DE69616593T2 - Phenylimidazolidine und deren verwendung als anti-androgene mittel - Google Patents

Phenylimidazolidine und deren verwendung als anti-androgene mittel

Info

Publication number
DE69616593T2
DE69616593T2 DE69616593T DE69616593T DE69616593T2 DE 69616593 T2 DE69616593 T2 DE 69616593T2 DE 69616593 T DE69616593 T DE 69616593T DE 69616593 T DE69616593 T DE 69616593T DE 69616593 T2 DE69616593 T2 DE 69616593T2
Authority
DE
Germany
Prior art keywords
phenylimidazolidine
represent
androgen agent
substituted
androgen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69616593T
Other languages
English (en)
Other versions
DE69616593D1 (de
Inventor
Andre Claussner
Francois Goubet
Jean-Georges Teutsch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Publication of DE69616593D1 publication Critical patent/DE69616593D1/de
Application granted granted Critical
Publication of DE69616593T2 publication Critical patent/DE69616593T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69616593T 1995-12-22 1996-12-19 Phenylimidazolidine und deren verwendung als anti-androgene mittel Expired - Fee Related DE69616593T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9515323A FR2742749B1 (fr) 1995-12-22 1995-12-22 Nouvelles phenylimidazolidines comportant notamment un radical nitrooxy ou carbonyloxy, procede et intermediaires de preparation, application comme medicaments, nouvelles utilisations et compositions pharmaceutiques
PCT/FR1996/002029 WO1997023464A1 (fr) 1995-12-22 1996-12-19 Phenylimidazolidines et leur utilisation comme agent anti-androgene

Publications (2)

Publication Number Publication Date
DE69616593D1 DE69616593D1 (de) 2001-12-06
DE69616593T2 true DE69616593T2 (de) 2002-06-27

Family

ID=9485838

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69616593T Expired - Fee Related DE69616593T2 (de) 1995-12-22 1996-12-19 Phenylimidazolidine und deren verwendung als anti-androgene mittel

Country Status (12)

Country Link
US (1) US6242611B1 (de)
EP (1) EP0869946B1 (de)
JP (1) JP2000502669A (de)
AT (1) ATE207906T1 (de)
AU (1) AU1180797A (de)
DE (1) DE69616593T2 (de)
DK (1) DK0869946T3 (de)
ES (1) ES2163665T3 (de)
FR (1) FR2742749B1 (de)
PT (1) PT869946E (de)
WO (1) WO1997023464A1 (de)
ZA (1) ZA9610418B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000024366A1 (de) * 1998-10-23 2000-05-04 Aventis Pharma Deutschland Gmbh Zubereitungen zur topischen applikation von antiandrogen wirksamen substanzen
JP2004509072A (ja) * 2000-06-28 2004-03-25 ブリストル−マイヤーズ　スクイブ　カンパニー 選択的アンドロゲン受容体モジュレーター並びにその同定、設計及び使用方法
US20040077605A1 (en) * 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US7001911B2 (en) * 2000-06-28 2006-02-21 Bristol-Myers Squibb Company Fused cyclic modulators of nuclear hormone receptor function
US6953679B2 (en) 2000-09-19 2005-10-11 Bristol-Myers Squibb Company Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
EP1854798A3 (de) * 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Kondensierte heterozyklische Succinimid-Verbindungen und Analoga daraus, Modulatoren der nuklearen Hormonrezeptorfunktion
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
ES2310622T3 (es) * 2001-12-19 2009-01-16 Bristol-Myers Squibb Company Compuestos heterociclicos condensados y analogos de los mismos, moduladores de la funcion de los receptores nucleares de hormonas.
US6875438B2 (en) * 2002-04-27 2005-04-05 Aventis Pharma Deutschland Gmbh Preparations for topical administration of substances having antiandrogenic activity
JP2007514442A (ja) * 2003-12-19 2007-06-07 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 前立腺癌治療を評価するための方法および物質
NZ550102A (en) * 2004-02-24 2010-10-29 Univ California Methods and materials for assessing prostate cancer therapies and compounds (thiohydantoine derivatives)
US7709517B2 (en) 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
US7709516B2 (en) 2005-06-17 2010-05-04 Endorecherche, Inc. Helix 12 directed non-steroidal antiandrogens
HUE053877T2 (hu) 2006-03-27 2021-07-28 Univ California Androgén receptormodulátor a prosztatarák és az androgén receptorral összefüggõ betegségek kezeléséhez
NZ572374A (en) 2006-03-29 2011-12-22 Univ California Diarylthiohydantoin compounds
US8168667B2 (en) 2006-05-31 2012-05-01 Galapagos Nv Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such
US9284345B2 (en) 2007-04-12 2016-03-15 Endorecherche, Inc. 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators
CA2703635C (en) 2007-10-26 2017-06-27 Michael E. Jung Diarylhydantoin compounds as androgen receptor modulators
CN102482230B (zh) 2009-09-10 2016-01-06 苏州开拓药业有限公司 雄激素受体拮抗剂及其用途
CN106983749A (zh) 2010-02-16 2017-07-28 亚拉冈制药公司 雄激素受体调节剂及其用途
BR112013023028B1 (pt) 2011-03-10 2021-09-21 Suzhou Kintor Pharmaceuticals, Inc Composto de fórmula (i) ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica e formulação farmacêutica tópica
BR112015006705A8 (pt) 2012-09-26 2019-08-27 Aragon Pharmaceuticals Inc antiandrogênios para o tratamento de câncer de próstata resistente à castração não metastático e usos destes
JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
US9682960B2 (en) 2013-12-19 2017-06-20 Endorecherche, Inc. Non-steroidal antiandrogens and selective androgen receptor modulators with a pyridyl moiety
CN103965112A (zh) * 2014-05-13 2014-08-06 上海孚一生物科技有限公司 一种具有抗雄激素活性的化合物、制备方法及其应用
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
CA3079135A1 (en) 2017-10-16 2019-04-25 Arturo Molina Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411981A (en) * 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
FR2693461B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2694290B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
TW521073B (en) * 1994-01-05 2003-02-21 Hoechst Marion Roussel Inc New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them
FR2725206B1 (fr) * 1994-09-29 1996-12-06 Roussel Uclaf Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
AU1180797A (en) 1997-07-17
DK0869946T3 (da) 2002-02-18
DE69616593D1 (de) 2001-12-06
ATE207906T1 (de) 2001-11-15
ZA9610418B (en) 1997-12-11
EP0869946B1 (de) 2001-10-31
ES2163665T3 (es) 2002-02-01
FR2742749A1 (fr) 1997-06-27
US6242611B1 (en) 2001-06-05
FR2742749B1 (fr) 1998-02-06
JP2000502669A (ja) 2000-03-07
EP0869946A1 (de) 1998-10-14
PT869946E (pt) 2002-04-29
WO1997023464A1 (fr) 1997-07-03

Similar Documents

Publication Publication Date Title
DE69616593D1 (de) Phenylimidazolidine und deren verwendung als anti-androgene mittel
DE60017440D1 (de) Elektrochrome vorrichtung
ATE444065T1 (de) 4(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidon-deriva e als pde-4-hemmer zur behandlung von neurologischen syndromen
ATE233730T1 (de) Acylsulfamoylbenzoesäureamide, diese enthaltende nutzpflanzenschützende mittel und verfahren zu ihrer herstellung
TR200400376T4 (tr) Yeni, ilaç olarak kullanılabilen antikolinerjikler ve bunların imalatı için yöntem
BG98740A (en) Substituted pyrazolylpyrazoles, methods for their preparation, preparation of intermediate products and the usage of the compounds as herbicides
DK142084A (da) N-phenyl-n'-cycloalkylalkanoyl-piperaziner og fremgangsmaade til fremstilling heraf
FI974447A0 (fi) Semikarbatsonit, joilla on keskushermostoaktiivisuutta, ja niitä sisältävät farmaseuttiset valmisteet
DE69728544D1 (de) Totalsynthese von acylfulvenen mit antitumorwirkung
ID21450A (id) S-oksida dan s,s-dioksida tetrahidrotiopiran pheniloksazolidinon
ATE163921T1 (de) Azoxycyanbenzol-derivate
DK1086096T3 (da) Benzamider med tetrahydrofuranyloxy-substituenter som inhibitorer af phosphodiesterase 4
DE69516186D1 (de) Verwendung von Beta-Aminopropionsäure-Derivaten als Fungizide
DE69511260T2 (de) Bicyclische amidinderivate als no-synthetase inhibitoren
BR0114812A (pt) Derivados de 2-pirimidinilóxi-n-aril-benzilamina, seus processos de preparo e uso
ATE333457T1 (de) Zyklische gmp-spezifische phosphodiesteraseinhibitoren
DK0604186T3 (da) HIV-proteaseinhibitorer, som er egnede til behandling af AIDS
DE69402935D1 (de) Substituierte arylalkylaminobenzyl-aminopropanamide, ihre herstellung und verwendung als antiepileptische, neuroprotektive und antidepressive mittel
DE60121048D1 (de) PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE
FI973111A (fi) Substituoidut fenyyliyhdisteet endoteliiniantagonisteina
DK0648763T3 (da) Ny fremgangsmåde til fremstilling af afledede svovlforbindelser af imidazol og de opnåede nye mellemstoffer
ATE153657T1 (de) Cyclische benzylamino-, benzylamido- und benzylimido derivate als antipsychotische wirkstoffe
ATE205835T1 (de) Akarizid und insektizid wirksame, substituierte pyrimidine und verfahren zu ihrer herstellung
DE60228134D1 (de) Substituierte hydrazone als hemmer von cyclooxygenase-2
TR200001122T2 (tr) Farmasötikler olarak bifenil türevleri.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee