DE69718177D1 - Substituierte pyrimidinderivate und ihre pharmazeutische anwendung - Google Patents

Substituierte pyrimidinderivate und ihre pharmazeutische anwendung

Info

Publication number
DE69718177D1
DE69718177D1 DE69718177T DE69718177T DE69718177D1 DE 69718177 D1 DE69718177 D1 DE 69718177D1 DE 69718177 T DE69718177 T DE 69718177T DE 69718177 T DE69718177 T DE 69718177T DE 69718177 D1 DE69718177 D1 DE 69718177D1
Authority
DE
Germany
Prior art keywords
pct
heterocyclic derivatives
date feb
sec
pharmaceutical application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69718177T
Other languages
English (en)
Other versions
DE69718177T2 (de
Inventor
Robert Brown
John Newcombe
Sophie Stokes
David Waterson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9617060.0A external-priority patent/GB9617060D0/en
Priority claimed from GBGB9703027.4A external-priority patent/GB9703027D0/en
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of DE69718177D1 publication Critical patent/DE69718177D1/de
Application granted granted Critical
Publication of DE69718177T2 publication Critical patent/DE69718177T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69718177T 1996-08-14 1997-07-25 Substituierte pyrimidinderivate und ihre pharmazeutische anwendung Expired - Fee Related DE69718177T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9617060.0A GB9617060D0 (en) 1996-08-14 1996-08-14 Chemical compounds
GBGB9703027.4A GB9703027D0 (en) 1997-02-14 1997-02-14 Chemical compounds
PCT/GB1997/002029 WO1998006705A1 (en) 1996-08-14 1997-07-25 Substituted pyrimidine derivatives and their pharmaceutical use

Publications (2)

Publication Number Publication Date
DE69718177D1 true DE69718177D1 (de) 2003-02-06
DE69718177T2 DE69718177T2 (de) 2003-10-23

Family

ID=26309870

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69718177T Expired - Fee Related DE69718177T2 (de) 1996-08-14 1997-07-25 Substituierte pyrimidinderivate und ihre pharmazeutische anwendung

Country Status (18)

Country Link
US (1) US6093718A (de)
EP (1) EP0925286B1 (de)
JP (1) JP2000516602A (de)
KR (1) KR20000029984A (de)
CN (1) CN1228087A (de)
AT (1) ATE230399T1 (de)
AU (1) AU3701797A (de)
BG (1) BG103190A (de)
BR (1) BR9711135A (de)
CA (1) CA2260872A1 (de)
CZ (1) CZ45699A3 (de)
DE (1) DE69718177T2 (de)
IL (1) IL128428A0 (de)
NO (1) NO990663L (de)
PL (1) PL331599A1 (de)
SK (1) SK18499A3 (de)
TR (1) TR199900303T2 (de)
WO (1) WO1998006705A1 (de)

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JP2001511799A (ja) 1997-02-13 2001-08-14 ゼネカ・リミテッド オキシド−スクアレンシクラーゼ阻害剤として有用なヘテロ環式化合物
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CN102439015B (zh) 2009-05-12 2015-05-13 杨森制药有限公司 1,2,4-三唑并[4,3-a]吡啶衍生物和其作为mGluR2受体的正向变构调节剂的用途
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Also Published As

Publication number Publication date
SK18499A3 (en) 1999-07-12
CZ45699A3 (cs) 1999-05-12
BR9711135A (pt) 1999-08-17
EP0925286B1 (de) 2003-01-02
NO990663L (no) 1999-04-12
NO990663D0 (no) 1999-02-12
CN1228087A (zh) 1999-09-08
EP0925286A1 (de) 1999-06-30
IL128428A0 (en) 2000-01-31
WO1998006705A1 (en) 1998-02-19
ATE230399T1 (de) 2003-01-15
AU3701797A (en) 1998-03-06
KR20000029984A (ko) 2000-05-25
BG103190A (en) 1999-11-30
DE69718177T2 (de) 2003-10-23
PL331599A1 (en) 1999-08-02
TR199900303T2 (xx) 1999-06-21
JP2000516602A (ja) 2000-12-12
CA2260872A1 (en) 1998-02-19
US6093718A (en) 2000-07-25

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