DE69534064D1 - Monoklonale antikörper die die remyelinisierung des zentralnervensystems fördern - Google Patents

Monoklonale antikörper die die remyelinisierung des zentralnervensystems fördern

Info

Publication number
DE69534064D1
DE69534064D1 DE69534064T DE69534064T DE69534064D1 DE 69534064 D1 DE69534064 D1 DE 69534064D1 DE 69534064 T DE69534064 T DE 69534064T DE 69534064 T DE69534064 T DE 69534064T DE 69534064 D1 DE69534064 D1 DE 69534064D1
Authority
DE
Germany
Prior art keywords
nervous system
central nervous
promote
remyelinisation
monoclonal antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69534064T
Other languages
English (en)
Other versions
DE69534064T2 (de
Inventor
Moses Rodriguez
J Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mayo Foundation for Medical Education and Research
Original Assignee
Mayo Foundation for Medical Education and Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayo Foundation for Medical Education and Research filed Critical Mayo Foundation for Medical Education and Research
Publication of DE69534064D1 publication Critical patent/DE69534064D1/de
Application granted granted Critical
Publication of DE69534064T2 publication Critical patent/DE69534064T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/863—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgM

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69534064T 1994-04-29 1995-04-27 MONOKLONALE ANTIKÖRPER zur FÖRDERung DER Remyelinisierung des zentralen Nervensystems Expired - Lifetime DE69534064T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US236520 1994-04-29
US08/236,520 US5591629A (en) 1994-04-29 1994-04-29 Monoclonal antibodies which promote central nervous system remyelination
PCT/US1995/005262 WO1995030004A1 (en) 1994-04-29 1995-04-27 Monoclonal antibodies which promote central nervous system remyelination

Publications (2)

Publication Number Publication Date
DE69534064D1 true DE69534064D1 (de) 2005-04-14
DE69534064T2 DE69534064T2 (de) 2006-01-12

Family

ID=22889861

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69534064T Expired - Lifetime DE69534064T2 (de) 1994-04-29 1995-04-27 MONOKLONALE ANTIKÖRPER zur FÖRDERung DER Remyelinisierung des zentralen Nervensystems

Country Status (13)

Country Link
US (1) US5591629A (de)
EP (1) EP0801679B1 (de)
JP (1) JP3789472B2 (de)
KR (1) KR100406551B1 (de)
CN (1) CN1152939A (de)
AT (1) ATE290597T1 (de)
AU (1) AU699724B2 (de)
CA (1) CA2188919C (de)
DE (1) DE69534064T2 (de)
ES (1) ES2238073T3 (de)
MX (1) MX9605257A (de)
NZ (1) NZ284757A (de)
WO (1) WO1995030004A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7473423B2 (en) 1994-04-29 2009-01-06 Mayo Foundation For Medical Education And Research Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system
AU4373197A (en) * 1996-09-19 1998-04-14 Diagnocure Inc. Recombinant single chain antibodies directed against the gp54 cancer marker, composition comprising same and use thereof
AU740904B2 (en) * 1997-03-20 2001-11-15 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Recombinant antibodies and immunoconjugates targeted to CD-22 bearing cells and tumors
ES2527760T3 (es) * 1998-07-23 2015-01-29 Yeda Research And Development Co., Ltd. Tratamiento de enfermedad de Crohn con copolímero 1 y polipéptidos
WO2000005250A1 (en) 1998-07-23 2000-02-03 Yeda Research And Development Co., Ltd Treatment of autoimmune conditions with copolymer 1 and related copolymers and peptides
US6800287B2 (en) * 1998-09-25 2004-10-05 Yeda Research And Development Co., Ltd. Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
ZA200206457B (en) * 2000-02-18 2003-08-13 Yeda Res & Dev Oral, nasal and pulmonary dosage formulations of copolymer 1.
JP5670608B2 (ja) 2000-05-10 2015-02-18 メイヨ ファンデーション フォア メディカル エディケイション アンド リサーチ 髄鞘再形成を誘導する能力を有するヒトＩｇＭ抗体、および、特に中枢神経系における、その診断使用及び治療使用
US20020077278A1 (en) * 2000-06-05 2002-06-20 Yong V. Wee Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders
WO2002076503A1 (en) * 2000-06-20 2002-10-03 Mayo Foundation For Medical Education And Research Treatment of central nervous system diseases by antibodies against glatiramer acetate
SI1459065T1 (sl) 2001-12-04 2010-11-30 Teva Pharma Postopki za merjenje potentnosti glatiramer acetata
DE10212108A1 (de) * 2002-03-13 2003-10-02 Tegenero Ag Verwendung einer an CD28 bindenden Wirksubstanz zur Herstellung einer pharmazeutischen Zusammensetzung
US7052694B2 (en) * 2002-07-16 2006-05-30 Mayo Foundation For Medical Education And Research Dendritic cell potentiation
WO2004110355A2 (en) * 2003-05-16 2004-12-23 Mayo Foundation For Medical Education & Research Compositions and methods including a recombinant human mab that promotes cns remyelination
US7582261B2 (en) * 2003-11-18 2009-09-01 Sharp Kabuhsiki Kaisha Electricity supplying device, electricity supplying apparatus, sample detection device, and sample detection apparatus
US20050130177A1 (en) * 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
US7501119B2 (en) * 2004-06-30 2009-03-10 Mayo Foundation For Medical Education And Research Methods and molecules for modulating an immune response
US20060099203A1 (en) 2004-11-05 2006-05-11 Pease Larry R B7-DC binding antibody
US8445008B2 (en) * 2008-10-17 2013-05-21 Medtronic, Inc. Reduction of infection associated with medical device
EP2701723B1 (de) 2011-04-28 2017-08-30 Mayo Foundation For Medical Education And Research Dna-aptamere zur remyelinisierungsförderung
SG10201708048XA (en) 2013-03-18 2017-10-30 Biocerox Prod Bv Humanized anti-cd134 (ox40) antibodies and uses thereof
US11242398B2 (en) 2017-08-01 2022-02-08 Remd Biotherapeutics, Inc. Anti-OX40 antibodies and methods of activating OX40

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992004442A1 (en) * 1990-09-07 1992-03-19 The Regents Of The University Of California Glial antiproliferative proteins

Also Published As

Publication number Publication date
ES2238073T3 (es) 2005-08-16
NZ284757A (en) 1997-07-27
ATE290597T1 (de) 2005-03-15
CA2188919C (en) 2010-04-06
JP3789472B2 (ja) 2006-06-21
EP0801679A1 (de) 1997-10-22
EP0801679B1 (de) 2005-03-09
CN1152939A (zh) 1997-06-25
JPH10503479A (ja) 1998-03-31
WO1995030004A1 (en) 1995-11-09
US5591629A (en) 1997-01-07
AU699724B2 (en) 1998-12-10
DE69534064T2 (de) 2006-01-12
AU2399095A (en) 1995-11-29
KR100406551B1 (ko) 2004-05-20
MX9605257A (es) 1997-09-30
CA2188919A1 (en) 1995-11-09
KR970702918A (ko) 1997-06-10

Similar Documents

Publication Publication Date Title
ATE290597T1 (de) Monoklonale antikörper die die remyelinisierung des zentralnervensystems fördern
ATE143376T1 (de) Gegen die beta-kette des leukozyten-adhäsions- rezeptors gerichtete monoklonale antikörper, verfahren zu ihrer herstellung und ihre verwendung
IT1286169B1 (it) Dispositivo separatore bloccabile di un cinghietto,utilizzabile con caschi da bicicletta e simili.
DE69509975T2 (de) Ferritträger für elektrophotographische Entwickler, und Entwickler die Träger enthaltend
CA2021594A1 (en) Antibody to human interleukin-6 receptor
MY104946A (en) Antigen antibody conjugate.
EP0811013A4 (de) Isolierte nonapeptide welche durch hla-molecule presentiert werden und deren anwendungen
DE69806658D1 (de) Vorrichtung für die Reformierung von Kraftstoffen
EP0679660A4 (de) Monoklonaler antikörper gegen tyrosinase aus mensche
DE69603656D1 (de) Gasdichte Sekundärzelle
NZ331299A (en) Antibody variants with reduced affinity for a cell-surface antigen
UA50708C2 (uk) Моноклональне антитіло, яке має здатність розпізнавати антиген, який викликає апоптоз мієлоїдних клітин, фрагмент f(ab)2 моноклонального антитіла, гібридома ferm bp-4382
BR9710450A (pt) Anticorpo passivamente administrado que intensifica a eficiencia de conversÆo de alimenta-Æo
HUP9801223A3 (en) Method for enhancing the antibody response to specific antigens with interleukin-10
DE19681475T1 (de) Schultergurtsystem mit gesteuerter Kraft
TR199501668A2 (tr) Gelistirilmis cocuk bezi tespit dili.
EP0727046A4 (de) Transfizierte zelllinien die autoantigene exprimieren und ihre verwendung in immunotests zur erkennung von autoimmunkrankheiten
FR2683491B1 (fr) Convertisseur d'energie pour ceinture de securite.
DE69838646D1 (de) Isolierte decapeptide, die an hla moleküle binden, sowie deren verwendung
NO972522D0 (no) Monoklonale antistoffer med immunoundertrykkende aktivitet
DE3850993T2 (de) Monoklonaler Antikörper spezifisch gegen humane Pankreas-Phospholipase-A2.
DE3851855D1 (de) Gegen die Gamma-Kette des T-Zell-Rezeptors gerichteter monoklonaler Antikörper.
KR960033677U (ko) 펫트병·캔 겸용 압축 전처리 장치
Newman Regenerative abysses, reflective myopias, and the assassination of Oscar Romero: A Turnerian analysis of social drama and the development of anti-systemic religious paradigms during the Salvadoran rebellion
DE59607033D1 (de) Lastabhängiger Bremskraftregler

Legal Events

Date Code Title Description
8364 No opposition during term of opposition