EP3432873A4 - Zusammensetzungen und verfahren zur bestimmung des vorhandenseins von aktiven leukozytenzellen unter verwendung eines elektrochemischen tests - Google Patents

Zusammensetzungen und verfahren zur bestimmung des vorhandenseins von aktiven leukozytenzellen unter verwendung eines elektrochemischen tests Download PDF

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Publication number
EP3432873A4
EP3432873A4 EP17770862.5A EP17770862A EP3432873A4 EP 3432873 A4 EP3432873 A4 EP 3432873A4 EP 17770862 A EP17770862 A EP 17770862A EP 3432873 A4 EP3432873 A4 EP 3432873A4
Authority
EP
European Patent Office
Prior art keywords
compositions
determining
methods
leukocyte cells
electrochemical assay
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP17770862.5A
Other languages
English (en)
French (fr)
Other versions
EP3432873A1 (de
Inventor
Andrew Neil FLEISCHMAN
Javad Parvizi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CLEU DIAGNOSTICS, LLC
Original Assignee
Parvizi Surgical Innovation LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parvizi Surgical Innovation LLC filed Critical Parvizi Surgical Innovation LLC
Publication of EP3432873A1 publication Critical patent/EP3432873A1/de
Publication of EP3432873A4 publication Critical patent/EP3432873A4/de
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP17770862.5A 2016-03-22 2017-03-17 Zusammensetzungen und verfahren zur bestimmung des vorhandenseins von aktiven leukozytenzellen unter verwendung eines elektrochemischen tests Pending EP3432873A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662311405P 2016-03-22 2016-03-22
US201662352560P 2016-06-21 2016-06-21
PCT/US2017/022976 WO2017165222A1 (en) 2016-03-22 2017-03-17 Compositions and methods for derermining the presence of active leukocyte cells using an electrochemical assay

Publications (2)

Publication Number Publication Date
EP3432873A1 EP3432873A1 (de) 2019-01-30
EP3432873A4 true EP3432873A4 (de) 2020-01-08

Family

ID=59899759

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17770862.5A Pending EP3432873A4 (de) 2016-03-22 2017-03-17 Zusammensetzungen und verfahren zur bestimmung des vorhandenseins von aktiven leukozytenzellen unter verwendung eines elektrochemischen tests

Country Status (4)

Country Link
EP (1) EP3432873A4 (de)
JP (1) JP2019515681A (de)
CA (1) CA3018776A1 (de)
WO (1) WO2017165222A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11104933B1 (en) 2016-03-22 2021-08-31 Cleu Diagnostics, Llc Compositions and methods for determining the presence of active leukocyte cells using an electrochemical assay
WO2019094575A1 (en) * 2017-11-08 2019-05-16 Gorski Waldemar Redox substrates for leukocyte esterase
EP4275043A1 (de) 2021-01-08 2023-11-15 Alpspitz Bioscience GmbH Verwendung von biomarkern zur vorhersage des klinischen und/oder behandlungsergebnisses einer person

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4677060A (en) * 1981-02-06 1987-06-30 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Process for determining the pH value in the interior of a cell
EP0698600A1 (de) * 1994-08-22 1996-02-28 Bayer Corporation Zusammensetzung, Verfahren und System zum Nachweis von Leukocyten, Esterasen oder Proteasen in einer Testprobe
DE19829707A1 (de) * 1998-07-03 2000-01-05 Macherey Nagel Gmbh & Co Hg Diagnostisches Mittel zum Nachweis von Leukozyten, Elastasen, Esterasen und Proteasen
US6503725B2 (en) * 1999-01-21 2003-01-07 Hypoguard America Limited Composition and device for detecting leukocytes in urine
WO2003043583A2 (en) * 2001-11-20 2003-05-30 Seattle Genetics, Inc. Treatment of immunological disorders using anti-cd30 antibodies
WO2009089680A1 (en) * 2007-12-19 2009-07-23 Dan Yang Method of modulating membrane potential of a cell

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897444A (en) * 1985-05-31 1990-01-30 The Research Foundation Of The State University Of New York Immobilized fluorogenic substrates for enzymes; and processes for their preparation
JPH03244396A (ja) * 1990-02-23 1991-10-31 Terumo Corp 加水分解酵素の検出方法およびそれに使用する検出器具
CA2161574A1 (en) * 1994-11-15 1996-05-16 James Noffsinger Methodology for colorimetrically determining the concentration of white blood cells in a biological fluid
US6893868B2 (en) * 1997-02-20 2005-05-17 Onco Immunin, Inc. Homo-doubly labeled compositions for the detection of enzyme activity in biological samples
US20100226931A1 (en) * 2004-06-24 2010-09-09 Nicholas Valiante Compounds for immunopotentiation
WO2010036930A1 (en) 2008-09-26 2010-04-01 Javad Parvizi Methods and kits for detecting joint infection
US20160040209A1 (en) 2013-04-02 2016-02-11 Board Of Regents, The University Of Texas System Fast quantification of enzyme activity by electroanalysis

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4677060A (en) * 1981-02-06 1987-06-30 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Process for determining the pH value in the interior of a cell
EP0698600A1 (de) * 1994-08-22 1996-02-28 Bayer Corporation Zusammensetzung, Verfahren und System zum Nachweis von Leukocyten, Esterasen oder Proteasen in einer Testprobe
DE19829707A1 (de) * 1998-07-03 2000-01-05 Macherey Nagel Gmbh & Co Hg Diagnostisches Mittel zum Nachweis von Leukozyten, Elastasen, Esterasen und Proteasen
US6503725B2 (en) * 1999-01-21 2003-01-07 Hypoguard America Limited Composition and device for detecting leukocytes in urine
WO2003043583A2 (en) * 2001-11-20 2003-05-30 Seattle Genetics, Inc. Treatment of immunological disorders using anti-cd30 antibodies
WO2009089680A1 (en) * 2007-12-19 2009-07-23 Dan Yang Method of modulating membrane potential of a cell

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; FUNAMA, JUN-ICHI ET AL: "Enkephalin dimers cross-linked by diaminobenzene for homodimeric opioid receptors expressed in COS-7 cells", XP002795738, retrieved from STN Database accession no. 2006:506020 *
FUNAMA JUN-ICHI ET AL: "Enkephalin dimers cross-linked by diaminobenzene for homodimeric opioid receptors expressed in COS-7 cells", PEPTIDE SCIENCE, PROTEIN RESEARCH FOUNDATION, MINOO, JP, vol. 2005/42nd, 1 January 2006 (2006-01-01), pages 211 - 212, XP009517308, ISSN: 1344-7661 *
See also references of WO2017165222A1 *
SEONG RYONG NAM ET AL: "Control of Macroscopic Helicity by Using the Sergeants‐and‐Soldiers Principle in Organogels", CHEMISTRY - A EUROPEAN JOURNAL, vol. 14, no. 20, 7 July 2008 (2008-07-07), pages 6040 - 6043, XP055196873, ISSN: 0947-6539, DOI: 10.1002/chem.200800702 *
VICENTE MARTÍ-CENTELLES ET AL: "Zinc(ii) coordination polymers with pseudopeptidic ligands", CRYSTENGCOMM, vol. 13, no. 23, 1 January 2011 (2011-01-01), pages 6997 - 7008, XP055643928, DOI: 10.1039/c1ce05872j *
WOLFGANG SCHOENFELDER ET AL: "Synthese von mehrfach homochiral-analog substituierten Benzolderivaten", CHEMISCHE BERICHTE, 1 January 1980 (1980-01-01), pages 1855 - 1866, XP055057858, Retrieved from the Internet <URL:http://onlinelibrary.wiley.com/store/10.1002/cber.19801130521/asset/19801130521_ftp.pdf?v=1&t=her47tet&s=d19acc2325266e016b7191a65b32ea6fac910a00> [retrieved on 20130326], DOI: 10.1002/cber.19801130521 *

Also Published As

Publication number Publication date
CA3018776A1 (en) 2017-09-28
WO2017165222A1 (en) 2017-09-28
JP2019515681A (ja) 2019-06-13
EP3432873A1 (de) 2019-01-30

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