DE69535260D1 - Verwendung eines nicht-neutralisierenden Antikörpers spezifisch für die beta-Untereinheit von luteinisierendem Hormon zur Erhöhung der Fertilität - Google Patents
Verwendung eines nicht-neutralisierenden Antikörpers spezifisch für die beta-Untereinheit von luteinisierendem Hormon zur Erhöhung der FertilitätInfo
- Publication number
- DE69535260D1 DE69535260D1 DE69535260T DE69535260T DE69535260D1 DE 69535260 D1 DE69535260 D1 DE 69535260D1 DE 69535260 T DE69535260 T DE 69535260T DE 69535260 T DE69535260 T DE 69535260T DE 69535260 D1 DE69535260 D1 DE 69535260D1
- Authority
- DE
- Germany
- Prior art keywords
- present
- stimulating
- fertility
- luteinizing hormone
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000009151 Luteinizing Hormone Human genes 0.000 title abstract 4
- 108010073521 Luteinizing Hormone Proteins 0.000 title abstract 4
- 230000035558 fertility Effects 0.000 title abstract 4
- 229940040129 luteinizing hormone Drugs 0.000 title abstract 3
- 230000003472 neutralizing effect Effects 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 230000004936 stimulating effect Effects 0.000 abstract 3
- 102000011022 Chorionic Gonadotropin Human genes 0.000 abstract 2
- 108010062540 Chorionic Gonadotropin Proteins 0.000 abstract 2
- 102000003886 Glycoproteins Human genes 0.000 abstract 2
- 108090000288 Glycoproteins Proteins 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- 239000011230 binding agent Substances 0.000 abstract 2
- 230000004071 biological effect Effects 0.000 abstract 2
- 229940088597 hormone Drugs 0.000 abstract 2
- 239000005556 hormone Substances 0.000 abstract 2
- 229940084986 human chorionic gonadotropin Drugs 0.000 abstract 2
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 abstract 1
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 abstract 1
- 102000006771 Gonadotropins Human genes 0.000 abstract 1
- 108010086677 Gonadotropins Proteins 0.000 abstract 1
- 206010033266 Ovarian Hyperstimulation Syndrome Diseases 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 229940028334 follicle stimulating hormone Drugs 0.000 abstract 1
- 239000002622 gonadotropin Substances 0.000 abstract 1
- 239000003933 gonadotropin antagonist Substances 0.000 abstract 1
- 229940094892 gonadotropins Drugs 0.000 abstract 1
- 230000003054 hormonal effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Reproductive Health (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Gynecology & Obstetrics (AREA)
- Immunology (AREA)
- Pregnancy & Childbirth (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Beans For Foods Or Fodder (AREA)
- Control Of Eletrric Generators (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19938294A | 1994-02-18 | 1994-02-18 | |
| US199382 | 1994-02-18 | ||
| PCT/US1995/002067 WO1995022340A1 (en) | 1994-02-18 | 1995-02-17 | Methods for altering fertility |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69535260D1 true DE69535260D1 (de) | 2006-11-23 |
| DE69535260T2 DE69535260T2 (de) | 2007-08-09 |
Family
ID=22737277
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69534723T Expired - Lifetime DE69534723T2 (de) | 1994-02-18 | 1995-02-17 | Einzelketten-Gonadotropin |
| DE69535260T Expired - Lifetime DE69535260T2 (de) | 1994-02-18 | 1995-02-17 | Verwendung eines nicht-neutralisierenden Antikörpers spezifisch für die beta-Untereinheit von luteinisierendem Hormon zur Erhöhung der Fertilität |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69534723T Expired - Lifetime DE69534723T2 (de) | 1994-02-18 | 1995-02-17 | Einzelketten-Gonadotropin |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7001597B1 (de) |
| EP (3) | EP0751782B1 (de) |
| JP (3) | JPH09509418A (de) |
| AT (2) | ATE314392T1 (de) |
| AU (1) | AU695111B2 (de) |
| CA (1) | CA2183564C (de) |
| DE (2) | DE69534723T2 (de) |
| DK (1) | DK0751782T3 (de) |
| ES (2) | ES2273335T3 (de) |
| PT (1) | PT751782E (de) |
| WO (1) | WO1995022340A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2250975A1 (en) * | 1996-04-15 | 1997-10-23 | The Board Of Trustees Of The Leland Stanford Junior University | Soluble 7-transmembrane domain g-protein-coupled receptor compositions and methods |
| AU4964197A (en) * | 1996-11-12 | 1998-06-03 | Teikoku Hormone Mfg. Co., Ltd. | Recombinant single-stranded equine chorionic gonadotropin |
| ZA987497B (en) * | 1997-09-08 | 1999-02-23 | Akzo Nobel Nv | Expression of gonadotropins in dictyostelium |
| US6635256B1 (en) * | 1998-10-19 | 2003-10-21 | Washington University | Glycoprotein hormone compositions comprising two β subunits and methods of use thereof |
| US6103501A (en) * | 1997-11-17 | 2000-08-15 | Washington University | Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof |
| US5981249A (en) * | 1998-02-05 | 1999-11-09 | Spectral Diagnostics, Inc. | Single-chain polypeptides comprising creatine kinase M and creatine kinase B |
| WO2000017360A1 (en) * | 1998-09-22 | 2000-03-30 | University Of Maryland, Baltimore | Cystine knot growth factor mutants |
| DE19910394A1 (de) * | 1999-03-03 | 2000-09-07 | Schering Ag | Substanzen für die Fertilitätskontrolle |
| US6342411B1 (en) * | 1999-09-03 | 2002-01-29 | Motorola Inc. | Electronic component and method for manufacture |
| KR20010077538A (ko) * | 2000-02-03 | 2001-08-20 | 김강권 | 단일체인 융모성성선자극호르몬 및 그 제조방법 |
| WO2001081406A2 (en) * | 2000-04-25 | 2001-11-01 | Washington University | Single-chain fertility hormones with variable lh activity |
| JP2001333772A (ja) | 2000-04-25 | 2001-12-04 | Washington Univ | 可変性の活性を有する単鎖稔性ホルモン |
| US6987172B2 (en) | 2001-03-05 | 2006-01-17 | Washington University In St. Louis | Multifunctional single chain glycoprotein hormones comprising three or more β subunits |
| PL1518863T3 (pl) * | 2003-09-26 | 2011-05-31 | Inst Nat De La Rech Agronomique Inra | Przeciwciała modulujące aktywność końskiej gonadotropiny kosmówkowej |
| EP3765841A4 (de) * | 2018-03-16 | 2022-06-08 | Quest Diagnostics Investments LLC | Massenspektrometrische bestimmung von testosteron in multiplexierten patientenproben |
| BR102019004147A2 (pt) | 2019-02-28 | 2020-10-06 | Ouro Fino Saude Animal Participacoes S.A. | Gonadotrofina coriônica equina recombinante (recg) biologicamente ativa e processo para obtenção da mesma, composição veterinária e uso |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4514505A (en) * | 1982-05-21 | 1985-04-30 | The Trustees Of Columbia University In The City Of New York | Monoclonal antibody mixtures and use thereof for enhanced sensitivity immunoassays |
| US5284778A (en) * | 1985-08-12 | 1994-02-08 | The Trustees Of Columbia University In The City Of New York | Sensitive bioassay using monoclonal antibodies which bind to hormone-receptor complexes |
| US4973577A (en) * | 1986-04-04 | 1990-11-27 | The Salk Institute For Biological Studies | FSH-releasing peptides |
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| DE3856559T2 (de) * | 1987-05-21 | 2004-04-29 | Micromet Ag | Multifunktionelle Proteine mit vorbestimmter Zielsetzung |
| WO1991016922A1 (en) * | 1990-05-08 | 1991-11-14 | University Of Medicine & Dentistry Of New Jersey | Analogs of glycoprotein hormones having altered immunological characteristics, efficacy and/or receptor specificity |
| ATE193540T1 (de) * | 1991-06-18 | 2000-06-15 | Univ New Jersey Med | Analoga von glykoproteinhormonen mit geänderter rezeptorbindungsspezifität und aktivität und verfahren zur darstellung und verwendung derselben |
| US5508261A (en) * | 1991-06-18 | 1996-04-16 | University Of Medicine & Dentistry Of New Jersey | Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same |
| WO1994012520A1 (en) * | 1992-11-20 | 1994-06-09 | Enzon, Inc. | Linker for linked fusion polypeptides |
| CN1157408C (zh) * | 1994-08-12 | 2004-07-14 | 华盛顿大学 | 以糖蛋白激素四成员家族的单链形式存在的糖蛋白激素活性的促效剂或拮抗剂 |
-
1995
- 1995-02-17 DE DE69534723T patent/DE69534723T2/de not_active Expired - Lifetime
- 1995-02-17 EP EP95911043A patent/EP0751782B1/de not_active Expired - Lifetime
- 1995-02-17 ES ES95911043T patent/ES2273335T3/es not_active Expired - Lifetime
- 1995-02-17 JP JP7521944A patent/JPH09509418A/ja active Pending
- 1995-02-17 WO PCT/US1995/002067 patent/WO1995022340A1/en active IP Right Grant
- 1995-02-17 AT AT97122148T patent/ATE314392T1/de active
- 1995-02-17 PT PT95911043T patent/PT751782E/pt unknown
- 1995-02-17 DK DK95911043T patent/DK0751782T3/da active
- 1995-02-17 EP EP06021253A patent/EP1849802A2/de not_active Withdrawn
- 1995-02-17 ES ES97122148T patent/ES2251731T3/es not_active Expired - Lifetime
- 1995-02-17 AU AU18787/95A patent/AU695111B2/en not_active Ceased
- 1995-02-17 DE DE69535260T patent/DE69535260T2/de not_active Expired - Lifetime
- 1995-02-17 EP EP97122148A patent/EP0839831B1/de not_active Expired - Lifetime
- 1995-02-17 AT AT95911043T patent/ATE342061T1/de active
- 1995-02-17 CA CA2183564A patent/CA2183564C/en not_active Expired - Fee Related
-
1997
- 1997-06-02 US US08/867,587 patent/US7001597B1/en not_active Expired - Fee Related
-
1998
- 1998-10-14 JP JP10292659A patent/JPH11263799A/ja active Pending
-
2001
- 2001-06-05 JP JP2001170329A patent/JP2002060347A/ja active Pending
-
2005
- 2005-09-16 US US11/229,140 patent/US20070253955A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2183564A1 (en) | 1995-08-24 |
| DE69534723D1 (de) | 2006-02-02 |
| EP0751782A1 (de) | 1997-01-08 |
| PT751782E (pt) | 2007-01-31 |
| JPH11263799A (ja) | 1999-09-28 |
| US20070253955A1 (en) | 2007-11-01 |
| EP1849802A2 (de) | 2007-10-31 |
| JPH09509418A (ja) | 1997-09-22 |
| EP0839831A2 (de) | 1998-05-06 |
| ES2251731T3 (es) | 2006-05-01 |
| ATE342061T1 (de) | 2006-11-15 |
| DE69534723T2 (de) | 2006-08-31 |
| ES2273335T3 (es) | 2007-05-01 |
| DE69535260T2 (de) | 2007-08-09 |
| AU1878795A (en) | 1995-09-04 |
| EP0751782A4 (de) | 2000-09-27 |
| US7001597B1 (en) | 2006-02-21 |
| ATE314392T1 (de) | 2006-01-15 |
| EP0839831A3 (de) | 1999-09-29 |
| AU695111B2 (en) | 1998-08-06 |
| DK0751782T3 (da) | 2007-01-29 |
| WO1995022340A1 (en) | 1995-08-24 |
| EP0751782B1 (de) | 2006-10-11 |
| JP2002060347A (ja) | 2002-02-26 |
| EP0839831B1 (de) | 2005-12-28 |
| CA2183564C (en) | 2010-07-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: LABORATOIRES SERONO S.A., COINSINS, VAUD, CH |