DE69530689D1 - Heparin-binding protein zur behandlung von sepsis - Google Patents

Heparin-binding protein zur behandlung von sepsis

Info

Publication number
DE69530689D1
DE69530689D1 DE69530689T DE69530689T DE69530689D1 DE 69530689 D1 DE69530689 D1 DE 69530689D1 DE 69530689 T DE69530689 T DE 69530689T DE 69530689 T DE69530689 T DE 69530689T DE 69530689 D1 DE69530689 D1 DE 69530689D1
Authority
DE
Germany
Prior art keywords
binding protein
hbp
protein
heparin
produced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69530689T
Other languages
English (en)
Other versions
DE69530689T2 (de
Inventor
Hans Jakob Hem Flodgaard
Poul Baad Rasmussen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LEUKOTECH AS COPENHAGEN
Original Assignee
LEUKOTECH AS COPENHAGEN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LEUKOTECH AS COPENHAGEN filed Critical LEUKOTECH AS COPENHAGEN
Application granted granted Critical
Publication of DE69530689D1 publication Critical patent/DE69530689D1/de
Publication of DE69530689T2 publication Critical patent/DE69530689T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE69530689T 1994-04-21 1995-03-17 Heparin-binding protein zur behandlung von sepsis Expired - Fee Related DE69530689T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DK46494 1994-04-21
DK46494 1994-04-21
DK145294 1994-12-21
DK145294 1994-12-21
PCT/DK1995/000121 WO1995028949A1 (en) 1994-04-21 1995-03-17 Heparin-binding protein for the treatment of sepsis and processes for its preparation

Publications (2)

Publication Number Publication Date
DE69530689D1 true DE69530689D1 (de) 2003-06-12
DE69530689T2 DE69530689T2 (de) 2004-03-25

Family

ID=26064054

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69530689T Expired - Fee Related DE69530689T2 (de) 1994-04-21 1995-03-17 Heparin-binding protein zur behandlung von sepsis

Country Status (15)

Country Link
EP (1) EP0762889B1 (de)
JP (1) JPH09512168A (de)
CN (1) CN1146724A (de)
AT (1) ATE239494T1 (de)
AU (1) AU703963B2 (de)
CA (1) CA2188395A1 (de)
CZ (1) CZ289439B6 (de)
DE (1) DE69530689T2 (de)
FI (1) FI964227A0 (de)
HU (1) HU221638B1 (de)
NO (1) NO964465L (de)
NZ (2) NZ332683A (de)
PL (1) PL316935A1 (de)
RU (1) RU2200573C2 (de)
WO (1) WO1995028949A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5607916A (en) * 1989-07-05 1997-03-04 The Board Of Regents Of The University Of Oklahoma Method and composition for the treatment of septic shock
WO1999000416A1 (en) * 1997-06-25 1999-01-07 Novo Nordisk A/S Use of heparin-binding protein for inhibiting entry of pathogens into mononuclear cells
WO1999000417A1 (en) * 1997-06-25 1999-01-07 Novo Nordisk A/S Production of heparin-binding protein in mammalian cells
JP2002542813A (ja) * 1999-04-29 2002-12-17 レウコテク アクティーゼルスカブ 組換哺乳動物細胞におけるヘパリン結合性タンパク質の発現
GB0521276D0 (en) * 2005-10-19 2005-11-30 Lewitt Moira S Medical uses and therapies based upon the action of azurocidin on IGFBP-1
GB0711327D0 (en) 2007-06-12 2007-07-25 Hansa Medical Ab Diagnostic method
GB201016161D0 (en) * 2010-09-24 2010-11-10 Hansa Medical Ab Diagnostic method
GB201102108D0 (en) 2011-02-07 2011-03-23 Hansa Medical Ab Diagnostic method
CN110903375A (zh) * 2019-10-12 2020-03-24 南京立顶生物科技有限公司 一种肝素结合蛋白生产提纯方法
CN110726846B (zh) * 2019-12-04 2022-08-26 南京市儿童医院 Hbp蛋白作为川崎病的诊断标志物的应用
CN113945718A (zh) * 2020-03-04 2022-01-18 上海奥普生物医药股份有限公司 一种肝素结合蛋白检测试剂盒、制备方法及用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL89661A (en) * 1988-03-17 1999-05-09 Novo Nordisk As Heparin binding proteins
US5089274A (en) * 1989-02-14 1992-02-18 Incyte Pharmaceuticals, Inc. Use of bactericidal/permeability increasing protein or biologically active analogs thereof to treat endotoxin-related disorders
US5484885A (en) * 1989-07-05 1996-01-16 Emory University Chemotactic, antibiotic and lipopolysaccharide-binding peptide fragments of CAP37
GB9017008D0 (en) * 1990-08-02 1990-09-19 Erba Carlo Spa Process for the enzymatic preparation of basic fibroblast growth factor

Also Published As

Publication number Publication date
CZ308296A3 (en) 1997-08-13
WO1995028949A1 (en) 1995-11-02
DE69530689T2 (de) 2004-03-25
NO964465D0 (no) 1996-10-21
ATE239494T1 (de) 2003-05-15
CA2188395A1 (en) 1995-11-02
FI964227A (fi) 1996-10-21
CZ289439B6 (cs) 2002-01-16
RU2200573C2 (ru) 2003-03-20
PL316935A1 (en) 1997-02-17
JPH09512168A (ja) 1997-12-09
HU221638B1 (hu) 2002-12-28
CN1146724A (zh) 1997-04-02
EP0762889B1 (de) 2003-05-07
HUT75557A (en) 1997-05-28
NZ332683A (en) 2001-06-29
EP0762889A1 (de) 1997-03-19
HU9602895D0 (en) 1996-12-30
AU2303395A (en) 1995-11-16
AU703963B2 (en) 1999-04-01
FI964227A0 (fi) 1996-10-21
NO964465L (no) 1996-10-21
NZ284434A (en) 1998-12-23

Similar Documents

Publication Publication Date Title
DE69034261D1 (de) Antikörper gegen VLA-4
FR2646437B1 (fr) Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
PT816380E (pt) Proteina ocif e metodos para a sua producao
BR9610511A (pt) Molécula de dna de forma circular útil em terapia gênica compreendendo ao menos uma sequência nucléica de interesse processo para sua produção célula recombinante composição farmacêutica utilização de uma molécula de dna e processo de produção de uma proteína recombinante
DE69131580D1 (de) GDF-1 und UOG1 Proteine
DE69530689D1 (de) Heparin-binding protein zur behandlung von sepsis
ES8103976A1 (es) Un metodo de producir proteinas de interferon humano de for-ma le
DE69637844D1 (de) Neues tgf-beta-ahnliches cytokin
Ryan et al. Coagulation and the expression of cell‐mediated immunity
DE69233143D1 (de) Anti-hiv-proteine gap31, dap30 und dap32, die sie kodierende dna und ihre therapeutische nutzung
DE68907735D1 (de) Genfragmente, die die variable region eines anti-hiv-antikoerpers codieren, von diesen exprimierte chimaere anti-hiv-antikoerper und verfahren zu deren herstellung.
CA2126182A1 (en) Humanized antibodies reactive with gpiib/iiia
ES2171563T3 (es) Nueva familia de inhibidores de proteasas, y otras sustancias de actividad biologica.
RU96122777A (ru) Связывающий гепарин белок для лечения сепсиса и способы его получения
ATE22899T1 (de) Antithrombin-heparin komplex.
MX9604953A (es) Proteina que une heparina, para el tratamiento de sepsis y procesos para su preparacion.
AU2459188A (en) Anticoagulative protein pp4-x, and its preparation and use
ATE309371T1 (de) Protein mit dnase-aktivität
Takeda et al. The production of a cytotoxic factor by mouse peritoneal macrophages and macrophage hybridomas treated with various stimulating agents
FR2555577B1 (fr) Nouveaux derives de peptides, leur procede de preparation et leur emploi comme reactif biologique
Damme et al. Identification by sequence analysis of chemotactic factors for monocytes produced by normal and transformed cells stimulated with virus, double‐stranded RNA or cytokine
Yasuda et al. Partial purification and characterization of feline gamma-like interferon
EP0603393A4 (de) Rekombinantes humanes interleukin-6 mit homogenem n-terminus und seine herstellung.
IT8620463A0 (it) Procedimento di purificazione di eparine, frazioni e frammenti eparinici.
WO2001077285A3 (fr) Nouveau polypeptide, proteine 13 de la famille des amidases, et polynucleotide codant pour ce polypeptide

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee