DE69635207T2 - Auf Chromosom 1 lokalisiertes Gen dessen Genprodukt mit der Alzheimerschen Krankheit assoziiert ist. - Google Patents

Auf Chromosom 1 lokalisiertes Gen dessen Genprodukt mit der Alzheimerschen Krankheit assoziiert ist. Download PDF

Info

Publication number
DE69635207T2
DE69635207T2 DE69635207T DE69635207T DE69635207T2 DE 69635207 T2 DE69635207 T2 DE 69635207T2 DE 69635207 T DE69635207 T DE 69635207T DE 69635207 T DE69635207 T DE 69635207T DE 69635207 T2 DE69635207 T2 DE 69635207T2
Authority
DE
Germany
Prior art keywords
sequence
nucleic acid
disease
gene
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69635207T
Other languages
German (de)
English (en)
Other versions
DE69635207D1 (de
Inventor
Ephrat Levy-Lahad
E. Rudolph TANZI
D. Gerard SCHELLENBERG
Wilma Wasco
D. Thomas BIRD
John Mulligan
J. David GALAS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
UCB Manufacturing Inc
Original Assignee
EPHRAT LEVY LAHAD
Ephrat Levy-Lahad Seattle
VA MEDICAL CT SEATTLE
General Hospital Corp
Darwin Molecular Corp
Seattle VA Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EPHRAT LEVY LAHAD, Ephrat Levy-Lahad Seattle, VA MEDICAL CT SEATTLE, General Hospital Corp, Darwin Molecular Corp, Seattle VA Medical Center filed Critical EPHRAT LEVY LAHAD
Publication of DE69635207D1 publication Critical patent/DE69635207D1/de
Application granted granted Critical
Publication of DE69635207T2 publication Critical patent/DE69635207T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hospice & Palliative Care (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69635207T 1995-07-07 1996-07-05 Auf Chromosom 1 lokalisiertes Gen dessen Genprodukt mit der Alzheimerschen Krankheit assoziiert ist. Expired - Lifetime DE69635207T2 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US95695P 1995-07-07 1995-07-07
US956P 1995-07-07
US167595P 1995-07-28 1995-07-28
US1675P 1995-07-28
US217495P 1995-08-11 1995-08-11
US2174P 1995-08-11
US232895P 1995-08-14 1995-08-14
US2328P 1995-08-14
PCT/US1996/011386 WO1997003192A2 (en) 1995-07-07 1996-07-05 Chromosome 1 gene and gene products related to alzheimer's disease

Publications (2)

Publication Number Publication Date
DE69635207D1 DE69635207D1 (de) 2006-02-02
DE69635207T2 true DE69635207T2 (de) 2006-06-22

Family

ID=27485043

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69635207T Expired - Lifetime DE69635207T2 (de) 1995-07-07 1996-07-05 Auf Chromosom 1 lokalisiertes Gen dessen Genprodukt mit der Alzheimerschen Krankheit assoziiert ist.

Country Status (7)

Country Link
US (2) US6468791B1 (enExample)
EP (2) EP1637600A1 (enExample)
JP (3) JP4073955B2 (enExample)
AT (1) ATE305039T1 (enExample)
CA (1) CA2226255A1 (enExample)
DE (1) DE69635207T2 (enExample)
WO (1) WO1997003192A2 (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5986054A (en) 1995-04-28 1999-11-16 The Hospital For Sick Children, Hsc Research And Development Limited Partnership Genetic sequences and proteins related to alzheimer's disease
US6210919B1 (en) 1995-04-28 2001-04-03 Hsc Research And Development Limited Partnership Genetic sequences and proteins related to alzheimer's disease
JP5379119B2 (ja) * 1995-04-28 2013-12-25 エイチエスシー リサーチ アンド ディベロップメント リミテッド アルツハイマー病に関連する遺伝子配列およびタンパク質、ならびにその使用
US6531586B1 (en) 1995-04-28 2003-03-11 The Hospital For Sick Children Genetic sequences related to Alzheimer's Disease
WO1997007213A2 (en) * 1995-08-16 1997-02-27 President And Fellows Of Harvard College Assay for identifying genes causing chromosome non-disjunction
AU732508B2 (en) * 1996-01-26 2001-04-26 Governing Council Of The University Of Toronto, The Nucleic acids and proteins related to Alzheimer's disease, and uses therefor
ES2128265B1 (es) * 1997-06-04 2000-03-01 Euroespes S A Kit genetico para la caracterizacion molecular de la enfermedad de alzheimer.
US7588766B1 (en) 2000-05-26 2009-09-15 Elan Pharma International Limited Treatment of amyloidogenic disease
US6761888B1 (en) 2000-05-26 2004-07-13 Neuralab Limited Passive immunization treatment of Alzheimer's disease
US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
US7790856B2 (en) 1998-04-07 2010-09-07 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
TWI239847B (en) * 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
WO1999035501A1 (en) 1998-01-09 1999-07-15 The Governing Council Of The University Of Toronto Presenilin protein interactions
PE20020574A1 (es) 2000-12-06 2002-07-02 Wyeth Corp Anticuerpos humanizados que reconocen el peptido amiloideo beta
US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
JP2003018991A (ja) * 2001-06-27 2003-01-21 Japan Science & Technology Corp プレセニリン−２遺伝子エキソン５欠損型スプライシング異常の生成に関与する核酸
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
TWI374893B (en) 2003-05-30 2012-10-21 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
WO2006066089A1 (en) 2004-12-15 2006-06-22 Neuralab Limited Humanized amyloid beta antibodies for use in improving cognition
TW200636066A (en) 2004-12-15 2006-10-16 Elan Pharm Inc Humanized antibodies that recognize beta amyloid peptide
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
AU2007260532B2 (en) * 2006-06-12 2013-06-06 Car-Ber Investments Inc Nozzle testing apparatus and method
US8003097B2 (en) 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
ES2498040T3 (es) 2007-07-27 2014-09-24 Janssen Alzheimer Immunotherapy Tratamiento de enfermedades amiloidogénicas con anticuerpos anti-beta humanizados
JO3076B1 (ar) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
AU2012358647B2 (en) * 2011-12-20 2015-01-15 Unilever Plc Isotropic liquid detergents comprising soil release polymer
US12227567B2 (en) 2017-07-25 2025-02-18 Truebinding, Inc. Treating cancer by blocking the interaction of TIM-3 and its ligand
CN116063520A (zh) 2019-01-30 2023-05-05 真和制药有限公司 抗gal3抗体及其用途
CN116157151A (zh) 2020-05-26 2023-05-23 真和制药有限公司 通过阻断半乳凝素-3治疗炎性疾病的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5986054A (en) * 1995-04-28 1999-11-16 The Hospital For Sick Children, Hsc Research And Development Limited Partnership Genetic sequences and proteins related to alzheimer's disease
US6210919B1 (en) * 1995-04-28 2001-04-03 Hsc Research And Development Limited Partnership Genetic sequences and proteins related to alzheimer's disease

Also Published As

Publication number Publication date
WO1997003192A3 (en) 1997-04-03
EP0846171B1 (en) 2005-09-21
JP2008035862A (ja) 2008-02-21
EP0846171A2 (en) 1998-06-10
ATE305039T1 (de) 2005-10-15
JP2008035863A (ja) 2008-02-21
US6468791B1 (en) 2002-10-22
WO1997003192A2 (en) 1997-01-30
DE69635207D1 (de) 2006-02-02
US20030180880A1 (en) 2003-09-25
CA2226255A1 (en) 1997-01-30
JP2001517922A (ja) 2001-10-09
JP4073955B2 (ja) 2008-04-09
EP1637600A1 (en) 2006-03-22

Similar Documents

Publication Publication Date Title
DE69635207T2 (de) Auf Chromosom 1 lokalisiertes Gen dessen Genprodukt mit der Alzheimerschen Krankheit assoziiert ist.
WO1997003192A9 (en) Chromosome 1 gene and gene products related to alzheimer's disease
DE69933044T2 (de) Zusammensetzungen und verfahren zur erhöhung der knochenmineralisierung
US6395960B1 (en) Transgenic mice expressing human presenilin proteins
DE69634421T2 (de) Gene und genprodukte bezogen auf das werner-syndrom
DE69430130T2 (de) Polypeptide von der semaphorin-genfamilie
CA2526900C (en) Truncated fragments of alpha-synuclein in lewy body disease
US20080131411A1 (en) Identification of the gene causing the mouse scurfy phenotype and its human ortholog
WO1997024435A9 (en) Genes and gene products related to werner's syndrome
US6248555B1 (en) Genetic alterations related to familial alzheimer's disease
US6998467B1 (en) Antibody specific for presenilin 1 and method of use thereof
DE10305082A1 (de) MIA-2 Protein
MXPA98001603A (en) Genetic alterations related to the disease of alzheimer heredita
Refolo Differential brain expression of the Alzheimer's amyloid precursor protein

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DARWIN MOLECULAR CORP., BOTHELL, WA., US

Owner name: THE GENERAL HOSPITAL CORP., BOSTON, MASS., US