DE69629460D1 - Biologisches verfahren zur herstellung von verbindungen auf der basis der dipeptiden - Google Patents

Biologisches verfahren zur herstellung von verbindungen auf der basis der dipeptiden

Info

Publication number
DE69629460D1
DE69629460D1 DE69629460T DE69629460T DE69629460D1 DE 69629460 D1 DE69629460 D1 DE 69629460D1 DE 69629460 T DE69629460 T DE 69629460T DE 69629460 T DE69629460 T DE 69629460T DE 69629460 D1 DE69629460 D1 DE 69629460D1
Authority
DE
Germany
Prior art keywords
dipeptides
biological method
connections based
producing connections
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69629460T
Other languages
English (en)
Other versions
DE69629460T2 (de
Inventor
Scott Borneman
Anil Goyal
J Conder
A Vinci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE69629460D1 publication Critical patent/DE69629460D1/de
Application granted granted Critical
Publication of DE69629460T2 publication Critical patent/DE69629460T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/463—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Botany (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69629460T 1995-04-11 1996-04-08 Biologisches verfahren zur herstellung von verbindungen auf der basis der dipeptiden Expired - Fee Related DE69629460T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41978795A 1995-04-11 1995-04-11
US419787 1995-04-11
PCT/US1996/004794 WO1996032468A2 (en) 1995-04-11 1996-04-08 Bioprocess for production of dipeptide based compounds

Publications (2)

Publication Number Publication Date
DE69629460D1 true DE69629460D1 (de) 2003-09-18
DE69629460T2 DE69629460T2 (de) 2004-06-24

Family

ID=23663762

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69629460T Expired - Fee Related DE69629460T2 (de) 1995-04-11 1996-04-08 Biologisches verfahren zur herstellung von verbindungen auf der basis der dipeptiden

Country Status (13)

Country Link
US (1) US6204008B1 (de)
EP (1) EP0820465B1 (de)
CN (1) CN1193998A (de)
AR (1) AR001594A1 (de)
AT (1) ATE247129T1 (de)
AU (1) AU5445596A (de)
BR (1) BR9608278A (de)
CZ (1) CZ321497A3 (de)
DE (1) DE69629460T2 (de)
EA (1) EA000736B1 (de)
ES (1) ES2203690T3 (de)
SK (1) SK138197A3 (de)
WO (1) WO1996032468A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1590917B1 (de) * 2003-01-28 2010-12-15 Cellport Systems, Inc. Ein System und ein Verfahren zum Steuern des Zugriffs von Anwendungen auf geschützte Mittel innerhalb eines sicheren Fahrzeugtelematiksystems
CN100420746C (zh) * 2005-06-24 2008-09-24 北京化工大学 重组降压肽的设计与发酵生产
GB0608368D0 (en) 2006-04-28 2006-06-07 Isis Innovation Process for making Oligopeptides
WO2014159247A1 (en) * 2013-03-14 2014-10-02 University Of Florida Research Foundation, Inc. Di-amino acid repeat-containing proteins associated with als
WO2016196324A1 (en) 2015-05-29 2016-12-08 University Of Floridia Research Foundation, Inc. Methods for diagnosing huntington's disease
WO2017176813A1 (en) 2016-04-04 2017-10-12 University Of Florida Research Foundation, Incorporated Manipulation of eif3 to modulate repeat associated non-atg (ran) translation
JP2020516674A (ja) 2017-04-17 2020-06-11 ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． ＰＫＲおよびｅＩＦ２Ａ−Ｐ経路によるＲＡＮタンパク質翻訳の調節
EP3688021A4 (de) 2017-09-26 2021-12-29 University of Florida Research Foundation, Incorporated Verwendung von metformin und analoga davon zur verminderung von ran-preotein-spiegeln in der behandlung von neurologischen störungen

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
GB2068971B (en) * 1980-01-30 1983-06-08 Searle & Co Recombinant dna techniques
EP0036258A3 (de) * 1980-03-14 1982-02-10 Cetus Corporation Verfahren zur Herstellung von Aspartam
US4555502A (en) 1982-09-30 1985-11-26 Merck & Co., Inc. Aminoacyl-containing dipeptide derivatives useful as antihypertensives
DD248961A1 (de) * 1984-05-22 1987-08-26 Akad Wissenschaften Ddr Verfahren zur herstellung wundheilungsfoerdernder praeparationen
US5089406A (en) 1987-01-07 1992-02-18 Allied-Signal Inc. Method of producing a gene cassette coding for polypeptides with repeating amino acid sequences
NL8700767A (nl) 1987-04-01 1988-11-01 Groningen Science Park Dipeptidase, isolering daarvan uit melkzuurbacterien, antilichamen tegen het dipeptidase, gebruik van het dipeptidase en van de antilichamen daartegen.
JPH07108232B2 (ja) * 1990-10-09 1995-11-22 エム・ディ・リサーチ株式会社 ペプチド又は蛋白質の製造方法
ATE373096T1 (de) * 1991-07-24 2007-09-15 Novartis Pharma Gmbh Expressionsvektor für prolylendopeptidase von flavobacterium meningosepticum
ATE253639T1 (de) 1991-08-19 2003-11-15 Daiichi Suntory Pharma Co Ltd Verfahren zur herstellung von peptiden
WO1994016082A1 (en) * 1992-12-30 1994-07-21 Communaute Economique Europeenne (Cee) X-prolyl-dipeptidyl-aminopeptidase from lactobacillus delbrückii ssp. lactis, nucleic acids coding for the same and its use in fermented foodstuff preparation processes

Also Published As

Publication number Publication date
CN1193998A (zh) 1998-09-23
AR001594A1 (es) 1997-11-26
ATE247129T1 (de) 2003-08-15
CZ321497A3 (cs) 1998-06-17
WO1996032468A3 (en) 1996-11-28
EA000736B1 (ru) 2000-02-28
DE69629460T2 (de) 2004-06-24
BR9608278A (pt) 1999-10-13
US6204008B1 (en) 2001-03-20
ES2203690T3 (es) 2004-04-16
SK138197A3 (en) 1998-07-08
EA199700310A1 (ru) 1998-04-30
EP0820465A2 (de) 1998-01-28
WO1996032468A2 (en) 1996-10-17
EP0820465B1 (de) 2003-08-13
AU5445596A (en) 1996-10-30

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee