DE69533833T2 - Verfahren zur Herstellung von Indolopyrrolocarbazol-Derivaten - Google Patents

Verfahren zur Herstellung von Indolopyrrolocarbazol-Derivaten Download PDF

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Publication number
DE69533833T2
DE69533833T2 DE69533833T DE69533833T DE69533833T2 DE 69533833 T2 DE69533833 T2 DE 69533833T2 DE 69533833 T DE69533833 T DE 69533833T DE 69533833 T DE69533833 T DE 69533833T DE 69533833 T2 DE69533833 T2 DE 69533833T2
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DE
Germany
Prior art keywords
compound
formula
group
preparation
ethyl acetate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69533833T
Other languages
German (de)
English (en)
Other versions
DE69533833D1 (de
Inventor
Katsuhisa Chuo-ku Kojiri
Hisao Kondo
Hiroharu Arakawa
Mitsuru Ohkubo
Hiroyuki Suda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Application granted granted Critical
Publication of DE69533833D1 publication Critical patent/DE69533833D1/de
Publication of DE69533833T2 publication Critical patent/DE69533833T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/12—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms
    • C07C243/16—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
DE69533833T 1994-05-09 1995-05-02 Verfahren zur Herstellung von Indolopyrrolocarbazol-Derivaten Expired - Fee Related DE69533833T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP11948394 1994-05-09
JP11948394 1994-05-09
JP14564894 1994-06-03
JP14564894 1994-06-03

Publications (2)

Publication Number Publication Date
DE69533833D1 DE69533833D1 (de) 2005-01-05
DE69533833T2 true DE69533833T2 (de) 2005-12-15

Family

ID=26457215

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69533833T Expired - Fee Related DE69533833T2 (de) 1994-05-09 1995-05-02 Verfahren zur Herstellung von Indolopyrrolocarbazol-Derivaten
DE69532198T Expired - Fee Related DE69532198T2 (de) 1994-05-09 1995-05-02 Antitumor-indolopyrolocarbazolderivat

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69532198T Expired - Fee Related DE69532198T2 (de) 1994-05-09 1995-05-02 Antitumor-indolopyrolocarbazolderivat

Country Status (14)

Country Link
EP (2) EP0760375B1 (enExample)
JP (1) JP3038921B2 (enExample)
KR (1) KR100312473B1 (enExample)
CN (2) CN1285605C (enExample)
AT (2) ATE283863T1 (enExample)
AU (1) AU683749B2 (enExample)
CA (1) CA2190007C (enExample)
CL (1) CL2004001117A1 (enExample)
DE (2) DE69533833T2 (enExample)
DK (2) DK1264836T3 (enExample)
ES (2) ES2230433T3 (enExample)
HK (1) HK1000890A1 (enExample)
PT (2) PT760375E (enExample)
TW (1) TW313566B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050058444A (ko) * 2002-08-23 2005-06-16 반유 세이야꾸 가부시끼가이샤 인돌로피롤로카르바졸 유도체의 제조법
CN101585861B (zh) * 2009-07-03 2012-10-24 复旦大学 N-糖基萘并咔唑化合物及其合成方法和应用
WO2025082431A1 (zh) * 2023-10-18 2025-04-24 正大天晴药业集团股份有限公司 一种吲哚衍生物治疗头颈部肿瘤的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94274A0 (en) * 1989-05-05 1991-03-10 Goedecke Ag Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
EP0528030B1 (en) * 1990-05-11 1997-09-17 Banyu Pharmaceutical Co., Ltd. Antitumor be-13793c derivative
NZ245203A (en) * 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
JP3603322B2 (ja) * 1992-12-14 2004-12-22 萬有製薬株式会社 インドロピロロカルバゾール誘導体の製造法
JP3707075B2 (ja) * 1994-06-13 2005-10-19 萬有製薬株式会社 グリコシルトランスフェラーゼをコードする遺伝子及びその用途
AU3086495A (en) * 1994-08-02 1996-03-04 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazoles

Also Published As

Publication number Publication date
ES2206501T3 (es) 2004-05-16
CL2004001117A1 (es) 2005-04-22
AU683749B2 (en) 1997-11-20
DK0760375T3 (da) 2003-12-29
DE69532198T2 (de) 2004-08-26
JP3038921B2 (ja) 2000-05-08
ATE255121T1 (de) 2003-12-15
KR970702869A (ko) 1997-06-10
EP0760375A4 (en) 2002-03-27
HK1000890A1 (en) 2004-01-09
PT760375E (pt) 2004-04-30
EP1264836B1 (en) 2004-12-01
CN1106400C (zh) 2003-04-23
CN1285605C (zh) 2006-11-22
TW313566B (enExample) 1997-08-21
PT1264836E (pt) 2005-02-28
DE69532198D1 (de) 2004-01-08
EP1264836A1 (en) 2002-12-11
DE69533833D1 (de) 2005-01-05
CN1153518A (zh) 1997-07-02
DK1264836T3 (da) 2005-03-07
CN1513865A (zh) 2004-07-21
CA2190007A1 (en) 1995-11-16
EP0760375B1 (en) 2003-11-26
CA2190007C (en) 2003-04-15
ES2230433T3 (es) 2005-05-01
AU2353595A (en) 1995-11-29
KR100312473B1 (ko) 2002-06-24
HK1067948A1 (en) 2005-04-22
EP0760375A1 (en) 1997-03-05
ATE283863T1 (de) 2004-12-15

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee