DE69600144T2 - Verfahren zur Reinigung und Krystallisierung von Iopamidol - Google Patents

Verfahren zur Reinigung und Krystallisierung von Iopamidol

Info

Publication number
DE69600144T2
DE69600144T2 DE69600144T DE69600144T DE69600144T2 DE 69600144 T2 DE69600144 T2 DE 69600144T2 DE 69600144 T DE69600144 T DE 69600144T DE 69600144 T DE69600144 T DE 69600144T DE 69600144 T2 DE69600144 T2 DE 69600144T2
Authority
DE
Germany
Prior art keywords
lopamidol
propanol
purification
crystallisation
aqueous solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69600144T
Other languages
English (en)
Other versions
DE69600144D1 (de
Inventor
William Dr Heggie
Mouro Vaz Azevedo Mendes Zi De
Lacerda E Oliveira Santos P De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hovione Inter AG
Original Assignee
Hovione Inter AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hovione Inter AG filed Critical Hovione Inter AG
Application granted granted Critical
Publication of DE69600144D1 publication Critical patent/DE69600144D1/de
Publication of DE69600144T2 publication Critical patent/DE69600144T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DE69600144T 1995-06-08 1996-06-05 Verfahren zur Reinigung und Krystallisierung von Iopamidol Expired - Lifetime DE69600144T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT101720A PT101720A (pt) 1995-06-08 1995-06-08 Processo para a purificacao e cristalizacao de iopamidol

Publications (2)

Publication Number Publication Date
DE69600144D1 DE69600144D1 (de) 1998-02-19
DE69600144T2 true DE69600144T2 (de) 1998-05-20

Family

ID=20085518

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69600144T Expired - Lifetime DE69600144T2 (de) 1995-06-08 1996-06-05 Verfahren zur Reinigung und Krystallisierung von Iopamidol

Country Status (9)

Country Link
EP (1) EP0747344B1 (de)
JP (1) JP2835313B2 (de)
AT (1) ATE162180T1 (de)
AU (1) AU695662B2 (de)
CA (1) CA2178369C (de)
CZ (1) CZ285258B6 (de)
DE (1) DE69600144T2 (de)
ES (1) ES2114336T3 (de)
PT (1) PT101720A (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT101919B (pt) * 1996-09-30 2000-01-31 Hovione Sociedade Quimica Sa Um processo para a purificacao de tohexol
ES2141691T3 (es) * 1997-02-11 2003-05-16 Bracco Int Bv Procedimiento para la cristalizacion de (s)-n,n'-bis(2-hidroxi-1-(hidroximetil)etil)-5-((2-hidroxi-1-oxopropil)amino)-2,4,6-triyodo-1,3-bencenodicarboxamida en un alcohol (c5-c6) lineal o ramificado o sus mezclas.
GB9720969D0 (en) * 1997-10-02 1997-12-03 Nycomed Imaging As Process
KR20000031642A (ko) * 1998-11-09 2000-06-05 강재헌 이오파미돌의 결정화 방법
NO20053687D0 (no) * 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process.
NO20053676D0 (no) * 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process
NO342021B1 (no) * 2005-07-29 2018-03-12 Ge Healthcare As Kontinuerlig krystalliseringsprosess
EP1966110B1 (de) 2005-12-19 2013-04-24 Ge Healthcare As Verfahren zur aufreinigung von iodixanol

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH608189A5 (de) * 1974-12-13 1978-12-29 Savac Ag
IL90326A (en) * 1988-06-02 1993-05-13 Guerbet Sa Non-ionic triiodobenzene compounds and contrast media containing them
IL110391A (en) * 1993-07-30 1998-12-06 Zambon Spa Process for the formation of infamidol
IT1271469B (it) * 1993-09-10 1997-05-28 Zambon Spa Processo per la preparazione di 5-ammino-2,2-dialchil-1,3 diossani
IT1274027B (it) * 1994-03-03 1997-07-14 Zambon Spa Processo per la preparazione e purificazione di mezzi di contrasto iodurati
JP4070235B2 (ja) * 1995-09-08 2008-04-02 ブラッコ・インテルナツィオナル・ベーヴェー （ｓ）−ｎ，ｎ’−ビス［２−ヒドロキシ−１−（ヒドロキシメチル）エチル］−５−［（２−ヒドロキシ−１−オキソプロピル）アミノ］−２，４，６−トリヨード−１，３−ベンゼンジカルボキサアミドの、水からの結晶化方法

Also Published As

Publication number Publication date
JP2835313B2 (ja) 1998-12-14
AU695662B2 (en) 1998-08-20
CA2178369C (en) 2001-10-16
AU5451296A (en) 1996-12-19
EP0747344B1 (de) 1998-01-14
ES2114336T3 (es) 1998-05-16
ATE162180T1 (de) 1998-01-15
CZ163296A3 (en) 1996-12-11
CZ285258B6 (cs) 1999-06-16
PT101720A (pt) 1997-01-31
DE69600144D1 (de) 1998-02-19
JPH08333319A (ja) 1996-12-17
CA2178369A1 (en) 1996-12-09
EP0747344A1 (de) 1996-12-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition