DE69714861T2 - Kombinationspräparat mit hemmender wirkung auf die abstossung von transplantaten, autoimmunerkrankungen und entzündungen, welches cyclosporin a und 40-0-(2-hydroxyethyl)-rapamycin enthält - Google Patents
Kombinationspräparat mit hemmender wirkung auf die abstossung von transplantaten, autoimmunerkrankungen und entzündungen, welches cyclosporin a und 40-0-(2-hydroxyethyl)-rapamycin enthältInfo
- Publication number
- DE69714861T2 DE69714861T2 DE69714861T DE69714861T DE69714861T2 DE 69714861 T2 DE69714861 T2 DE 69714861T2 DE 69714861 T DE69714861 T DE 69714861T DE 69714861 T DE69714861 T DE 69714861T DE 69714861 T2 DE69714861 T2 DE 69714861T2
- Authority
- DE
- Germany
- Prior art keywords
- rapamycin
- hydroxyethyl
- cyclosporin
- administration
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
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- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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Landscapes
- Health & Medical Sciences (AREA)
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9615942.1A GB9615942D0 (en) | 1996-07-30 | 1996-07-30 | Organic compounds |
| GBGB9705684.0A GB9705684D0 (en) | 1997-03-18 | 1997-03-18 | Organic compounds |
| PCT/EP1997/004123 WO1998004279A1 (en) | 1996-07-30 | 1997-07-29 | Pharmaceutical compositions for the treatment of transplant rejection, autoimmune or inflammatory conditions comprising cyclosporin a and 40-0-(2-hydroxiethyl)-rapamycin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69714861D1 DE69714861D1 (de) | 2002-09-26 |
| DE69714861T2 true DE69714861T2 (de) | 2003-05-22 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69736750T Expired - Lifetime DE69736750T2 (de) | 1996-07-30 | 1997-07-29 | Pharmazeutische zusammensetzungen zur behandlung der transplantatabstossung sowie der autoimmun- oder entzündlichen zustände |
| DE69714861T Expired - Lifetime DE69714861T2 (de) | 1996-07-30 | 1997-07-29 | Kombinationspräparat mit hemmender wirkung auf die abstossung von transplantaten, autoimmunerkrankungen und entzündungen, welches cyclosporin a und 40-0-(2-hydroxyethyl)-rapamycin enthält |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69736750T Expired - Lifetime DE69736750T2 (de) | 1996-07-30 | 1997-07-29 | Pharmazeutische zusammensetzungen zur behandlung der transplantatabstossung sowie der autoimmun- oder entzündlichen zustände |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6239124B1 (enExample) |
| EP (2) | EP1208847B8 (enExample) |
| JP (2) | JP3942641B2 (enExample) |
| AT (2) | ATE222502T1 (enExample) |
| AU (1) | AU730781B2 (enExample) |
| CA (1) | CA2261666C (enExample) |
| CY (1) | CY2391B1 (enExample) |
| DE (2) | DE69736750T2 (enExample) |
| DK (2) | DK1208847T3 (enExample) |
| ES (2) | ES2182112T3 (enExample) |
| NZ (1) | NZ333657A (enExample) |
| PT (2) | PT1208847E (enExample) |
| SI (1) | SI1208847T1 (enExample) |
| WO (1) | WO1998004279A1 (enExample) |
Families Citing this family (83)
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| ATE198041T1 (de) * | 1993-09-28 | 2000-12-15 | Scherer Gmbh R P | Herstellung von weichgelatinekapseln |
| US5858401A (en) * | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
| ATE222502T1 (de) * | 1996-07-30 | 2002-09-15 | Novartis Ag | Kombinationspräparat mit hemmender wirkung auf die abstossung von transplantaten, autoimmunerkrankungen und entzündungen, welches cyclosporin a und 40-0-(2-hydroxyethyl)-rapamycin enthält |
| US20030199425A1 (en) * | 1997-06-27 | 2003-10-23 | Desai Neil P. | Compositions and methods for treatment of hyperplasia |
| US6890546B2 (en) * | 1998-09-24 | 2005-05-10 | Abbott Laboratories | Medical devices containing rapamycin analogs |
| US20030129215A1 (en) * | 1998-09-24 | 2003-07-10 | T-Ram, Inc. | Medical devices containing rapamycin analogs |
| GB9825632D0 (en) * | 1998-11-23 | 1999-01-13 | Novartis Ag | Organic compounds |
| GB9826882D0 (en) | 1998-12-07 | 1999-01-27 | Novartis Ag | Organic compounds |
| US20020006901A1 (en) * | 1999-02-05 | 2002-01-17 | Aldo T. Iacono | Use of aerosolized cyclosporine for prevention and treatment of pulmonary disease |
| ATE474590T1 (de) | 1999-05-10 | 2010-08-15 | Paolo Brenner | Kombination von immunsuppressiven substanzen zur behandlung oder vorbeugung von transplantat abstossungen |
| US20040102425A1 (en) * | 2000-11-03 | 2004-05-27 | Barr Alexander Stephen | Selective glucocorticoid receptor agonists |
| US20020127263A1 (en) * | 2001-02-27 | 2002-09-12 | Wenda Carlyle | Peroxisome proliferator-acitvated receptor gamma ligand eluting medical device |
| US8741378B1 (en) | 2001-06-27 | 2014-06-03 | Advanced Cardiovascular Systems, Inc. | Methods of coating an implantable device |
| US20040137066A1 (en) * | 2001-11-26 | 2004-07-15 | Swaminathan Jayaraman | Rationally designed therapeutic intravascular implant coating |
| US6641611B2 (en) * | 2001-11-26 | 2003-11-04 | Swaminathan Jayaraman | Therapeutic coating for an intravascular implant |
| US20080145402A1 (en) * | 2001-09-10 | 2008-06-19 | Abbott Cardiovascular Systems Inc. | Medical Devices Containing Rapamycin Analogs |
| US20030054042A1 (en) * | 2001-09-14 | 2003-03-20 | Elaine Liversidge | Stabilization of chemical compounds using nanoparticulate formulations |
| CA2461730C (en) * | 2001-10-19 | 2012-05-15 | Isotechnika Inc. | Novel cyclosporin analog microemulsion preconcentrates |
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1997
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- 1997-07-29 WO PCT/EP1997/004123 patent/WO1998004279A1/en not_active Ceased
- 1997-07-29 EP EP01131018A patent/EP1208847B8/en not_active Expired - Lifetime
- 1997-07-29 ES ES97937526T patent/ES2182112T3/es not_active Expired - Lifetime
- 1997-07-29 AU AU40124/97A patent/AU730781B2/en not_active Expired
- 1997-07-29 DK DK01131018T patent/DK1208847T3/da active
- 1997-07-29 PT PT01131018T patent/PT1208847E/pt unknown
- 1997-07-29 US US09/230,618 patent/US6239124B1/en not_active Expired - Lifetime
- 1997-07-29 DE DE69736750T patent/DE69736750T2/de not_active Expired - Lifetime
- 1997-07-29 PT PT97937526T patent/PT956034E/pt unknown
- 1997-07-29 SI SI9730756T patent/SI1208847T1/sl unknown
- 1997-07-29 DK DK97937526T patent/DK0956034T3/da active
- 1997-07-29 CA CA2261666A patent/CA2261666C/en not_active Expired - Lifetime
- 1997-07-29 ES ES01131018T patent/ES2270948T3/es not_active Expired - Lifetime
- 1997-07-29 EP EP97937526A patent/EP0956034B1/en not_active Expired - Lifetime
- 1997-07-29 NZ NZ333657A patent/NZ333657A/xx not_active IP Right Cessation
- 1997-07-29 JP JP50851398A patent/JP3942641B2/ja not_active Expired - Lifetime
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- 1997-07-29 AT AT01131018T patent/ATE340586T1/de active
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2001
- 2001-01-11 US US09/758,301 patent/US6455518B2/en not_active Expired - Lifetime
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2003
- 2003-11-28 CY CY0300086A patent/CY2391B1/xx unknown
- 2003-12-08 JP JP2003408898A patent/JP4149905B2/ja not_active Expired - Lifetime
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| CA2261666C (en) | 2010-09-14 |
| AU4012497A (en) | 1998-02-20 |
| SI1208847T1 (sl) | 2007-06-30 |
| WO1998004279A1 (en) | 1998-02-05 |
| US20010008888A1 (en) | 2001-07-19 |
| EP1208847B8 (en) | 2007-02-14 |
| PT1208847E (pt) | 2007-07-24 |
| ES2270948T3 (es) | 2007-04-16 |
| EP0956034A1 (en) | 1999-11-17 |
| EP1208847A3 (en) | 2002-06-12 |
| ATE340586T1 (de) | 2006-10-15 |
| HK1023720A1 (en) | 2000-09-22 |
| EP1208847A2 (en) | 2002-05-29 |
| EP1208847B1 (en) | 2006-09-27 |
| DE69714861D1 (de) | 2002-09-26 |
| CY2391B1 (en) | 2004-09-10 |
| US6455518B2 (en) | 2002-09-24 |
| PT956034E (pt) | 2002-12-31 |
| JP2004210767A (ja) | 2004-07-29 |
| DE69736750D1 (de) | 2006-11-09 |
| AU730781B2 (en) | 2001-03-15 |
| JP2000505806A (ja) | 2000-05-16 |
| JP3942641B2 (ja) | 2007-07-11 |
| ES2182112T3 (es) | 2003-03-01 |
| JP4149905B2 (ja) | 2008-09-17 |
| NZ333657A (en) | 2000-05-26 |
| US6239124B1 (en) | 2001-05-29 |
| DK1208847T3 (da) | 2007-01-08 |
| DK0956034T3 (da) | 2002-12-16 |
| EP0956034B1 (en) | 2002-08-21 |
| CA2261666A1 (en) | 1998-02-05 |
| DE69736750T2 (de) | 2007-08-16 |
| ATE222502T1 (de) | 2002-09-15 |
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