DE69623267T2 - Stabiles polymerisiertes hämoglobin-blutersatzmittel - Google Patents
Stabiles polymerisiertes hämoglobin-blutersatzmittelInfo
- Publication number
- DE69623267T2 DE69623267T2 DE69623267T DE69623267T DE69623267T2 DE 69623267 T2 DE69623267 T2 DE 69623267T2 DE 69623267 T DE69623267 T DE 69623267T DE 69623267 T DE69623267 T DE 69623267T DE 69623267 T2 DE69623267 T2 DE 69623267T2
- Authority
- DE
- Germany
- Prior art keywords
- hemoglobin
- solution
- blood
- polymerized
- blood cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
- B32B15/09—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin comprising polyesters
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
- B32B15/085—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin comprising polyolefins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
- B32B15/088—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin comprising polyamides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/20—Layered products comprising a layer of metal comprising aluminium or copper
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/34—Layered products comprising a layer of synthetic resin comprising polyamides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/36—Layered products comprising a layer of synthetic resin comprising polyesters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2311/00—Metals, their alloys or their compounds
- B32B2311/02—Noble metals
- B32B2311/04—Gold
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2311/00—Metals, their alloys or their compounds
- B32B2311/02—Noble metals
- B32B2311/08—Silver
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2311/00—Metals, their alloys or their compounds
- B32B2311/24—Aluminium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2323/00—Polyalkenes
- B32B2323/10—Polypropylene
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2367/00—Polyesters, e.g. PET, i.e. polyethylene terephthalate
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2377/00—Polyamides
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/409,337 US5854209A (en) | 1995-03-23 | 1995-03-23 | Method for oxygenating tissue having reduced red blood cell flow |
US08/458,916 US5840852A (en) | 1995-03-23 | 1995-06-02 | Method for producing ultrapure stable polmerized hemoglobin blood-substitute |
US47349795A | 1995-06-07 | 1995-06-07 | |
US08/471,583 US5691452A (en) | 1995-03-23 | 1995-06-07 | Method for preserving a hemoglobin blood substitute |
US08/478,004 US5753616A (en) | 1986-11-10 | 1995-06-07 | Method for producing a stable polymerized hemoglobin blood-substitute |
US08/484,775 US5955581A (en) | 1986-11-10 | 1995-06-07 | Method for producing a stable polymerized hemoglobin blood-substitute |
US08/487,288 US5895810A (en) | 1995-03-23 | 1995-06-07 | Stable polymerized hemoglobin and use thereof |
PCT/US1996/004030 WO1996029346A1 (en) | 1995-03-23 | 1996-03-22 | Stable polymerized hemoglobin blood-substitute |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69623267D1 DE69623267D1 (de) | 2002-10-02 |
DE69623267T2 true DE69623267T2 (de) | 2003-04-17 |
Family
ID=27569756
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69623267T Expired - Lifetime DE69623267T2 (de) | 1995-03-23 | 1996-03-22 | Stabiles polymerisiertes hämoglobin-blutersatzmittel |
Country Status (11)
Country | Link |
---|---|
EP (5) | EP1094079A3 (de) |
JP (2) | JP4382877B2 (de) |
AT (2) | ATE222926T1 (de) |
AU (1) | AU705225B2 (de) |
CA (1) | CA2215697C (de) |
DE (1) | DE69623267T2 (de) |
DK (1) | DK0815138T3 (de) |
ES (1) | ES2179188T3 (de) |
NZ (1) | NZ305258A (de) |
PT (1) | PT815138E (de) |
WO (1) | WO1996029346A1 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6150507A (en) * | 1995-03-23 | 2000-11-21 | Biopure Corporation | Method for producing a purified hemoglobin product |
US6610832B1 (en) | 1995-03-23 | 2003-08-26 | Biopure Corporation | Preserving a hemoglobin blood substitute with a transparent overwrap |
US6271351B1 (en) * | 1995-03-23 | 2001-08-07 | Biopure Corporation | Method for preserving a hemoglobin blood substitute |
WO1996032130A1 (en) * | 1995-04-10 | 1996-10-17 | Baxter International Inc. | The use of cross-linked hemoglobin in treating subarachnoid hemorrhage |
AU4661797A (en) * | 1996-10-21 | 1998-05-15 | Baxter International Inc. | Therapeutic use of hemoglobin to treat head injury |
US5804551A (en) * | 1996-11-12 | 1998-09-08 | Baxter International Inc. | Pretraumatic use of hemoglobin |
US6139878A (en) * | 1998-04-27 | 2000-10-31 | Aventis Behring, Llc | Method for preparing a diafiltered stabilized blood product |
US6518010B2 (en) * | 2001-02-28 | 2003-02-11 | Biopure Corporation | Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier |
WO2002085111A1 (en) * | 2001-04-18 | 2002-10-31 | Northfield Laboratories | Flexible container system for storage of stabilized hemoglobin solutions |
US7001715B2 (en) | 2002-02-28 | 2006-02-21 | Biopure Corporation | Purification of red blood cells by separation and diafiltration |
CA2476177C (en) * | 2002-02-28 | 2011-06-14 | Biopure Corporation | Purification of red blood cells by separation and diafiltration |
TW200630385A (en) * | 2005-02-09 | 2006-09-01 | Vinnolit Gmbh & Co Kg | Process for the polymerisation of vinyl-containing monomers |
EP1865993A2 (de) * | 2005-04-05 | 2007-12-19 | Biopure Corporation | Sauerstoffangereicherte, polymerisierte hämoglobinlösungen und ihre verwendung zur sichtbarmachung von gewebe |
JP4665791B2 (ja) | 2005-04-15 | 2011-04-06 | ニプロ株式会社 | 酸素運搬体の脱一酸化炭素化方法、脱一酸化炭素化された酸素運搬体、その医薬組成物及び脱一酸化炭素化装置 |
WO2008021577A2 (en) | 2006-01-24 | 2008-02-21 | The Board Of Trustees Of The University Of Illinois | Polymerized hemoglobin media and its use in isolation and transplantation of islet cells |
US8961787B2 (en) | 2008-12-01 | 2015-02-24 | General Electric Company | Systems and methods for processing complex biological materials |
US20100151438A1 (en) * | 2008-12-12 | 2010-06-17 | General Electric Company | Methods and kits for enhancing sedimentation and recovery of cells in a sample |
CA2745214C (en) * | 2008-12-01 | 2017-11-21 | General Electric Company | System and method for separating cells from body fluids |
AU2010278768A1 (en) * | 2009-07-31 | 2012-03-15 | New Health Sciences, Inc. | Removal of oxygen from biological fluids |
WO2011046963A1 (en) | 2009-10-12 | 2011-04-21 | New Health Sciences, Inc. | Oxygen depletion devices and methods for removing oxygen from red blood cells |
WO2011046841A1 (en) * | 2009-10-12 | 2011-04-21 | New Health Sciences, Inc. | Blood storage bag system and depletion devices with oxygen and carbon dioxide depletion capabilities |
US9199016B2 (en) | 2009-10-12 | 2015-12-01 | New Health Sciences, Inc. | System for extended storage of red blood cells and methods of use |
US11284616B2 (en) | 2010-05-05 | 2022-03-29 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
US7989593B1 (en) * | 2010-05-27 | 2011-08-02 | Bing Lou Wong | Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof |
EP4091645A1 (de) | 2010-08-25 | 2022-11-23 | Hemanext Inc. | Verfahren zur erhöhung der qualität von erythrozyten und zur verlängerung ihrer lebensdauer während der lagerung |
EP4218412A1 (de) | 2010-11-05 | 2023-08-02 | Hemanext Inc. | Bestrahlung von roten blutkörperchen und anaerobe lagerung |
US8889830B2 (en) | 2011-03-01 | 2014-11-18 | Chuo University | Hemoglobin-albumin complex, and artificial plasma expander and artificial oxygen carrier containing the complex |
US9067004B2 (en) | 2011-03-28 | 2015-06-30 | New Health Sciences, Inc. | Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly |
PL2550973T3 (pl) | 2011-07-23 | 2014-03-31 | Sastomed Gmbh | Sprej do ran |
EP4074395B1 (de) | 2011-08-10 | 2024-01-24 | Hemanext Inc. | Integrierte leukozyten-, sauerstoff- und/oder co2-abreicherung und filtervorrichtung zum trennen von plasma |
CA2902061C (en) | 2013-02-28 | 2023-08-08 | New Health Sciences, Inc. | Gas depletion and gas addition devices for blood treatment |
US10279052B2 (en) | 2014-02-07 | 2019-05-07 | Pharmacophotonics, Inc. | Compositions and methods for measuring and expanding blood volume |
PT3268015T (pt) | 2015-03-10 | 2022-01-06 | Hemanext Inc | Kits descartáveis de redução de oxigénio, dispositivos e métodos de utilização dos mesmos |
EP3285711A4 (de) | 2015-04-23 | 2018-11-07 | New Health Sciences, Inc. | Anaerobe blutlagerbehälter |
CN114748503A (zh) | 2015-05-18 | 2022-07-15 | 希玛奈克斯特股份有限公司 | 储存全血的方法及其组合物 |
AU2017271545C1 (en) | 2016-05-27 | 2023-06-15 | Hemanext Inc. | Anaerobic blood storage and pathogen inactivation method |
JP7016124B2 (ja) | 2016-07-06 | 2022-02-04 | 学校法人 中央大学 | 虚血性疾患の治療剤 |
CN111315770A (zh) * | 2017-09-12 | 2020-06-19 | 第二医疗技术联合公司 | 无内毒素血红蛋白类原料药的生产系统和方法及无内毒素蛋白的纯化方法 |
CN110128531B (zh) * | 2019-05-17 | 2022-03-08 | 润方(北京)生物医药研究院有限公司 | 一种无碳酸酐酶血红蛋白的制备方法 |
WO2021072194A1 (en) * | 2019-10-11 | 2021-04-15 | Medical Technology Associates Ii, Inc. | Stabilized hemoglobin compositions and pharmaceutical formulations thereof |
CN112782319A (zh) * | 2021-02-09 | 2021-05-11 | 北京欧德福瑞医药科技发展有限公司 | 一种咖啡酸苯乙酯的分析方法 |
WO2023163750A1 (en) * | 2022-02-28 | 2023-08-31 | Ohio State Innovation Foundation | Polymerized hemoglobin size fractionated via tangential flow filtration with low auto oxidation rates |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5951334B2 (ja) * | 1979-02-26 | 1984-12-13 | 帝人株式会社 | 酸素捕捉組成物構造体 |
DE3277609D1 (en) * | 1982-01-07 | 1987-12-17 | Fresenius Ag | Preservation bag |
JPS58192552A (ja) * | 1982-05-06 | 1983-11-10 | テルモ株式会社 | 薬液を収容してなる合成樹脂製医療用バッグを収納した包装容器 |
JPS5984719A (ja) * | 1982-10-30 | 1984-05-16 | テルモ株式会社 | 長期間変質することのない薬液入りプラスチツク容器の製造方法 |
WO1988003408A1 (en) * | 1986-11-10 | 1988-05-19 | Biopure Corporation | Extra pure semi-synthetic blood substitute |
WO1989012456A1 (en) * | 1988-06-15 | 1989-12-28 | Baxter International Inc. | Method of purifying cross-linked hemoglobin |
JP3050887B2 (ja) * | 1990-01-12 | 2000-06-12 | 大日本印刷株式会社 | 血液バッグ抗菌包装システム |
WO1992008478A1 (en) * | 1990-11-20 | 1992-05-29 | Enzon, Inc. | Method of enhancing long-term storage stability of hemoglobin products |
US5264555A (en) * | 1992-07-14 | 1993-11-23 | Enzon, Inc. | Process for hemoglobin extraction and purification |
JPH0767936A (ja) * | 1993-07-12 | 1995-03-14 | Otsuka Pharmaceut Factory Inc | 輸液容器 |
AU692249B2 (en) * | 1994-03-28 | 1998-06-04 | Baxter International Inc. | Therapeutic use of hemoglobin in the treatment of blood vessel blockage |
-
1996
- 1996-03-22 DK DK96909855T patent/DK0815138T3/da active
- 1996-03-22 PT PT96909855T patent/PT815138E/pt unknown
- 1996-03-22 EP EP00204284A patent/EP1094079A3/de not_active Withdrawn
- 1996-03-22 AT AT96909855T patent/ATE222926T1/de not_active IP Right Cessation
- 1996-03-22 JP JP52865796A patent/JP4382877B2/ja not_active Expired - Fee Related
- 1996-03-22 NZ NZ305258A patent/NZ305258A/xx unknown
- 1996-03-22 ES ES96909855T patent/ES2179188T3/es not_active Expired - Lifetime
- 1996-03-22 AU AU53227/96A patent/AU705225B2/en not_active Ceased
- 1996-03-22 EP EP00204276A patent/EP1094078A3/de not_active Withdrawn
- 1996-03-22 EP EP96909855A patent/EP0815138B1/de not_active Expired - Lifetime
- 1996-03-22 CA CA002215697A patent/CA2215697C/en not_active Expired - Fee Related
- 1996-03-22 EP EP02075127A patent/EP1211261A3/de not_active Ceased
- 1996-03-22 EP EP00204281A patent/EP1093720B1/de not_active Expired - Lifetime
- 1996-03-22 WO PCT/US1996/004030 patent/WO1996029346A1/en active IP Right Grant
- 1996-03-22 DE DE69623267T patent/DE69623267T2/de not_active Expired - Lifetime
- 1996-03-22 AT AT00204281T patent/ATE447324T1/de not_active IP Right Cessation
-
2007
- 2007-03-19 JP JP2007071402A patent/JP2007260393A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP1094078A3 (de) | 2001-05-02 |
JPH11502821A (ja) | 1999-03-09 |
ATE222926T1 (de) | 2002-09-15 |
NZ305258A (en) | 2000-10-27 |
CA2215697A1 (en) | 1996-09-26 |
EP0815138B1 (de) | 2002-08-28 |
DE69623267D1 (de) | 2002-10-02 |
EP1093720B1 (de) | 2009-11-04 |
EP0815138A1 (de) | 1998-01-07 |
EP1094079A3 (de) | 2001-05-02 |
WO1996029346A1 (en) | 1996-09-26 |
EP1211261A2 (de) | 2002-06-05 |
DK0815138T3 (da) | 2002-12-23 |
JP2007260393A (ja) | 2007-10-11 |
AU5322796A (en) | 1996-10-08 |
EP1093720A1 (de) | 2001-04-25 |
AU705225B2 (en) | 1999-05-20 |
EP1211261A3 (de) | 2004-03-17 |
ES2179188T3 (es) | 2003-01-16 |
ATE447324T1 (de) | 2009-11-15 |
EP1094079A2 (de) | 2001-04-25 |
JP4382877B2 (ja) | 2009-12-16 |
CA2215697C (en) | 2009-08-18 |
EP1094078A2 (de) | 2001-04-25 |
PT815138E (pt) | 2002-12-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69623267T2 (de) | Stabiles polymerisiertes hämoglobin-blutersatzmittel | |
DK1121016T3 (da) | Fremgangsmåde til konservering af et hæmoglobinbloderstatningspræparat | |
ATE259644T1 (de) | Behandlung von hämoglobin enthaltenden erythrozyten mit stickstoffoxyd | |
EA199700110A1 (ru) | Композиция с высоким содержанием ацетаминофена для прямого прессования | |
MD960317A (ro) | Noile peptide-agoniste ale amilinei şi utilizarea lor | |
DK0913156T3 (da) | Anvendelse af aktiveret protein C til behandling af hyperkoagulationstilstande i forbindelse med sepsis | |
ATE241368T1 (de) | Präparation und stabilisation von zellen | |
HU901644D0 (en) | Process for producing tissue-plasminogene activator | |
MY102806A (en) | Human interleukin-3 and muteins thereof | |
GR3032307T3 (en) | Site-directed mutagenesis modified glycoprotein hormones and methods of use. | |
DE3878231D1 (de) | Neues cadiodilatin-fragment, prozess zu dessen herstellung und dessen anwendung. | |
Reis et al. | Comparative pharmacological actions of bradykinin and related kinins of larger molecular weights | |
Gibson et al. | The reaction of inositol hexaphosphate with hemoglobin | |
DK0772450T3 (da) | Fremgangsmåder til behandling af blødningsforstyrelser | |
GR3001375T3 (en) | Enhancement of prazosin | |
BG102222A (en) | The use of derivatives of the sulphaminic acid, acylsulphanomides or sulphamoylcarbamates for the preparation of a medicament for reducing lipoprotein levels | |
Shinozawa et al. | Purification and characteristics of photoreceptor light-activated guanosinetriphosphatase | |
ATE268377T1 (de) | Ex-vivo unter oxidativen stress behandelte cll- zellen zur behandlung chronischer lymphozytärer läukemie (cll) | |
DK0496866T3 (da) | Hæmoglobin-oligomerbaseret præparat og fremgangsmåde til fremstilling deraf | |
Stabilini et al. | Viability of Glutaraldehyde Cross-Linked Hemoglobin as “In Vivo” O2 Carrier | |
Saffran et al. | Kinetics of the bohr effect of menhaden hemoglobin, brevoortia tyrannus | |
Prydz | Factor VII and Tissue Thromboplastin | |
Hahn et al. | Alterations of Binding Capacities of Dopamine Receptors After Treatment with Haloperidol and Sulpiride in Rat Brain | |
YU4797A (sh) | Žučne kiseline i njihovi derivati kao hipoglikemična sredstva | |
EP0667153A4 (de) | Verfahren zur herstellung eines zusammensetzung für ein medikament in fester form. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |