DE69632252D1 - Verfahren zur erkennung von klonalen populationen von transformierten zellen in einer genomisch heterogenen zellulären probe - Google Patents

Verfahren zur erkennung von klonalen populationen von transformierten zellen in einer genomisch heterogenen zellulären probe

Info

Publication number
DE69632252D1
DE69632252D1 DE69632252T DE69632252T DE69632252D1 DE 69632252 D1 DE69632252 D1 DE 69632252D1 DE 69632252 T DE69632252 T DE 69632252T DE 69632252 T DE69632252 T DE 69632252T DE 69632252 D1 DE69632252 D1 DE 69632252D1
Authority
DE
Germany
Prior art keywords
heterogenic
genomically
transformed cells
cellular sample
clonal populations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69632252T
Other languages
English (en)
Other versions
DE69632252T2 (de
Inventor
N Lapidus
P Shuber
M Ulmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Exact Sciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26679107&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69632252(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/700,583 external-priority patent/US5670325A/en
Application filed by Exact Sciences Corp filed Critical Exact Sciences Corp
Application granted granted Critical
Publication of DE69632252D1 publication Critical patent/DE69632252D1/de
Publication of DE69632252T2 publication Critical patent/DE69632252T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69632252T 1995-12-22 1996-12-20 Verfahren zur erkennung von klonalen populationen von transformierten zellen in einer genomisch heterogenen zellulären probe Expired - Lifetime DE69632252T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US700583 1985-02-11
US913795P 1995-12-22 1995-12-22
US9137P 1995-12-22
US08/700,583 US5670325A (en) 1996-08-14 1996-08-14 Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
PCT/US1996/020627 WO1997023651A1 (en) 1995-12-22 1996-12-20 Methods for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample

Publications (2)

Publication Number Publication Date
DE69632252D1 true DE69632252D1 (de) 2004-05-27
DE69632252T2 DE69632252T2 (de) 2005-04-14

Family

ID=26679107

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69632252T Expired - Lifetime DE69632252T2 (de) 1995-12-22 1996-12-20 Verfahren zur erkennung von klonalen populationen von transformierten zellen in einer genomisch heterogenen zellulären probe

Country Status (7)

Country Link
EP (1) EP0815263B1 (de)
AT (1) ATE264922T1 (de)
AU (1) AU711754B2 (de)
CA (1) CA2211702C (de)
DE (1) DE69632252T2 (de)
ES (1) ES2220997T3 (de)
WO (1) WO1997023651A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6100029A (en) * 1996-08-14 2000-08-08 Exact Laboratories, Inc. Methods for the detection of chromosomal aberrations
US6203993B1 (en) 1996-08-14 2001-03-20 Exact Science Corp. Methods for the detection of nucleic acids
US6300077B1 (en) 1996-08-14 2001-10-09 Exact Sciences Corporation Methods for the detection of nucleic acids
US6566101B1 (en) * 1997-06-16 2003-05-20 Anthony P. Shuber Primer extension methods for detecting nucleic acids
IL135852A0 (en) * 1997-10-28 2001-05-20 Univ California A method for detecting dna base mismatch
CA2331254A1 (en) * 1998-06-16 1999-12-23 Exact Laboratories, Inc. Methods for the detection of nucleic acids
US20020001800A1 (en) * 1998-08-14 2002-01-03 Stanley N. Lapidus Diagnostic methods using serial testing of polymorphic loci
AU1704000A (en) * 1998-08-14 2000-03-14 Exact Laboratories, Inc. Method for diagnostic screening
AU1526400A (en) * 1998-11-23 2000-06-19 Exact Laboratories, Inc. Method for detecting target sequences in small proportions in heterogeneous samples
WO2000031298A1 (en) * 1998-11-23 2000-06-02 Exact Laboratories, Inc. Methods for detecting lower-frequency molecules
US6280947B1 (en) 1999-08-11 2001-08-28 Exact Sciences Corporation Methods for detecting nucleotide insertion or deletion using primer extension
AU6733800A (en) * 1999-08-30 2001-03-26 Japan Science And Technology Corporation Highly sensitive method of detecting gene mutation
US6586177B1 (en) 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
ATE458831T1 (de) 1999-12-07 2010-03-15 Exact Sciences Corp Verfahren zum nachweis von lungenneoplasmen in fäkalen proben
US6911308B2 (en) 2001-01-05 2005-06-28 Exact Sciences Corporation Methods for detecting, grading or monitoring an H. pylori infection
US6428964B1 (en) 2001-03-15 2002-08-06 Exact Sciences Corporation Method for alteration detection
US7776524B2 (en) 2002-02-15 2010-08-17 Genzyme Corporation Methods for analysis of molecular events
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence
US9777314B2 (en) 2005-04-21 2017-10-03 Esoterix Genetic Laboratories, Llc Analysis of heterogeneous nucleic acid samples

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302509A (en) * 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
ATE205542T1 (de) * 1992-03-04 2001-09-15 Univ California Vergleichende genomhybridisierung
US6214542B1 (en) * 1992-10-20 2001-04-10 The United States Of America As Represented By The Department Of Health And Human Services Quantification of indicators of fibrosis
US5436142A (en) * 1992-11-12 1995-07-25 Cold Spring Harbor Laboratory Methods for producing probes capable of distingushing variant genomic sequences
EP0664339A4 (de) * 1993-07-09 1999-04-28 Wakunaga Seiyaku Kk Methode und testsatz zur unterscheidung von dna.
US5472842A (en) * 1993-10-06 1995-12-05 The Regents Of The University Of California Detection of amplified or deleted chromosomal regions

Also Published As

Publication number Publication date
DE69632252T2 (de) 2005-04-14
CA2211702C (en) 1999-05-25
AU1430797A (en) 1997-07-17
JPH10503384A (ja) 1998-03-31
WO1997023651A1 (en) 1997-07-03
AU711754B2 (en) 1999-10-21
JP3325270B2 (ja) 2002-09-17
EP0815263A1 (de) 1998-01-07
CA2211702A1 (en) 1997-07-03
EP0815263B1 (de) 2004-04-21
ATE264922T1 (de) 2004-05-15
ES2220997T3 (es) 2004-12-16

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8327 Change in the person/name/address of the patent owner

Owner name: GENZYME CORP., CAMBRIDGE, MASS., US

8328 Change in the person/name/address of the agent

Representative=s name: KLUNKER, SCHMITT-NILSON, HIRSCH, 80796 MUENCHEN

R082 Change of representative

Ref document number: 815263

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