DE69731955D1 - Kombination von saurer protease-enzyme und saure puffers und ihre verwendung - Google Patents

Kombination von saurer protease-enzyme und saure puffers und ihre verwendung

Info

Publication number
DE69731955D1
DE69731955D1 DE69731955T DE69731955T DE69731955D1 DE 69731955 D1 DE69731955 D1 DE 69731955D1 DE 69731955 T DE69731955 T DE 69731955T DE 69731955 T DE69731955 T DE 69731955T DE 69731955 D1 DE69731955 D1 DE 69731955D1
Authority
DE
Germany
Prior art keywords
acid
combination
protease enzymes
buffers
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69731955T
Other languages
English (en)
Other versions
DE69731955T2 (de
Inventor
J Norton
Glen Gillis
Michael Bishop
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lipotec USA Inc
Original Assignee
Active Organics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Active Organics Inc filed Critical Active Organics Inc
Publication of DE69731955D1 publication Critical patent/DE69731955D1/de
Application granted granted Critical
Publication of DE69731955T2 publication Critical patent/DE69731955T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/488—Aspartic endopeptidases (3.4.23), e.g. pepsin, chymosin, renin, cathepsin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/04—Preparations for care of the skin for chemically tanning the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69731955T 1996-06-13 1997-06-13 Kombination von saurer protease-enzyme und saure puffers und ihre verwendung Expired - Lifetime DE69731955T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/664,056 US5976556A (en) 1996-06-13 1996-06-13 Combination of acid protease enzymes and acidic buffers and uses thereof
US664056 1996-06-13
PCT/US1997/010427 WO1997047283A1 (en) 1996-06-13 1997-06-13 Combination of acid protease enzymes and acidic buffers and uses thereof

Publications (2)

Publication Number Publication Date
DE69731955D1 true DE69731955D1 (de) 2005-01-20
DE69731955T2 DE69731955T2 (de) 2005-12-22

Family

ID=24664334

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69731955T Expired - Lifetime DE69731955T2 (de) 1996-06-13 1997-06-13 Kombination von saurer protease-enzyme und saure puffers und ihre verwendung

Country Status (11)

Country Link
US (2) US5976556A (de)
EP (2) EP1598057B1 (de)
JP (2) JP4681087B2 (de)
KR (1) KR20000016635A (de)
AT (2) ATE552891T1 (de)
AU (1) AU3396597A (de)
DE (1) DE69731955T2 (de)
DK (1) DK0921785T3 (de)
ES (2) ES2235239T3 (de)
PT (1) PT921785E (de)
WO (1) WO1997047283A1 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976556A (en) * 1996-06-13 1999-11-02 Active Organics, Inc. Combination of acid protease enzymes and acidic buffers and uses thereof
JP2002515903A (ja) * 1997-02-12 2002-05-28 ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド セリンプロテアーゼと局所レチノイドの組成物
FR2761363B1 (fr) * 1997-03-28 1999-11-26 Oreal Polypeptide purifie de l'epiderme et son utilisation
EP1049424A4 (de) * 1998-01-06 2001-11-28 Nicholas A Sceusa Arzneidosierung basierend auf dem teorell-mayer-gradienten
WO1999040887A1 (fr) * 1998-02-10 1999-08-19 Shiseido Company, Ltd. Composition emulsionnees de type aqueux
FR2777185B1 (fr) * 1998-04-08 2001-03-16 Serobiologiques Lab Sa Composition cosmetique et/ou pharmaceutique pour le traitement des rides et procede de traitement mettant en oeuvre cette composition
US6656701B2 (en) * 1999-07-16 2003-12-02 Actim Organics, Inc Combination of acid protease enzymes and acidic buffers and uses thereof
US6416769B1 (en) * 2000-03-03 2002-07-09 Australian Importers, Ltd. Cosmetic compositions comprising exfoliating enzymes and uses thereof
DE10042576B4 (de) * 2000-08-15 2004-08-12 Coty B.V. Kosmetischer Basiskomplex und dessen Verwendung
JP2002284665A (ja) * 2001-03-23 2002-10-03 Nippon Hypox Lab Inc 化粧料
US20030021775A1 (en) * 2001-07-27 2003-01-30 Ramot University Authority For Applied Research & Industrial Development Ltd. Device for and method of controlled enzymatic removal and retrieval of tissue
US7364565B2 (en) * 2001-07-27 2008-04-29 Ramot At Tel Aviv University Ltd. Controlled enzymatic removal and retrieval of cells
US6858215B2 (en) * 2002-06-14 2005-02-22 Carol J. Buck Compositions and methods for softening, thinning and removing hyperkeratotic tissue
US6835385B2 (en) * 2002-06-14 2004-12-28 Carol J. Buck Compositions and methods for softening, thinning and removing hyperkeratotic tissue
JP3907659B2 (ja) * 2002-07-02 2007-04-18 株式会社ノエビア 皮膚外用剤
EP1587515A4 (de) * 2002-08-23 2009-02-04 Peter K Law Biologische hautreparatur und verbesserung
AU2004280233A1 (en) * 2003-10-09 2005-04-21 Arbios Technology, Inc. Non-invasive system for detecting skin cancer
US20070244195A1 (en) * 2004-05-18 2007-10-18 Burkhart Craig N Treatment methods with peroxides and tertiary amines
US7928052B2 (en) * 2004-12-09 2011-04-19 Dow Global Technologies Llc Enzyme stabilization
US8278359B2 (en) 2005-02-25 2012-10-02 Johnson & Johnson Consumer Companies, Inc. Compositions containing amines and use thereof to treat acne or reduce the appearance of oil or pores on the skin
US20070027152A1 (en) * 2005-07-27 2007-02-01 Clark Kathleen L Topical anti-pruritic compositions and methods of action of same
JP2007145931A (ja) * 2005-11-25 2007-06-14 Ecobio 動物用耳穴洗浄剤
US7776339B2 (en) * 2006-01-11 2010-08-17 Active Organics, Lp Extract of R. miehei
US20070264222A1 (en) * 2006-05-10 2007-11-15 Biohealth Advance, Llc Enhanced protection against skin injury in humans
FR2909554B1 (fr) * 2006-12-08 2013-11-01 Biorecept Lab Composition cosmetique anti-rides comprenant de l'acide hyaluronique
US7381433B1 (en) 2007-01-08 2008-06-03 Johnson & Johnson Consumer Companies, Inc. Compositions containing an extract of a primula denticulata and use thereof
EP2011471A1 (de) * 2007-07-02 2009-01-07 Johnson & Johnson Consumer France SAS Schäumende Ölzubereitungen
US7854936B2 (en) 2008-01-14 2010-12-21 Active Organics, Inc. Anti-inflammatory hydrolysate of C. versicolor
TWI395593B (zh) 2008-03-06 2013-05-11 Halozyme Inc 可活化的基質降解酵素之活體內暫時性控制
EP2662090A1 (de) 2008-04-14 2013-11-13 Halozyme, Inc. Modifizierte Hyaluronidasen und ihre Verwendungen bei der Behandlung von Erkrankungen und Zuständen im Zusammenhang mit Hyaluronan
FR2930727B1 (fr) * 2008-04-30 2012-10-05 Evolution Dermatologique Lab Composition pour le traitement des etats seborrheiques.
ITTO20080579A1 (it) * 2008-07-28 2010-01-29 Chiara Cesano Composizione per la rigenerazione di tessuto ipertrofico, relativi prodotti ed usi
EP2403523A1 (de) 2009-03-06 2012-01-11 Halozyme, Inc. Temperaturempfindliche mutanten von matrix metalloprotease 1 und ihre verwendungen
CN102471766A (zh) * 2009-07-17 2012-05-23 科洛普拉斯特公司 带有酶的粘性贴片
EP2316436A1 (de) 2009-10-30 2011-05-04 Johnson & Johnson GmbH Band, insbesondere Klebeband zur Behandlung von Hauterkrankungen mit mindestens einem Film, insbesondere einem löslichen Film, mit mindestens einem Enzym
EP2316438A1 (de) 2009-10-30 2011-05-04 Johnson & Johnson GmbH Band, insbesondere Klebeband zur Behandlung von Hauterkrankungen mit mindestens einem Hyperkeratosehemmer und/oder mindestens einem keratinolytischem Wirkstoff
US20110152384A1 (en) * 2009-12-17 2011-06-23 Gunn Euen T Mild leave-on skin care compositions
EP2340803A1 (de) * 2009-12-30 2011-07-06 Brands Asia Pacific Limited Zusammensetzung zum Entfernen abgestorbener Hautzellen und Pad für Hände und Füße enthaltend besagte Zusammensetzung
WO2012095702A1 (en) * 2011-01-13 2012-07-19 Medestea Internazionale S.P.A. A composition for the regeneration of atrophic tissues
WO2012154903A1 (en) 2011-05-10 2012-11-15 Active Organics, Inc. Compositions containing extracts of mucor miehei and mucor rouxii
FR2984725B1 (fr) * 2011-12-26 2014-01-31 Achaladanelle Utilisation d'une composition cosmetique ou dermocosmetique pour lutter contre les effets du tabac sur la peau
WO2014107745A1 (en) 2013-01-07 2014-07-10 Halozyme, Inc. Metal sensitive mutants of matrix metalloproteases and uses thereof
KR101531479B1 (ko) * 2014-11-21 2015-06-26 세원셀론텍(주) 의료용 재료로 사용하기 위한 고농도 콜라겐 제조방법
EP3236903B1 (de) 2014-12-23 2021-04-21 Intellectual Property Associates, LLC Verfahren und formulierungen zur transdermalen verabreichung
KR102078140B1 (ko) * 2015-03-13 2020-02-17 주식회사 엘지생활건강 ｐＨ 완충 시스템을 갖는 유화 화장료 조성물
KR101865764B1 (ko) * 2017-01-13 2018-06-11 주식회사 아미코스메틱 천연 복합 추출물 및 미세침 분말을 유효성분으로 포함하는 각질 박리용 화장료 조성물
EP3681479B1 (de) 2017-09-15 2024-01-31 Dyve Biosciences, Inc. Natriumhydrogencarbonat zur verwendung in der behandlung von gicht und verwandten erkrankungen

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU439288A1 (ru) * 1971-07-29 1974-08-15 Республиканский Ожоговый Центр При Грьковском Научно-Исследовательском Институте Травматологии И Ортопедии Средство дл растворени некротизированных тканей
US4363815A (en) * 1975-07-23 1982-12-14 Yu Ruey J Alpha hydroxyacids, alpha ketoacids and their use in treating skin conditions
US4021572A (en) * 1975-07-23 1977-05-03 Scott Eugene J Van Prophylactic and therapeutic treatment of acne vulgaris utilizing lactamides and quaternary ammonium lactates
JPS60215621A (ja) * 1984-04-12 1985-10-29 Kao Corp 弱酸性入浴剤
US5431913A (en) * 1992-01-24 1995-07-11 Phillips; Eva J. Skin cleansing and exfoliant composition and method of treating skin
DK72593D0 (da) * 1993-06-18 1993-06-18 Symbicom Ab Rekombinant protein
GB9319104D0 (en) * 1993-09-15 1993-11-03 Unilever Plc Skin care method & composition
US5516517A (en) * 1994-05-02 1996-05-14 Exfoliation Cleansing Hydration Oxygenation Corporation Method for nutritional oxygenation of the skin
US5976556A (en) * 1996-06-13 1999-11-02 Active Organics, Inc. Combination of acid protease enzymes and acidic buffers and uses thereof

Also Published As

Publication number Publication date
JP2007302680A (ja) 2007-11-22
US5976556A (en) 1999-11-02
EP0921785A1 (de) 1999-06-16
JP4681087B2 (ja) 2011-05-11
WO1997047283A1 (en) 1997-12-18
JP2000512298A (ja) 2000-09-19
EP0921785A4 (de) 2002-02-13
US6569437B1 (en) 2003-05-27
ATE552891T1 (de) 2012-04-15
PT921785E (pt) 2005-05-31
ATE284670T1 (de) 2005-01-15
KR20000016635A (ko) 2000-03-25
ES2235239T3 (es) 2005-07-01
DK0921785T3 (da) 2005-04-18
EP1598057A1 (de) 2005-11-23
DE69731955T2 (de) 2005-12-22
AU3396597A (en) 1998-01-07
EP0921785B1 (de) 2004-12-15
ES2383682T3 (es) 2012-06-25
EP1598057B1 (de) 2012-04-11

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