ATE290597T1 - Monoklonale antikörper die die remyelinisierung des zentralnervensystems fördern - Google Patents

Monoklonale antikörper die die remyelinisierung des zentralnervensystems fördern

Info

Publication number
ATE290597T1
ATE290597T1 AT95917195T AT95917195T ATE290597T1 AT E290597 T1 ATE290597 T1 AT E290597T1 AT 95917195 T AT95917195 T AT 95917195T AT 95917195 T AT95917195 T AT 95917195T AT E290597 T1 ATE290597 T1 AT E290597T1
Authority
AT
Austria
Prior art keywords
nervous system
central nervous
promote
remyelinization
monoclonal antibodies
Prior art date
Application number
AT95917195T
Other languages
English (en)
Inventor
Moses Rodriguez
David J Miller
Original Assignee
Mayo Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayo Foundation filed Critical Mayo Foundation
Application granted granted Critical
Publication of ATE290597T1 publication Critical patent/ATE290597T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/863—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgM

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT95917195T 1994-04-29 1995-04-27 Monoklonale antikörper die die remyelinisierung des zentralnervensystems fördern ATE290597T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/236,520 US5591629A (en) 1994-04-29 1994-04-29 Monoclonal antibodies which promote central nervous system remyelination
PCT/US1995/005262 WO1995030004A1 (en) 1994-04-29 1995-04-27 Monoclonal antibodies which promote central nervous system remyelination

Publications (1)

Publication Number Publication Date
ATE290597T1 true ATE290597T1 (de) 2005-03-15

Family

ID=22889861

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95917195T ATE290597T1 (de) 1994-04-29 1995-04-27 Monoklonale antikörper die die remyelinisierung des zentralnervensystems fördern

Country Status (13)

Country Link
US (1) US5591629A (de)
EP (1) EP0801679B1 (de)
JP (1) JP3789472B2 (de)
KR (1) KR100406551B1 (de)
CN (1) CN1152939A (de)
AT (1) ATE290597T1 (de)
AU (1) AU699724B2 (de)
CA (1) CA2188919C (de)
DE (1) DE69534064T2 (de)
ES (1) ES2238073T3 (de)
MX (1) MX9605257A (de)
NZ (1) NZ284757A (de)
WO (1) WO1995030004A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7473423B2 (en) * 1994-04-29 2009-01-06 Mayo Foundation For Medical Education And Research Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system
AU4373197A (en) * 1996-09-19 1998-04-14 Diagnocure Inc. Recombinant single chain antibodies directed against the gp54 cancer marker, composition comprising same and use thereof
US7541034B1 (en) * 1997-03-20 2009-06-02 The United States Of America As Represented By The Department Of Health And Human Services Recombinant antibodies and immunoconjugates targeted to CD-22 bearing cells and tumors
EP1098902A4 (de) 1998-07-23 2002-07-24 Yeda Res & Dev Behandlung von autoimmunkrankheiten mittels copolymer 1 und ähnlichen copolymeren und peptiden
ES2527760T3 (es) * 1998-07-23 2015-01-29 Yeda Research And Development Co., Ltd. Tratamiento de enfermedad de Crohn con copolímero 1 y polipéptidos
US6800287B2 (en) 1998-09-25 2004-10-05 Yeda Research And Development Co., Ltd. Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
US7022663B2 (en) * 2000-02-18 2006-04-04 Yeda Research And Development Co., Ltd. Oral, nasal and pulmonary dosage formulations of copolymer 1
AU2000261978B2 (en) * 2000-05-10 2006-07-06 Mayo Foundation For Medical Education And Research Human igm antibodies with the capability of inducing remyelination, and diagnostic and therapeutic uses thereof particularly in the central nervous system
US20020077278A1 (en) * 2000-06-05 2002-06-20 Yong V. Wee Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders
WO2002076503A1 (en) * 2000-06-20 2002-10-03 Mayo Foundation For Medical Education And Research Treatment of central nervous system diseases by antibodies against glatiramer acetate
MXPA04005433A (es) 2001-12-04 2004-10-11 Teva Pharma Proceso para la medicion de la potencia de acetato de glatiramero.
DE10212108A1 (de) * 2002-03-13 2003-10-02 Tegenero Ag Verwendung einer an CD28 bindenden Wirksubstanz zur Herstellung einer pharmazeutischen Zusammensetzung
US7052694B2 (en) * 2002-07-16 2006-05-30 Mayo Foundation For Medical Education And Research Dendritic cell potentiation
US8460665B2 (en) * 2003-05-16 2013-06-11 Mayo Foundation For Medical Education And Research Compositions and methods including a recombinant human MAB that promotes CNS remyelination
US7582261B2 (en) * 2003-11-18 2009-09-01 Sharp Kabuhsiki Kaisha Electricity supplying device, electricity supplying apparatus, sample detection device, and sample detection apparatus
US20050130177A1 (en) * 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
US7501119B2 (en) * 2004-06-30 2009-03-10 Mayo Foundation For Medical Education And Research Methods and molecules for modulating an immune response
US20060099203A1 (en) * 2004-11-05 2006-05-11 Pease Larry R B7-DC binding antibody
US8445008B2 (en) * 2008-10-17 2013-05-21 Medtronic, Inc. Reduction of infection associated with medical device
US9150867B2 (en) 2011-04-28 2015-10-06 Mayo Foundation For Medical Education And Research DNA aptamers for promoting remyelination
MD20180107A2 (ro) 2013-03-18 2019-06-30 Biocerox Products B.V. Anticorpi anti-CD134 (OX40) umanizaţi şi utilizarea acestora
US11999778B2 (en) 2016-05-13 2024-06-04 The Board Of Regents Of The University Of Texas System VH4 antibodies and compositions comprising the same
WO2019028182A2 (en) * 2017-08-01 2019-02-07 Remd Biotherapeutics, Inc. TREATMENT OF CANCER USING ANTIBODIES BINDING TO THE HUMAN CD134 RECEPTOR (OX40)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8864691A (en) * 1990-09-07 1992-03-30 Regents Of The University Of California, The Glial antiproliferative proteins

Also Published As

Publication number Publication date
WO1995030004A1 (en) 1995-11-09
EP0801679A1 (de) 1997-10-22
CN1152939A (zh) 1997-06-25
ES2238073T3 (es) 2005-08-16
CA2188919C (en) 2010-04-06
US5591629A (en) 1997-01-07
KR100406551B1 (ko) 2004-05-20
EP0801679B1 (de) 2005-03-09
AU2399095A (en) 1995-11-29
MX9605257A (es) 1997-09-30
DE69534064D1 (de) 2005-04-14
NZ284757A (en) 1997-07-27
CA2188919A1 (en) 1995-11-09
JP3789472B2 (ja) 2006-06-21
KR970702918A (ko) 1997-06-10
AU699724B2 (en) 1998-12-10
DE69534064T2 (de) 2006-01-12
JPH10503479A (ja) 1998-03-31

Similar Documents

Publication Publication Date Title
ATE290597T1 (de) Monoklonale antikörper die die remyelinisierung des zentralnervensystems fördern
ATE143376T1 (de) Gegen die beta-kette des leukozyten-adhäsions- rezeptors gerichtete monoklonale antikörper, verfahren zu ihrer herstellung und ihre verwendung
IT1286169B1 (it) Dispositivo separatore bloccabile di un cinghietto,utilizzabile con caschi da bicicletta e simili.
CA2021594A1 (en) Antibody to human interleukin-6 receptor
MY104946A (en) Antigen antibody conjugate.
EP0811013A4 (de) Isolierte nonapeptide welche durch hla-molecule presentiert werden und deren anwendungen
DE69806658D1 (de) Vorrichtung für die Reformierung von Kraftstoffen
EP0679660A4 (de) Monoklonaler antikörper gegen tyrosinase aus mensche
NO963414L (no) Festestropp
NZ331299A (en) Antibody variants with reduced affinity for a cell-surface antigen
FR2733250B1 (fr) Anticorps monoclonaux anti-gp130, et leurs utilisations
BR9710450A (pt) Anticorpo passivamente administrado que intensifica a eficiencia de conversÆo de alimenta-Æo
DE19681475T1 (de) Schultergurtsystem mit gesteuerter Kraft
TR199501668A2 (tr) Gelistirilmis cocuk bezi tespit dili.
DE69608588D1 (de) Befestigungsvorrichtung für Fahrradsattel
FR2683491B1 (fr) Convertisseur d'energie pour ceinture de securite.
DE69838646D1 (de) Isolierte decapeptide, die an hla moleküle binden, sowie deren verwendung
NO972522D0 (no) Monoklonale antistoffer med immunoundertrykkende aktivitet
DE69611275T2 (de) Reitsattel
EP0670494A3 (de) Immunotest für Anti-Treponema-Pallidum Antikörper.
DE3850993D1 (de) Monoklonaler Antikörper spezifisch gegen humane Pankreas-Phospholipase-A2.
DE3851855D1 (de) Gegen die Gamma-Kette des T-Zell-Rezeptors gerichteter monoklonaler Antikörper.
EP0629857A3 (de) Immunoassay zur quantitativen Bestimmung von Antigenen.
TW288020B (en) Monoclonal antibodies specific to methamphetamine, hybridoma producing the antibodies, kits containing the antibodies and uses thereof
KR960033677U (ko) 펫트병·캔 겸용 압축 전처리 장치

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties