DE69530851D1 - Monitorvorrichtung für den strahl eines durchflusszytometers - Google Patents

Monitorvorrichtung für den strahl eines durchflusszytometers

Info

Publication number
DE69530851D1
DE69530851D1 DE69530851T DE69530851T DE69530851D1 DE 69530851 D1 DE69530851 D1 DE 69530851D1 DE 69530851 T DE69530851 T DE 69530851T DE 69530851 T DE69530851 T DE 69530851T DE 69530851 D1 DE69530851 D1 DE 69530851D1
Authority
DE
Germany
Prior art keywords
jet
monitor device
flow cytometer
cytometer
monitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69530851T
Other languages
English (en)
Other versions
DE69530851T2 (de
Inventor
Den Engh Ger Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Original Assignee
University of Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington filed Critical University of Washington
Publication of DE69530851D1 publication Critical patent/DE69530851D1/de
Application granted granted Critical
Publication of DE69530851T2 publication Critical patent/DE69530851T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N2015/1406—Control of droplet point

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69530851T 1994-10-14 1995-10-13 Monitorvorrichtung für den strahl eines durchflusszytometers Expired - Lifetime DE69530851T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US323352 1994-10-14
US08/323,352 US5602039A (en) 1994-10-14 1994-10-14 Flow cytometer jet monitor system
PCT/US1995/013502 WO1996012172A1 (en) 1994-10-14 1995-10-13 Flow cytometer jet monitor system

Publications (2)

Publication Number Publication Date
DE69530851D1 true DE69530851D1 (de) 2003-06-26
DE69530851T2 DE69530851T2 (de) 2004-01-22

Family

ID=23258849

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69530851T Expired - Lifetime DE69530851T2 (de) 1994-10-14 1995-10-13 Monitorvorrichtung für den strahl eines durchflusszytometers

Country Status (8)

Country Link
US (1) US5602039A (de)
EP (1) EP0786079B1 (de)
JP (1) JPH10507525A (de)
AU (1) AU691693B2 (de)
CA (1) CA2201332C (de)
DE (1) DE69530851T2 (de)
ES (1) ES2196086T3 (de)
WO (1) WO1996012172A1 (de)

Families Citing this family (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19549015C1 (de) * 1995-12-28 1997-04-03 Siemens Ag Verfahren und Anordnung zur Überwachung eines abreißenden Flüssigkeitstrahls
EP1017987B1 (de) * 1997-01-31 2005-06-15 The Horticulture And Food Research Institute Of New Zealand Limited Optische vorrichtung und methode
EP1018012A4 (de) 1997-09-26 2002-10-09 Univ Washington Simultan ablaufende partikeltrennung und chemische reaktion
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6071689A (en) 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
AU775339B2 (en) * 1998-02-20 2004-07-29 Dako Colorado, Inc. A vibratory system for a sorting flow cytometer
US6746873B1 (en) 1998-02-20 2004-06-08 Xy, Inc. Vibratory system for a sorting flow cytometer
US6211477B1 (en) 1998-02-26 2001-04-03 Becton Dickinson And Company Electrostatic deceleration system for flow cytometer
US6248590B1 (en) 1998-02-27 2001-06-19 Cytomation, Inc. Method and apparatus for flow cytometry
AU3897999A (en) * 1998-05-14 1999-11-29 Luminex Corporation Multi-analyte diagnostic system and computer implemented process for same
CA2338194C (en) 1998-07-30 2013-09-10 Edward L. Squires Equine system for non-surgical artificial insemination
US6110427A (en) * 1998-08-14 2000-08-29 Becton, Dickinson And Company Flow regulator to maintain controllable volumetric flow rate
US6372506B1 (en) 1999-07-02 2002-04-16 Becton, Dickinson And Company Apparatus and method for verifying drop delay in a flow cytometer
US6813017B1 (en) 1999-10-20 2004-11-02 Becton, Dickinson And Company Apparatus and method employing incoherent light emitting semiconductor devices as particle detection light sources in a flow cytometer
US7024316B1 (en) * 1999-10-21 2006-04-04 Dakocytomation Colorado, Inc. Transiently dynamic flow cytometer analysis system
US7208265B1 (en) * 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
US6263745B1 (en) 1999-12-03 2001-07-24 Xy, Inc. Flow cytometer nozzle and flow cytometer sample handling methods
CA2408939C (en) * 2000-05-09 2011-11-08 Xy, Inc. High purity x-chromosome bearing and y-chromosome bearing populations of spermatozoa
US6809804B1 (en) 2000-05-11 2004-10-26 Becton, Dickinson And Company System and method for providing improved event reading and data processing capabilities in a flow cytometer
US20040031071A1 (en) * 2000-10-05 2004-02-12 Xy, Inc. System of hysteroscopic insemination of mares
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
CA2822983C (en) 2000-11-29 2017-05-09 Xy, Llc System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
KR20020065192A (ko) * 2001-02-06 2002-08-13 주식회사 디지털 피봇 액적 사이즈 제어방법 및 제어 시스템
US7345758B2 (en) 2001-05-17 2008-03-18 Cytopeia Apparatus for analyzing and sorting biological particles
ES2405320T3 (es) 2001-05-17 2013-05-30 Beckman Coulter, Inc. Citómetro de flujo con un sistema de alienación óptica automatizado activo
US20030211009A1 (en) * 2001-05-18 2003-11-13 Buchanan Kris S. Rapid multi-material sample input system
US6976590B2 (en) 2002-06-24 2005-12-20 Cytonome, Inc. Method and apparatus for sorting particles
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
US7362424B2 (en) * 2002-04-24 2008-04-22 The Institute For Systems Biology Compositions and methods for drop boundary detection and radiation beam alignment
EP1542529A4 (de) * 2002-07-22 2006-08-09 Xy Inc Spermazellenverfahrenssystem
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
DK2283724T3 (en) * 2002-08-01 2016-04-04 Xy Llc Heterospermic insemination to assess sperm function
WO2004017041A2 (en) * 2002-08-15 2004-02-26 Xy, Inc. High resolution flow cytometer
DE10241545A1 (de) * 2002-09-05 2004-03-25 Gkss-Forschungszentrum Geesthacht Gmbh Vorrichtung zur Überführung eines kontinuierlichen Flüssigkeitsstroms in einen Strom aus Flüssigkeitströpfchen
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
US7201875B2 (en) * 2002-09-27 2007-04-10 Becton Dickinson And Company Fixed mounted sorting cuvette with user replaceable nozzle
US6941005B2 (en) * 2002-11-01 2005-09-06 Coulter International Corp. Monitoring and control of droplet sorting
CA2512729C (en) 2003-01-09 2014-09-16 Macrogenics, Inc. Identification and engineering of antibodies with variant fc regions and methods of using same
CN102830053A (zh) 2003-03-28 2012-12-19 英格朗公司 用于分拣颗粒和提供性别分拣的动物精子的设备、方法和程序
WO2004104178A2 (en) 2003-05-15 2004-12-02 Xy, Inc. Efficient haploid cell sorting for flow cytometer systems
JP2007531523A (ja) 2004-03-29 2007-11-08 モンサント テクノロジー エルエルシー Ｘまたはｙ染色体担持豊富化集団に仕分けるための精子懸濁液
JP2008507287A (ja) 2004-07-22 2008-03-13 モンサント テクノロジー エルエルシー 精子細胞の集団を富化する方法
PT1771729E (pt) 2004-07-27 2015-12-31 Beckman Coulter Inc Acentuação da discriminação da citometria de fluxo com transformação geométrica
ES2971647T3 (es) 2005-04-15 2024-06-06 Macrogenics Inc Diacuerpos covalentes y usos de los mismos
US9889197B2 (en) 2005-04-15 2018-02-13 Macrogenics, Inc. Covalently-associated diabody complexes that possess charged coil domains and that are capable of enhanced binding to serum albumin
US7618770B2 (en) * 2005-07-29 2009-11-17 Xy, Inc. Methods and apparatus for reducing protein content in sperm cell extenders
DK1919503T3 (en) 2005-08-10 2014-12-15 Macrogenics Inc Identification and preparation of antibodies with variant fc regions and methods of use thereof
US7835599B2 (en) 2005-08-25 2010-11-16 Institut National D'optique Flow cytometry analysis across optical fiber
US7324724B2 (en) * 2005-10-21 2008-01-29 Institut National D'optique Optical fiber devices using component insertion
WO2007127936A2 (en) 2006-04-27 2007-11-08 Pikamab, Inc. Methods and compositions for antibody therapy
WO2011085465A1 (en) 2010-01-18 2011-07-21 Institut National D'optique Flow cytometry analysis across optical fiber
MX2009013816A (es) 2007-06-21 2010-02-24 Macrogenics Inc Diacuerpos covalentes y usos de los mismos.
WO2009123894A2 (en) 2008-04-02 2009-10-08 Macrogenics, Inc. Her2/neu-specific antibodies and methods of using same
EP2252631B1 (de) 2008-04-02 2016-04-13 MacroGenics, Inc. Bcr-komplex-spezifische antikörper und verfahren zu ihrer verwendung
CA2726845C (en) 2008-06-04 2017-09-26 Macrogenics, Inc. Antibodies with altered binding to fcrn and methods of using same
JP5734201B2 (ja) 2008-12-19 2015-06-17 マクロジェニクス，インコーポレーテッド 共有結合型ダイアボディ及びその使用
WO2010132053A1 (en) 2009-05-13 2010-11-18 Indevr, Inc. Flow measurement and control for improved quantification of particles in flow cytometry
JP5446563B2 (ja) 2009-08-06 2014-03-19 ソニー株式会社 微小粒子分取装置、および該微小粒子分取装置を用いたフローサイトメーター
US8589851B2 (en) * 2009-12-15 2013-11-19 Memoir Systems, Inc. Intelligent memory system compiler
ITTO20100651A1 (it) 2010-07-28 2012-01-29 Ist Sperimentale It Lazzaro Spallanza Procedimento ed apparecchiatura per la caratterizzazione e la separazione di spermatozoi con sensori micrometrici a leva sospesa
MX349622B (es) 2010-09-08 2017-08-07 Halozyme Inc Metodos para evaluar e identificar o evolucionar proteinas terapeuticas condicionalmente activas.
US9562109B2 (en) 2010-11-05 2017-02-07 Zymeworks Inc. Stable heterodimeric antibody design with mutations in the Fc domain
WO2012162068A2 (en) 2011-05-21 2012-11-29 Macrogenics, Inc. Deimmunized serum-binding domains and their use for extending serum half-life
EP2732395B1 (de) * 2011-08-25 2018-04-04 Sony Corporation Charakterisierung von bewegungsfehlern in einem strom aus bewegten mikroeinheiten
CA2854233C (en) 2011-11-04 2020-05-12 Zymeworks Inc. Stable heterodimeric antibody design with mutations in the fc domain
JP5601424B2 (ja) 2012-03-30 2014-10-08 ソニー株式会社 微小粒子分取装置及び該装置における流体ストリーム最適化方法
US9915935B2 (en) 2012-03-30 2018-03-13 Sony Corporation Microchip-type optical measuring apparatus and optical position adjusting method thereof
JP5924077B2 (ja) 2012-03-30 2016-05-25 ソニー株式会社 微小粒子分取装置及び微小粒子分取装置における軌道方向判定方法
WO2013166594A1 (en) 2012-05-10 2013-11-14 Zymeworks Inc. Heteromultimer constructs of immunoglobulin heavy chains with mutations in the fc domain
US10634601B2 (en) 2012-09-19 2020-04-28 Inguran, Llc Nozzle assembly for a flow cytometry system and methods of manufacture
US11668640B2 (en) 2015-03-06 2023-06-06 Inguran, Llc Nozzle assembly for a flow cytometry system and methods of manufacture
BR112015006181B1 (pt) 2012-09-19 2021-01-05 Inguran, Llc sistema de citômetro de fluxo
EP3910318B1 (de) 2013-01-28 2024-06-12 Sony Group Corporation Mikropartikelsortiervorrichtung sowie verfahren und programm zum sortieren von mikropartikeln
CN105431725B (zh) 2013-03-14 2019-04-19 塞通诺米/St有限责任公司 无操作员式颗粒处理系统和方法
WO2014169231A1 (en) 2013-04-12 2014-10-16 Norton Pierce O Automated set-up for cell sorting
EP2989457B1 (de) 2013-04-26 2023-10-04 Becton, Dickinson and Company Verfahren und systeme zur lichterfassung unter verwendung einer internen totalreflexion
JP6447506B2 (ja) 2013-10-16 2019-01-09 ソニー株式会社 粒子分取装置及び粒子分取方法
WO2015122071A1 (ja) * 2014-02-13 2015-08-20 ソニー株式会社 粒子分取装置、粒子分取方法、プログラム及び粒子分取システム
JP6657625B2 (ja) 2014-09-05 2020-03-04 ソニー株式会社 液滴分取装置、液滴分取方法及びプログラム
CN107003225B (zh) 2014-12-04 2020-08-18 贝克顿·迪金森公司 流式细胞术细胞分选系统及其使用方法
US9709769B2 (en) 2014-12-10 2017-07-18 Becton, Dickinson And Company Methods for optically aligning light collection components and optically aligned light collection systems thereof
CN107209102B (zh) 2015-02-18 2021-03-02 贝克顿·迪金森公司 光学检测系统及其使用方法
EP3311135B1 (de) 2015-06-17 2023-11-01 Becton, Dickinson and Company Streukappenanordnung für optischen detektor mit abnehmbarem streubalken und verfahren zur verwendung davon
KR20230157532A (ko) 2015-10-13 2023-11-16 벡톤 디킨슨 앤드 컴퍼니 다중모드 형광 이미징 유동 세포 계측 시스템
CN108139312B (zh) 2015-10-19 2021-02-05 索尼公司 图像处理设备、微粒分选设备和图像处理方法
EP3426296A4 (de) 2016-03-10 2019-11-20 Becton, Dickinson and Company Verfahren zur bewertung einer zellulären probe für her-2/neu-expression und zusammensetzungen zur durchführung davon
US10324019B2 (en) 2016-03-17 2019-06-18 Becton, Dickinson And Company Cell sorting using a high throughput fluorescence flow cytometer
ES2969779T3 (es) 2016-04-15 2024-05-22 Becton Dickinson Co Clasificador de gotículas cerrado, métodos de uso del mismo y kit
ES2926537T3 (es) 2016-04-22 2022-10-26 Becton Dickinson Co Depósito de alta densidad para la producción de matrices
JP7023244B2 (ja) 2016-05-12 2022-02-21 ビーディー バイオサイエンス 画像解像度が改良された蛍光イメージングフローサイトメトリー
JP6825010B2 (ja) 2016-05-26 2021-02-03 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 遠心法によるリポソーム調製のための方法及び装置
EP3513167B1 (de) 2016-09-13 2023-05-24 Becton, Dickinson and Company Durchflusszytometer mit optischer entzerrung
US10732094B2 (en) 2016-10-03 2020-08-04 Becton, Dickinson And Company Methods and systems for determining a drop delay of a flow stream in a flow cytometer
WO2018111536A1 (en) 2016-12-14 2018-06-21 Becton, Dickinson And Company Methods and compositions for obtaining a tuberculosis assessment in a subject
CA3052595A1 (en) 2017-02-08 2018-08-16 Becton, Dickinson And Company Dried dye reagent devices and methods for making and using the same
EP3586104A4 (de) 2017-02-27 2020-12-16 Becton, Dickinson and Company Lichtdetektionssysteme und verfahren zur verwendung davon
SG11202006481YA (en) 2018-01-23 2020-08-28 Becton Dickinson Co Systems for dynamic light detection obscuration and methods for using thereof
JP2021519841A (ja) 2018-03-30 2021-08-12 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ ペンダントクロモフォアを有する水溶性ポリマー色素
US10914671B2 (en) 2018-04-27 2021-02-09 Becton, Dickinson And Company Flow cytometers having enclosed droplet sorters with controlled aerosol content and methods of using the same
WO2019209713A1 (en) 2018-04-27 2019-10-31 Becton, Dickinson And Company Collection systems for flow cytometrically sorted samples and methods of using the same
JP7416729B2 (ja) 2018-06-19 2024-01-17 ベクトン・ディキンソン・アンド・カンパニー 検出器アレイのための可変多重化スイッチ、システム、およびその使用方法
US11099066B2 (en) 2018-06-28 2021-08-24 Becton, Dickinson And Company Light detection systems having input and output modulators, and methods of use thereof
US20200056979A1 (en) 2018-08-15 2020-02-20 Becton, Dickinson And Company Flowrate and vacuum controlled fluid management system for a flow type particle analyzer
EP3874254A4 (de) 2018-10-30 2022-08-03 Becton, Dickinson and Company Teilchensortiermodul mit ausrichtungsfenster, systeme und verwendungsverfahren dafür
US11009400B2 (en) 2018-12-28 2021-05-18 Becton, Dickinson And Company Methods for spectrally resolving fluorophores of a sample and systems for same
US11137337B2 (en) 2019-01-21 2021-10-05 Essen Instruments, Inc. Flow cytometry with data analysis for optimized dilution of fluid samples for flow cytometry investigation
US11085868B2 (en) 2019-02-08 2021-08-10 Becton, Dickinson And Company Droplet sorting decision modules, systems and methods of use thereof
EP3867626A4 (de) 2019-03-22 2022-11-09 Becton, Dickinson and Company Spektrale zerlegung von fluoreszenzbildgebung unter verwendung von radiofrequenz-multiplex anregungsdaten
JP7466563B2 (ja) 2019-03-29 2024-04-15 ベクトン・ディキンソン・アンド・カンパニー 粒子の区別に使用するためのパラメータ
EP3969881A4 (de) 2019-05-14 2023-01-25 Becton, Dickinson and Company Phasenkalibrierung für die bildgebungsdurchflusszytometrie
WO2020243475A1 (en) 2019-05-30 2020-12-03 Becton, Dickinson And Company Phase-correction of radiofrequency-multiplexed signals
WO2021007075A1 (en) 2019-07-10 2021-01-14 Becton, Dickinson And Company Reconfigurable integrated circuits for adjusting cell sorting classification
US11635375B2 (en) 2019-11-20 2023-04-25 Becton, Dickinson And Company Light detection module with adjustable sensitivity
EP4078184A4 (de) 2019-12-20 2023-05-03 Becton, Dickinson and Company Verfahren zur quantifizierung von oberflächenmarkern extrazellulärer vesikel und zusammensetzungen zur durchführung des verfahrens
JP2023511761A (ja) 2020-01-31 2023-03-22 ベクトン・ディキンソン・アンド・カンパニー 訓練ゲートを調整してフローサイトメータデータに適応させるための方法およびシステム
US11709116B2 (en) 2020-02-04 2023-07-25 Sartorius Bioanalytical Instruments, Inc. Liquid flourescent dye concentrate for flow cytometry evaluation of virus-size particles and related products and methods
EP4100720A4 (de) 2020-02-07 2023-07-26 Becton, Dickinson and Company Geclusterte wellenlängenmultiplex-lichtdetektionssysteme und verfahren zu ihrer verwendung
EP4111176A4 (de) 2020-02-26 2023-08-16 Becton, Dickinson and Company Lichtdetektionssysteme, die einen sekundären streulichtdetektor aufweisen, und verfahren zur verwendung derselben
EP4111169A4 (de) 2020-02-27 2023-08-09 Becton, Dickinson and Company Verfahren zur identifizierung von gesättigten datensignalen in der zellsortierung und systeme dafür
CN115280134A (zh) 2020-03-17 2022-11-01 贝克顿·迪金森公司 用于光检测的增益匹配放大器
EP4136429A4 (de) 2020-04-16 2023-11-15 Becton, Dickinson and Company Systeme zum lichtdetektionsarray-multiplexing und verfahren dafür
US11662297B2 (en) 2020-04-28 2023-05-30 Becton, Dickinson And Company Method for index sorting unique phenotypes and systems for same
US11879827B2 (en) 2020-04-29 2024-01-23 Becton, Dickinson And Company Methods for modulation and synchronous detection in a flow cytometer and systems for same
US11781964B2 (en) 2020-05-05 2023-10-10 Becton, Dickinson And Company Methods for determining detector gain in a flow cytometer
EP4147029A4 (de) 2020-05-06 2023-11-01 Becton, Dickinson and Company Verfahren und systeme zur charakterisierung von überlaufstreuung in durchflusszytometerdaten
CN115867971A (zh) 2020-05-18 2023-03-28 贝克顿·迪金森公司 用于检测数据中的异质性的分辨率指数及其使用方法
EP4168801A1 (de) 2020-06-22 2023-04-26 Westfälische Wilhelms-Universität Münster Sperma-stratifizierung
US11754487B2 (en) 2020-06-24 2023-09-12 Becton, Dickinson And Company Flow cytometric droplet dispensing systems and methods for using the same
US11680889B2 (en) 2020-06-26 2023-06-20 Becton, Dickinson And Company Dual excitation beams for irradiating a sample in a flow stream and methods for using same
CN113376080A (zh) * 2021-06-11 2021-09-10 宋卓 液流装置及包含该装置的分析分选设备
FR3126043A1 (fr) * 2021-08-04 2023-02-10 Univers 2020 Installation de cytométrie en flux comportant un système de détection optique, notamment pour le traitement de cellules du type spermatozoïde
US20230046207A1 (en) 2021-08-10 2023-02-16 Becton, Dickinson And Company Outlet fittings for reducing bubbles at the interface with a flow cell, and flow cytometers and methods using the same
US20230053122A1 (en) 2021-08-10 2023-02-16 Becton, Dickinson And Company Clamps for operably coupling an optical component to a mounting block, and methods and systems for using the same

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3299354A (en) * 1962-07-05 1967-01-17 Coulter Electronics Aperture tube structure for particle study apparatus
US3810010A (en) * 1968-11-02 1974-05-07 Telefunken Patent Particle analysis method and apparatus wherein liquid containing particles is sucked into a constricted flow path
US3661460A (en) * 1970-08-28 1972-05-09 Technicon Instr Method and apparatus for optical analysis of the contents of a sheathed stream
US3826364A (en) * 1972-05-22 1974-07-30 Univ Leland Stanford Junior Particle sorting method and apparatus
US3761941A (en) * 1972-10-13 1973-09-25 Mead Corp Phase control for a drop generating and charging system
US4070617A (en) * 1974-05-08 1978-01-24 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Device for controlling the particle flow in an apparatus for measuring the properties of particles suspended in liquid
US3973196A (en) * 1974-05-24 1976-08-03 Coulter Electronics, Inc. Method and apparatus for ejecting a metered amount of particulate sample
US3963606A (en) * 1974-06-03 1976-06-15 Coulter Electronics, Inc. Semi-automatic adjusting delay for an electronic particle separator
US4014611A (en) * 1975-04-30 1977-03-29 Coulter Electronics, Inc. Aperture module for use in particle testing apparatus
US3960449A (en) * 1975-06-05 1976-06-01 The Board Of Trustees Of Leland Stanford Junior University Measurement of angular dependence of scattered light in a flowing stream
US4302166A (en) * 1976-04-22 1981-11-24 Coulter Electronics, Inc. Droplet forming apparatus for use in producing uniform particles
US4162282A (en) * 1976-04-22 1979-07-24 Coulter Electronics, Inc. Method for producing uniform particles
US4230558A (en) * 1978-10-02 1980-10-28 Coulter Electronics, Inc. Single drop separator
US4325483A (en) * 1979-08-20 1982-04-20 Ortho Diagnostics, Inc. Method for detecting and controlling flow rates of the droplet forming stream of an electrostatic particle sorting apparatus
US4318480A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method and apparatus for positioning the point of droplet formation in the jetting fluid of an electrostatic sorting device
US4318481A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method for automatically setting the correct phase of the charge pulses in an electrostatic flow sorter
US4318483A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Automatic relative droplet charging time delay system for an electrostatic particle sorting system using a relatively moveable stream surface sensing system
US4318482A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Method for measuring the velocity of a perturbed jetting fluid in an electrostatic particle sorting system
US4317520A (en) * 1979-08-20 1982-03-02 Ortho Diagnostics, Inc. Servo system to control the spatial position of droplet formation of a fluid jet in a cell sorting apparatus
US4691829A (en) * 1980-11-03 1987-09-08 Coulter Corporation Method of and apparatus for detecting change in the breakoff point in a droplet generation system
US4487320A (en) * 1980-11-03 1984-12-11 Coulter Corporation Method of and apparatus for detecting change in the breakoff point in a droplet generation system
US4395676A (en) * 1980-11-24 1983-07-26 Coulter Electronics, Inc. Focused aperture module
US4361400A (en) * 1980-11-26 1982-11-30 The United States Of America As Represented By The United States Department Of Energy Fluidic assembly for an ultra-high-speed chromosome flow sorter
US4818103A (en) * 1981-05-15 1989-04-04 Ratcom Flow cytometry
US4673288A (en) * 1981-05-15 1987-06-16 Ratcom, Inc. Flow cytometry
US4515274A (en) * 1981-12-02 1985-05-07 Coulter Corporation Particle analyzing and sorting apparatus
SU1056008A1 (ru) * 1982-01-25 1983-11-23 Предприятие П/Я Р-6681 Проточный цитофлуориметр
US4538733A (en) * 1983-10-14 1985-09-03 Becton, Dickinson And Company Particle sorter with neutralized collection wells and method of using same
US4631483A (en) * 1984-02-01 1986-12-23 Coulter Electronics, Inc. Particle analyzing apparatus and method of moving particles in suspension through such apparatus
JPS61139747A (ja) * 1984-12-12 1986-06-27 Canon Inc 粒子解析装置
JPS61159135A (ja) * 1984-12-31 1986-07-18 Canon Inc 粒子解析装置
DE3851458T2 (de) * 1987-04-08 1995-02-09 Hitachi Ltd Vorrichtung mit einer scheideförmigen Durchflusszelle.
JPS63262565A (ja) * 1987-04-20 1988-10-28 Hitachi Ltd フロ−セル
US4845025A (en) * 1987-11-10 1989-07-04 Coulter Corporation Biological sample mixing apparatus and method
JPH0224535A (ja) * 1988-07-12 1990-01-26 Canon Inc 粒子解析装置
JPH0718785B2 (ja) * 1988-09-19 1995-03-06 株式会社日立製作所 フローセル装置
US4981580A (en) * 1989-05-01 1991-01-01 Coulter Corporation Coincidence arbitration in a flow cytomery sorting system
JPH0353164A (ja) * 1989-07-20 1991-03-07 Canon Inc サンプル供給装置及びこれを用いたサンプル測定装置
US5005981A (en) * 1989-09-08 1991-04-09 Becton, Dickinson And Company Apparatus for method for causing vortices in a test tube
US5215376A (en) * 1989-09-08 1993-06-01 Becton, Dickinson And Company Method for causing vortices in a test tube
DE69014507T2 (de) * 1989-09-13 1995-04-13 Tiyoda Seisakusho Koushoku Kk Gerät zur Zellenvorbehandlung für Durchfluss-Zytometrie.
JP3049254B2 (ja) * 1990-02-08 2000-06-05 シスメックス株式会社 ２種類の光源を備えた光学式粒子分析装置
JPH0716392B2 (ja) * 1990-06-20 1995-03-01 株式会社ピーシーシーテクノロジー 細胞融合及び融合細胞選別システム
JPH0710226B2 (ja) * 1990-06-20 1995-02-08 株式会社ピーシーシーテクノロジー プロトプラスト攪拌装置並びにそれを含む細胞融合装置及びフローサイトメーター装置
US5259593A (en) * 1990-08-30 1993-11-09 University Of Southern California Apparatus for droplet stream manufacturing
JP2874746B2 (ja) * 1990-11-22 1999-03-24 シスメックス株式会社 フローイメージングサイトメータにおけるフローセル機構
JP3121849B2 (ja) * 1991-02-27 2001-01-09 シスメックス株式会社 フローイメージサイトメータ
JPH0734012B2 (ja) * 1991-02-27 1995-04-12 東亜医用電子株式会社 フローイメージサイトメータ
US5144224A (en) * 1991-04-01 1992-09-01 Larsen Lawrence E Millimeter wave flow cytometer
US5199576A (en) * 1991-04-05 1993-04-06 University Of Rochester System for flexibly sorting particles
US5412466A (en) * 1991-07-26 1995-05-02 Toa Medical Electronics Co., Ltd. Apparatus for forming flattened sample flow for analyzing particles
US5370842A (en) * 1991-11-29 1994-12-06 Canon Kabushiki Kaisha Sample measuring device and sample measuring system
US5359907A (en) * 1992-11-12 1994-11-01 Horiba Instruments, Inc. Method and apparatus for dry particle analysis

Also Published As

Publication number Publication date
EP0786079B1 (de) 2003-05-21
ES2196086T3 (es) 2003-12-16
AU691693B2 (en) 1998-05-21
JPH10507525A (ja) 1998-07-21
AU3962695A (en) 1996-05-06
US5602039A (en) 1997-02-11
DE69530851T2 (de) 2004-01-22
WO1996012172A1 (en) 1996-04-25
CA2201332A1 (en) 1996-04-25
CA2201332C (en) 2006-07-04
EP0786079A1 (de) 1997-07-30

Similar Documents

Publication Publication Date Title
DE69530851D1 (de) Monitorvorrichtung für den strahl eines durchflusszytometers
DE59711615D1 (de) Reinigungsvorrichtung für die Turbine eines Turboladers
DE69411540D1 (de) Apparat - verteiler für den siebkörper eines mähdreschers
DE69519618T2 (de) Schutzkappenanordnung für den Durchflusskanal eines medizinischen Geräts
DE69612127T2 (de) Vorrichtung zum verbinden der Abschnitte eines Perforationsstranges
ATE213968T1 (de) Vorrichtung zum haltern eines fluidischen bauteils
DE69518352D1 (de) Technik zum Absperren eines Rohres
DE69816171D1 (de) Verriegelungs-Vorrichtung für den Handgriff eines Durchflussreglers
DE69505993D1 (de) Düse zum extrudieren eines fluidstromes
DE69424037D1 (de) Vorrichtung zum Absperren des Innenraumes eines Rohres
DE69512146D1 (de) Aufspreizvorrichtung für den Flügel eines Geschosses
DE69519296T2 (de) Verriegelung für verbinder eines entfernbaren geräts
DE69521018T2 (de) Optisches filter für den bildschirm eines anzeigegerätes
DE69332716D1 (de) Schnelltrennkupplung für sondenspitze eines laparaskops
FR2723981B1 (fr) Dispositif de prelevement d'air auto-regule a la source pour turbomachine
DE69423406D1 (de) Einrichtung für den Anschluss eines Schlittens
FR2725512B1 (fr) Dispositif d'evaluation de la planeite d'un produit en defilement
DE69526052D1 (de) Vorrichtung zur Bewegungsübertragung für den oszillierenden Arm eines Regners
DE19680940D2 (de) Vorrichtung zum Bestimmen der Form eines Pferderückens
DE9421608U1 (de) Vorrichtung zum Abdichten des Überganges zwischen einem Sprüharm und seinem Lagerteil einer Geschirrspülmaschine
DE69500920D1 (de) Vorrichtung für den mast eines segelbootes
DE69512714D1 (de) Steuereinrichtung für den Wagen eines Seriendruckers
DE9413463U1 (de) Vorrichtung zum Verbinden eines Kabels
DE59708308D1 (de) Haltevorrichtung für den Versorgungsschlauch eines zahnärztlichen Handstückes
DE9412074U1 (de) Vorrichtung zum Reinigen eines Flüssigkeitsbades

Legal Events

Date Code Title Description
8364 No opposition during term of opposition