DE69534472D1 - Transkriptionsmodulatoren tetracyklin-regulierte - Google Patents
Transkriptionsmodulatoren tetracyklin-regulierteInfo
- Publication number
- DE69534472D1 DE69534472D1 DE69534472T DE69534472T DE69534472D1 DE 69534472 D1 DE69534472 D1 DE 69534472D1 DE 69534472 T DE69534472 T DE 69534472T DE 69534472 T DE69534472 T DE 69534472T DE 69534472 D1 DE69534472 D1 DE 69534472D1
- Authority
- DE
- Germany
- Prior art keywords
- tet operator
- tetracycline
- analogue
- absence
- genes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/20—Animal model comprising regulated expression system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
- C12N2830/003—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor tet inducible
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/005—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/005—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB
- C12N2830/006—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB tet repressible
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/32—Vector systems having a special element relevant for transcription being an silencer not forming part of the promoter region
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27063794A | 1994-07-01 | 1994-07-01 | |
US08/275,876 US5654168A (en) | 1994-07-01 | 1994-07-15 | Tetracycline-inducible transcriptional activator and tetracycline-regulated transcription units |
US08/383,754 US5789156A (en) | 1993-06-14 | 1995-02-03 | Tetracycline-regulated transcriptional inhibitors |
US08/486,814 US5866755A (en) | 1993-06-14 | 1995-06-07 | Animals transgenic for a tetracycline-regulated transcriptional inhibitor |
PCT/US1995/008179 WO1996001313A1 (en) | 1994-07-01 | 1995-06-29 | Tetracycline-regulated transcriptional modulators |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69534472D1 true DE69534472D1 (de) | 2006-02-02 |
DE69534472T2 DE69534472T2 (de) | 2006-06-14 |
Family
ID=27501005
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE0804565T Pending DE804565T1 (de) | 1994-07-01 | 1995-06-29 | Transkriptionsmodulatoren tetracyklin-regulierte |
DE69534472T Expired - Lifetime DE69534472T2 (de) | 1994-07-01 | 1995-06-29 | Transkriptionsmodulatoren tetracyklin-regulierte |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE0804565T Pending DE804565T1 (de) | 1994-07-01 | 1995-06-29 | Transkriptionsmodulatoren tetracyklin-regulierte |
Country Status (13)
Country | Link |
---|---|
US (2) | US5866755A (de) |
EP (2) | EP0804565B1 (de) |
JP (3) | JP4054058B2 (de) |
CN (2) | CN1523112A (de) |
AT (1) | ATE305034T1 (de) |
AU (1) | AU3092395A (de) |
CA (1) | CA2193122C (de) |
DE (2) | DE804565T1 (de) |
DK (1) | DK0804565T3 (de) |
ES (1) | ES2139552T3 (de) |
FI (1) | FI965287A (de) |
NO (1) | NO315375B1 (de) |
WO (1) | WO1996001313A1 (de) |
Families Citing this family (110)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5888981A (en) | 1993-06-14 | 1999-03-30 | Basf Aktiengesellschaft | Methods for regulating gene expression |
US5859310A (en) | 1993-06-14 | 1999-01-12 | Basf Aktiengesellschaft | Mice transgenic for a tetracycline-controlled transcriptional activator |
AU684524B2 (en) | 1993-06-14 | 1997-12-18 | Tet Systems Holding Gmbh & Co. Kg | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters |
US5912411A (en) * | 1993-06-14 | 1999-06-15 | University Of Heidelberg | Mice transgenic for a tetracycline-inducible transcriptional activator |
US5589362A (en) * | 1993-06-14 | 1996-12-31 | Basf Aktiengesellschaft | Tetracycline regulated transcriptional modulators with altered DNA binding specificities |
FR2732348B1 (fr) * | 1995-03-31 | 1997-04-30 | Rhone Poulenc Rorer Sa | Systeme d'expression conditionnel |
US5851796A (en) * | 1995-06-07 | 1998-12-22 | Yale University | Autoregulatory tetracycline-regulated system for inducible gene expression in eucaryotes |
FR2735789B1 (fr) * | 1995-06-23 | 1997-07-25 | Centre Nat Rech Scient | Adenovirus recombinants, leur utilisation pour preparer des aav, lignee cellulaire complementaire et compositions pharmaceutiques les contenant |
GB9526509D0 (en) * | 1995-12-23 | 1996-02-28 | Univ Dundee | Gene control |
DE19635568C1 (de) * | 1996-09-02 | 1998-03-26 | Gsf Forschungszentrum Umwelt | Vektorsysteme zur konditionalen Genexpression |
WO1998013502A2 (en) * | 1996-09-27 | 1998-04-02 | Icos Corporation | Method to identify compounds for disrupting protein/protein interactions |
US7008776B1 (en) | 1996-12-06 | 2006-03-07 | Aventis Pharmaceuticals Inc. | Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol |
WO1998037185A2 (en) * | 1997-02-20 | 1998-08-27 | The Board Of Regents Of The University Of Texas System | Vectors for controlled gene expression |
DE19707493C1 (de) * | 1997-02-25 | 1998-02-26 | Univ Ludwigs Albert | Nucleinsäurekonstrukte zur lang andauernden Expression von Transgenen |
AU745049B2 (en) | 1997-03-11 | 2002-03-07 | Regents Of The University Of Minnesota | DNA-based transposon system for the introduction of nucleic acid into DNA of a cell |
PL336523A1 (en) | 1997-04-28 | 2000-07-03 | Rhone Poulenc Rorer Sa | Intraneoplastic delivery of an angiogenesis antagonist by means of adenoviruses in order to treat neoplasms |
US6087166A (en) * | 1997-07-03 | 2000-07-11 | Basf Aktiengesellschaft | Transcriptional activators with graded transactivation potential |
US20030040038A1 (en) * | 1997-08-22 | 2003-02-27 | Steven F. Dowdy | Inducible regulatory system and use thereof |
US5885779A (en) * | 1997-09-09 | 1999-03-23 | University Of British Columbia | Repressed trans-activator system for characterization of protein-protein interactions |
US6576469B1 (en) | 1997-09-10 | 2003-06-10 | President And Fellows Of Harvard College | Inducible methods for repressing gene function |
CA2306448A1 (en) | 1997-10-16 | 1999-04-22 | Board Of Regents, The University Of Texas System | Models and treatments for cardiac hypertrophy in relation with nf-at3 function |
EP1721986A1 (de) * | 1997-10-29 | 2006-11-15 | Genetics Institute, LLC | Schnellerzeugung von stabilen Säugertier-Zelllinien mit Gewinnung eines hohen Gehalts von rekombinanten Proteinen |
US6136536A (en) * | 1997-10-29 | 2000-10-24 | Genetics Institute, Inc. | Rapid generation of stable mammalian cell lines producing high levels of recombinant proteins |
US5968773A (en) * | 1997-11-14 | 1999-10-19 | Heddle; John A. | System and method for regulation of gene expression |
ES2308327T3 (es) * | 1997-11-18 | 2008-12-01 | Pioneer Hi-Bred International, Inc. | Composiciones y metodos para modificacion genetica de plantas. |
DE19751587A1 (de) | 1997-11-21 | 1999-07-29 | Hoechst Marion Roussel De Gmbh | Onkogen- oder virusgesteuerte Expressionssysteme |
US6153383A (en) | 1997-12-09 | 2000-11-28 | Verdine; Gregory L. | Synthetic transcriptional modulators and uses thereof |
DE19756975A1 (de) | 1997-12-20 | 1999-06-24 | Hoechst Marion Roussel De Gmbh | Bindungspartner für Inhibitoren von cyclinabhängigen Kinasen und ihre Verwendung zur Suche nach Inhibitoren, zur Diagnose oder zur Therapie einer Erkrankung |
DE69926729T2 (de) | 1998-01-08 | 2006-06-08 | Aventis Pharmaceuticals Inc. | Transgenes kaninchen, dass ein funktionelles menschliches lipoprotein(a) exprimiert |
JP2002508972A (ja) * | 1998-01-16 | 2002-03-26 | ファルマシア・アンド・アップジョン・カンパニー | テトラサイクリン−制御可能なエレメントを用いる可能な抗微生物標的としての微生物遺伝子を確認するための自律制御系 |
US6878516B1 (en) | 1998-01-16 | 2005-04-12 | Pharmacia & Upjohn Company | Autoregulatory system for validating microbial genes as possible antimicrobial targets using a tetracycline-controllable element |
US7160682B2 (en) | 1998-11-13 | 2007-01-09 | Regents Of The University Of Minnesota | Nucleic acid transfer vector for the introduction of nucleic acid into the DNA of a cell |
EP1151119A1 (de) * | 1999-02-09 | 2001-11-07 | Rhobio | Verfahren zur hemmung der expression von zielgenen in pflanzen |
US6291226B1 (en) | 1999-02-25 | 2001-09-18 | National Research Council Of Canada | Adenovirus mutants with deleted protease gene |
US6890726B1 (en) | 1999-04-06 | 2005-05-10 | Oklahoma Medical Research Foundation | Method for selecting recombinase variants with altered specificity |
US6287813B1 (en) | 1999-04-23 | 2001-09-11 | Cistronics Cell Technology Gmbh | Antibiotic-based gene regulation system |
WO2000068399A2 (en) * | 1999-05-11 | 2000-11-16 | Regents Of The University Of Minnesota | Vector-mediated delivery of integrating transposon sequences |
WO2001000815A1 (en) * | 1999-05-28 | 2001-01-04 | Sangamo Biosciences, Inc. | Molecular switches |
WO2000075347A2 (en) * | 1999-06-07 | 2000-12-14 | Wolfgang Hillen | Tet repressor-based transcriptional regulatory proteins |
JP4896327B2 (ja) | 1999-08-23 | 2012-03-14 | ダナ−ファーバー キャンサー インスティテュート,インコーポレイテッド | Pd−1、b7−4の受容体、およびその使用 |
AU784883B2 (en) | 1999-12-30 | 2006-07-20 | President And Fellows Of Harvard College | Methods and compositions relating to modulation of hepatocyte growth, plasma cell differentiation or T cell subset activity by modulation of XBP-1 activity |
WO2001088192A2 (en) | 2000-05-12 | 2001-11-22 | The Johns Hopkins University | A method for generating hypermutable organisms |
US20040204379A1 (en) * | 2000-06-19 | 2004-10-14 | Cheng Seng H. | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
FR2811681A1 (fr) * | 2000-07-17 | 2002-01-18 | Commissariat Energie Atomique | Procede de criblage de la translocation nucleo-cytoplasmique de proteines sous l'effet d'un stimulus, d'elements y etant impliques et kits de mise en oeuvre |
JP2004505647A (ja) * | 2000-08-18 | 2004-02-26 | ジヤンセル・エス・アー | 条件的阻害によるトランスジーンの発現をインビボで調節する方法 |
FR2813085A1 (fr) * | 2000-08-18 | 2002-02-22 | Aventis Pharma Sa | Systeme de regulation in vivo de l'expression d'un transgene par inhibition conditionnelle |
FR2814642B1 (fr) | 2000-10-03 | 2005-07-01 | Ass Pour Le Dev De La Rech En | Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee |
US7129343B2 (en) * | 2001-02-13 | 2006-10-31 | University Of Florida | Bi-directional dual promoter complex with enhanced promoter activity for transgene expression in eukaryotes |
WO2002079499A1 (en) | 2001-04-02 | 2002-10-10 | Wyeth | Pd-1, a receptor for b7-4, and uses therefor |
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1995
- 1995-06-07 US US08/486,814 patent/US5866755A/en not_active Expired - Lifetime
- 1995-06-29 CN CNA2003101143911A patent/CN1523112A/zh active Pending
- 1995-06-29 ES ES95926605T patent/ES2139552T3/es not_active Expired - Lifetime
- 1995-06-29 DE DE0804565T patent/DE804565T1/de active Pending
- 1995-06-29 AT AT95926605T patent/ATE305034T1/de not_active IP Right Cessation
- 1995-06-29 DK DK95926605T patent/DK0804565T3/da active
- 1995-06-29 AU AU30923/95A patent/AU3092395A/en not_active Abandoned
- 1995-06-29 WO PCT/US1995/008179 patent/WO1996001313A1/en active IP Right Grant
- 1995-06-29 EP EP95926605A patent/EP0804565B1/de not_active Expired - Lifetime
- 1995-06-29 JP JP50391596A patent/JP4054058B2/ja not_active Expired - Lifetime
- 1995-06-29 EP EP00204031A patent/EP1092771B1/de not_active Expired - Lifetime
- 1995-06-29 CA CA002193122A patent/CA2193122C/en not_active Expired - Lifetime
- 1995-06-29 DE DE69534472T patent/DE69534472T2/de not_active Expired - Lifetime
- 1995-06-29 CN CN95194899.7A patent/CN1167504A/zh active Pending
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- 1996-12-30 NO NO19965623A patent/NO315375B1/no not_active IP Right Cessation
- 1996-12-31 FI FI965287A patent/FI965287A/fi not_active Application Discontinuation
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- 1999-02-02 US US09/241,347 patent/US20040003417A1/en not_active Abandoned
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- 2007-08-20 JP JP2007214003A patent/JP4682176B2/ja not_active Expired - Lifetime
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JPH11506901A (ja) | 1999-06-22 |
ATE305034T1 (de) | 2005-10-15 |
DK0804565T3 (da) | 2006-02-06 |
WO1996001313A1 (en) | 1996-01-18 |
US5866755A (en) | 1999-02-02 |
JP2007295938A (ja) | 2007-11-15 |
EP1092771A3 (de) | 2001-08-01 |
US20040003417A1 (en) | 2004-01-01 |
EP0804565A1 (de) | 1997-11-05 |
CN1523112A (zh) | 2004-08-25 |
JP2008011862A (ja) | 2008-01-24 |
FI965287A0 (fi) | 1996-12-31 |
EP0804565B1 (de) | 2005-09-21 |
DE69534472T2 (de) | 2006-06-14 |
NO315375B1 (no) | 2003-08-25 |
DE804565T1 (de) | 2000-05-04 |
NO965623D0 (no) | 1996-12-30 |
ES2139552T3 (es) | 2006-04-16 |
JP4820344B2 (ja) | 2011-11-24 |
CN1167504A (zh) | 1997-12-10 |
JP4682176B2 (ja) | 2011-05-11 |
EP1092771A2 (de) | 2001-04-18 |
ES2139552T1 (es) | 2000-02-16 |
JP4054058B2 (ja) | 2008-02-27 |
NO965623L (no) | 1997-02-28 |
CA2193122A1 (en) | 1996-01-18 |
EP1092771B1 (de) | 2012-12-12 |
CA2193122C (en) | 2005-08-23 |
AU3092395A (en) | 1996-01-25 |
FI965287A (fi) | 1997-02-28 |
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