DE69708461T2 - Bioresponsive pharmakologisch aktive polymere und daraus hergestellte gegenstände - Google Patents

Bioresponsive pharmakologisch aktive polymere und daraus hergestellte gegenstände

Info

Publication number
DE69708461T2
DE69708461T2 DE69708461T DE69708461T DE69708461T2 DE 69708461 T2 DE69708461 T2 DE 69708461T2 DE 69708461 T DE69708461 T DE 69708461T DE 69708461 T DE69708461 T DE 69708461T DE 69708461 T2 DE69708461 T2 DE 69708461T2
Authority
DE
Germany
Prior art keywords
pharmacologically active
objects made
active polymers
bioresponsive pharmacologically
bioresponsive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69708461T
Other languages
English (en)
Other versions
DE69708461D1 (de
Inventor
Paul J Santerre
Marc W Mittelman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Interface Biologics Inc
Original Assignee
Paul J Santerre
Marc W Mittelman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paul J Santerre, Marc W Mittelman filed Critical Paul J Santerre
Application granted granted Critical
Publication of DE69708461D1 publication Critical patent/DE69708461D1/de
Publication of DE69708461T2 publication Critical patent/DE69708461T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/72—Polyisocyanates or polyisothiocyanates
    • C08G18/73—Polyisocyanates or polyisothiocyanates acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/595—Polyamides, e.g. nylon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/50—Polyethers having heteroatoms other than oxygen
    • C08G18/5021—Polyethers having heteroatoms other than oxygen having nitrogen
    • C08G18/5024—Polyethers having heteroatoms other than oxygen having nitrogen containing primary and/or secondary amino groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
DE69708461T 1996-02-15 1997-02-10 Bioresponsive pharmakologisch aktive polymere und daraus hergestellte gegenstände Expired - Lifetime DE69708461T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1169996P 1996-02-15 1996-02-15
US1439196P 1996-03-28 1996-03-28
PCT/CA1997/000089 WO1997029778A2 (en) 1996-02-15 1997-02-10 Bioresponsive pharmacologically-active polymers and articles made therefrom

Publications (2)

Publication Number Publication Date
DE69708461D1 DE69708461D1 (de) 2002-01-03
DE69708461T2 true DE69708461T2 (de) 2002-06-27

Family

ID=26682693

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69708461T Expired - Lifetime DE69708461T2 (de) 1996-02-15 1997-02-10 Bioresponsive pharmakologisch aktive polymere und daraus hergestellte gegenstände

Country Status (7)

Country Link
US (1) US5798115A (de)
EP (1) EP0874643B1 (de)
JP (1) JP4341986B2 (de)
AU (1) AU705101B2 (de)
CA (1) CA2243649C (de)
DE (1) DE69708461T2 (de)
WO (1) WO1997029778A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006033312A1 (de) * 2006-07-17 2008-01-31 Heraeus Kulzer Gmbh Dentales Implantatsystemteil mit einer Beschichtung

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19638570A1 (de) * 1996-09-20 1998-03-26 Bayer Ag Wirkstoffhaltige thermoplastische Polyurethane
US6468519B1 (en) * 1997-09-10 2002-10-22 Rutgers, The State University Of New Jersey Polyanhydrides with biologically active degradation products
US7122615B1 (en) 1998-09-10 2006-10-17 Rutgers, The State University Of New Jersey Polyanhydrides with therapeutically useful degradation products
US6486214B1 (en) * 1997-09-10 2002-11-26 Rutgers, The State University Of New Jersey Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby
WO2000007633A1 (de) * 1998-08-07 2000-02-17 Leica Microsystems Ag Medizinisches gerät
US6366794B1 (en) * 1998-11-20 2002-04-02 The University Of Connecticut Generic integrated implantable potentiostat telemetry unit for electrochemical sensors
US20030099682A1 (en) * 1998-11-20 2003-05-29 Francis Moussy Apparatus and method for control of tissue/implant interactions
US6585767B1 (en) * 1998-11-23 2003-07-01 Agion Technologies, Inc. Antimicrobial suturing ring for heart valve
US6787302B2 (en) * 1999-10-25 2004-09-07 Genprime, Inc. Method and apparatus for prokaryotic and eukaryotic cell quantitation
US6673568B1 (en) * 1999-10-25 2004-01-06 Genprime, Inc. Method and apparatus for prokaryotic and eukaryotic cell quantitation
US20040038948A1 (en) 1999-12-07 2004-02-26 Uhrich Kathryn E. Therapeutic compositions and methods
US7179849B2 (en) * 1999-12-15 2007-02-20 C. R. Bard, Inc. Antimicrobial compositions containing colloids of oligodynamic metals
US6579539B2 (en) 1999-12-22 2003-06-17 C. R. Bard, Inc. Dual mode antimicrobial compositions
US20010049422A1 (en) * 2000-04-14 2001-12-06 Phaneuf Matthew D. Methods of applying antibiotic compounds to polyurethane biomaterials using textile dyeing technology
WO2002055614A2 (en) * 2001-01-12 2002-07-18 Dsm Ip Assets B.V. Radiation-curable composition and products coated therewith
CA2349989A1 (en) * 2001-06-07 2002-12-07 Paul J. Santerre Bioactive surface modifiers for polymers and articles made therefrom
US20050129732A1 (en) * 2001-07-13 2005-06-16 Flow Focusing, Inc. Biodegradable, antibiotic, controlled release tape
DE10146814A1 (de) * 2001-09-18 2003-04-03 Uronova Gmbh Medizinisches Nahtmaterial
MXPA04005332A (es) 2001-12-03 2005-05-16 Bard Inc C R Dispositivo medico resistente a microbios, revestimiento polimerico resistente a microbios y metodos para producir los mismos.
US20030216758A1 (en) * 2001-12-28 2003-11-20 Angiotech Pharmaceuticals, Inc. Coated surgical patches
US20030166823A1 (en) * 2002-03-01 2003-09-04 Thomas Daly Polymers with antimicrobial, bioresistant and fungal resistant properties
US7037527B2 (en) * 2002-01-25 2006-05-02 University Of Rhode Island Bifunctionalized polyester material for surface treatment and biomodification
US20030162273A1 (en) * 2002-02-04 2003-08-28 Anastasios Melis Modulation of sulfate permease for photosynthetic hydrogen production
US8313760B2 (en) 2002-05-24 2012-11-20 Angiotech International Ag Compositions and methods for coating medical implants
DE60328486D1 (de) * 2002-05-24 2009-09-03 Angiotech Int Ag Zusammensetzungen und verfahren zur beschichtung medizinischer implantate
US20040002552A1 (en) * 2002-06-26 2004-01-01 Thomas Daly Esters with antimicrobial, bioresistant and fungal resistant properties
US20090137838A1 (en) * 2006-05-24 2009-05-28 Thomas Daly Esters with antimicrobial, bioresistant and fungal resistant properties
US7439376B2 (en) * 2002-06-26 2008-10-21 Tpat Ip Llc Esters with antimicrobial, bioresistant and fungal resistant properties
WO2004006863A2 (en) * 2002-07-17 2004-01-22 Rutgers, The State University Therapeutic devices for patterned cell growth
US7488757B2 (en) 2003-03-24 2009-02-10 Becton, Dickinson And Company Invisible antimicrobial glove and hand antiseptic
JP2006525445A (ja) * 2003-04-23 2006-11-09 ザ ユニバーシティ オブ アクロン 封鎖反応性材料本特許出願は、２００３年４月２３日に出願された米国仮特許出願第６０／４６４，８７９号に基づく優先権を主張する。
US20040215335A1 (en) * 2003-04-25 2004-10-28 Brin David S. Methods and apparatus for treatment of aneurysmal tissue
DE10352575B3 (de) * 2003-11-11 2005-05-04 Leica Microsystems Nussloch Gmbh Kryostat mit einem Innenbehälter zur Aufnahme eines Mikrotoms
CA2467321A1 (en) * 2004-05-14 2005-11-14 Paul J. Santerre Polymeric coupling agents and pharmaceutically-active polymers made therefrom
AU2005244037A1 (en) * 2004-05-14 2005-11-24 Interface Biologics Inc. Polymeric coupling agents and pharmaceutically-active polymers made therefrom
US8246569B1 (en) 2004-08-17 2012-08-21 California Institute Of Technology Implantable intraocular pressure drain
CA2586927A1 (en) * 2004-11-09 2006-05-18 Angiotech Biocoatings Corp. Antimicrobial needle coating for extended infusion
US20060099332A1 (en) * 2004-11-10 2006-05-11 Mats Eriksson Process for producing a repair coating on a coated metallic surface
US7794742B2 (en) * 2005-02-08 2010-09-14 University Of Washington Devices for promoting epithelial cell differentiation and keratinization
AU2005100176A4 (en) * 2005-03-01 2005-04-07 Gym Tv Pty Ltd Garbage bin clip
US7517914B2 (en) * 2005-04-04 2009-04-14 Boston Scientificscimed, Inc. Controlled degradation materials for therapeutic agent delivery
US20060258994A1 (en) * 2005-05-12 2006-11-16 Avery Robert L Implantable delivery device for administering pharmacological agents to an internal portion of a body
EP1991240A4 (de) * 2006-02-28 2012-12-12 Tyco Healthcare Antimikrobiotika freisetzende polymere
ATE497797T1 (de) * 2006-03-14 2011-02-15 Univ Southern California Mems-vorrichtung zur wirkstofffreisetzung
EP2102144A4 (de) 2006-09-13 2011-03-23 Univ Rutgers Wirkstoffe und ihre oligomere und polymere
JP2008133359A (ja) * 2006-11-28 2008-06-12 Headway Advanced Materials Inc 分散性があり長期効果タイプの防カビ機能を有するポリイソシアネート及びそのカビ防止材料
AT505312A1 (de) * 2007-05-15 2008-12-15 Recticel Schlafkomfort Gmbh Sc Polyurethan-werkstoff mit einer bioziden ausrüstung
US9308124B2 (en) * 2007-12-20 2016-04-12 University Of Southern California Apparatus and methods for delivering therapeutic agents
WO2009089094A2 (en) 2008-01-03 2009-07-16 University Of Southern California Implantable drug-delivery devices, and apparatus and methods for refilling the devices
CA2720721A1 (en) * 2008-04-07 2009-10-15 Interface Biologics, Inc. Combination therapy for the treatment of bacterial infections
EP2323716B1 (de) * 2008-05-08 2015-03-04 MiniPumps, LLC Arzneiabgabepumpen
US9849238B2 (en) 2008-05-08 2017-12-26 Minipumps, Llc Drug-delivery pump with intelligent control
CN102202719B (zh) * 2008-05-08 2014-11-26 迷你泵有限责任公司 可植入泵和用于可植入泵的插管
CA2723723C (en) 2008-05-08 2019-06-25 Replenish Pumps, Llc Implantable drug-delivery devices, and apparatus and methods for filling the devices
PT2355853T (pt) * 2008-10-10 2017-03-15 Polyactiva Pty Ltd Conjugados polímero biodegradável ¿ unidade bioativa
EP2340271B1 (de) * 2008-10-10 2018-12-05 PolyActiva Pty Ltd. Konjugate aus polymer-bioaktiven stoffen
US8535655B2 (en) 2008-10-10 2013-09-17 Polyactiva Pty Ltd. Biodegradable polymer—bioactive moiety conjugates
WO2011022484A1 (en) 2009-08-18 2011-02-24 Replenish Pumps. Llc Electrolytic drug-delivery pump with adaptive control
US8741317B2 (en) 2010-08-19 2014-06-03 Rutgers, The State University Of New Jersey Slow-degrading polymers comprising salicylic acid for undelayed and sustained drug delivery
US20140023692A1 (en) * 2010-11-26 2014-01-23 Lisa Claire Du Toit Drug delivery device
US9603997B2 (en) 2011-03-14 2017-03-28 Minipumps, Llc Implantable drug pumps and refill devices therefor
US10286146B2 (en) 2011-03-14 2019-05-14 Minipumps, Llc Implantable drug pumps and refill devices therefor
US9919099B2 (en) 2011-03-14 2018-03-20 Minipumps, Llc Implantable drug pumps and refill devices therefor
US9144579B2 (en) 2012-08-17 2015-09-29 Rutgers, The State University Of New Jersey Polyesters and methods of use thereof
US20140120057A1 (en) 2012-10-25 2014-05-01 Rutgers, The State University Of New Jersey Polymers and methods thereof for wound healing
US9387250B2 (en) 2013-03-15 2016-07-12 Rutgers, The State University Of New Jersey Therapeutic compositions for bone repair
US9862672B2 (en) 2013-05-29 2018-01-09 Rutgers, The State University Of New Jersey Antioxidant-based poly(anhydride-esters)
US10023521B2 (en) 2014-06-13 2018-07-17 Rutgers, The State University Of New Jersey Process and intermediates for preparing poly(anhydride-esters)
JP6930918B6 (ja) 2015-04-10 2021-12-15 ラトガーズ， ザ ステイト ユニバーシティ オブ ニュー ジャージー コウジ酸ポリマー
IT201700013100A1 (it) * 2017-02-07 2018-08-07 Golden Lady Co Spa Uso di una poliammide modificata per la produzione di prodotti tessili anti-batterici
KR20200121816A (ko) 2018-02-02 2020-10-26 리플 테라퓨틱스 코포레이션 스테로이드 이량체를 포함하는 유리 제제 및 이의 용도
CN109354662B (zh) * 2018-11-02 2021-11-02 湖南博隽生物医药有限公司 一种防感染内置式血液透析管用材料及其制备方法
JP2022548464A (ja) * 2019-07-10 2022-11-21 リップル セラピューティクス コーポレーションズ 二量体ステロイドプロドラッグを含む表面コーティングおよび埋込み可能なデバイス、およびその使用
EP4146664A2 (de) 2020-05-01 2023-03-15 Ripple Therapeutics Corporation Heterodimerzusammensetzungen und verfahren zur behandlung von augenerkrankungen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4670444B1 (en) * 1980-09-03 1999-02-09 Bayer Ag and-naphthyridine-3-carboxylic acids and antibacte7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-rial agents containing these compounds
US5219564A (en) * 1990-07-06 1993-06-15 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
US5474765A (en) * 1992-03-23 1995-12-12 Ut Sw Medical Ctr At Dallas Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells
US5405919A (en) * 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
US5449720A (en) * 1993-05-24 1995-09-12 Biotech Australia Pty Limited Amplification of the VB12 uptake system using polymers
US5609867A (en) * 1994-11-01 1997-03-11 American Cyanamid Company Polymeric antitumor agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006033312A1 (de) * 2006-07-17 2008-01-31 Heraeus Kulzer Gmbh Dentales Implantatsystemteil mit einer Beschichtung

Also Published As

Publication number Publication date
CA2243649C (en) 2009-08-04
WO1997029778A2 (en) 1997-08-21
AU705101B2 (en) 1999-05-13
EP0874643B1 (de) 2001-11-21
JP2000505434A (ja) 2000-05-09
EP0874643A2 (de) 1998-11-04
DE69708461D1 (de) 2002-01-03
US5798115A (en) 1998-08-25
AU1538997A (en) 1997-09-02
CA2243649A1 (en) 1997-08-21
JP4341986B2 (ja) 2009-10-14
WO1997029778A3 (en) 1997-09-25

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