DE69626041D1 - Fluoreszenzfarbstoffe des typs sulfobenz(e)indocyanine - Google Patents

Fluoreszenzfarbstoffe des typs sulfobenz(e)indocyanine

Info

Publication number
DE69626041D1
DE69626041D1 DE69626041T DE69626041T DE69626041D1 DE 69626041 D1 DE69626041 D1 DE 69626041D1 DE 69626041 T DE69626041 T DE 69626041T DE 69626041 T DE69626041 T DE 69626041T DE 69626041 D1 DE69626041 D1 DE 69626041D1
Authority
DE
Germany
Prior art keywords
sulfobenz
indocyanine
type
fluorescence dyes
dyes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69626041T
Other languages
English (en)
Inventor
Ciana Leopoldo Della
Andrea Grignani
Mariacristina Cassullo
Giuseppe Caputo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innosense Srl
Original Assignee
Innosense Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innosense Srl filed Critical Innosense Srl
Application granted granted Critical
Publication of DE69626041D1 publication Critical patent/DE69626041D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/533Production of labelled immunochemicals with fluorescent label
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/80Fluorescent dyes, e.g. rhodamine
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/815Test for named compound or class of compounds
    • Y10S436/817Steroids or hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Luminescent Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Detergent Compositions (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
DE69626041T 1995-10-09 1996-10-08 Fluoreszenzfarbstoffe des typs sulfobenz(e)indocyanine Expired - Lifetime DE69626041D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95MI002049A IT1276833B1 (it) 1995-10-09 1995-10-09 Coloranti fluorescenti della famiglia della solfo benz e indocianina
PCT/EP1996/004377 WO1997013810A1 (en) 1995-10-09 1996-10-08 SULFO BENZ[e]INDOCYANINE FLUORESCENT DYES

Publications (1)

Publication Number Publication Date
DE69626041D1 true DE69626041D1 (de) 2003-03-06

Family

ID=11372321

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69626041T Expired - Lifetime DE69626041D1 (de) 1995-10-09 1996-10-08 Fluoreszenzfarbstoffe des typs sulfobenz(e)indocyanine

Country Status (6)

Country Link
US (1) US6136612A (de)
EP (1) EP0876428B1 (de)
AU (1) AU706668B2 (de)
DE (1) DE69626041D1 (de)
IT (1) IT1276833B1 (de)
WO (1) WO1997013810A1 (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6593148B1 (en) 1994-03-01 2003-07-15 Li-Cor, Inc. Cyanine dye compounds and labeling methods
DE19717904A1 (de) 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
KR100337169B1 (ko) 1998-07-20 2002-05-18 최중갑 복합염료 조성물을 이용한 폴리머 겔상의 dna의 검출방법 및
US7547721B1 (en) 1998-09-18 2009-06-16 Bayer Schering Pharma Ag Near infrared fluorescent contrast agent and fluorescence imaging
JP2000095758A (ja) 1998-09-18 2000-04-04 Schering Ag 近赤外蛍光造影剤および蛍光造影方法
US6605434B1 (en) 1999-03-16 2003-08-12 Human Genome Sciences, Inc. Direct bacterial lysate sequencing
DE19937024A1 (de) * 1999-08-05 2001-02-08 Bayer Ag Verwendung von Acylsulfonamido substituierten Polymethin-Farbstoffen als Fluoreszenz-Farbstoffe und/oder Marker
WO2001050646A1 (en) * 1999-12-30 2001-07-12 Morphics Technology, Inc. A configurable multimode despreader for spread spectrum applications
US6716994B1 (en) 2000-01-04 2004-04-06 Applera Corporation Mobility-Modifying Cyanine Dyes
AU2001232818A1 (en) * 2000-01-18 2001-07-31 Mallinckrodt, Inc. Hydrophilic cyanine dyes
US7790144B2 (en) 2000-01-18 2010-09-07 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
CA2424454C (en) * 2000-09-19 2010-07-20 Li-Cor, Inc. Cyanine dyes
US7597878B2 (en) * 2000-09-19 2009-10-06 Li-Cor, Inc. Optical fluorescent imaging
US6656451B1 (en) 2000-10-16 2003-12-02 Mallinckrodt, Inc. Indole compounds as novel dyes for organ function monitoring
US6335450B1 (en) * 2000-11-09 2002-01-01 Beckman Coulter, Inc. Efficient cyclic-bridged cyanine dyes
US6331632B1 (en) * 2000-11-09 2001-12-18 Beckman Coulter, Inc. Cyanine dye phosphoramidites
US6710363B1 (en) * 2000-11-27 2004-03-23 Uview Ultraviolet Systems, Inc. Detection lamp equipped with light-emitting diode
EP1209205A1 (de) 2000-11-28 2002-05-29 Innosense S.r.l. Verbesserte Verfahren und Methode zur Herstellung von asymmetrischen monofunktionalisierten Indocyaninmarkern sowie erhaltene Verbindungen
EP1211294B1 (de) * 2000-11-28 2008-08-13 Visen Medical, Inc. Verbessertes Verfahren und Methode zur Herstellung von asymmetrischen monofunktionalisierten Indocyaninmarkern sowie erhaltene Verbindungen
US6800438B2 (en) * 2000-12-28 2004-10-05 Xerox Corporation Imager for DNA sequencer
JP4319363B2 (ja) * 2001-01-15 2009-08-26 富士フイルム株式会社 ネガ型画像記録材料
WO2002068537A2 (en) 2001-02-28 2002-09-06 Stratagene Fluorescent dye
US20030124194A1 (en) * 2002-01-02 2003-07-03 Gaw Debra A. Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor
AU2003225763A1 (en) * 2002-03-11 2003-09-29 Visen Medical, Inc. Optical imaging probes
EP1539728A2 (de) * 2002-07-01 2005-06-15 Guava Technologies, Inc. Fluoreszierende farbstoffe, energietransferpaare und verfahren
US20040132092A1 (en) * 2003-01-03 2004-07-08 Stetson Christopher M. Determining the density of functional moieties on polymer reagents
WO2004108902A2 (en) * 2003-06-04 2004-12-16 Visen Medical, Inc. Biocompatible fluorescent silicon nanoparticles
ITPZ20030002A1 (it) * 2003-08-12 2005-02-13 Giuseppe Caputo Composti del tipo cianina aventi un braccio di legame alchinilico
US8227621B2 (en) 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
AU2006284565B2 (en) 2005-09-02 2013-05-30 Visen Medical, Inc. Biocompatible N, N-disubstituted sulfonamide-containing fluorescent dye labels
US7947256B2 (en) * 2005-09-02 2011-05-24 Visen Medical, Inc. Biocompatible fluorescent imaging agents
WO2007028118A2 (en) 2005-09-02 2007-03-08 Visen Medical, Inc. Nicotinic acid and picolinic acid derived near-infrared fluorophores
WO2007111669A2 (en) 2005-12-22 2007-10-04 Visen Medical, Inc. Combined x-ray and optical tomographic imaging system
WO2007136413A2 (en) 2005-12-22 2007-11-29 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
ITSV20060002A1 (it) * 2006-01-19 2007-07-20 Ferrania Technologies Spa Colorante fluorescente di tipo cianinico
JP4958461B2 (ja) * 2006-03-30 2012-06-20 富士フイルム株式会社 近赤外吸収色素含有硬化性組成物
WO2008002236A1 (en) * 2006-06-28 2008-01-03 Ge Healthcare Bio-Sciences Ab Method of detecting interactions between protein components
DK2118206T3 (en) 2007-02-09 2018-06-18 Visen Medical Inc POLYCYCLOF COLORS AND APPLICATION THEREOF
WO2008109832A2 (en) * 2007-03-08 2008-09-12 Visen Medical, Inc. Viable near-infrared fluorochrome labeled cells and methods of making and using same
CN101743022A (zh) * 2007-05-16 2010-06-16 通用电气医疗集团股份有限公司 光学成像剂
WO2009055095A1 (en) 2007-10-19 2009-04-30 Visen Medical, Inc. Imaging systems featuring waveguiding compensation
EP3320923B1 (de) 2008-01-18 2022-04-06 Visen Medical, Inc. Fluoreszierende bildgebungsmittel
CN102026671B (zh) 2008-03-14 2014-09-03 Visen医药公司 整联蛋白靶向试剂及使用其的体内和体外成像方法
US8864821B2 (en) * 2008-11-26 2014-10-21 Visen Medical, Inc. Methods and compositions for identifying subjects at risk of developing stent thrombosis
WO2010121163A2 (en) * 2009-04-17 2010-10-21 Li-Cor, Inc. Fluorescent imaging with substituted cyanine dyes
US20110021908A1 (en) * 2009-05-27 2011-01-27 Lumicell Diagnostics, Inc. Methods and systems for spatially identifying abnormal cells
US9155471B2 (en) 2009-05-27 2015-10-13 Lumicell, Inc'. Methods and systems for spatially identifying abnormal cells
US8401618B2 (en) * 2009-08-28 2013-03-19 Visen Medical, Inc. Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique
WO2011038006A1 (en) 2009-09-22 2011-03-31 Visen Medical, Inc. Systems and methods for virtual index-matching of diffusive media
EP2530093B1 (de) 2010-01-28 2018-11-21 National UniversityCorporation Mie University Indocyaninverbindung, syntheseverfahren dafür, reinigungsverfahren dafür, diagnosezusammensetzung mit der indocyaninverbindung, vorrichtung zur messung von in-vivo-bewegungen sowie vorrichtung zur visualisierung von zirkulationen mithilfe der diagnosezusammensetzung
JP5817073B2 (ja) * 2010-01-28 2015-11-18 国立大学法人三重大学 新規インドシアニン化合物を用いた診断用組成物及び分析方法
DE102010022110A1 (de) * 2010-05-31 2011-12-01 LMU Universität München Department Chemie Cyaninfarbstoffe als Kontrastmittel zur Unterstützung der Augenchirurgie
WO2012054784A1 (en) 2010-10-20 2012-04-26 Li-Cor, Inc. Fluorescent imaging with substituted cyanine dyes
US9314304B2 (en) 2010-12-08 2016-04-19 Lumicell, Inc. Methods and system for image guided cell ablation with microscopic resolution
US10053447B2 (en) 2010-12-21 2018-08-21 Pierce Biotechnology, Inc Fluorescent compounds
WO2012154885A2 (en) 2011-05-09 2012-11-15 Visen Medical, Inc. Carbonic anhydrase targeting agents and methods of using same
US8889884B1 (en) 2011-07-14 2014-11-18 Pierce Biotechnology, Inc. Phosphine derivatives of fluorescent compounds
US9249307B2 (en) 2011-08-16 2016-02-02 Pierce Biotechnology, Inc. Benzocyanine compounds
US9751868B2 (en) 2012-02-28 2017-09-05 Pierce Biotechnology, Inc. Benzocyanine compounds
EP2804860B1 (de) 2012-03-02 2016-06-15 Pierce Biotechnology, Inc. Indol-derivate als markierungsfarbstoff für biomoleküle
CN114042171A (zh) 2012-03-30 2022-02-15 文森医学公司 细菌成像剂及其使用方法
US9371362B2 (en) 2012-08-15 2016-06-21 Visen Medical, Inc. Prostate specific antigen agents and methods of using same for prostate cancer imaging
WO2014035712A1 (en) 2012-08-28 2014-03-06 Pierce Biotechnology, Inc. Benzopyrylium compounds
WO2014062716A1 (en) 2012-10-15 2014-04-24 Visen Medical, Inc. Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources
WO2014152389A1 (en) 2013-03-14 2014-09-25 Lumicell, Inc. Imaging agent for detection of diseased cells
CN105073761B (zh) 2013-03-15 2020-10-20 文森医学公司 用于体外和体内成像和检测的取代的硅杂蒽阳离子红至近红外荧光染料
EP2970674B1 (de) 2013-03-15 2018-12-12 VisEn Medical, Inc. 4,4-disubstituierte cyclohexyl-verbrückte heptamethin-cyanin-farbstoffe und verwendungen davon
WO2015103420A1 (en) 2013-12-31 2015-07-09 Memorial Sloan Kettering Cancer Center Systems, methods, and apparatus for multichannel imaging of fluorescent sources in real time
KR20170094268A (ko) 2014-12-15 2017-08-17 메모리얼 슬로안-케터링 캔서 센터 향상된 신경-결합 선택성을 갖는 고리형 펩티드, 상기 고리형 펩티드와 결합된 나노입자, 및 실시간 생체내 신경 조직 영상화를 위한 이들의 용도
KR20180093961A (ko) 2015-12-15 2018-08-22 메모리얼 슬로안-케터링 캔서 센터 조직 구별, 예를 들어, 수술 중 시각화를 위한 영상화 시스템 및 방법
BR112019010947A2 (pt) 2016-11-30 2019-10-01 Univ Cornell nanopartículas ultrapequenas funcionalizadas por inibidores e métodos das mesmas
KR101973456B1 (ko) * 2017-10-17 2019-04-29 울산과학기술원 미토콘드리아에 표적화되는 수용성 화합물, 이를 포함하는 조성물 및 이의 제조방법
EP4015004A1 (de) 2020-12-18 2022-06-22 Phi Pharma SA Proteoglykanspezifische verzweigte peptide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5230781A (en) * 1984-03-29 1993-07-27 Li-Cor, Inc. Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes
US5268486A (en) * 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
JP2713976B2 (ja) * 1987-04-24 1998-02-16 イーストマン コダック カンパニー 写真フィルター組成物
CA1337923C (en) * 1988-07-07 1996-01-16 Richard Lee Parton Infrared filter dye for photographic element
DE3912046B4 (de) * 1988-09-02 2004-03-25 Carnegie Mellon University Verfahren zum Markieren einer Komponente einer wäßrigen Flüssigkeit und lumineszenzphotostabiles Reaktionsprodukt
WO1991000440A1 (en) * 1989-07-04 1991-01-10 Kabushiki Kaisha Kubota Clutch operating device of vehicle
JP2663033B2 (ja) * 1990-02-22 1997-10-15 富士写真フイルム株式会社 ハロゲン化銀乳剤
EP0626427B1 (de) * 1993-05-26 2001-08-16 Agfa-Gevaert N.V. Im nahen Infrarot absorbierende Farbstoffe und diese enthaltende photographische Aufzeichnungselemente
US5453505A (en) * 1994-06-30 1995-09-26 Biometric Imaging, Inc. N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels

Also Published As

Publication number Publication date
ITMI952049A1 (it) 1997-04-09
EP0876428B1 (de) 2004-11-17
AU7288296A (en) 1997-04-30
WO1997013810A1 (en) 1997-04-17
AU706668B2 (en) 1999-06-17
ITMI952049A0 (de) 1995-10-09
US6136612A (en) 2000-10-24
IT1276833B1 (it) 1997-11-03
EP0876428A1 (de) 1998-11-11

Similar Documents

Publication Publication Date Title
DE69626041D1 (de) Fluoreszenzfarbstoffe des typs sulfobenz(e)indocyanine
DE69616584T2 (de) Fluoreszierende farbstoffmischungen
DE69618971D1 (de) Fluoreszierende farbstoffmischungen
DE59711530D1 (de) Färbemittel
DE69622588T2 (de) Fluorometer
DE59608872D1 (de) Naphthalinlactamimid-Fluoreszenzfarbstoffe
DE59509353D1 (de) Haarfärbemittel
DE69601845T2 (de) Farbstoffbehälter
DE69816192D1 (de) Haarfärbemittel
DE59503964D1 (de) Disazofarbstoffe
DE59508925D1 (de) Oxidationshaarfärbemittel
KR960007696A (ko) 2,4,6-트리아미노-3-시아노피리딘 커플링 성분을 함유하는 아조티오펜 염료
DE69407288T2 (de) Farbstoffbildempfangselement
DE59807840D1 (de) Disazofarbstoffe
DE59508671D1 (de) Cyaniminogruppen enthaltende Fluoreszenzfarbstoffe
DE69821203D1 (de) Haarfarbemittel
ATE276726T1 (de) Färbemittel
DE59808302D1 (de) Farbstoffzubereitungen
BR9803285A (pt) Misturas de corantes azo
DE19618586B8 (de) Monoazo-Dispersionsfarbstoffe
DE69707698D1 (de) Anthrachinonpolysulfonamidfarbstoffe
DE59508968D1 (de) Haarfärbemittel
DE59601762D1 (de) Pyridonmethidazofarbstoffe
DE59702493D1 (de) Dispersionsfarbstoffe
DE59607408D1 (de) Mischungen von Monoazopyridonfarbstoffen

Legal Events

Date Code Title Description
8332 No legal effect for de