DE69513248D1 - Zusammensetzung, Verfahren und System zum Nachweis von Leukocyten, Esterasen oder Proteasen in einer Testprobe - Google Patents

Zusammensetzung, Verfahren und System zum Nachweis von Leukocyten, Esterasen oder Proteasen in einer Testprobe

Info

Publication number
DE69513248D1
DE69513248D1 DE69513248T DE69513248T DE69513248D1 DE 69513248 D1 DE69513248 D1 DE 69513248D1 DE 69513248 T DE69513248 T DE 69513248T DE 69513248 T DE69513248 T DE 69513248T DE 69513248 D1 DE69513248 D1 DE 69513248D1
Authority
DE
Germany
Prior art keywords
esterases
leukocytes
proteases
detection
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69513248T
Other languages
English (en)
Other versions
DE69513248T2 (de
Inventor
Gary Michael Johnson
Robert J Schaeper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Inc
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Publication of DE69513248D1 publication Critical patent/DE69513248D1/de
Application granted granted Critical
Publication of DE69513248T2 publication Critical patent/DE69513248T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • C12Q2334/70—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases the product, e.g. phenol, naphthol being diazotised in situ, e.g. with Fast Red
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/805—Test papers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/903—Diazo reactions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69513248T 1994-08-22 1995-08-09 Zusammensetzung, Verfahren und System zum Nachweis von Leukocyten, Esterasen oder Proteasen in einer Testprobe Expired - Lifetime DE69513248T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/293,723 US5464739A (en) 1994-08-22 1994-08-22 Composition method for determining the presence of leukocyte cells, esterase or protease in a test sample

Publications (2)

Publication Number Publication Date
DE69513248D1 true DE69513248D1 (de) 1999-12-16
DE69513248T2 DE69513248T2 (de) 2000-05-11

Family

ID=23130291

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69513248T Expired - Lifetime DE69513248T2 (de) 1994-08-22 1995-08-09 Zusammensetzung, Verfahren und System zum Nachweis von Leukocyten, Esterasen oder Proteasen in einer Testprobe

Country Status (4)

Country Link
US (2) US5464739A (de)
EP (1) EP0698600B1 (de)
JP (1) JP4033921B2 (de)
DE (1) DE69513248T2 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629173A (en) * 1990-08-09 1997-05-13 Genentech, Inc. Methods of use of serine protease variants having peptide ligase activity
EP0750045A1 (de) * 1995-06-22 1996-12-27 Chemunex Verfahren zum Nachweis von Harnleiterinfektionen
US5846754A (en) * 1996-05-28 1998-12-08 Bayer Corporation Enzyme determination with protease inactivation
US5738728A (en) * 1996-07-26 1998-04-14 Bio Dot, Inc. Precision metered aerosol dispensing apparatus
USRE38281E1 (en) 1996-07-26 2003-10-21 Biodot, Inc. Dispensing apparatus having improved dynamic range
US5916524A (en) * 1997-07-23 1999-06-29 Bio-Dot, Inc. Dispensing apparatus having improved dynamic range
US5743960A (en) * 1996-07-26 1998-04-28 Bio-Dot, Inc. Precision metered solenoid valve dispenser
US5741554A (en) * 1996-07-26 1998-04-21 Bio Dot, Inc. Method of dispensing a liquid reagent
KR980010425A (ko) * 1996-07-30 1998-04-30 안홍원 뇨중 백혈구 및 단백질 분해 효소 검출을 위한 조성물 및 측정기구
US6537505B1 (en) 1998-02-20 2003-03-25 Bio Dot, Inc. Reagent dispensing valve
JP3298824B2 (ja) * 1998-03-13 2002-07-08 アークレイ株式会社 白血球計数方法および白血球計数装置
DE19829707C2 (de) * 1998-07-03 2002-07-18 Macherey Nagel Gmbh & Co Hg Diagnostisches Mittel zum Nachweis von Leukozyten, Elastasen, Esterasen und Proteasen
US6348324B1 (en) 1999-01-21 2002-02-19 Hypoguard America Limited Composition and device for detecting leukocytes in urine
US6528652B1 (en) * 1999-01-21 2003-03-04 Chronimed Composition and device for detecting leukocytes in urine
GB9913487D0 (en) * 1999-06-11 1999-08-11 Pirzad Ramin Dust mite detection
AU2003206919A1 (en) * 2002-02-25 2003-09-09 Ciba Specialty Chemicals Holding Inc. Method of colouring keratin-containing fibres
US6709868B2 (en) * 2002-05-20 2004-03-23 Portascience Inc. Method and apparatus for measuring white blood cell count
US20040029205A1 (en) * 2002-07-30 2004-02-12 Small Parker Adams Diagnostic system for differentiating sputum from saliva
US7282349B2 (en) 2003-12-16 2007-10-16 Kimberly-Clark Worldwide, Inc. Solvatochromatic bacterial detection
US7399608B2 (en) * 2003-12-16 2008-07-15 Kimberly-Clark Worldwide, Inc. Microbial detection and quantification
US7300770B2 (en) * 2004-12-16 2007-11-27 Kimberly-Clark Worldwide, Inc. Detection of microbe contamination on elastomeric articles
US7906276B2 (en) 2004-06-30 2011-03-15 Kimberly-Clark Worldwide, Inc. Enzymatic detection techniques
US7521226B2 (en) 2004-06-30 2009-04-21 Kimberly-Clark Worldwide, Inc. One-step enzymatic and amine detection technique
US20060127459A1 (en) * 2004-12-15 2006-06-15 Lei Huang Urogenital infection inhibition
US20060223052A1 (en) * 2005-03-30 2006-10-05 Kimberly-Clark Worldwide, Inc. Technique for detecting microorganisms
US8003399B2 (en) * 2005-08-31 2011-08-23 Kimberly-Clark Worldwide, Inc. Nitrite detection technique
US7504235B2 (en) * 2005-08-31 2009-03-17 Kimberly-Clark Worldwide, Inc. Enzyme detection technique
US7265560B2 (en) * 2005-11-23 2007-09-04 Therm-O-Disc, Incorporated Temperature compensated vapor sensor
US7727513B2 (en) * 2005-12-15 2010-06-01 Kimberly-Clark Worldwide, Inc. Method for screening for bacterial conjunctivitis
US7727206B2 (en) * 2005-12-27 2010-06-01 Gorres Geoffrey H Device for monitoring a patient for a urinary tract infection
US8758989B2 (en) * 2006-04-06 2014-06-24 Kimberly-Clark Worldwide, Inc. Enzymatic detection techniques
US20080057534A1 (en) * 2006-08-31 2008-03-06 Kimberly-Clark Worldwide, Inc. Microbe-sensitive indicators and use of the same
US8044257B2 (en) 2006-10-30 2011-10-25 Kimberly-Clark Worldwide, Inc. Absorbent article containing lateral flow assay device
US7897360B2 (en) 2006-12-15 2011-03-01 Kimberly-Clark Worldwide, Inc. Enzyme detection techniques
US7935538B2 (en) 2006-12-15 2011-05-03 Kimberly-Clark Worldwide, Inc. Indicator immobilization on assay devices
US8043272B2 (en) * 2007-04-30 2011-10-25 Kimberly-Clark Worldwide, Inc. Collection and testing of infant urine using an absorbent article
US20080269707A1 (en) 2007-04-30 2008-10-30 Kimberly-Clark Worldwide, Inc. Lateral Flow Device for Attachment to an Absorbent Article
EP2181330B2 (de) * 2007-08-31 2016-08-31 Statens Serum Institut Zusammensetzungen und mittel zur diagnose mikrobieller infektionen
US20090142275A1 (en) * 2007-11-29 2009-06-04 Kimberly-Clark Worldwide, Inc. Wound Suture Capable of Identifying the Presence of Bacteria
US8180421B2 (en) * 2007-12-12 2012-05-15 Kimberly-Clark Worldwide, Inc. Resonance energy transfer based detection of nosocomial infection
US9103796B2 (en) 2007-12-14 2015-08-11 Kimberly-Clark Worldwide, Inc. Multi-layered devices for analyte detection
ES2573804T3 (es) * 2009-01-26 2016-06-10 Siemens Healthcare Diagnostics Inc. Método de detección de tiras reactivas para análisis de orina comprometidas por la humedad ambiental
US20150369747A1 (en) 2011-07-15 2015-12-24 Siemens Healthcare Diagnostics Inc. Device and method for detection of humidity-compromised urine test strips
JP2019515681A (ja) * 2016-03-22 2019-06-13 パービッチ サージカル イノベーション， エルエルシーＰａｒｖｉｚｉ Ｓｕｒｇｉｃａｌ Ｉｎｎｏｖａｔｉｏｎ， Ｌｌｃ 電気化学的検査を用いた活性を有する白血球細胞の存在測定のための組成物及び方法
US11104933B1 (en) 2016-03-22 2021-08-31 Cleu Diagnostics, Llc Compositions and methods for determining the presence of active leukocyte cells using an electrochemical assay
WO2019094575A1 (en) * 2017-11-08 2019-05-16 Gorski Waldemar Redox substrates for leukocyte esterase
CN115109066B (zh) * 2022-06-30 2023-04-07 武汉工程大学 一种大斯托克斯位移检测弹性蛋白酶的荧光探针及其制备方法与应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1128371A (en) 1965-10-04 1968-09-25 Miles Lab Diagnostic composition
JPS5257121A (en) 1975-11-01 1977-05-11 Microbial Chem Res Found Process for novel physiologycal active n-acylpeptide
US4064236A (en) * 1975-12-23 1977-12-20 Merck & Co., Inc. Peptide carbazates and pharmaceutical composition
DE2836644A1 (de) * 1978-08-22 1980-03-06 Boehringer Mannheim Gmbh Diagnostisches mittel zum nachweis von leukozyten in koerperfluessigkeiten und dafuer geeignete chromogene
DE2854987A1 (de) 1978-12-20 1980-06-26 Boehringer Mannheim Gmbh Diagnostische mittel zum nachweis proteolytischer enzyme und dafuer geeignete chromogene
DE2905531A1 (de) * 1979-02-14 1981-01-08 Boehringer Mannheim Gmbh Diagnostisches mittel zum nachweis von leukozyten in koerperfluessigkeiten
US4421761A (en) * 1981-01-27 1983-12-20 Hokko Chemical Industry Co. Ltd. Thiophene derivatives
DE3403974A1 (de) * 1984-02-04 1985-08-14 Bayer Ag, 5090 Leverkusen Optisch aktive phenoxypropionsaeure-derivate
US4657855A (en) * 1984-04-06 1987-04-14 Miles Laboratories, Inc. Composition and test device for determining the presence of leukocytes, esterase and protease in a test sample
US4645842A (en) * 1984-04-06 1987-02-24 Miles Laboratories, Inc. Pyrrole compounds for detecting the presence of hydrolytic analytes
DE3413077A1 (de) 1984-04-06 1985-10-17 Miles Laboratories, Inc., Elkhart, Ind. Chromogene aminosaeure- und peptidester, verfahren zu deren herstellung, verwendung dieser verbindungen in analysenverfahren sowie mittel zum nachweis esterolytischer und/oder proteolytischer enzyme
US4637979A (en) * 1984-04-06 1987-01-20 Miles Laboratories, Inc. Composition and test device for determining the presence of leukocytes containing a zwitterion coupling agent
DE3413078A1 (de) * 1984-04-06 1985-10-24 Miles Laboratories, Inc., Elkhart, Ind. Chromogene aminosaeure- und peptidester, verfahren zu deren herstellung, verwendung dieser verbindungen in analysenverfahren sowie mittel zum nachweis esterolytischer und/oder proteolytischer enzyme
US5707559A (en) 1986-07-17 1998-01-13 Tropix, Inc. Chemiluminescent 1,2-dioxetane compounds
JP3169216B2 (ja) 1988-07-08 2001-05-21 プロメガ・バイオサイエンシーズ・インコーポレイテッド 蛍光性ベンゾチアゾール誘導体の製法及び用途
DE8906448U1 (de) 1989-05-25 1989-07-13 Hoolt, Albertus G., Purmerend Zeitschrift o.dgl.
JPH05168497A (ja) * 1991-12-25 1993-07-02 Wako Pure Chem Ind Ltd エステル分解酵素又は蛋白分解酵素の測定用試薬

Also Published As

Publication number Publication date
JP4033921B2 (ja) 2008-01-16
JPH0867651A (ja) 1996-03-12
US5512450A (en) 1996-04-30
EP0698600A1 (de) 1996-02-28
DE69513248T2 (de) 2000-05-11
EP0698600B1 (de) 1999-11-10
US5464739A (en) 1995-11-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SIEMENS HEALTHCARE DIAGNOSTICS INC. (N.D.GES.D, US

8328 Change in the person/name/address of the agent

Representative=s name: MAIER, D., DIPL.-ING. UNIV., PAT.-ASS., 81739 MUEN