ramael A method and kit for the quantitative and/or qualitative detection of components in a sample
JP2007509042A (ja) * 2003-09-29 2007-04-12 ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 造血前駆細胞の接着、分化および遊走を変化させるための方法
WO2005047903A1 (en) * 2003-11-07 2005-05-26 Upstate Usa. Inc. A method for generating antibody conjugates that preserves antigen recognition
EP1531183A1 (de) * 2003-11-14 2005-05-18 bioMérieux BV Methode zur Vervielfältigung von RNA-Sequenzen
EP1697750B1 (de) 2003-12-01 2013-03-20 Dako Denmark A/S Verfahren und zusammensetzungen für den immunhistochemischen nachweis
US20050250147A1 (en) * 2004-05-10 2005-11-10 Macevicz Stephen C Digital profiling of polynucleotide populations
US20060094025A1 (en) * 2004-11-02 2006-05-04 Getts Robert C Methods for detection of microrna molecules
EP1851551A2 (de) * 2005-02-03 2007-11-07 Perkinelmer Las, Inc. Ultrasensitive detektionssysteme mit mehrdimensionalen signalen
US7939331B2 (en) 2005-03-07 2011-05-10 Life Technologies Corporation Isotopically-labeled proteome standards
US20060204999A1 (en) * 2005-03-14 2006-09-14 Stephen Macevicz Detecting molecular complexes
US7550264B2 (en) * 2005-06-10 2009-06-23 Datascope Investment Corporation Methods and kits for sense RNA synthesis
US7494776B2 (en) * 2005-07-07 2009-02-24 Beckman Coulter, Inc. Labeled complementary oligonucleotides to detect oligonucleotide-linked ligands
US20070048741A1 (en) * 2005-08-24 2007-03-01 Getts Robert C Methods and kits for sense RNA synthesis
US20070105124A1 (en) * 2005-11-08 2007-05-10 Getts Robert C Methods and kits for nucleic acid amplification
US7537897B2 (en) * 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting
US20090002703A1 (en) * 2006-08-16 2009-01-01 Craig Edward Parman Methods and systems for quantifying isobaric labels and peptides
US20100190167A1 (en) * 2007-02-14 2010-07-29 Genisphere Inc. Methods, Reagents and Kits for Detection of Nucleic Acid Molecules
US8685899B2 (en) 2007-02-14 2014-04-01 Genisphere Inc. Methods, reagents and kits for detection of nucleic acid molecules
WO2009070640A2 (en) 2007-11-28 2009-06-04 Great Basin Scientific Methods and compositions for amplifying a detectable signal
WO2010017544A2 (en) 2008-08-08 2010-02-11 Genisphere, Inc. Long-acting dna dendrimers and methods thereof
WO2010062556A1 (en) 2008-10-27 2010-06-03 Qiagen Gaithersburg Inc. Fast results hybrid capture assay and system
DE102008062372B3 (de) * 2008-12-17 2010-06-17 Medizinische Hochschule Hannover Nachweiskonjugat und Verfahren zur Analyse
EP2370820B1 (de) 2008-12-31 2016-02-24 Abbott Point Of Care, Inc. Verfahren und vorrichtung für einen immuntest unter verwendung von nukleotidkonjugaten
ES2644516T3 (es) * 2009-01-28 2017-11-29 Qiagen Gaithersburg, Inc. Método y ensayo de preparación de muestras de gran volumen específico de secuencia
CN102414327B (zh) 2009-05-01 2015-04-08 奇亚根盖瑟斯堡股份有限公司 用于在样品中检测rna剪接形式的非靶向扩增方法
WO2011032124A1 (en) 2009-09-14 2011-03-17 Qiagen Gaithersburg, Inc. Compositions and methods for recovery of nucleic acids or proteins from tissue samples fixed in cytology media
US9315857B2 (en) 2009-12-15 2016-04-19 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse label-tags
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
JP6103941B2 (ja) 2010-01-29 2017-03-29 キアジェン ゲイサーズバーグ インコーポレイテッド 核酸の配列特異的精製および多重分析のための方法および組成物
WO2011094528A2 (en) 2010-01-29 2011-08-04 Qiagen Gaithersburg, Inc. Method of determining and confirming the presence of an hpv in a sample
US20110206611A1 (en) 2010-02-24 2011-08-25 Genisphere, Llc DNA Dendrimers as Thermal Ablation Devices
WO2011146629A2 (en) 2010-05-19 2011-11-24 Qiagen Gaithersburg Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
US9376727B2 (en) 2010-05-25 2016-06-28 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically truncated probes
ES2595433T3 (es) 2010-09-21 2016-12-30 Population Genetics Technologies Ltd. Aumento de la confianza en las identificaciones de alelos con el recuento molecular
US9885092B2 (en) 2011-02-24 2018-02-06 Qiagen Gaithersburg Inc. Materials and methods for detection of HPV nucleic acids
EP2807269B1 (de) * 2012-01-23 2018-05-02 Ventana Medical Systems, Inc. Polymerstabilisierung chromogener lösungen
SG11201405274WA (en) 2012-02-27 2014-10-30 Cellular Res Inc Compositions and kits for molecular counting
ES2776673T3 (es) 2012-02-27 2020-07-31 Univ North Carolina Chapel Hill Métodos y usos para etiquetas moleculares
US9670529B2 (en) 2012-02-28 2017-06-06 Population Genetics Technologies Ltd. Method for attaching a counter sequence to a nucleic acid sample
WO2013177046A1 (en) 2012-05-21 2013-11-28 Solulink, Inc. Methods and/or use of oligonucleotide conjugates for suppressing background due to cross-hybridization
US9651549B2 (en) 2012-07-13 2017-05-16 Genisphere, Llc Lateral flow assays using DNA dendrimers
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
KR102393608B1 (ko) 2012-09-04 2022-05-03 가던트 헬쓰, 인크. 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
WO2015017586A1 (en) * 2013-07-30 2015-02-05 President And Fellows Of Harvard College Quantitative dna-based imaging and super-resolution imaging
SG10201806890VA (en) 2013-08-28 2018-09-27 Cellular Res Inc Massively parallel single cell analysis
US9582877B2 (en) 2013-10-07 2017-02-28 Cellular Research, Inc. Methods and systems for digitally counting features on arrays
CN106062214B (zh) 2013-12-28 2020-06-09 夸登特健康公司 用于检测遗传变异的方法和系统
US9909167B2 (en) * 2014-06-23 2018-03-06 The Board Of Trustees Of The Leland Stanford Junior University On-slide staining by primer extension
ES2824700T3 (es) 2015-02-19 2021-05-13 Becton Dickinson Co Análisis unicelular de alto rendimiento que combina información proteómica y genómica
US9727810B2 (en) 2015-02-27 2017-08-08 Cellular Research, Inc. Spatially addressable molecular barcoding
EP3277843A2 (de) 2015-03-30 2018-02-07 Cellular Research, Inc. Verfahren und zusammensetzungen für kombinatorische barcodierung
CN107580632B (zh) 2015-04-23 2021-12-28 贝克顿迪金森公司 用于全转录组扩增的方法和组合物
WO2016196229A1 (en) 2015-06-01 2016-12-08 Cellular Research, Inc. Methods for rna quantification
WO2017044574A1 (en) 2015-09-11 2017-03-16 Cellular Research, Inc. Methods and compositions for nucleic acid library normalization
WO2017106314A1 (en) 2015-12-14 2017-06-22 The Penn State Research Foundation Polymer-based signal amplification for protein and cell detection
WO2017106768A1 (en) 2015-12-17 2017-06-22 Guardant Health, Inc. Methods to determine tumor gene copy number by analysis of cell-free dna
US10822643B2 (en) 2016-05-02 2020-11-03 Cellular Research, Inc. Accurate molecular barcoding
US10301677B2 (en) 2016-05-25 2019-05-28 Cellular Research, Inc. Normalization of nucleic acid libraries
CN109074430B (zh) 2016-05-26 2022-03-29 贝克顿迪金森公司 分子标记计数调整方法
US10202641B2 (en) 2016-05-31 2019-02-12 Cellular Research, Inc. Error correction in amplification of samples
US10640763B2 (en) 2016-05-31 2020-05-05 Cellular Research, Inc. Molecular indexing of internal sequences
WO2018058073A2 (en) 2016-09-26 2018-03-29 Cellular Research, Inc. Measurement of protein expression using reagents with barcoded oligonucleotide sequences
EP3539035B1 (de) 2016-11-08 2024-04-17 Becton, Dickinson and Company Verfahren zur klassifizierung von expressionsprofilen
KR20190077061A (ko) 2016-11-08 2019-07-02 셀룰러 리서치, 인크. 세포 표지 분류 방법
JP7104048B2 (ja) 2017-01-13 2022-07-20 セルラー リサーチ， インコーポレイテッド 流体チャネルの親水性コーティング
CN110382708A (zh) 2017-02-01 2019-10-25 赛卢拉研究公司 使用阻断性寡核苷酸进行选择性扩增
CA3059559A1 (en) 2017-06-05 2018-12-13 Becton, Dickinson And Company Sample indexing for single cells
EP3728636A1 (de) 2017-12-19 2020-10-28 Becton, Dickinson and Company Mit oligonukleotiden assoziierte teilchen
US10871485B2 (en) 2018-04-13 2020-12-22 Rarecyte, Inc. Kits for labeling of biomarkers and methods of using the same
US11773441B2 (en) 2018-05-03 2023-10-03 Becton, Dickinson And Company High throughput multiomics sample analysis
JP7358388B2 (ja) 2018-05-03 2023-10-10 ベクトン・ディキンソン・アンド・カンパニー 反対側の転写物末端における分子バーコーディング
US11639517B2 (en) 2018-10-01 2023-05-02 Becton, Dickinson And Company Determining 5′ transcript sequences
US11932849B2 (en) 2018-11-08 2024-03-19 Becton, Dickinson And Company Whole transcriptome analysis of single cells using random priming
EP3894552A1 (de) 2018-12-13 2021-10-20 Becton, Dickinson and Company Selektive verlängerung in der vollständigen transkriptomanalyse von einzelzellen
CN113287014A (zh) * 2018-12-27 2021-08-20 生物辐射实验室股份有限公司 循序多重蛋白质印迹
US11371076B2 (en) 2019-01-16 2022-06-28 Becton, Dickinson And Company Polymerase chain reaction normalization through primer titration
EP3914728B1 (de) 2019-01-23 2023-04-05 Becton, Dickinson and Company Mit antikörpern assoziierte oligonukleotide
US11965208B2 (en) 2019-04-19 2024-04-23 Becton, Dickinson And Company Methods of associating phenotypical data and single cell sequencing data
US11939622B2 (en) 2019-07-22 2024-03-26 Becton, Dickinson And Company Single cell chromatin immunoprecipitation sequencing assay
CN114729350A (zh) 2019-11-08 2022-07-08 贝克顿迪金森公司 使用随机引发获得用于免疫组库测序的全长v(d)j信息
WO2021146207A1 (en) 2020-01-13 2021-07-22 Becton, Dickinson And Company Methods and compositions for quantitation of proteins and rna
WO2021231779A1 (en) 2020-05-14 2021-11-18 Becton, Dickinson And Company Primers for immune repertoire profiling
US11932901B2 (en) 2020-07-13 2024-03-19 Becton, Dickinson And Company Target enrichment using nucleic acid probes for scRNAseq
CN114544966B (zh) * 2020-11-11 2023-05-09 艾克发(北京)生物技术有限公司 一种多重信号放大系统及其在免疫吸附夹心法检测中的应用
CN116635533A (zh) 2020-11-20 2023-08-22 贝克顿迪金森公司 高表达的蛋白和低表达的蛋白的谱分析

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175270A (en) * 1986-09-10 1992-12-29 Polyprobe, Inc. Reagents for detecting and assaying nucleic acid sequences
US5656731A (en) * 1987-10-15 1997-08-12 Chiron Corporation Nucleic acid-amplified immunoassay probes
US6121056A (en) * 1993-02-24 2000-09-19 Dade Behring Inc. Random detection of antigens with antibodies immobilized on soluble submicron particles
ATE178717T1 (de) * 1993-02-24 1999-04-15 Dade Behring Inc Immobilisierung von reagenzien für spezifische bindungsassay
AU6913394A (en) * 1993-05-13 1994-12-12 United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nucleic acid tagged immunoassay
US5635602A (en) * 1993-08-13 1997-06-03 The Regents Of The University Of California Design and synthesis of bispecific DNA-antibody conjugates
US5912332A (en) * 1996-07-26 1999-06-15 Hybridon, Inc. Affinity-based purification of oligonucleotides using soluble multimeric oligonucleotides

Also Published As

Publication number Publication date
ATE320819T1 (de) 2006-04-15
US6117631A (en) 2000-09-12
AU4914097A (en) 1998-05-22
EP0951297B1 (de) 2006-03-22
CA2270227C (en) 2005-02-08
ES2260787T3 (es) 2006-11-01
JP3786970B2 (ja) 2006-06-21
DE69735532T2 (de) 2006-11-23
US6110687A (en) 2000-08-29
CA2270227A1 (en) 1998-05-07
WO1998018488A1 (en) 1998-05-07
EP0951297A4 (de) 2002-01-02
AU718804B2 (en) 2000-04-20
EP0951297A1 (de) 1999-10-27
JP2001503517A (ja) 2001-03-13

Similar Documents

Publication Publication Date Title
DE69735532D1 (de) Bestimmung von antigenen mittels oligonukleotid-antikörper-konjugaten
DK0914155T3 (da) Monoklonale antistoffer, der er spepcifikke for det ekstracellulære domæne af prostataspecifikt membran-antigen
BR9607098A (pt) Novos inibidores seletivos de neuraminidas virais ou bacterianas
DK1064303T3 (da) Monoklonale antistoffer, der er specifikke for det prostataspecifikke membranantigens ekstracellulære domæne
EP1288313A3 (de) System und Verfahren zum Testen von Nukleinsäuremolekülen
ATE222254T1 (de) Verwendung von einem metalloporphyrinkonjugat für den nachweis biologischer verbindungen
JPH05504481A (ja) 改良された抗体―酵素直接接合体及びその製造方法
SE0001670D0 (sv) Mass-spectrometry-based biosensor
CA2417161A1 (en) Method for immuno-detection of epitopes
CY1110429T1 (el) Προσδιορισμος
FR2799281B1 (fr) Procede et dispositif de detection d'une reaction de reconnaissance moleculaire
CY1106384T1 (el) Δοκιμασιες τροποποιητη υποδοχεα ενepγοποιουμενου απο πρωτεαση (par)
HUP9801448A2 (hu) Eljárás antitesttermelés kimutatására
ES2158961T3 (es) Procedimiento de dosificacion de un hapteno segun una tecnica de competicion.
US20160146804A1 (en) Dna-conjugated antibodies for improved antibody affinity and reduced antibody cross reactivity
AU1705801A (en) Dynamic determination of analytes
MX9704717A (es) Antigeno, anticuerpos y ensayo de diagnostico para la enfermedad de alzheimer.
SE9502765D0 (sv) Analysförfarande

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: GENISPHERE INC., HATFIELD, PA., US

8327 Change in the person/name/address of the patent owner

Owner name: GENISPHERE, LLC., HATFIELD, PA., US