ATE202279T1 - Apparat und verfahren zur herstellung fester formen mit gesteuerter freisetzung des wirkstoffs - Google Patents

Apparat und verfahren zur herstellung fester formen mit gesteuerter freisetzung des wirkstoffs

Info

Publication number
ATE202279T1
ATE202279T1 AT95913940T AT95913940T ATE202279T1 AT E202279 T1 ATE202279 T1 AT E202279T1 AT 95913940 T AT95913940 T AT 95913940T AT 95913940 T AT95913940 T AT 95913940T AT E202279 T1 ATE202279 T1 AT E202279T1
Authority
AT
Austria
Prior art keywords
controlled release
active substance
producing solid
pct
solid molds
Prior art date
Application number
AT95913940T
Other languages
English (en)
Inventor
Lorenzo Rodriguez
Maurizio Cini
Cristina Cavallari
Giuseppe Motta
Original Assignee
Saitec Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Saitec Srl filed Critical Saitec Srl
Application granted granted Critical
Publication of ATE202279T1 publication Critical patent/ATE202279T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/18—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic using a vibrating apparatus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Glanulating (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Moulds For Moulding Plastics Or The Like (AREA)
  • Molds, Cores, And Manufacturing Methods Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT95913940T 1994-08-03 1995-04-06 Apparat und verfahren zur herstellung fester formen mit gesteuerter freisetzung des wirkstoffs ATE202279T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITBO940379A IT1274879B (it) 1994-08-03 1994-08-03 Apparecchio e metodo per preparare forme farmaceutiche solide a rilascio controllato del principio attivo.
PCT/IT1995/000048 WO1996003979A1 (en) 1994-08-03 1995-04-06 Apparatus and method for preparing solid forms with controlled release of the active ingredient

Publications (1)

Publication Number Publication Date
ATE202279T1 true ATE202279T1 (de) 2001-07-15

Family

ID=11339983

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95913940T ATE202279T1 (de) 1994-08-03 1995-04-06 Apparat und verfahren zur herstellung fester formen mit gesteuerter freisetzung des wirkstoffs

Country Status (19)

Country Link
US (1) US5707636A (de)
EP (1) EP0726765B1 (de)
JP (1) JPH09503441A (de)
KR (1) KR100348935B1 (de)
CN (1) CN1213735C (de)
AT (1) ATE202279T1 (de)
AU (1) AU693539B2 (de)
BR (1) BR9506305A (de)
CA (1) CA2173221A1 (de)
DE (1) DE69521406T2 (de)
DK (1) DK0726765T3 (de)
ES (1) ES2159632T3 (de)
GR (1) GR3036548T3 (de)
IT (1) IT1274879B (de)
MX (1) MX9601279A (de)
PT (1) PT726765E (de)
RU (1) RU2142792C1 (de)
TW (1) TW343149B (de)
WO (1) WO1996003979A1 (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9819272D0 (en) * 1998-09-03 1998-10-28 Andaris Ltd Microparticles
US6602521B1 (en) * 1998-09-29 2003-08-05 Impax Pharmaceuticals, Inc. Multiplex drug delivery system suitable for oral administration
DE10009996B4 (de) * 2000-03-02 2005-10-13 Cognis Ip Management Gmbh Feststoffgranulate mit monodisperser Korngrößenverteilung, ein Verfahren zu ihrer Herstellung sowie ihre Verwendung
FR2809011B1 (fr) * 2000-05-22 2002-11-15 Sederma Sa Utilisation du beurre de karite incorpore dans les microcapsules fixees sur tout textile pour augmenter l'hydratation cutanee
DE20019711U1 (de) * 2000-11-20 2002-04-04 Soering Gmbh Ultraschall-Gerät zur Behandlung septischer Wunden
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
US8012136B2 (en) * 2003-05-20 2011-09-06 Optimyst Systems, Inc. Ophthalmic fluid delivery device and method of operation
ATE501766T1 (de) * 2003-05-20 2011-04-15 James F Collins Ophthalmisches arzneimittelabgabesystem
JP4939217B2 (ja) * 2003-08-06 2012-05-23 グリューネンタ−ル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 乱用防止剤形
DE10336400A1 (de) * 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE10361596A1 (de) * 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE102005005446A1 (de) * 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE102004020220A1 (de) * 2004-04-22 2005-11-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
US7413690B1 (en) 2003-10-29 2008-08-19 The University Of Mississippi Process and apparatus for producing spherical pellets using molten solid matrices
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102004032103A1 (de) * 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) * 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US20080075811A1 (en) * 2006-09-23 2008-03-27 Peter Horlacher Coated particles and their use
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
EP2022557A1 (de) * 2007-08-06 2009-02-11 Laboratories Development LLC Verfahren zur Herstellung von granuliertem gefrorenem Pulver
EP2205221A2 (de) * 2007-10-23 2010-07-14 Koninklijke Philips Electronics N.V. Verfahren zur herstellung von polymermikropartikeln
EP2101131A1 (de) 2007-12-31 2009-09-16 Terruzzi Fercalx S.p.A. Gefriertrocknungsverfahren sowie System dafür
WO2009092601A1 (en) 2008-01-25 2009-07-30 Grünenthal GmbH Pharmaceutical dosage form
US20090212133A1 (en) * 2008-01-25 2009-08-27 Collins Jr James F Ophthalmic fluid delivery device and method of operation
MX2010012039A (es) * 2008-05-09 2010-11-30 Gruenenthal Gmbh Proceso para la preparacion de una formulacion de polvo intermedia y una forma de dosificacion solida final bajo el uso de un paso de congelacion por rocio.
RU2567723C2 (ru) 2009-07-22 2015-11-10 Грюненталь Гмбх Стабильная при окислении, прочная на излом лекарственная форма
BR112012001547A2 (pt) 2009-07-22 2016-03-08 Gruenenthal Gmbh forma de dosagem farmacêutica extrusada por fusão a quente
ES2606227T3 (es) * 2010-02-03 2017-03-23 Grünenthal GmbH Preparación de una composición farmacéutica en polvo mediante una extrusora
WO2012009702A1 (en) 2010-07-15 2012-01-19 Corinthian Ophthalmic, Inc. Method and system for performing remote treatment and monitoring
WO2012009696A2 (en) 2010-07-15 2012-01-19 Corinthian Ophthalmic, Inc. Ophthalmic drug delivery
CA2805426C (en) 2010-07-15 2020-03-24 Corinthian Ophthalmic, Inc. Drop generating device
US10154923B2 (en) 2010-07-15 2018-12-18 Eyenovia, Inc. Drop generating device
RU2604676C2 (ru) 2010-09-02 2016-12-10 Грюненталь Гмбх Устойчивая к разрушению лекарственная форма, содержащая неорганическую соль
PE20131126A1 (es) 2010-09-02 2013-10-21 Gruenenthal Chemie Forma de dosificacion resistente a alteracion que comprende un polimero anionico
RU2449777C1 (ru) * 2010-12-20 2012-05-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Новосибирский национальный исследовательский государственный университет" (Новосибирский государственный университет, НГУ) Способ получения высокодисперсного парацетамола
CA2839123A1 (en) 2011-07-29 2013-02-07 Grunenthal Gmbh Tamper-resistant tablet providing immediate drug release
DK2736497T3 (da) 2011-07-29 2017-11-13 Gruenenthal Gmbh Stød-resistent tablet, der tilvejebringer en øjeblikkelig frigivelse af et lægemiddel.
WO2013090468A1 (en) 2011-12-12 2013-06-20 Corinthian Ophthalmic, Inc. High modulus polymeric ejector mechanism, ejector device, and methods of use
US20130225697A1 (en) 2012-02-28 2013-08-29 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
WO2013156453A1 (en) 2012-04-18 2013-10-24 Grünenthal GmbH Tamper resistant and dose-dumping resistant pharmaceutical dosage form
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
AR096438A1 (es) 2013-05-29 2015-12-30 Gruenenthal Gmbh Forma de dosificación resistente al uso indebido con perfil de liberación bimodal, proceso
US9452271B2 (en) 2013-05-29 2016-09-27 General Electric Company Nebulizer systems and methods
CA2907950A1 (en) 2013-05-29 2014-12-04 Grunenthal Gmbh Tamper-resistant dosage form containing one or more particles
AU2014289187B2 (en) 2013-07-12 2019-07-11 Grunenthal Gmbh Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
MX371372B (es) 2013-11-26 2020-01-28 Gruenenthal Gmbh Preparacion de una composicion farmaceutica en polvo por medio de criomolienda.
EP3142646A1 (de) 2014-05-12 2017-03-22 Grünenthal GmbH Manipulationssichere kapselformulierung mit tapentadol mit unmittelbarer freisetzung
JP2017516789A (ja) 2014-05-26 2017-06-22 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング エタノール過量放出に対して防護されている多粒子
US20180310550A9 (en) * 2015-04-21 2018-11-01 Basf Se Method for producing particles comprising a hydrocarbon wax in a continuous phase and a pesticide dispersed in the continuous phase by generating droplets with a vibrating nozzle
KR20170139158A (ko) 2015-04-24 2017-12-18 그뤼넨탈 게엠베하 즉시 방출되고 용매 추출 방지된 변조 방지된 투여 형태
CA2998259A1 (en) 2015-09-10 2017-03-16 Grunenthal Gmbh Protecting oral overdose with abuse deterrent immediate release formulations
CN108623724A (zh) * 2017-03-17 2018-10-09 江苏华昌织物有限公司 用于信息素缓释的高分子微球的制备方法
CN111093742B (zh) 2017-06-10 2022-09-16 艾诺维亚股份有限公司 用于处理流体并将流体输送到眼睛的方法和设备

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2828206A (en) * 1954-02-24 1958-03-25 Roseuberg Adolf Stabilized fat-soluble vitamins and methods of making same
US3078216A (en) * 1961-04-11 1963-02-19 American Cyanamid Co Prolonged release oral pharmaceutical preparations
BR6457270D0 (pt) * 1963-03-04 1973-09-20 Merck & Co Inc Processo de preparacao de uma composicao farmaceutica provendo uma liberacao prolongada de uma droga no aparelho gastro intestinal
US3432593A (en) * 1963-09-18 1969-03-11 Key Pharm Inc Delayed and sustained release type pharmaceutical preparation
US3922339A (en) * 1974-06-20 1975-11-25 Kv Pharm Co Sustained release medicant
SE418247B (sv) * 1975-11-17 1981-05-18 Haessle Ab Sett att framstella kroppar med reglerad frigoring av en aktiv komponent
DE2725849C3 (de) * 1977-06-08 1980-11-13 Hobeg Hochtemperaturreaktor-Brennelement Gmbh, 6450 Hanau Vorrichtung zur Herstellung von kugelförmigen Teilchen
DK151608C (da) * 1982-08-13 1988-06-20 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk peroralt polydepotpraeparat med kontrolleret afgivelse
US4779806A (en) * 1984-07-23 1988-10-25 Massachusetts Institute Of Technology Ultrasonically modulated polymeric devices for delivering compositions
US4657543A (en) * 1984-07-23 1987-04-14 Massachusetts Institute Of Technology Ultrasonically modulated polymeric devices for delivering compositions
FR2571980A1 (fr) * 1984-10-22 1986-04-25 Extramet Sa Procede et dispositif de fabrication de micro-billes calibrees et micro-billes obtenues.
DE3669103D1 (de) * 1986-11-14 1990-04-05 Puetter Medice Chem Pharm Ibuprofen enthaltendes arzneimittel.
US5019400A (en) * 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
FR2657257B1 (fr) * 1990-01-19 1994-09-02 Rhone Poulenc Sante Procede de preparation de medicaments sous forme de perles.
FR2664851B1 (fr) * 1990-07-20 1992-10-16 Oreal Procede de compactage d'un melange pulverulent permettant d'obtenir un produit compact absorbant ou partiellement delitable et produit obtenu par ce procede.

Also Published As

Publication number Publication date
EP0726765B1 (de) 2001-06-20
MX9601279A (es) 1998-11-30
JPH09503441A (ja) 1997-04-08
RU2142792C1 (ru) 1999-12-20
AU693539B2 (en) 1998-07-02
EP0726765A1 (de) 1996-08-21
ITBO940379A1 (it) 1996-02-03
DK0726765T3 (da) 2001-10-15
US5707636A (en) 1998-01-13
CA2173221A1 (en) 1996-02-15
CN1213735C (zh) 2005-08-10
TW343149B (en) 1998-10-21
IT1274879B (it) 1997-07-25
DE69521406T2 (de) 2002-05-02
ES2159632T3 (es) 2001-10-16
BR9506305A (pt) 1997-08-05
WO1996003979A1 (en) 1996-02-15
KR960704529A (ko) 1996-10-09
ITBO940379A0 (it) 1994-08-03
PT726765E (pt) 2001-12-28
CN1135175A (zh) 1996-11-06
KR100348935B1 (ko) 2002-12-28
AU2113795A (en) 1996-03-04
DE69521406D1 (de) 2001-07-26
GR3036548T3 (en) 2001-12-31

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