DE69635516T2 - Verwendung von Emulsionen enthaltend in lipide eingeschlossene flussige Fluorocarbone für gezielte diagnostische Verfahren in vivo - Google Patents

Verwendung von Emulsionen enthaltend in lipide eingeschlossene flussige Fluorocarbone für gezielte diagnostische Verfahren in vivo Download PDF

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Publication number
DE69635516T2
DE69635516T2 DE69635516T DE69635516T DE69635516T2 DE 69635516 T2 DE69635516 T2 DE 69635516T2 DE 69635516 T DE69635516 T DE 69635516T DE 69635516 T DE69635516 T DE 69635516T DE 69635516 T2 DE69635516 T2 DE 69635516T2
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DE
Germany
Prior art keywords
emulsion
biotinylated
avidin
acoustic
pbs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69635516T
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German (de)
English (en)
Other versions
DE69635516D1 (de
Inventor
M. Gregory LANZA
A. Samuel WICKLINE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Barnes Hospital
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Barnes Hospital
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Filing date
Publication date
Priority claimed from US08/488,743 external-priority patent/US5690907A/en
Application filed by Barnes Hospital filed Critical Barnes Hospital
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Publication of DE69635516D1 publication Critical patent/DE69635516D1/de
Publication of DE69635516T2 publication Critical patent/DE69635516T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806Suspensions, emulsions, colloids, dispersions
    • A61K49/1812Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/586Liposomes, microcapsules or cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Hydrogenated Pyridines (AREA)
DE69635516T 1995-06-08 1996-06-06 Verwendung von Emulsionen enthaltend in lipide eingeschlossene flussige Fluorocarbone für gezielte diagnostische Verfahren in vivo Expired - Fee Related DE69635516T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/488,743 US5690907A (en) 1995-06-08 1995-06-08 Avidin-biotin conjugated emulsions as a site specific binding system
US488743 1995-06-08
US647277 1996-05-23
US08/647,277 US5780010A (en) 1995-06-08 1996-05-23 Method of MRI using avidin-biotin conjugated emulsions as a site specific binding system
PCT/US1996/010425 WO1996041647A1 (en) 1995-06-08 1996-06-06 Site specific binding system, imaging compositions and methods

Publications (2)

Publication Number Publication Date
DE69635516D1 DE69635516D1 (de) 2006-01-05
DE69635516T2 true DE69635516T2 (de) 2006-08-10

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE69635516T Expired - Fee Related DE69635516T2 (de) 1995-06-08 1996-06-06 Verwendung von Emulsionen enthaltend in lipide eingeschlossene flussige Fluorocarbone für gezielte diagnostische Verfahren in vivo

Country Status (8)

Country Link
US (2) US5780010A (enExample)
EP (1) EP0831933B1 (enExample)
JP (1) JP4082463B2 (enExample)
AU (1) AU710837B2 (enExample)
CA (1) CA2222544C (enExample)
DE (1) DE69635516T2 (enExample)
ES (1) ES2252755T3 (enExample)
WO (1) WO1996041647A1 (enExample)

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Also Published As

Publication number Publication date
CA2222544A1 (en) 1996-12-27
AU6179196A (en) 1997-01-09
US5780010A (en) 1998-07-14
US5989520A (en) 1999-11-23
EP0831933B1 (en) 2005-11-30
EP0831933A1 (en) 1998-04-01
ES2252755T3 (es) 2006-05-16
DE69635516D1 (de) 2006-01-05
EP0831933A4 (en) 2001-05-30
WO1996041647A1 (en) 1996-12-27
JP4082463B2 (ja) 2008-04-30
JP2001527509A (ja) 2001-12-25
AU710837B2 (en) 1999-09-30
CA2222544C (en) 2008-07-22

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