DE69533921D1 - Verfahren zur reduktion von fehlfunktionen des immunsystems und der hämostase während des extrakorporalen kreislaufs - Google Patents

Verfahren zur reduktion von fehlfunktionen des immunsystems und der hämostase während des extrakorporalen kreislaufs

Info

Publication number
DE69533921D1
DE69533921D1 DE69533921T DE69533921T DE69533921D1 DE 69533921 D1 DE69533921 D1 DE 69533921D1 DE 69533921 T DE69533921 T DE 69533921T DE 69533921 T DE69533921 T DE 69533921T DE 69533921 D1 DE69533921 D1 DE 69533921D1
Authority
DE
Germany
Prior art keywords
hemostase
immune system
extracorporeal circulation
during extracorporeal
reducing malfunctions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69533921T
Other languages
English (en)
Other versions
DE69533921T2 (de
Inventor
A Rollins
R Smith
P Squinto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Alexion Pharmaceuticals Inc
Original Assignee
Yale University
Alexion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yale University, Alexion Pharmaceuticals Inc filed Critical Yale University
Publication of DE69533921D1 publication Critical patent/DE69533921D1/de
Application granted granted Critical
Publication of DE69533921T2 publication Critical patent/DE69533921T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3687—Chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69533921T 1994-03-23 1995-03-22 Verfahren zur reduktion von fehlfunktionen des immunsystems und der hämostase während des extrakorporalen kreislaufs Expired - Fee Related DE69533921T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21739194A 1994-03-23 1994-03-23
US217391 1994-03-23
PCT/US1995/003614 WO1995025540A1 (en) 1994-03-23 1995-03-22 Method for reducing immune and hemostatic dysfunctions during extracorporeal circulation

Publications (2)

Publication Number Publication Date
DE69533921D1 true DE69533921D1 (de) 2005-02-17
DE69533921T2 DE69533921T2 (de) 2005-12-01

Family

ID=22810875

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69533921T Expired - Fee Related DE69533921T2 (de) 1994-03-23 1995-03-22 Verfahren zur reduktion von fehlfunktionen des immunsystems und der hämostase während des extrakorporalen kreislaufs

Country Status (7)

Country Link
US (1) US5853722A (de)
EP (1) EP0751787B1 (de)
AU (1) AU2191795A (de)
CA (1) CA2186108A1 (de)
DE (1) DE69533921T2 (de)
ES (1) ES2236706T3 (de)
WO (1) WO1995025540A1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69534701T2 (de) * 1994-09-23 2006-10-19 Alexion Pharmaceuticals, Inc., Cheshire Verfahren zur behandlung von entzündlichen gelenkerkrankungen
JP2001513576A (ja) 1997-08-26 2001-09-04 グリアテック インコーポレイテッド 側副経路を介する補体活性化を阻害するためのプロセス
US6956107B2 (en) * 1998-02-20 2005-10-18 Tanox, Inc. Inhibitors of complement activation
US7112327B2 (en) * 1998-02-20 2006-09-26 Tanox, Inc. Inhibition of complement activation
SI1054693T1 (sl) * 1998-02-20 2009-04-30 Genentech Inc Inhibitorji aktivacije komplementa
EP1061972A1 (de) * 1998-03-16 2000-12-27 Medtronic, Inc. Hämostatisches system und komponenten für einen extrakorporalen kreislauf
DE19913707A1 (de) 1999-03-26 2000-10-05 Privates Inst Bioserv Gmbh Immunadsorber zur Sepsistherapie
CA2408883A1 (en) * 2000-05-19 2001-11-29 The Center For Blood Research, Inc. Methods for diagnosing and treating hemostatic disorders by modulating p-selectin activity
EP2113516B1 (de) * 2000-10-10 2014-05-21 Genentech, Inc. C5 Antikörper, die die Typ II Aktivierung von Endothelialzellen inhibieren
ES2309167T3 (es) 2001-02-19 2008-12-16 Merck Patent Gmbh Metodo para identificar epitotes de celulas t y metodo para preparar moleculas con inmunogenicidad reducida.
CA2454562A1 (en) * 2001-07-26 2003-02-06 Alexion Pharmaceuticals, Inc. Method of improving cognitive function
US7682793B2 (en) * 2001-08-01 2010-03-23 Chauhan Anil K Immune complexes
EP1878441B1 (de) * 2001-08-17 2018-01-24 Genentech, Inc. Komplement-Inhibitoren, die an C5 und C5a binden, ohne die Bildung von C5b zu hemmen
ES2283594T5 (es) * 2001-08-17 2016-03-15 Genentech, Inc. Inhibidores de la ruta del complemento que se unen a C5 y C5a sin impedir la formación de C5b
CA2473786A1 (en) * 2002-01-22 2003-07-31 Alexion Pharmaceuticals, Inc. Method of prophylaxis against large myocardial infarctions
US7361339B2 (en) 2003-01-09 2008-04-22 Alexion Pharmaceuticals, Inc. Methods for reducing morality associated with acute myocardial infarction
US20040208865A1 (en) * 2003-02-12 2004-10-21 Chauhan Anil K. Immune complexes
US7135538B2 (en) 2003-11-12 2006-11-14 General Electric Company Transparent polycarbonate-polysiloxane copolymer blend, method for the preparation thereof, and article derived therefrom
US8048437B2 (en) * 2004-04-21 2011-11-01 Richard Nagler Medical device with surface coating comprising bioactive compound
MX2007006245A (es) 2004-12-08 2007-07-25 Sirion Therapeutics Inc Metodos, analisis y composiciones para tratar enfermedades relacionadas con retinol.
WO2007056227A2 (en) * 2005-11-04 2007-05-18 Genentech, Inc. Use of complement pathway inhibitors to treat ocular diseases
CN105085682A (zh) 2006-11-02 2015-11-25 健泰科生物技术公司 人源化的抗-d因子抗体
CR20170001A (es) 2008-04-28 2017-08-10 Genentech Inc Anticuerpos anti factor d humanizados
DE102008045127A1 (de) 2008-09-01 2010-03-04 Heinrich, Hans-Werner, Prof. Dr. Filtersystem zur extrakorporalen Abreicherung von aktivierten Polymorphkernigen Granuloyzten (Polymorphonuclear leukocytes-PMNs)
US8758287B2 (en) 2008-11-12 2014-06-24 Marv Enterprises, LLC Utilization of stents for the treatment of blood borne carcinomas
US9216386B2 (en) 2009-03-17 2015-12-22 Marv Enterprises, LLC Sequential extracorporeal treatment of bodily fluids
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
NZ628625A (en) 2012-02-20 2016-03-31 Swedish Orphan Biovitrum Ab Publ Polypeptides binding to human complement c5
US20150027950A1 (en) * 2012-03-27 2015-01-29 Marv Enterprises, LLC Treatment for atherosclerosis
US20150056608A1 (en) * 2012-05-21 2015-02-26 Marv Enterprises, LLC Method for Treating Infectious Diseases Using Emissive Energy
US9132171B2 (en) 2012-05-23 2015-09-15 Wisconsin Alumni Research Foundation Test of insulin as a drug to reduce restenosis of vessels
KR20160042438A (ko) 2013-08-12 2016-04-19 제넨테크, 인크. 보체-연관 상태의 치료를 위한 조성물 및 방법
EP2886140A1 (de) * 2013-12-17 2015-06-24 University of Limerick Vorrichtung zur extrakorporalen Behandlung von Blut
PE20161440A1 (es) 2014-05-01 2017-01-26 Genentech Inc Variantes del anticuerpo anti-factor d y sus usos
CA2986957A1 (en) 2015-06-03 2016-12-08 Children's Hospital Medical Center Compositions and methods for treating neonatal biliary atresia
CN108472382A (zh) 2015-10-30 2018-08-31 豪夫迈·罗氏有限公司 抗-因子d抗体变体缀合物及其用途
CN108289951A (zh) 2015-10-30 2018-07-17 豪夫迈·罗氏有限公司 抗-因子d抗体和缀合物
EP3468990B1 (de) 2016-06-14 2024-03-27 Regeneron Pharmaceuticals, Inc. Anti-c5-antikörper und verwendungen davon
MX2020006113A (es) 2017-12-13 2020-08-24 Regeneron Pharma Combinaciones de anticuerpos anti-c5 y usos de las mismas.
US20190247560A1 (en) * 2018-02-13 2019-08-15 Gambro Lundia Ab Extracorporeal devices and methods of treating complement factor related diseases
CN114502210A (zh) 2019-09-30 2022-05-13 埃莫图内股份公司 用于体外治疗体液的组合件

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4686100A (en) * 1985-04-02 1987-08-11 The Board Of Trustees Of The Leland Stanford Junior University Method for the treatment of adult respiratory distress syndrome
US5366986A (en) * 1988-04-15 1994-11-22 T Cell Sciences, Inc. Compounds which inhibit complement and/or suppress immune activity
US5506247A (en) * 1988-04-15 1996-04-09 T Cell Sciences, Inc. Compounds that inhibit complement and/or suppress immune activity
US5135916A (en) * 1989-06-12 1992-08-04 Oklahoma Medical Research Foundation Inhibition of complement mediated inflammatory response
SE9100142L (sv) * 1991-01-17 1992-07-18 Bengt Sandberg En metod och ett system foer foerbaettrad in vivo reducering av diagnostiska och/eller terapeutiska substanser medelst extrakorporeal borttagning, och anvaendandet av naemnda substanser foer detta aendamaal

Also Published As

Publication number Publication date
ES2236706T3 (es) 2005-07-16
DE69533921T2 (de) 2005-12-01
WO1995025540A1 (en) 1995-09-28
CA2186108A1 (en) 1995-09-28
AU2191795A (en) 1995-10-09
US5853722A (en) 1998-12-29
EP0751787A1 (de) 1997-01-08
EP0751787A4 (de) 1999-06-16
EP0751787B1 (de) 2005-01-12

Similar Documents

Publication Publication Date Title
DE69533921D1 (de) Verfahren zur reduktion von fehlfunktionen des immunsystems und der hämostase während des extrakorporalen kreislaufs
DE69329461D1 (de) Verfahren zur extraktion und reinigung von hamoglobin
DE69226347D1 (de) Methode zum Erzeugen und Ausführen von komplexen Verfahren
DE69318734D1 (de) System und verfahren zur injektion von zellulose
DE69427826D1 (de) Verfahren und system zur reinigung von bohrlöchern
EP0529916A3 (en) System and method for efficient execution of outer join operations
DE69316639T2 (de) System und verfahren zur schnittstellenbildung fur transaktion-verarbeitungssystem
DE69322470D1 (de) System und Verfahren zur Lokalisierung von Videosegmentübergängen
DE3888205D1 (de) Verfahren zur behandlung von lungenaffektionen und zubereitungen dafür.
DE69517955D1 (de) Verfahren und gerät zur nichtinvasiven vorhersage von hämatokrit
DE69533683D1 (de) Verfahren und Vorrichtung zum Filetieren des Körpers von Schlachtgeflügel
DE69225480D1 (de) Verfahren zum induktionsheizen von verbundwerkstoffen
DE3852413D1 (de) Verfahren und System zur Erzeugung von visuellen Bildern.
DE69526322T2 (de) System und Verfahren zur Indexierung von Multimedia-Programmen
DE19581659T1 (de) Lagersystem und Verfahren zum Metallisieren von Durchgängen
ATE210142T1 (de) Verfahren zur isolierung und reinigung von 2'- deoxy-2',2'-difluornucleosiden
DE69603277D1 (de) Verfahren zur plasma aktivierten wärmebehandlung von titannitrid
DE3669328D1 (de) Verfahren und anlage zur serienmaessigen, verzugsarmen thermomechanischen behandlung von werkstuecken sowie anwendung des verfahrens.
KR960010915A (ko) 사의 열처리를 위한 장치 및 방법
DE69512038T2 (de) Verfahren zur kontinuierlichen kochung von würze
DE69305411T3 (de) System und Verfahren zur Beseitigung von Mikroorganismen
DE69533774D1 (de) Verfahren und system zur verteilten kontrolle von hardware
DE59406285D1 (de) Verfahren und aufbereitungsanlage zur regeneration von wechselfiltern
DE69514960T2 (de) Schlackbehandlungssystem und -methode
EP0680020A3 (de) Vorrichtung und Verfahren zum direkten Berechnen von Schnitzkoordinaten.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee