DE69637323D1 - Verfahren und Vorrichtung zur Analyse von Verbindungen in einer Lösung mittels Massenspektrometrie - Google Patents

Verfahren und Vorrichtung zur Analyse von Verbindungen in einer Lösung mittels Massenspektrometrie

Info

Publication number
DE69637323D1
DE69637323D1 DE69637323T DE69637323T DE69637323D1 DE 69637323 D1 DE69637323 D1 DE 69637323D1 DE 69637323 T DE69637323 T DE 69637323T DE 69637323 T DE69637323 T DE 69637323T DE 69637323 D1 DE69637323 D1 DE 69637323D1
Authority
DE
Germany
Prior art keywords
solution
mass spectrometry
analyzing compounds
analyzing
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69637323T
Other languages
English (en)
Other versions
DE69637323T2 (de
Inventor
Atsumu Hirabayashi
Yukiko Hirabayashi
Minoru Sakairi
Yasuaki Takada
Takayuki Nabeshima
Hideaki Koizumi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hitachi Ltd
Original Assignee
Hitachi Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi Ltd filed Critical Hitachi Ltd
Application granted granted Critical
Publication of DE69637323D1 publication Critical patent/DE69637323D1/de
Publication of DE69637323T2 publication Critical patent/DE69637323T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • H01J49/167—Capillaries and nozzles specially adapted therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Plasma & Fusion (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
DE69637323T 1995-09-07 1996-09-06 Verfahren und Vorrichtung zur Analyse von Verbindungen in einer Lösung mittels Massenspektrometrie Expired - Lifetime DE69637323T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22989195 1995-09-07
JP22989195A JP3353561B2 (ja) 1995-09-07 1995-09-07 溶液の質量分析に関する方法と装置

Publications (2)

Publication Number Publication Date
DE69637323D1 true DE69637323D1 (de) 2007-12-27
DE69637323T2 DE69637323T2 (de) 2008-02-21

Family

ID=16899346

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69637323T Expired - Lifetime DE69637323T2 (de) 1995-09-07 1996-09-06 Verfahren und Vorrichtung zur Analyse von Verbindungen in einer Lösung mittels Massenspektrometrie

Country Status (4)

Country Link
US (2) US5898175A (de)
EP (1) EP0762473B1 (de)
JP (1) JP3353561B2 (de)
DE (1) DE69637323T2 (de)

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US6462337B1 (en) * 2000-04-20 2002-10-08 Agilent Technologies, Inc. Mass spectrometer electrospray ionization
US6147347A (en) * 1994-03-15 2000-11-14 Hitachi, Ltd. Ion source and mass spectrometer instrument using the same
JP3372862B2 (ja) * 1998-03-25 2003-02-04 株式会社日立製作所 生体液の質量分析装置
US6074880A (en) 1998-08-28 2000-06-13 Transgenomic, Inc. Sample analyte containing solution fraction collection system, and method of use
US6245227B1 (en) * 1998-09-17 2001-06-12 Kionix, Inc. Integrated monolithic microfabricated electrospray and liquid chromatography system and method
EP1113850A4 (de) 1998-09-17 2006-02-01 Advion Biosciences Inc Integriertes monolytisches, auf mikrobasis hersgestelltes elektrospray und verfahren und vorrichtung zur flüssigkeitschromatographie
JP3982094B2 (ja) * 1999-02-10 2007-09-26 株式会社日立製作所 マルチキャピラリイオン化質量分析装置
US6633031B1 (en) 1999-03-02 2003-10-14 Advion Biosciences, Inc. Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method
CA2395694C (en) 1999-12-30 2006-11-21 Advion Biosciences, Inc. Multiple electrospray device, systems and methods
WO2001053819A1 (en) 2000-01-18 2001-07-26 Advion Biosciences, Inc. Separation media, multiple electrospray nozzle system and method
US6768119B2 (en) * 2000-04-06 2004-07-27 De La Mora Juan F. Method and apparatus to produce ions and nanodrops from Taylor cones at reduced pressure
AU5273401A (en) * 2000-04-18 2001-11-12 Kang-Ho Ahn Apparatus for manufacturing ultra-fine particles using electrospray device and method thereof
US7368708B2 (en) * 2000-05-25 2008-05-06 Agilent Technologies, Inc. Apparatus for producing ions from an electrospray assembly
US6879162B2 (en) * 2000-11-07 2005-04-12 Sri International System and method of micro-fluidic handling and dispensing using micro-nozzle structures
US6995024B2 (en) * 2001-08-27 2006-02-07 Sri International Method and apparatus for electrostatic dispensing of microdroplets
BR0200690A (pt) * 2002-03-04 2004-03-23 Embrapa Pesquisa Agropecuaria Método para detecção de proteinas de origem em misturas complexas
JP2003331776A (ja) * 2002-05-10 2003-11-21 Hitachi Ltd イオン源および質量分析装置および質量分析方法
DE10236344B4 (de) 2002-08-08 2007-03-29 Bruker Daltonik Gmbh Ionisieren an Atmosphärendruck für massenspektrometrische Analysen
AU2003286502A1 (en) * 2002-10-21 2004-05-13 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Contiguous capillary electrospray sources and analytical device
WO2005042127A2 (en) * 2003-05-29 2005-05-12 Upchurch Scientific, Inc. Improved apparatus and methods for electrospray applications
US7015466B2 (en) * 2003-07-24 2006-03-21 Purdue Research Foundation Electrosonic spray ionization method and device for the atmospheric ionization of molecules
US7053558B2 (en) * 2003-09-03 2006-05-30 Sri International System and method for controlling emission by a micro-fabricated charge-emission device
JP3991023B2 (ja) * 2003-10-31 2007-10-17 株式会社日立ハイテクノロジーズ 質量分析装置
EP1734560B1 (de) 2004-03-30 2013-04-10 University of Yamanashi Ionisierungsverfahren und -einrichtung für die massenanalyse
US8232521B2 (en) * 2007-02-02 2012-07-31 Waters Technologies Corporation Device and method for analyzing a sample
WO2009124298A2 (en) * 2008-04-04 2009-10-08 Agilent Technologies, Inc. Ion sources for improved ionization
JP5098079B2 (ja) * 2008-06-27 2012-12-12 国立大学法人山梨大学 イオン化分析方法および装置
EP2666182B1 (de) * 2011-01-20 2019-11-13 Purdue Research Foundation (Prf) Synchronisation einer ionenerzeugung mit zyklierung einer diskontinuierlichen atmosphärischen schnittstelle
CN106601582A (zh) * 2016-11-22 2017-04-26 上海裕达实业有限公司 一种基于电喷雾电离源的超声波振动装置
CN106840825A (zh) * 2017-03-01 2017-06-13 上海通微分析技术有限公司 一种电隔离装置及其制作方法
JP7313906B2 (ja) * 2019-05-28 2023-07-25 キヤノン株式会社 画像処理方法、画像処理装置、撮像システム、および、プログラム
CN111505103A (zh) * 2020-04-29 2020-08-07 哈尔滨工业大学（威海） 气溶胶气-液界面短存活中间体检测装置及方法与应用
US11635353B2 (en) * 2020-06-17 2023-04-25 The United States Of America, As Represented By The Secretary Of The Navy Sample collection device
GB202211210D0 (en) * 2022-08-01 2022-09-14 Micromass Ltd Electrospray device

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS583592B2 (ja) * 1978-09-08 1983-01-21 日本分光工業株式会社 質量分析計への試料導入方法及び装置
US4300044A (en) * 1980-05-07 1981-11-10 Iribarne Julio V Method and apparatus for the analysis of chemical compounds in aqueous solution by mass spectroscopy of evaporating ions
US4935624A (en) * 1987-09-30 1990-06-19 Cornell Research Foundation, Inc. Thermal-assisted electrospray interface (TAESI) for LC/MS
US4861988A (en) * 1987-09-30 1989-08-29 Cornell Research Foundation, Inc. Ion spray apparatus and method
US4977785A (en) * 1988-02-19 1990-12-18 Extrel Corporation Method and apparatus for introduction of fluid streams into mass spectrometers and other gas phase detectors
US5130538A (en) * 1989-05-19 1992-07-14 John B. Fenn Method of producing multiply charged ions and for determining molecular weights of molecules by use of the multiply charged ions of molecules
JP2633974B2 (ja) * 1990-04-18 1997-07-23 株式会社日立製作所 試料のイオン化および質量分析のための装置
US5170053A (en) * 1990-08-30 1992-12-08 Finnigan Corporation Electrospray ion source and interface apparatus and method
IT1247521B (it) * 1991-04-24 1994-12-17 Erba Strumentazione Metodo e dispositivo per interfacciare uno spettometro di massa
US5122670A (en) * 1991-05-17 1992-06-16 Finnigan Corporation Multilayer flow electrospray ion source using improved sheath liquid
DE69229914T2 (de) * 1991-05-21 2000-04-20 Analytica Of Brandford, Inc. Verfahren und Apparat zur Verbesserung der Sprühionisation von gelösten Stoffen
US5306910A (en) * 1992-04-10 1994-04-26 Millipore Corporation Time modulated electrified spray apparatus and process
US5223226A (en) * 1992-04-14 1993-06-29 Millipore Corporation Insulated needle for forming an electrospray
US5349186A (en) * 1993-06-25 1994-09-20 The Governors Of The University Of Alberta Electrospray interface for mass spectrometer and method of supplying analyte to a mass spectrometer
US5423964A (en) * 1993-08-02 1995-06-13 Battelle Memorial Institute Combined electrophoresis-electrospray interface and method
US5559326A (en) * 1995-07-28 1996-09-24 Hewlett-Packard Company Self generating ion device for mass spectrometry of liquids

Also Published As

Publication number Publication date
US5898175A (en) 1999-04-27
EP0762473A3 (de) 1997-05-07
JP3353561B2 (ja) 2002-12-03
US6114693A (en) 2000-09-05
EP0762473A2 (de) 1997-03-12
EP0762473B1 (de) 2007-11-14
JPH0982269A (ja) 1997-03-28
DE69637323T2 (de) 2008-02-21

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