DE69717406D1 - Chirale Diphosphin-Verbindung, Zwischenprodukte zu ihrer Herstellung, Übergangsmetall-Komplexe davon und asymmetrischer Hydrierungskatalysator - Google Patents

Chirale Diphosphin-Verbindung, Zwischenprodukte zu ihrer Herstellung, Übergangsmetall-Komplexe davon und asymmetrischer Hydrierungskatalysator

Info

Publication number
DE69717406D1
DE69717406D1 DE69717406T DE69717406T DE69717406D1 DE 69717406 D1 DE69717406 D1 DE 69717406D1 DE 69717406 T DE69717406 T DE 69717406T DE 69717406 T DE69717406 T DE 69717406T DE 69717406 D1 DE69717406 D1 DE 69717406D1
Authority
DE
Germany
Prior art keywords
intermediates
preparation
transition metal
metal complexes
hydrogenation catalyst
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69717406T
Other languages
English (en)
Other versions
DE69717406T2 (de
Inventor
Takao Saito
Tohru Yokozawa
Zhang Xiaoyaong
Noboru Sayo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takasago International Corp
Original Assignee
Takasago Perfumery Industry Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takasago Perfumery Industry Co filed Critical Takasago Perfumery Industry Co
Application granted granted Critical
Publication of DE69717406D1 publication Critical patent/DE69717406D1/de
Publication of DE69717406T2 publication Critical patent/DE69717406T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
    • B01J31/2442—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring comprising condensed ring systems
    • B01J31/2447—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring comprising condensed ring systems and phosphine-P atoms as substituents on a ring of the condensed system or on a further attached ring
    • B01J31/2452—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring comprising condensed ring systems and phosphine-P atoms as substituents on a ring of the condensed system or on a further attached ring with more than one complexing phosphine-P atom
    • B01J31/2457—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring comprising condensed ring systems and phosphine-P atoms as substituents on a ring of the condensed system or on a further attached ring with more than one complexing phosphine-P atom comprising aliphatic or saturated rings, e.g. Xantphos
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0046—Ruthenium compounds
    • C07F15/0053—Ruthenium compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0073—Rhodium compounds
    • C07F15/008—Rhodium compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/04—Nickel compounds
    • C07F15/045—Nickel compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/60—Reduction reactions, e.g. hydrogenation
    • B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
    • B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
    • B01J2231/643—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of R2C=O or R2C=NR (R= C, H)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/02—Compositional aspects of complexes used, e.g. polynuclearity
    • B01J2531/0261—Complexes comprising ligands with non-tetrahedral chirality
    • B01J2531/0266—Axially chiral or atropisomeric ligands, e.g. bulky biaryls such as donor-substituted binaphthalenes, e.g. "BINAP" or "BINOL"
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/821—Ruthenium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/822—Rhodium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/824—Palladium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/827—Iridium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/84—Metals of the iron group
    • B01J2531/847—Nickel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/18—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms
    • B01J31/1805—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony as complexing atoms, e.g. in pyridine ligands, or in resonance therewith, e.g. in isocyanide ligands C=N-R or as complexed central atoms the ligands containing nitrogen
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • B01J31/2282—Unsaturated compounds used as ligands
    • B01J31/2295—Cyclic compounds, e.g. cyclopentadienyls
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE69717406T 1996-12-26 1997-12-24 Chirale Diphosphin-Verbindung, Zwischenprodukte zu ihrer Herstellung, Übergangsmetall-Komplexe davon und asymmetrischer Hydrierungskatalysator Expired - Lifetime DE69717406T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP35981896A JP3148136B2 (ja) 1996-12-26 1996-12-26 新規なキラルジホスフィン化合物、その製造中間体、該ジホス フィン化合物を配位子とする遷移金属錯体並びに該錯体を含む 不斉水素化触媒

Publications (2)

Publication Number Publication Date
DE69717406D1 true DE69717406D1 (de) 2003-01-09
DE69717406T2 DE69717406T2 (de) 2003-08-14

Family

ID=18466453

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69717406T Expired - Lifetime DE69717406T2 (de) 1996-12-26 1997-12-24 Chirale Diphosphin-Verbindung, Zwischenprodukte zu ihrer Herstellung, Übergangsmetall-Komplexe davon und asymmetrischer Hydrierungskatalysator

Country Status (4)

Country Link
US (1) US5872273A (de)
EP (1) EP0850945B1 (de)
JP (1) JP3148136B2 (de)
DE (1) DE69717406T2 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6162929A (en) * 1997-12-23 2000-12-19 Hoffmann-La Roche Inc. Process for the manufacture of bisphosphine oxide and bisphosphonate compounds
JP3549390B2 (ja) * 1998-03-23 2004-08-04 高砂香料工業株式会社 ルテニウム−ホスフィン錯体及びその製造方法
JP3640565B2 (ja) * 1999-03-31 2005-04-20 高砂香料工業株式会社 ルテニウム−光学活性ホスフィン錯体混合物、その製法およびこれを用いた不斉水素化触媒
EP0955303B1 (de) * 1998-05-08 2006-11-08 Takasago International Corporation Ruthenium-iodo optisch aktiver Phosphinkomplex
DE69908889T2 (de) 1998-11-19 2004-05-06 Solvias Ag Chirale Diphenyldiphosphine und d-8 Metall-Komplexe davon
US6288280B1 (en) * 1999-07-09 2001-09-11 Hoffmann-La Roche Inc. Racemization of atropisomeric bis(phosphine oxide) compounds
JP3844927B2 (ja) 2000-01-07 2006-11-15 高砂香料工業株式会社 ジホスフィンオキシドおよびジホスホナートの製造方法
JP4601779B2 (ja) * 2000-07-25 2010-12-22 高砂香料工業株式会社 光学活性アルコールの製造方法
CA2427579C (en) * 2000-11-17 2009-11-03 The Penn State Research Foundation Ortho substituted chiral phosphines and phosphinites and their use in asymmetric catalytic reactions
FR2830254B1 (fr) * 2001-09-28 2004-09-17 Synkem Nouvelles diphosphines, leurs complexes avec des metaux de transition et leur utilisation en synthese asymetrique
AU2002354100A1 (en) 2001-12-07 2003-06-17 Takeda Chemical Industries, Ltd. Process for preparation of diphosphine compounds and intermediates for the process
JP4348126B2 (ja) 2002-09-06 2009-10-21 高砂香料工業株式会社 光学活性アミノアルコール類の製造方法
CN1768046A (zh) * 2003-04-07 2006-05-03 索尔维亚斯股份公司 胺取代的二苯基二膦及其在用于不对称合成的金属配合物中的应用
EP1528053A1 (de) * 2003-10-31 2005-05-04 Lonza Ag Verfahren zur Herstellung von (S)- oder (R)-4-halo-3-hydroxybutyraten
DE102004022397A1 (de) * 2004-05-06 2005-12-01 Consortium für elektrochemische Industrie GmbH Chirale C2-symmetrische Biphenyle, deren Herstellung sowie Metallkomplexe enthaltend diese Liganden und deren Verwendung als Katalysatoren in chirogenen Synthesen
JP4926043B2 (ja) * 2004-05-11 2012-05-09 ザ・ホンコン・ポリテクニック・ユニバーシティ 医薬組成物
JP4490211B2 (ja) * 2004-08-27 2010-06-23 高砂香料工業株式会社 光学活性３−キヌクリジノール類の製造方法
US20060165580A1 (en) * 2005-01-26 2006-07-27 The Regents Of The University Of California Heterogeneous copper catalysts
JP4855196B2 (ja) * 2005-09-22 2012-01-18 高砂香料工業株式会社 置換光学活性ジホスフィン化合物
US7312347B2 (en) 2005-09-22 2007-12-25 Takasago International Corporation Substituted optically active disphosphine compound
JP2008169201A (ja) 2006-12-11 2008-07-24 Tokyo Univ Of Agriculture & Technology 新規光学活性ビアリールリン化合物とその製造方法
US8641711B2 (en) * 2007-05-04 2014-02-04 Covidien Lp Method and apparatus for gastrointestinal tract ablation for treatment of obesity
EP2098531A1 (de) 2008-03-05 2009-09-09 National University Corporation Tokyo University of Agriculture and Technology Achsenasymmetrische Phosphorverbindung und Verfahren zu ihrer Herstellung
JP5135264B2 (ja) * 2009-03-12 2013-02-06 独立行政法人科学技術振興機構 ホスホン酸類縁体の製造方法、及び触媒
EP2289897A1 (de) * 2009-09-01 2011-03-02 Sanofi-Aventis Fotochemisches Verfahren zur Artemisinin-Bildung
AU2010293907B2 (en) * 2009-09-11 2016-03-03 Huvepharma Italia S.R.L Process for the production of artemisinin intermediates
FR2952638A1 (fr) 2009-11-17 2011-05-20 Univ Strasbourg Procede de phosphination catalytique double ou triple de composes di, tri ou tetrahalobiaryles, intermediaires employes, composes obtenus et leurs utilisations
JP5825672B2 (ja) 2011-12-22 2015-12-02 高砂香料工業株式会社 高純度セラミド類の製造方法
CN103087106B (zh) * 2013-01-31 2016-02-03 中国科学院上海有机化学研究所 含有n－芳基的手性膦氮类化合物、合成方法以及应用
CN103145557B (zh) * 2013-03-27 2015-06-03 石家庄手性化学有限公司 一种光学纯度的s-4-氯-3-羟基丁酸乙酯的制备方法
CN104909992A (zh) * 2015-06-03 2015-09-16 黄山天香科技股份有限公司 一种用2s-反-5-甲基-2-(1-甲基乙基)环己酮制备(1r,2s,5r)-2-异丙基-5-甲基环己醇的方法
EP3558977B1 (de) 2016-12-20 2020-10-28 Bristol-Myers Squibb Company Verfahren zur herstellung von tetrahydrocarbazolcarboxamidverbindungen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4330730A1 (de) * 1993-09-10 1995-03-16 Bayer Ag Neue Bisphosphine für asymmetrische Hydrierkatalysatoren
DE4415682A1 (de) * 1994-05-04 1995-11-09 Hoechst Ag Palladium Katalysatoren mit sulfonierten Bisphosphinen als Liganden, Verfahren zu ihrer Herstellung und ihre Verwendung für Carbonylierungsreaktionen
DE4422672A1 (de) * 1994-06-30 1996-01-04 Hoechst Ag Halogenierte Biphenyl-2,2'-diyl-bis-diphenylphosphine, ihre Herstellung und ihre Verwendung
IT1270082B (it) * 1994-07-12 1997-04-28 Univ Degli Studi Milano Difosfine eteroaromatiche come leganti chirali, complessi tra dette difosfine e metalli di transizione ed impiego di detti complessi come catalizzatori chirali
JP3770639B2 (ja) * 1995-10-31 2006-04-26 高砂香料工業株式会社 光学活性ジホスフィンの製造方法

Also Published As

Publication number Publication date
EP0850945A1 (de) 1998-07-01
JPH10182678A (ja) 1998-07-07
EP0850945B1 (de) 2002-11-27
DE69717406T2 (de) 2003-08-14
US5872273A (en) 1999-02-16
JP3148136B2 (ja) 2001-03-19

Similar Documents

Publication Publication Date Title
DE69717406D1 (de) Chirale Diphosphin-Verbindung, Zwischenprodukte zu ihrer Herstellung, Übergangsmetall-Komplexe davon und asymmetrischer Hydrierungskatalysator
GC0000068A (en) Catalyst composition.
DE69718642D1 (de) Spätübergangsmetall-trägerkatalysatorsysteme
DE69922086D1 (de) Funktionsangepasste Legierung, ihre Verwendung und Verfahren zu ihrer Herstellung
AU2900499A (en) Substituted aminomethylphosphines as ligands for catalysts
MX9911931A (es) Nuevos catalizadores
BR9913221B1 (pt) composiÇço catalisadora suportada de metaloceno.
DE69818240D1 (de) Neue katalysatoren
DE59810127D1 (de) Bispyrazolazaverbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Haarfärbemittel
ATA906196A (de) Fungizides mittel, eine verbindung hierfür, verfahren zu ihrer herstellung und verfahren zu ihrer verwendung
SG74630A1 (en) A shaped metal fixed-bed catalyst, a process for its preparation and its use
KR970701588A (ko) 니켈 함유 수소화반응 촉매(Nickel-Containing Hydrogenation Catalysts)
AU2881199A (en) Substituted 1,4-dihydro-4-oxonicotinic carboxamides: gaba brain receptor ligands
DE69803332D1 (de) Hartmolybdänlegierung, verschliessfeste Legierung und Verfahren zu ihrer Herstellung
HUT75297A (en) Processes for epoxidising prochiral olefins, new catalysts therefor, preparation and intermediates thereof
AU1088799A (en) Multiple catalyst bed radial flow reactor
DE59802412D1 (de) Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
AU4952199A (en) Catalytic asymmetric hydrogenation, hydroformylation, and hydrovinylation via transition metal catalysts with phosphines and phosphites
DE69717651D1 (de) Molybdän-haltige oxidationskatalysatoren
NO986096L (no) Katalysator for hydrokrakking av destillat, og fremgangsmÕte for fremstilling derav
ZA97559B (en) Dihalopropene compounds, their use and intermediates for their production.
DE69827939D1 (de) Oxim-verbindungen, ihre anwendung und zwischenprodukte zu ihrer herstellung
GB0012988D0 (en) Catalytic composition for oligomerisation
NO986094L (no) Katalysator for destillathydrofining, og fremgangsmÕte for fremstilling derav
DE69737265D1 (de) Herstellung nickelenthaltenden, gesinterten, verfestigten, feritischen rostfreien stahls

Legal Events

Date Code Title Description
8364 No opposition during term of opposition