DE69533921D1 - Verfahren zur reduktion von fehlfunktionen des immunsystems und der hämostase während des extrakorporalen kreislaufs - Google Patents

Verfahren zur reduktion von fehlfunktionen des immunsystems und der hämostase während des extrakorporalen kreislaufs

Info

Publication number
DE69533921D1
DE69533921D1 DE69533921T DE69533921T DE69533921D1 DE 69533921 D1 DE69533921 D1 DE 69533921D1 DE 69533921 T DE69533921 T DE 69533921T DE 69533921 T DE69533921 T DE 69533921T DE 69533921 D1 DE69533921 D1 DE 69533921D1
Authority
DE
Germany
Prior art keywords
hemostase
immune system
extracorporeal circulation
during extracorporeal
reducing malfunctions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69533921T
Other languages
English (en)
Other versions
DE69533921T2 (de
Inventor
A Rollins
R Smith
P Squinto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Alexion Pharmaceuticals Inc
Original Assignee
Yale University
Alexion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yale University, Alexion Pharmaceuticals Inc filed Critical Yale University
Publication of DE69533921D1 publication Critical patent/DE69533921D1/de
Application granted granted Critical
Publication of DE69533921T2 publication Critical patent/DE69533921T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3687—Chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69533921T 1994-03-23 1995-03-22 Verfahren zur reduktion von fehlfunktionen des immunsystems und der hämostase während des extrakorporalen kreislaufs Expired - Fee Related DE69533921T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21739194A 1994-03-23 1994-03-23
US217391 1994-03-23
PCT/US1995/003614 WO1995025540A1 (en) 1994-03-23 1995-03-22 Method for reducing immune and hemostatic dysfunctions during extracorporeal circulation

Publications (2)

Publication Number Publication Date
DE69533921D1 true DE69533921D1 (de) 2005-02-17
DE69533921T2 DE69533921T2 (de) 2005-12-01

Family

ID=22810875

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69533921T Expired - Fee Related DE69533921T2 (de) 1994-03-23 1995-03-22 Verfahren zur reduktion von fehlfunktionen des immunsystems und der hämostase während des extrakorporalen kreislaufs

Country Status (7)

Country Link
US (1) US5853722A (de)
EP (1) EP0751787B1 (de)
AU (1) AU2191795A (de)
CA (1) CA2186108A1 (de)
DE (1) DE69533921T2 (de)
ES (1) ES2236706T3 (de)
WO (1) WO1995025540A1 (de)

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ES2252746T3 (es) 1994-09-23 2006-05-16 Alexion Pharmaceuticals, Inc. Procedimientos para el tratamiento de la enfermedad inflamatoria articular.
AU756490B2 (en) 1997-08-26 2003-01-16 Abgenix, Inc. A process for inhibiting complement activation via the alternative pathway
US7112327B2 (en) 1998-02-20 2006-09-26 Tanox, Inc. Inhibition of complement activation
US6956107B2 (en) * 1998-02-20 2005-10-18 Tanox, Inc. Inhibitors of complement activation
EP3056516A1 (de) * 1998-02-20 2016-08-17 Genentech, Inc. Hemmer der komplementär aktivierung
WO1999047190A1 (en) * 1998-03-16 1999-09-23 Medtronic, Inc. Hemostatic system and components for extracorporeal circuit
DE19913707A1 (de) 1999-03-26 2000-10-05 Privates Inst Bioserv Gmbh Immunadsorber zur Sepsistherapie
DE60118362T2 (de) * 2000-05-19 2007-05-24 The Center for Blood Research, Inc., Boston VERFAHREN ZUR BEHANDLUNG VON HÄMOSTATISCHEN STÖRUNGEN DURCH LöSLICHES P-SELECTIN
PT1325033E (pt) * 2000-10-10 2010-04-15 Genentech Inc Inibição da activação do complemento c5 para o tratamento e a prevenção da rejeição diferida de um xenoenxertos ou de uma rejeição vascular aguda
KR100899970B1 (ko) 2001-02-19 2009-05-28 메르크 파텐트 게엠베하 Ｔ-세포 에피토프의 동정 방법 및 감소된 면역원성을 갖는분자의 제조를 위한 용도
CA2454562A1 (en) * 2001-07-26 2003-02-06 Alexion Pharmaceuticals, Inc. Method of improving cognitive function
WO2003012396A2 (en) * 2001-08-01 2003-02-13 Chauhan Anil K Immune complexes
EP3372243A1 (de) 2001-08-17 2018-09-12 Genentech, Inc. Komplement-inhibitoren, die an c5 und c5a binden, ohne die bildung von c5b zu hemmen
ES2283594T5 (es) 2001-08-17 2016-03-15 Genentech, Inc. Inhibidores de la ruta del complemento que se unen a C5 y C5a sin impedir la formación de C5b
JP2006502089A (ja) * 2002-01-22 2006-01-19 アレクシオン ファーマシューティカルズ， インコーポレイテッド 広範囲の心筋梗塞に対する予防方法
US7361339B2 (en) 2003-01-09 2008-04-22 Alexion Pharmaceuticals, Inc. Methods for reducing morality associated with acute myocardial infarction
WO2004071446A2 (en) * 2003-02-12 2004-08-26 Chauhan Anil K Immune complexes
US7135538B2 (en) 2003-11-12 2006-11-14 General Electric Company Transparent polycarbonate-polysiloxane copolymer blend, method for the preparation thereof, and article derived therefrom
WO2005118020A1 (en) * 2004-04-21 2005-12-15 Allvivo, Inc. Surface coating comprising bioactive compound
NZ554734A (en) 2004-12-08 2009-03-31 Sirion Therapeutics Inc Methods, Assays And Compositions For Treating Retinol-Related Diseases
CN107929731A (zh) * 2005-11-04 2018-04-20 健泰科生物技术公司 利用补体途径抑制剂治疗眼部疾病
ES2700609T3 (es) 2006-11-02 2019-02-18 Genentech Inc Anticuerpos anti-factor D humanizados y sus usos
CR20170001A (es) 2008-04-28 2017-08-10 Genentech Inc Anticuerpos anti factor d humanizados
DE102008045127A1 (de) 2008-09-01 2010-03-04 Heinrich, Hans-Werner, Prof. Dr. Filtersystem zur extrakorporalen Abreicherung von aktivierten Polymorphkernigen Granuloyzten (Polymorphonuclear leukocytes-PMNs)
US8758287B2 (en) 2008-11-12 2014-06-24 Marv Enterprises, LLC Utilization of stents for the treatment of blood borne carcinomas
WO2010107789A1 (en) 2009-03-17 2010-09-23 Marv Enterprises Llc Sequential extracorporeal treatment of bodily fluids
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
KR102336895B1 (ko) 2012-02-20 2021-12-08 스위디쉬 오르펀 바이오비트럼 에이비 (피유비엘) 인간 보체 c5에 결합하는 폴리펩티드
US20150027950A1 (en) * 2012-03-27 2015-01-29 Marv Enterprises, LLC Treatment for atherosclerosis
WO2013177099A1 (en) * 2012-05-21 2013-11-28 Felder Mitchell S Method for treating infectious diseases using emissive energy
US9132171B2 (en) 2012-05-23 2015-09-15 Wisconsin Alumni Research Foundation Test of insulin as a drug to reduce restenosis of vessels
KR20180021234A (ko) 2013-08-12 2018-02-28 제넨테크, 인크. 보체-연관 상태의 치료를 위한 조성물 및 방법
EP2886140A1 (de) 2013-12-17 2015-06-24 University of Limerick Vorrichtung zur extrakorporalen Behandlung von Blut
WO2015168468A1 (en) 2014-05-01 2015-11-05 Genentech, Inc. Anti-factor d antibody variants and uses thereof
EP3302529A4 (de) 2015-06-03 2019-02-06 The Children's Hospital Medical Center Zusammensetzungen und verfahren zur behandlung von gallengangatresie bei neugeborenen
EP3368090A1 (de) 2015-10-30 2018-09-05 H. Hoffnabb-La Roche Ag Anti-faktor-d-antikörpervarianten-konjugate und verwendungen davon
JP2018534930A (ja) 2015-10-30 2018-11-29 ジェネンテック， インコーポレイテッド 抗ｄ因子抗体及びコンジュゲート
JP7102353B2 (ja) 2016-06-14 2022-07-19 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 抗ｃ５抗体及びそれらの使用
MA51147A (fr) 2017-12-13 2021-03-24 Regeneron Pharma Associations d'anticorps anti-c5 et utilisations associées
US20190247560A1 (en) * 2018-02-13 2019-08-15 Gambro Lundia Ab Extracorporeal devices and methods of treating complement factor related diseases
WO2021063708A1 (en) 2019-09-30 2021-04-08 Hemotune Ag Assembly for extracorporeal treatment of body fluids

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4686100A (en) * 1985-04-02 1987-08-11 The Board Of Trustees Of The Leland Stanford Junior University Method for the treatment of adult respiratory distress syndrome
US5366986A (en) * 1988-04-15 1994-11-22 T Cell Sciences, Inc. Compounds which inhibit complement and/or suppress immune activity
US5506247A (en) * 1988-04-15 1996-04-09 T Cell Sciences, Inc. Compounds that inhibit complement and/or suppress immune activity
US5135916A (en) * 1989-06-12 1992-08-04 Oklahoma Medical Research Foundation Inhibition of complement mediated inflammatory response
SE9100142L (sv) * 1991-01-17 1992-07-18 Bengt Sandberg En metod och ett system foer foerbaettrad in vivo reducering av diagnostiska och/eller terapeutiska substanser medelst extrakorporeal borttagning, och anvaendandet av naemnda substanser foer detta aendamaal

Also Published As

Publication number Publication date
US5853722A (en) 1998-12-29
WO1995025540A1 (en) 1995-09-28
EP0751787B1 (de) 2005-01-12
EP0751787A4 (de) 1999-06-16
ES2236706T3 (es) 2005-07-16
DE69533921T2 (de) 2005-12-01
AU2191795A (en) 1995-10-09
CA2186108A1 (en) 1995-09-28
EP0751787A1 (de) 1997-01-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee