DE69521406T2 - Apparat und verfahren zur herstellung fester formen mit gesteuerter freisetzung des wirkstoffs - Google Patents

Apparat und verfahren zur herstellung fester formen mit gesteuerter freisetzung des wirkstoffs

Info

Publication number
DE69521406T2
DE69521406T2 DE69521406T DE69521406T DE69521406T2 DE 69521406 T2 DE69521406 T2 DE 69521406T2 DE 69521406 T DE69521406 T DE 69521406T DE 69521406 T DE69521406 T DE 69521406T DE 69521406 T2 DE69521406 T2 DE 69521406T2
Authority
DE
Germany
Prior art keywords
controlled release
active substance
producing solid
pct
solid shapes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69521406T
Other languages
English (en)
Other versions
DE69521406D1 (de
Inventor
Lorenzo Rodriguez
Maurizio Cini
Cristina Cavallari
Giuseppe Motta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Udf System Srl Gorle Bergamo It
Original Assignee
Saitec SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Saitec SRL filed Critical Saitec SRL
Application granted granted Critical
Publication of DE69521406D1 publication Critical patent/DE69521406D1/de
Publication of DE69521406T2 publication Critical patent/DE69521406T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/18—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic using a vibrating apparatus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Glanulating (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Moulds For Moulding Plastics Or The Like (AREA)
  • Molds, Cores, And Manufacturing Methods Thereof (AREA)
DE69521406T 1994-08-03 1995-04-06 Apparat und verfahren zur herstellung fester formen mit gesteuerter freisetzung des wirkstoffs Expired - Lifetime DE69521406T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITBO940379A IT1274879B (it) 1994-08-03 1994-08-03 Apparecchio e metodo per preparare forme farmaceutiche solide a rilascio controllato del principio attivo.
PCT/IT1995/000048 WO1996003979A1 (en) 1994-08-03 1995-04-06 Apparatus and method for preparing solid forms with controlled release of the active ingredient

Publications (2)

Publication Number Publication Date
DE69521406D1 DE69521406D1 (de) 2001-07-26
DE69521406T2 true DE69521406T2 (de) 2002-05-02

Family

ID=11339983

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69521406T Expired - Lifetime DE69521406T2 (de) 1994-08-03 1995-04-06 Apparat und verfahren zur herstellung fester formen mit gesteuerter freisetzung des wirkstoffs

Country Status (19)

Country Link
US (1) US5707636A (de)
EP (1) EP0726765B1 (de)
JP (1) JPH09503441A (de)
KR (1) KR100348935B1 (de)
CN (1) CN1213735C (de)
AT (1) ATE202279T1 (de)
AU (1) AU693539B2 (de)
BR (1) BR9506305A (de)
CA (1) CA2173221A1 (de)
DE (1) DE69521406T2 (de)
DK (1) DK0726765T3 (de)
ES (1) ES2159632T3 (de)
GR (1) GR3036548T3 (de)
IT (1) IT1274879B (de)
MX (1) MX9601279A (de)
PT (1) PT726765E (de)
RU (1) RU2142792C1 (de)
TW (1) TW343149B (de)
WO (1) WO1996003979A1 (de)

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US8545463B2 (en) * 2003-05-20 2013-10-01 Optimyst Systems Inc. Ophthalmic fluid reservoir assembly for use with an ophthalmic fluid delivery device
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US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
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DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE102005005446A1 (de) * 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE10361596A1 (de) * 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
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US7413690B1 (en) 2003-10-29 2008-08-19 The University Of Mississippi Process and apparatus for producing spherical pellets using molten solid matrices
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DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
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JP5774853B2 (ja) 2008-01-25 2015-09-09 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 医薬投薬形
TWI524904B (zh) * 2008-05-09 2016-03-11 歌林達股份有限公司 製備醫藥用固體劑型，尤指錠劑之方法，及製備固體劑型，尤指錠劑之前驅物之方法
CA2765971C (en) 2009-07-22 2017-08-22 Gruenenthal Gmbh Hot-melt extruded controlled release dosage form
JP2012533586A (ja) * 2009-07-22 2012-12-27 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 酸化安定化された不正使用防止剤形
ES2606227T3 (es) * 2010-02-03 2017-03-23 Grünenthal GmbH Preparación de una composición farmacéutica en polvo mediante una extrusora
EA201390120A3 (ru) 2010-07-15 2013-09-30 Коринтиан Офтэлмик, Инк. Доставка офтальмологических лекарственных средств
EA201390122A1 (ru) 2010-07-15 2014-05-30 Коринтиан Офтэлмик, Инк. Устройство для генерирования капель
JP2013531548A (ja) 2010-07-15 2013-08-08 コリンシアン オフサルミック，インコーポレイティド 遠隔治療及び遠隔モニタリングを実施する方法及びシステム
US10154923B2 (en) 2010-07-15 2018-12-18 Eyenovia, Inc. Drop generating device
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RU2449777C1 (ru) * 2010-12-20 2012-05-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Новосибирский национальный исследовательский государственный университет" (Новосибирский государственный университет, НГУ) Способ получения высокодисперсного парацетамола
PT2736497T (pt) 2011-07-29 2017-11-30 Gruenenthal Gmbh Comprimido resistente a adulteração proporcionando libertação imediata de fármaco
CN103841964A (zh) 2011-07-29 2014-06-04 格吕伦塔尔有限公司 提供药物立即释放的抗破碎片剂
CN104487028A (zh) 2011-12-12 2015-04-01 艾诺维亚股份有限公司 高模量聚合物喷射器机构、喷射器装置及其使用方法
JP6117249B2 (ja) 2012-02-28 2017-04-19 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 薬理学的に活性な化合物および陰イオン性ポリマーを含むタンパーレジスタント剤形
WO2013156453A1 (en) 2012-04-18 2013-10-24 Grünenthal GmbH Tamper resistant and dose-dumping resistant pharmaceutical dosage form
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
CA2913209A1 (en) 2013-05-29 2014-12-04 Grunenthal Gmbh Tamper resistant dosage form with bimodal release profile
US9452271B2 (en) 2013-05-29 2016-09-27 General Electric Company Nebulizer systems and methods
MX371432B (es) 2013-05-29 2020-01-30 Gruenenthal Gmbh Forma de dosificacion resistente al uso indebido que contiene una o mas particulas.
MX368846B (es) 2013-07-12 2019-10-18 Gruenenthal Gmbh Forma de dosificación resistente a la alteración que contiene polímero de acetato de etilen-vinilo.
EP3073994A1 (de) 2013-11-26 2016-10-05 Grünenthal GmbH Herstellung einer pulverförmigen pharmazeutischen zusammensetzung mittels kryogenen mahlens
EP3142646A1 (de) 2014-05-12 2017-03-22 Grünenthal GmbH Manipulationssichere kapselformulierung mit tapentadol mit unmittelbarer freisetzung
EA201692388A1 (ru) 2014-05-26 2017-05-31 Грюненталь Гмбх Лекарственная форма в виде множества частиц, защищенная от вызываемого этанолом сброса дозы
US20180310550A9 (en) * 2015-04-21 2018-11-01 Basf Se Method for producing particles comprising a hydrocarbon wax in a continuous phase and a pesticide dispersed in the continuous phase by generating droplets with a vibrating nozzle
EA035434B1 (ru) 2015-04-24 2020-06-15 Грюненталь Гмбх Защищенная от применения не по назначению лекарственная форма с немедленным высвобождением и устойчивостью к экстракции растворителями
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Also Published As

Publication number Publication date
JPH09503441A (ja) 1997-04-08
ATE202279T1 (de) 2001-07-15
ES2159632T3 (es) 2001-10-16
ITBO940379A0 (it) 1994-08-03
CA2173221A1 (en) 1996-02-15
DK0726765T3 (da) 2001-10-15
RU2142792C1 (ru) 1999-12-20
EP0726765B1 (de) 2001-06-20
AU2113795A (en) 1996-03-04
DE69521406D1 (de) 2001-07-26
TW343149B (en) 1998-10-21
AU693539B2 (en) 1998-07-02
BR9506305A (pt) 1997-08-05
EP0726765A1 (de) 1996-08-21
GR3036548T3 (en) 2001-12-31
CN1213735C (zh) 2005-08-10
IT1274879B (it) 1997-07-25
US5707636A (en) 1998-01-13
WO1996003979A1 (en) 1996-02-15
ITBO940379A1 (it) 1996-02-03
MX9601279A (es) 1998-11-30
KR960704529A (ko) 1996-10-09
CN1135175A (zh) 1996-11-06
PT726765E (pt) 2001-12-28
KR100348935B1 (ko) 2002-12-28

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Owner name: UDF SYSTEM S.R.L., GORLE, BERGAMO, IT