DE69535223D1 - Verfahren und vorrichtung zur elektrochemilumineszenz-detektion magnetischer partikeln - Google Patents

Verfahren und vorrichtung zur elektrochemilumineszenz-detektion magnetischer partikeln

Info

Publication number
DE69535223D1
DE69535223D1 DE69535223T DE69535223T DE69535223D1 DE 69535223 D1 DE69535223 D1 DE 69535223D1 DE 69535223 T DE69535223 T DE 69535223T DE 69535223 T DE69535223 T DE 69535223T DE 69535223 D1 DE69535223 D1 DE 69535223D1
Authority
DE
Germany
Prior art keywords
capture
distribution
magnetic field
active species
magnetic particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69535223T
Other languages
English (en)
Other versions
DE69535223T2 (de
Inventor
B Talley
K Leland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioveris Corp
Original Assignee
Bioveris Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioveris Corp filed Critical Bioveris Corp
Application granted granted Critical
Publication of DE69535223D1 publication Critical patent/DE69535223D1/de
Publication of DE69535223T2 publication Critical patent/DE69535223T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
    • G01N21/69—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence specially adapted for fluids, e.g. molten metal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Pyridine Compounds (AREA)
  • Hard Magnetic Materials (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69535223T 1994-11-10 1995-11-13 Verfahren und Vorrichtung zu Elektrochemilumineszenz-Detektion magnetischer Partikel Expired - Lifetime DE69535223T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US339237 1982-01-13
US08/339,237 US5744367A (en) 1994-11-10 1994-11-10 Magnetic particle based electrochemiluminescent detection apparatus and method
PCT/US1995/014847 WO1996015440A1 (en) 1994-11-10 1995-11-13 Magnetic particle based electrochemiluminescent detection apparatus and method

Publications (2)

Publication Number Publication Date
DE69535223D1 true DE69535223D1 (de) 2006-10-26
DE69535223T2 DE69535223T2 (de) 2007-09-20

Family

ID=23328109

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69535223T Expired - Lifetime DE69535223T2 (de) 1994-11-10 1995-11-13 Verfahren und Vorrichtung zu Elektrochemilumineszenz-Detektion magnetischer Partikel

Country Status (8)

Country Link
US (2) US5744367A (de)
EP (1) EP0871864B1 (de)
JP (2) JPH10509798A (de)
AT (1) ATE339682T1 (de)
AU (1) AU4501596A (de)
DE (1) DE69535223T2 (de)
ES (1) ES2273339T3 (de)
WO (1) WO1996015440A1 (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7462322B2 (en) * 1991-02-06 2008-12-09 Bioveris Corporation Methods and apparatus for improved luminescence assays
US5744367A (en) * 1994-11-10 1998-04-28 Igen International, Inc. Magnetic particle based electrochemiluminescent detection apparatus and method
US6319670B1 (en) * 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
US6429025B1 (en) 1996-06-28 2002-08-06 Caliper Technologies Corp. High-throughput screening assay systems in microscale fluidic devices
FR2764381A1 (fr) * 1997-06-09 1998-12-11 Univ De Neuchatel Detecteur electrochimioluminescent
AU2006201608B2 (en) * 1998-05-11 2007-06-07 Bioveris Corporation Improved Apparatus and Methods for Carrying Out Electrochemiluminescence Test Measurements
US6200531B1 (en) 1998-05-11 2001-03-13 Igen International, Inc. Apparatus for carrying out electrochemiluminescence test measurements
US6300143B1 (en) * 1999-03-01 2001-10-09 Idec Pharmaceuticals Corporation Electrochemiluminescent assays for eukaryotic cells
US6136268A (en) * 1999-08-17 2000-10-24 Orion Diagnostica Method for luminescence measurements
US7141436B2 (en) * 1999-11-03 2006-11-28 Science And Technology Corp. Immunoassay and reagents and kits for performing the same
US6846429B2 (en) 2001-01-16 2005-01-25 E. I. Du Pont De Nemours And Company Transparent paramagnetic polymer
US7169578B2 (en) * 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
US7285412B2 (en) * 2001-07-27 2007-10-23 Surface Logix Inc. Device for magnetic immobilization of cells
US7169577B2 (en) * 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
US20030040129A1 (en) * 2001-08-20 2003-02-27 Shah Haresh P. Binding assays using magnetically immobilized arrays
WO2003072830A1 (en) * 2002-02-22 2003-09-04 Purdue Research Foundation Magnetic nanomaterials and methods for detection of biological materials
US7214427B2 (en) * 2002-03-21 2007-05-08 Aviva Biosciences Corporation Composite beads comprising magnetizable substance and electro-conductive substance
CA2493905A1 (en) * 2002-06-20 2003-12-31 Sudeep M. Kumar Electrochemiluminescence flow cell and flow cell components
AU2003256285A1 (en) * 2002-06-28 2004-01-19 Igen International, Inc. Improved assay systems and components
EP1532274A4 (de) * 2002-06-28 2006-09-27 Purdue Research Foundation Magnetische nanomaterialien und verfahren zum nachweis biologischer materialien
WO2004027379A2 (en) * 2002-09-20 2004-04-01 Novus Molecular, Inc. Methods and devices for active bioassay
US9790539B2 (en) * 2004-06-30 2017-10-17 Russell Biotech, Inc. Methods and reagents for improved selection of biological molecules
CA2587945A1 (en) * 2004-11-17 2007-04-12 Bioveris Electrochemiluminescent assay
US20060275841A1 (en) * 2004-12-20 2006-12-07 Martin Blankfard Assay method and apparatus with reduced sample matrix effects
US7611908B2 (en) * 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
US7300631B2 (en) 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
US7648844B2 (en) * 2005-05-02 2010-01-19 Bioscale, Inc. Method and apparatus for detection of analyte using an acoustic device
US7749445B2 (en) * 2005-05-02 2010-07-06 Bioscale, Inc. Method and apparatus for analyzing bioprocess fluids
KR101385384B1 (ko) * 2005-06-03 2014-04-14 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 단일 패러데이 전극에서의 전기발생 화학발광 및 전기화학
WO2006138284A2 (en) 2005-06-15 2006-12-28 Callida Genomics, Inc. Nucleic acid analysis by random mixtures of non-overlapping fragments
US20070116600A1 (en) * 2005-06-23 2007-05-24 Kochar Manish S Detection device and methods associated therewith
US8227261B2 (en) * 2005-11-23 2012-07-24 Bioscale, Inc. Methods and apparatus for assay measurements
US20080118402A1 (en) * 2006-11-21 2008-05-22 David Brancazio Method and apparatus for analyte processing
US8202491B2 (en) 2006-11-21 2012-06-19 Bioscale, Inc. Apparatus for analyte processing
US8026071B2 (en) * 2007-03-12 2011-09-27 Fabrico Technology, Inc. Systems and methods for detecting target analytes
JP2010525326A (ja) * 2007-04-19 2010-07-22 ウェルスタット バイオロジックス コーポレイション 分離されていない循環癌細胞由来のＨｅｒ−２／ｎｅｕタンパク質の上昇したレベルの検出および治療
US7635566B2 (en) 2007-06-29 2009-12-22 Population Genetics Technologies Ltd. Methods and compositions for isolating nucleic acid sequence variants
WO2009033056A1 (en) * 2007-09-06 2009-03-12 Bioscale, Inc. Reusable detection surfaces and methods of using same
US8397762B2 (en) * 2008-02-04 2013-03-19 Bioscale, Inc. Fluidic system with improved flow characteristics
JP2009222533A (ja) 2008-03-17 2009-10-01 Hitachi High-Technologies Corp 自動分析装置
SI2271938T1 (sl) 2008-04-11 2014-07-31 Board Of Regents Of The University Of Texas System Postopek in naprava za ojačenje električno generirane kemiluminiscence nanodelcev
EP2626693A3 (de) 2008-05-08 2014-10-01 Board of Regents of the University of Texas System Nanostrukturierte lumineszente Materialien zur Verwendung in elektrogenerierter Chemolumineszenz
WO2011100358A2 (en) * 2010-02-09 2011-08-18 Fabrico Technology, Inc. Systems and methods for detecting target analytes
US9557326B2 (en) 2010-06-09 2017-01-31 Hitachi High-Technologies Corporation Sample analyzing device and sample analyzing method
CN101957322B (zh) * 2010-08-17 2012-01-11 中国科学院苏州纳米技术与纳米仿生研究所 一种用于电化学发光检测的流通池及其系统
US8941966B2 (en) 2010-09-17 2015-01-27 Koninklijke Philips N.V. Magnetic system for particle attraction in a plurality of chambers
WO2012051476A1 (en) 2010-10-15 2012-04-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Mid-infrared imaging of microarrays
WO2013099648A1 (ja) * 2011-12-28 2013-07-04 株式会社 日立ハイテクノロジーズ 試料分析装置及び試料分析方法
US9791465B2 (en) * 2012-02-22 2017-10-17 Hitachi High-Technologies Corporation Automatic analyzer
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9081001B2 (en) 2012-05-15 2015-07-14 Wellstat Diagnostics, Llc Diagnostic systems and instruments
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
CN103048314A (zh) * 2012-10-25 2013-04-17 宁波大学 一种负载量子点包被纳米金介孔材料构建的电化学发光免疫传感器及对hiv的检测方法
JP6239243B2 (ja) * 2013-02-08 2017-11-29 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 自動分析装置
ES2911684T3 (es) 2014-02-21 2022-05-20 Harvard College Diseño de novo de proteínas alostéricas
EP2977765A1 (de) * 2014-07-23 2016-01-27 Roche Diagniostics GmbH Probenbehälterträger, Laborprobenverteilungssystem und Laborautomatisierungssystem
US9663780B2 (en) 2014-10-15 2017-05-30 Alpaqua Engineering, LLC Solid-core ring-magnet
EP3093071A1 (de) 2015-05-11 2016-11-16 Roche Diagniostics GmbH Reagenzglasträger
EP3211426A1 (de) 2016-02-25 2017-08-30 Roche Diagnostics GmbH Probenbehälterträger
JP6731815B2 (ja) * 2016-09-08 2020-07-29 株式会社日立ハイテク 自動分析装置
WO2019190954A1 (en) 2018-03-26 2019-10-03 Rootpath Genomics, Inc. Target binding moiety compositions and methods of use
US11242519B2 (en) 2018-08-23 2022-02-08 Alpaqua Engineering, LLC Discontinuous wall hollow core magnet
US11951476B2 (en) * 2020-11-19 2024-04-09 Rutgers, The State University Of New Jersey Electronic-sensing and magnetic-modulation (ESMM) biosensor for phagocytosis quantification in pathogenic infections and methods of use thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2650528A1 (de) * 1976-11-04 1978-05-18 Kloeckner Humboldt Deutz Ag Magnetscheider
GB2053576A (en) * 1979-06-19 1981-02-04 Coin Controls Magnet holder
US4554088A (en) * 1983-05-12 1985-11-19 Advanced Magnetics Inc. Magnetic particles for use in separations
US4628037A (en) * 1983-05-12 1986-12-09 Advanced Magnetics, Inc. Binding assays employing magnetic particles
US4695393A (en) * 1983-05-12 1987-09-22 Advanced Magnetics Inc. Magnetic particles for use in separations
US4698302A (en) * 1983-05-12 1987-10-06 Advanced Magnetics, Inc. Enzymatic reactions using magnetic particles
US4695392A (en) * 1983-05-12 1987-09-22 Advanced Magnetics Inc. Magnetic particles for use in separations
US4518627A (en) * 1984-09-04 1985-05-21 Polaroid Corporation Apparatus and method for disorienting magnetic particles in magnetic recording media
US5238808A (en) * 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
DE3582649D1 (de) * 1984-11-01 1991-05-29 Technicon Instr Magnetisch empfindlicher reagenstraeger und verfahren zur herstellung.
US5147806A (en) * 1988-04-29 1992-09-15 Igen, Inc. Method and apparatus for conducting electrochemiluminescence measurements
EP0674176B1 (de) * 1987-11-04 2004-02-04 Igen International, Inc. Lumineszente Rhenium-Komplexe und Verfahren zur Herstellung
WO1990005301A1 (en) * 1988-11-03 1990-05-17 Igen, Inc. Electrochemiluminescent assays
IL100867A (en) * 1991-02-06 1995-12-08 Igen Inc Method and device for improved luminescence testing
IL100866A (en) * 1991-02-06 1995-10-31 Igen Inc Luminescence test method and device based on magnetic tiny particles, containing many magnets
CA2112675C (en) * 1991-07-10 2007-03-20 Richard J. Massey Methods and apparatus for improved luminescence assays using particle concentration and chemiluminescence detection
US5250084A (en) * 1992-07-28 1993-10-05 C Four Pty. Ltd. Abrasive tools and process of manufacture
JP2578712B2 (ja) * 1992-11-13 1997-02-05 株式会社トミー精工 蒸気滅菌器
DE19501916A1 (de) * 1994-01-24 1995-07-27 Hitachi Ltd Verfahren und Analysator zum Immuntest unter Verwendung magnetischer Teilchen
US5744367A (en) * 1994-11-10 1998-04-28 Igen International, Inc. Magnetic particle based electrochemiluminescent detection apparatus and method
US5781005A (en) * 1995-06-07 1998-07-14 Allegro Microsystems, Inc. Hall-effect ferromagnetic-article-proximity sensor

Also Published As

Publication number Publication date
DE69535223T2 (de) 2007-09-20
AU4501596A (en) 1996-06-06
EP0871864A1 (de) 1998-10-21
JP2006184294A (ja) 2006-07-13
ATE339682T1 (de) 2006-10-15
ES2273339T3 (es) 2007-05-01
WO1996015440A1 (en) 1996-05-23
EP0871864A4 (de) 1999-02-10
JPH10509798A (ja) 1998-09-22
US5744367A (en) 1998-04-28
US6133043A (en) 2000-10-17
EP0871864B1 (de) 2006-09-13

Similar Documents

Publication Publication Date Title
ATE339682T1 (de) Verfahren und vorrichtung zur elektrochemilumineszenz-detektion magnetischer partikeln
DE60214674D1 (de) Verfahren und vorrichtung zur detektion und messung von anhäufungen magnetischer teilchen
ATE357663T1 (de) Teilchenförmiges markierungsmittel verwendendes analytassay
DE69117942D1 (de) Verfahren und vorrichtung zur optischen messung der konzentration eines analyten
DE69425321D1 (de) Vorrichtung zum erfassen von verfälschten dokumenten
SE9201089D0 (sv) Detektorer foer separationsprocesser
DE3852108D1 (de) Vorrichtung und verfahren zur optischen messung der konzentration an material.
ATE146603T1 (de) Vorrichtung zur prüfung von mit magnetischen eigenschaften ausgestatteten messobjekten
ATE186783T1 (de) Verfahren und system zur altlastendetektion
DE3850651T2 (de) Vorrichtung und verfahren zur schnellen detektion von bildfehlehrn.
DE69112090D1 (de) Verfahren und Vorrichtung zur Messung von Musterdimensionen.
DE69712614T2 (de) Magnetische partikel, substrat solche partikel enthaltend, sicherheitsdokument und methode zur erfassung solcher partikel
EP0814342A3 (de) Detektionsgerät für magnetische Substanze in minimaler Menge in untersuchten langen Gegenständen
DE3863245D1 (de) Verfahren und vorrichtung zur optischen messung von teilchenabmessungen in weiten wertebereichen.
CA2122070A1 (en) Method and apparatus for detecting magnetic discontinuities in a sample of magnetizable material
ATE100204T1 (de) Verfahren und vorrichtung zur messung der chemilumineszenz.
DE60039323D1 (de) Verfahren und Vorrichtung zur Messung des von einer beleuchteten Probe ausgehenden Lichts mit Eliminierung des Einflusses von Hintergrundlicht
DE69115176T2 (de) Verfahren und Vorrichtung zur Messung und zur Anzeige von magnetischen Feldern.
JPH0293394A (ja) 金属検出機
DE3860234D1 (de) Geraet zur ermittlung von kernmagnetischen spektren aus raeumlich selektierbaren bereichen eines untersuchungsobjektes.
DE69409671D1 (de) Verfahren und vorrichtung zur magnetischen kontrolle metallischer produkte
DE69518504T2 (de) Detektion von verunreinigungen in metallagglomeraten
DE3869651D1 (de) Vorrichtung zur detektion des gehaltes an ferromagnetischen partikeln eines fluidums.
DE3784702T2 (de) Verfahren und vorrichtung zum nachweis und zur mengenbestimmung von bakterien.
DE69735319D1 (de) Methode zur Verbesserung der Empfindlichkeit und Linearität eines Elektroneneinfangdetektors und entsprechende Vorrichtung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition