DE69718812T2 - Zell/gewebekultursystem und -verfahren - Google Patents
Zell/gewebekultursystem und -verfahren Download PDFInfo
- Publication number
- DE69718812T2 DE69718812T2 DE69718812T DE69718812T DE69718812T2 DE 69718812 T2 DE69718812 T2 DE 69718812T2 DE 69718812 T DE69718812 T DE 69718812T DE 69718812 T DE69718812 T DE 69718812T DE 69718812 T2 DE69718812 T2 DE 69718812T2
- Authority
- DE
- Germany
- Prior art keywords
- container
- cells
- harvesting
- sterile
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 18
- 238000003306 harvesting Methods 0.000 claims abstract description 121
- 239000002609 medium Substances 0.000 claims abstract description 51
- 239000000654 additive Substances 0.000 claims abstract description 43
- 239000002054 inoculum Substances 0.000 claims abstract description 39
- 239000001963 growth medium Substances 0.000 claims abstract description 27
- 230000003816 axenic effect Effects 0.000 claims abstract description 12
- 238000012258 culturing Methods 0.000 claims abstract description 6
- 239000006143 cell culture medium Substances 0.000 claims abstract description 5
- 239000003104 tissue culture media Substances 0.000 claims abstract description 5
- 239000007789 gas Substances 0.000 claims description 38
- 239000000463 material Substances 0.000 claims description 29
- 239000003795 chemical substances by application Substances 0.000 claims description 25
- 238000011109 contamination Methods 0.000 claims description 23
- 239000012535 impurity Substances 0.000 claims description 22
- 239000000356 contaminant Substances 0.000 claims description 20
- 239000012530 fluid Substances 0.000 claims description 9
- 239000004033 plastic Substances 0.000 claims description 8
- 229920003023 plastic Polymers 0.000 claims description 8
- 238000013022 venting Methods 0.000 claims description 6
- 230000002265 prevention Effects 0.000 claims description 5
- 239000004698 Polyethylene Substances 0.000 claims description 4
- -1 polyethylene Polymers 0.000 claims description 4
- 229920000573 polyethylene Polymers 0.000 claims description 4
- GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 claims description 2
- 239000004677 Nylon Substances 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 239000005038 ethylene vinyl acetate Substances 0.000 claims description 2
- 229920001778 nylon Polymers 0.000 claims description 2
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 2
- 229920000515 polycarbonate Polymers 0.000 claims description 2
- 239000004417 polycarbonate Substances 0.000 claims description 2
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 2
- 239000004800 polyvinyl chloride Substances 0.000 claims description 2
- 238000007599 discharging Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 17
- 239000002912 waste gas Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 75
- 229910001220 stainless steel Inorganic materials 0.000 description 8
- 239000010935 stainless steel Substances 0.000 description 8
- 230000000996 additive effect Effects 0.000 description 5
- 230000004927 fusion Effects 0.000 description 5
- 230000003068 static effect Effects 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 238000002156 mixing Methods 0.000 description 4
- 229910052710 silicon Inorganic materials 0.000 description 4
- 239000010703 silicon Substances 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 230000005484 gravity Effects 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000004062 sedimentation Methods 0.000 description 3
- 238000011144 upstream manufacturing Methods 0.000 description 3
- 238000009423 ventilation Methods 0.000 description 3
- 241000863480 Vinca Species 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000000417 fungicide Substances 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- OVSKIKFHRZPJSS-DOMIDYPGSA-N 2-(2,4-dichlorophenoxy)acetic acid Chemical compound OC(=O)[14CH2]OC1=CC=C(Cl)C=C1Cl OVSKIKFHRZPJSS-DOMIDYPGSA-N 0.000 description 1
- HABAPWZXRLIZDL-UHFFFAOYSA-N 2-chloro-2-phenoxyacetic acid Chemical compound OC(=O)C(Cl)OC1=CC=CC=C1 HABAPWZXRLIZDL-UHFFFAOYSA-N 0.000 description 1
- NEZONWMXZKDMKF-JTQLQIEISA-N Alkannin Chemical compound C1=CC(O)=C2C(=O)C([C@@H](O)CC=C(C)C)=CC(=O)C2=C1O NEZONWMXZKDMKF-JTQLQIEISA-N 0.000 description 1
- 240000001829 Catharanthus roseus Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- FAIXYKHYOGVFKA-UHFFFAOYSA-N Kinetin Natural products N=1C=NC=2N=CNC=2C=1N(C)C1=CC=CO1 FAIXYKHYOGVFKA-UHFFFAOYSA-N 0.000 description 1
- 241001071917 Lithospermum Species 0.000 description 1
- 241001124569 Lycaenidae Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000004687 Nylon copolymer Substances 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 239000003570 air Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- UNNKKUDWEASWDN-UHFFFAOYSA-N alkannin Natural products CC(=CCC(O)c1cc(O)c2C(=O)C=CC(=O)c2c1O)C UNNKKUDWEASWDN-UHFFFAOYSA-N 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000012364 cultivation method Methods 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- QANMHLXAZMSUEX-UHFFFAOYSA-N kinetin Chemical compound N=1C=NC=2N=CNC=2C=1NCC1=CC=CO1 QANMHLXAZMSUEX-UHFFFAOYSA-N 0.000 description 1
- 229960001669 kinetin Drugs 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000008450 motivation Effects 0.000 description 1
- 239000006272 natural pesticide Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229930000044 secondary metabolite Natural products 0.000 description 1
- QZRSVBDWRWTHMT-UHFFFAOYSA-M silver;3-carboxy-3,5-dihydroxy-5-oxopentanoate Chemical compound [Ag+].OC(=O)CC(O)(C([O-])=O)CC(O)=O QZRSVBDWRWTHMT-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/14—Bags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/22—Transparent or translucent parts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Sustainable Development (AREA)
- Clinical Laboratory Science (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL11931096 | 1996-09-26 | ||
| IL11931096A IL119310A (en) | 1996-09-26 | 1996-09-26 | Cell/tissue culturing device and method |
| PCT/IL1997/000316 WO1998013469A1 (en) | 1996-09-26 | 1997-09-26 | Cell/tissue culturing device and method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69718812D1 DE69718812D1 (de) | 2003-03-06 |
| DE69718812T2 true DE69718812T2 (de) | 2004-01-22 |
Family
ID=11069322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69718812T Expired - Lifetime DE69718812T2 (de) | 1996-09-26 | 1997-09-26 | Zell/gewebekultursystem und -verfahren |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6391638B1 (https=) |
| EP (1) | EP0938544B1 (https=) |
| JP (1) | JP3987121B2 (https=) |
| AT (1) | ATE231912T1 (https=) |
| AU (1) | AU4318097A (https=) |
| CA (1) | CA2266851C (https=) |
| CZ (1) | CZ298148B6 (https=) |
| DE (1) | DE69718812T2 (https=) |
| DK (1) | DK0938544T3 (https=) |
| ES (1) | ES2191851T3 (https=) |
| HU (1) | HU226908B1 (https=) |
| IL (1) | IL119310A (https=) |
| PL (1) | PL190829B1 (https=) |
| WO (1) | WO1998013469A1 (https=) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006062634A1 (de) * | 2006-12-23 | 2008-06-26 | Stiftung Alfred-Wegener-Institut für Polar- und Meeresforschung Stiftung des öffentlichen Rechts | Kulturvorrichtung für aquatische Organismen |
| US7942925B2 (en) | 2001-07-09 | 2011-05-17 | Surpass Medical Ltd. | Implantable intraluminal device and method of using same in treating aneurysms |
| US8227230B2 (en) | 2003-04-27 | 2012-07-24 | Protalix Ltd. | Human lysosomal proteins from plant cell culture |
| US10364413B2 (en) | 2007-05-07 | 2019-07-30 | Protalix Ltd. | Large scale disposable bioreactor |
| DE102018128010A1 (de) * | 2018-11-08 | 2020-05-14 | Bastian Steudel | Bioreaktor zum Kultivieren von photoautotrophen Mikroorganismen und dessen Verwendung |
Families Citing this family (99)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL155588A0 (en) | 2003-04-27 | 2003-11-23 | Metabogal Ltd | Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby |
| US20050032211A1 (en) * | 1996-09-26 | 2005-02-10 | Metabogal Ltd. | Cell/tissue culturing device, system and method |
| FR2781202B1 (fr) * | 1998-07-16 | 2001-01-12 | Stedim Sa | Poches pour produits fluides bio-pharmaceutiques |
| GB9915874D0 (en) * | 1999-07-08 | 1999-09-08 | Biofence Ltd | Microorganism culture |
| EP2290050B1 (de) * | 1999-09-08 | 2012-06-13 | Levitronix Technologies, LLC | Bioreaktor |
| US7086778B2 (en) * | 2000-10-09 | 2006-08-08 | Levtech, Inc. | System using a levitating, rotating pumping or mixing element and related methods |
| US6635441B2 (en) * | 2001-02-08 | 2003-10-21 | Irm, Llc | Multi-sample fermentor and method of using same |
| JP4398125B2 (ja) * | 2001-12-05 | 2010-01-13 | 高木産業株式会社 | 細胞・組織培養装置 |
| US7168459B2 (en) * | 2002-04-12 | 2007-01-30 | Hynetics Llc | Feed bags and methods of use |
| USD475795S1 (en) | 2002-04-15 | 2003-06-10 | Michael K. Johnson | Liquid flow bubble release device |
| IL166340A0 (en) * | 2002-07-18 | 2006-01-16 | Kemire Phosphates Pty Ltd | Proliferation and delivery apparatus |
| EP1523350B1 (en) | 2002-07-19 | 2011-04-13 | Baxter International Inc. | System for performing peritoneal dialysis |
| US20100196345A1 (en) * | 2003-04-27 | 2010-08-05 | Protalix | Production of high mannose proteins in plant culture |
| FR2854901B1 (fr) * | 2003-05-13 | 2006-05-26 | Rhodia Chimie Sa | Procede de preparation d'une suspension de micro-organismes |
| US7176024B2 (en) * | 2003-05-30 | 2007-02-13 | Biolex, Inc. | Bioreactor for growing biological materials supported on a liquid surface |
| US20070113474A1 (en) * | 2003-05-30 | 2007-05-24 | Biolex, Inc. | Bioreactor for growing biological materials supported on a liquid surface |
| WO2005006838A2 (en) * | 2003-07-21 | 2005-01-27 | Ben-Gurion University Of The Negev | Flat panel photobioreactor |
| US8206973B2 (en) * | 2003-09-04 | 2012-06-26 | Gotohti.Com Inc | Automated biological growth and dispensing system |
| CA2545160A1 (en) | 2003-11-06 | 2005-05-19 | Compugen Ltd. | Variants of human glycoprotein hormone alpha chain: compositions and uses thereof |
| CA2552717C (en) * | 2004-01-07 | 2011-11-29 | Levtech, Inc. | Mixing bag with integral sparger and sensor receiver |
| US7875448B2 (en) * | 2004-01-12 | 2011-01-25 | Single Use Brx, Llc | Bioreactor systems and disposable bioreactor |
| GB0410118D0 (en) * | 2004-05-06 | 2004-06-09 | Glaxo Group Ltd | Novel bioreactor |
| MXPA06014099A (es) | 2004-06-04 | 2007-05-09 | Xcellerex Inc | Sistemas biorreactores desechables y metodos. |
| JP4570032B2 (ja) * | 2004-07-12 | 2010-10-27 | 応用地質株式会社 | フレキシブル培養バッグを用いる嫌気培養試験装置 |
| US8603805B2 (en) | 2005-04-22 | 2013-12-10 | Hyclone Laboratories, Inc. | Gas spargers and related container systems |
| ES2662589T3 (es) * | 2005-06-15 | 2018-04-09 | Zhejiang Jinyishengshi Bioengineering Co., Ltd. | Recipientes para cultivo en suspensión |
| WO2006138143A1 (en) * | 2005-06-15 | 2006-12-28 | Amprotein Corporation | Suspension culture vessels |
| US7628528B2 (en) * | 2005-10-26 | 2009-12-08 | PRS Biotech, Inc. | Pneumatic bioreactor |
| US8790913B2 (en) * | 2005-10-26 | 2014-07-29 | Pbs Biotech, Inc. | Methods of using pneumatic bioreactors |
| US20090047722A1 (en) * | 2005-12-09 | 2009-02-19 | Bionavitas, Inc. | Systems, devices, and methods for biomass production |
| GB2433266A (en) | 2005-12-16 | 2007-06-20 | Kevin Andrew Auton | Cell culture vessel |
| MX2008010770A (es) * | 2006-02-21 | 2009-03-06 | Univ Arizona State | Fotobiorreactor y usos para el mismo. |
| JP4986659B2 (ja) * | 2006-03-23 | 2012-07-25 | 藤森工業株式会社 | 培養袋及び培養器 |
| DE102006018824A1 (de) | 2006-04-22 | 2007-10-25 | Bayer Technology Services Gmbh | Einweg-Bioreaktor |
| DE102006022307A1 (de) * | 2006-05-11 | 2007-11-15 | Respironics Novametrix, LLC, Wallingford | Einwegbioreaktor mit Sensoranordnung |
| SG176507A1 (en) * | 2006-05-13 | 2011-12-29 | Advanced Tech Materials | Disposable bioreactor |
| WO2007142664A1 (en) * | 2006-06-08 | 2007-12-13 | Amprotein Corporation | A method to increase dissolved oxygen in a culture vessel |
| US9512392B2 (en) * | 2006-06-08 | 2016-12-06 | Zhejiang Jinyishengshi Bioengineering Co., Ltd | Method to increase dissolved oxygen in a culture vessel |
| JP5254226B2 (ja) * | 2006-07-14 | 2013-08-07 | エクセレレックス インク． | 環境保護用収容システム |
| MX2009001371A (es) * | 2006-08-10 | 2009-04-22 | Allen C Barnes | Metodo y dispositivo de pruebas biologicas portatil. |
| US10753927B2 (en) | 2006-09-22 | 2020-08-25 | ALERE TECHNOLOGIES GmbH | Methods for detecting an analyte |
| US20080131960A1 (en) * | 2006-11-15 | 2008-06-05 | Millipore Corporation | Self standing bioreactor construction |
| WO2008101127A2 (en) * | 2007-02-15 | 2008-08-21 | Broadley-James Corporation | Bioreactor jacket |
| US20100028990A1 (en) * | 2007-02-15 | 2010-02-04 | Broadley-James Corporation | Sterile bioreactor bag with integrated drive unit |
| US20100035321A1 (en) * | 2007-04-20 | 2010-02-11 | Bionavitas, Inc. | Systems, devices, and, methods for releasing biomass cell components |
| US7713730B2 (en) | 2007-04-24 | 2010-05-11 | Pbs Biotech, Inc. | Pneumatic bioreactor |
| WO2008136371A1 (ja) * | 2007-04-27 | 2008-11-13 | Toyo Seikan Kaisha, Ltd. | 細胞培養装置、細胞培養システム及び細胞培養方法 |
| GB2450337B (en) * | 2007-06-19 | 2009-06-17 | Cellexus Biosystems Plc | Cell culture and mixing vessel |
| WO2009004842A1 (ja) * | 2007-07-03 | 2009-01-08 | Idemitsu Kosan Co., Ltd. | ブタ浮腫病ワクチン |
| WO2009018498A2 (en) * | 2007-08-01 | 2009-02-05 | Bionavitas, Inc. | Illumination systems, devices, and methods for biomass production |
| EP2192924B1 (en) | 2007-08-20 | 2017-10-11 | Protalix Ltd. | Saccharide-containing protein conjugates and uses thereof |
| BE1017763A5 (nl) * | 2007-09-24 | 2009-06-02 | Proviron Holding | Bioreactor. |
| US7892332B2 (en) * | 2007-10-01 | 2011-02-22 | Baxter International Inc. | Dialysis systems having air traps with internal structures to enhance air removal |
| US7892331B2 (en) * | 2007-10-01 | 2011-02-22 | Baxter International Inc. | Dialysis systems having air separation chambers with internal structures to enhance air removal |
| US8444587B2 (en) | 2007-10-01 | 2013-05-21 | Baxter International Inc. | Fluid and air handling in blood and dialysis circuits |
| US7871462B2 (en) * | 2007-10-01 | 2011-01-18 | Baxter International Inc. | Dialysis systems having air separation chambers with internal structures to enhance air removal |
| US20090090022A1 (en) * | 2007-10-09 | 2009-04-09 | Hememics Biotechnologies, Inc. | Desiccation Chamber and Methods for Drying Biological Materials |
| US8123947B2 (en) * | 2007-10-22 | 2012-02-28 | Baxter International Inc. | Priming and air removal systems and methods for dialysis |
| US8114276B2 (en) | 2007-10-24 | 2012-02-14 | Baxter International Inc. | Personal hemodialysis system |
| US20090269849A1 (en) * | 2008-04-25 | 2009-10-29 | Pbs Biotech, Inc. | Bioreactor Apparatus |
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1997
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- 1997-09-26 CA CA002266851A patent/CA2266851C/en not_active Expired - Fee Related
- 1997-09-26 DE DE69718812T patent/DE69718812T2/de not_active Expired - Lifetime
- 1997-09-26 ES ES97941180T patent/ES2191851T3/es not_active Expired - Lifetime
- 1997-09-26 JP JP51546598A patent/JP3987121B2/ja not_active Expired - Fee Related
- 1997-09-26 CZ CZ0104799A patent/CZ298148B6/cs not_active IP Right Cessation
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7942925B2 (en) | 2001-07-09 | 2011-05-17 | Surpass Medical Ltd. | Implantable intraluminal device and method of using same in treating aneurysms |
| US8419787B2 (en) | 2001-11-23 | 2013-04-16 | Surpass Medical Ltd | Implantable intraluminal device and method of using same in treating aneurysms |
| US8227230B2 (en) | 2003-04-27 | 2012-07-24 | Protalix Ltd. | Human lysosomal proteins from plant cell culture |
| US8449876B2 (en) | 2003-04-27 | 2013-05-28 | Protalix Ltd. | Human lysosomal proteins from plant cell culture |
| US8741620B2 (en) | 2003-04-27 | 2014-06-03 | Protalix Ltd. | Human lysosomal proteins from plant cell culture |
| US9220737B2 (en) | 2003-04-27 | 2015-12-29 | Protalix Ltd. | Plant cell culture expressing human lysosomal proteins and uses thereof |
| DE102006062634A1 (de) * | 2006-12-23 | 2008-06-26 | Stiftung Alfred-Wegener-Institut für Polar- und Meeresforschung Stiftung des öffentlichen Rechts | Kulturvorrichtung für aquatische Organismen |
| US10364413B2 (en) | 2007-05-07 | 2019-07-30 | Protalix Ltd. | Large scale disposable bioreactor |
| DE102018128010A1 (de) * | 2018-11-08 | 2020-05-14 | Bastian Steudel | Bioreaktor zum Kultivieren von photoautotrophen Mikroorganismen und dessen Verwendung |
| DE102018128010B4 (de) * | 2018-11-08 | 2021-02-11 | Bastian Steudel | Bioreaktor zum Kultivieren von photoautotrophen Mikroorganismen und dessen Verwendung |
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9904529A2 (hu) | 2000-04-28 |
| JP3987121B2 (ja) | 2007-10-03 |
| PL190829B1 (pl) | 2006-02-28 |
| DE69718812D1 (de) | 2003-03-06 |
| WO1998013469A1 (en) | 1998-04-02 |
| DK0938544T3 (da) | 2003-05-26 |
| EP0938544A1 (en) | 1999-09-01 |
| ATE231912T1 (de) | 2003-02-15 |
| CA2266851C (en) | 2009-07-07 |
| CZ298148B6 (cs) | 2007-07-04 |
| CZ104799A3 (cs) | 1999-08-11 |
| CA2266851A1 (en) | 1998-04-02 |
| US6391638B1 (en) | 2002-05-21 |
| HU226908B1 (hu) | 2010-03-01 |
| IL119310A (en) | 1999-07-14 |
| JP2001502526A (ja) | 2001-02-27 |
| HUP9904529A3 (en) | 2001-07-30 |
| IL119310A0 (en) | 1996-12-05 |
| PL332483A1 (en) | 1999-09-13 |
| EP0938544B1 (en) | 2003-01-29 |
| AU4318097A (en) | 1998-04-17 |
| HK1023361A1 (en) | 2000-09-08 |
| ES2191851T3 (es) | 2003-09-16 |
| US20020110915A1 (en) | 2002-08-15 |
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