DE69512291T2 - Verstärkte absorbierbare Polymere - Google Patents
Verstärkte absorbierbare PolymereInfo
- Publication number
- DE69512291T2 DE69512291T2 DE69512291T DE69512291T DE69512291T2 DE 69512291 T2 DE69512291 T2 DE 69512291T2 DE 69512291 T DE69512291 T DE 69512291T DE 69512291 T DE69512291 T DE 69512291T DE 69512291 T2 DE69512291 T2 DE 69512291T2
- Authority
- DE
- Germany
- Prior art keywords
- poly
- succinimide
- dioxanone
- filler
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229920000642 polymer Polymers 0.000 title claims description 85
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical compound O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 claims description 150
- 229960002317 succinimide Drugs 0.000 claims description 75
- 239000000203 mixture Substances 0.000 claims description 63
- 239000000945 filler Substances 0.000 claims description 58
- VPVXHAANQNHFSF-UHFFFAOYSA-N 1,4-dioxan-2-one Chemical compound O=C1COCCO1 VPVXHAANQNHFSF-UHFFFAOYSA-N 0.000 claims description 49
- 239000002245 particle Substances 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 17
- 239000000178 monomer Substances 0.000 claims description 11
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims description 9
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical group CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims description 9
- -1 poly(ester anhydrides Chemical class 0.000 claims description 9
- 229920001577 copolymer Polymers 0.000 claims description 8
- 229920001519 homopolymer Polymers 0.000 claims description 8
- 229920000728 polyester Polymers 0.000 claims description 8
- 239000000835 fiber Substances 0.000 claims description 7
- 150000002596 lactones Chemical class 0.000 claims description 7
- 231100000252 nontoxic Toxicity 0.000 claims description 5
- 230000003000 nontoxic effect Effects 0.000 claims description 5
- SJDLIJNQXLJBBE-UHFFFAOYSA-N 1,4-dioxepan-2-one Chemical compound O=C1COCCCO1 SJDLIJNQXLJBBE-UHFFFAOYSA-N 0.000 claims description 4
- OZJPLYNZGCXSJM-UHFFFAOYSA-N 5-valerolactone Chemical compound O=C1CCCCO1 OZJPLYNZGCXSJM-UHFFFAOYSA-N 0.000 claims description 4
- 238000009826 distribution Methods 0.000 claims description 4
- 229920001400 block copolymer Polymers 0.000 claims description 3
- 238000010128 melt processing Methods 0.000 claims description 3
- AOLNDUQWRUPYGE-UHFFFAOYSA-N 1,4-dioxepan-5-one Chemical compound O=C1CCOCCO1 AOLNDUQWRUPYGE-UHFFFAOYSA-N 0.000 claims description 2
- 239000004952 Polyamide Substances 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
- 229920005576 aliphatic polyanhydride Polymers 0.000 claims description 2
- 229920005578 aromatic polyanhydride Polymers 0.000 claims description 2
- 125000004122 cyclic group Chemical group 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 229920001308 poly(aminoacid) Polymers 0.000 claims description 2
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims description 2
- 229920002627 poly(phosphazenes) Polymers 0.000 claims description 2
- 229920002647 polyamide Polymers 0.000 claims description 2
- 229920006149 polyester-amide block copolymer Polymers 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 235000002906 tartaric acid Nutrition 0.000 claims description 2
- YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 claims description 2
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 235000006408 oxalic acid Nutrition 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 claims 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 28
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 24
- 238000001746 injection moulding Methods 0.000 description 14
- 239000000463 material Substances 0.000 description 12
- 238000002156 mixing Methods 0.000 description 12
- 210000001519 tissue Anatomy 0.000 description 11
- 238000006243 chemical reaction Methods 0.000 description 10
- 239000011521 glass Substances 0.000 description 10
- 239000011159 matrix material Substances 0.000 description 10
- 229910052757 nitrogen Inorganic materials 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 8
- CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical compound OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 description 7
- 239000011541 reaction mixture Substances 0.000 description 7
- 239000012153 distilled water Substances 0.000 description 6
- 238000005187 foaming Methods 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 5
- 239000012065 filter cake Substances 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 4
- 229960005261 aspartic acid Drugs 0.000 description 4
- 229910001873 dinitrogen Inorganic materials 0.000 description 4
- 238000000227 grinding Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000004570 mortar (masonry) Substances 0.000 description 4
- 239000012299 nitrogen atmosphere Substances 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 235000003704 aspartic acid Nutrition 0.000 description 3
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000000113 differential scanning calorimetry Methods 0.000 description 3
- 230000009477 glass transition Effects 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229920002959 polymer blend Polymers 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 238000000967 suction filtration Methods 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 229920001059 synthetic polymer Polymers 0.000 description 3
- 238000002411 thermogravimetry Methods 0.000 description 3
- GWKOSRIHVSBBIA-REOHCLBHSA-N (3s)-3-aminooxolane-2,5-dione Chemical compound N[C@H]1CC(=O)OC1=O GWKOSRIHVSBBIA-REOHCLBHSA-N 0.000 description 2
- 238000005160 1H NMR spectroscopy Methods 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000002308 calcification Effects 0.000 description 2
- 235000011089 carbon dioxide Nutrition 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000004898 kneading Methods 0.000 description 2
- 238000010907 mechanical stirring Methods 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000012763 reinforcing filler Substances 0.000 description 2
- 238000007151 ring opening polymerisation reaction Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000007155 step growth polymerization reaction Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000005979 thermal decomposition reaction Methods 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 238000009827 uniform distribution Methods 0.000 description 2
- 230000004580 weight loss Effects 0.000 description 2
- BYEAHWXPCBROCE-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoropropan-2-ol Chemical compound FC(F)(F)C(O)C(F)(F)F BYEAHWXPCBROCE-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 1
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920001410 Microfiber Polymers 0.000 description 1
- XOJVVFBFDXDTEG-UHFFFAOYSA-N Norphytane Natural products CC(C)CCCC(C)CCCC(C)CCCC(C)C XOJVVFBFDXDTEG-UHFFFAOYSA-N 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229920006125 amorphous polymer Polymers 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 239000011256 inorganic filler Substances 0.000 description 1
- 229910003475 inorganic filler Inorganic materials 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 229910001092 metal group alloy Inorganic materials 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000003658 microfiber Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 238000006068 polycondensation reaction Methods 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 239000002954 polymerization reaction product Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 229920005604 random copolymer Polymers 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000009864 tensile test Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012719 thermal polymerization Methods 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L31/129—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing macromolecular fillers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L101/00—Compositions of unspecified macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
- C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L79/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen or carbon only, not provided for in groups C08L61/00 - C08L77/00
- C08L79/04—Polycondensates having nitrogen-containing heterocyclic rings in the main chain; Polyhydrazides; Polyamide acids or similar polyimide precursors
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Materials Engineering (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Composite Materials (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Biological Depolymerization Polymers (AREA)
Claims (10)
1. Absorbierbare Zusammensetzung, die ein absorbierbares Polymer umfaßt, das ausgewählt
ist aus der Gruppe, die aus aliphatischen Polyanhydriden, aromatischen Polyanhydriden,
Polylacton-Homopolymeren, Polylacton-Copolymeren, Poly(esteranhydriden),
Polyiminopolycarbonaten, Polyestern von Oxalsäure, Polyester von Äpfelsäure, Polyestern
von Weinsäure, Polyamiden, Poly(aminosäuren), ungiftigen Polypeptiden,
Poly(hydroxybutyrat), Poly(hydroxybutyrat-cohydroxyvalerat), von Bakterien abgeleiteten
Polyestern, Polyphosphazenen, Polyesteramiden und Blockcopolymeren von
Polyethylenglykol und Polylactonen besteht, die vom Körper absorbiert werden können, welche als
einen Füllstoff ein Poly[succinimid] in einer Menge enthält, die ausreichend ist, um die
Steifigkeit des Polymers zu erhöhen, mit Wiederholungseinheiten, die durch die folgende
Formel dargestellt sind:
2. Zusammensetzung nach Anspruch 1, dadurch gekennzeichnet, daß das synthetische
absorbierbare Polymer abgeleitet ist von wenigstens einem Lacton-Monomer.
3. Zusammensetzung nach Anspruch 2, dadurch gekennzeichnet, daß das Lacton-Monomer
ausgewählt ist aus der Gruppe, die aus Lactid, Glykolid, 1,4-Dioxanon,
Trimethylencarbonat, δ-Valerolacton, ε-Caprolacton, 1,4-Dioxepan-2-on, 1,5-Dioxepan-2-on, cyclischen
Dimeren derselben und Kombinationen von zwei oder mehreren derselben besteht.
4. Zusammensetzung nach Anspruch 3, dadurch gekennzeichnet, daß das absorbierbare
Polymer ausgewählt ist aus der Gruppe, die aus Homopolymeren von 1,4-Dioxanon und
Copolymeren von Lactid und Glykolid besteht.
5. Zusammensetzung nach Anspruch 4, dadurch gekennzeichnet, daß das absorbierbare
Polymer ein Homopolymer von 1,4-Dioxanon ist.
6. Zusammensetzung nach einem der Ansprüche 1 bis 5, dadurch gekennzeichnet, daß die
Menge des Poly[succinimid]-Füllstoffes im absorbierbaren Polymer zwischen 10 bis 80
Prozent, vorzugsweise 20 bis 40 Prozent, des Gewichts der Zusammensetzung liegt.
7. Zusammensetzung nach einem der Ansprüche 1 bis 6, dadurch gekennzeichnet, daß das
Poly[succinimid] in der Form eines Pulvers vorliegt, das vorzugsweise eine
Teilchengrößeverteilung zwischen 50 und 150 Mikrons aufweist.
8. Zusammensetzung nach einem der Ansprüche 1 bis 6, dadurch gekennzeichnet, daß das
Poly[succinimid] in der Form einer Endlos- oder Stapelfaser vorliegt.
9. Eine chirurgische Vorrichtung, wie etwa eine chirurgische Klammer oder ein Ligaturclip,
hergestellt aus der Zusammensetzung nach einem der Ansprüche 1 bis 8.
10. Chirurgische Vorrichtung nach Anspruch 9, dadurch gekennzeichnet, daß sie durch
Schmelzverarbeitung der Zusammensetzung hergestellt ist.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/208,391 US5397816A (en) | 1992-11-17 | 1994-03-08 | Reinforced absorbable polymers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69512291D1 DE69512291D1 (de) | 1999-10-28 |
| DE69512291T2 true DE69512291T2 (de) | 2000-02-03 |
Family
ID=22774442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69512291T Expired - Fee Related DE69512291T2 (de) | 1994-03-08 | 1995-03-07 | Verstärkte absorbierbare Polymere |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US5397816A (de) |
| EP (1) | EP0671177B1 (de) |
| JP (1) | JP3590665B2 (de) |
| AU (1) | AU685567B2 (de) |
| BR (1) | BR9500840A (de) |
| CA (1) | CA2144024A1 (de) |
| DE (1) | DE69512291T2 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0579503B1 (de) * | 1992-07-17 | 1997-11-05 | Ethicon Inc. | Strahlenhärtbare Urethan-Acrylatprepolymere und vernetzte Polymere |
| ATE244584T1 (de) * | 1995-01-16 | 2003-07-15 | Baxter Int | Selbsttragende flächengebilde aus vernetztem fibrin zur hemmung von postoperativen adhäsionen |
| WO1998002098A1 (en) | 1996-07-12 | 1998-01-22 | Baxter International Inc. | A fibrin delivery device and method for forming fibrin on a surface |
| ZA978537B (en) | 1996-09-23 | 1998-05-12 | Focal Inc | Polymerizable biodegradable polymers including carbonate or dioxanone linkages. |
| JP3483753B2 (ja) * | 1997-12-29 | 2004-01-06 | タキロン株式会社 | 生体内分解吸収性可塑性粘着物 |
| BE1012536A3 (fr) | 1998-11-04 | 2000-12-05 | Baxter Int | Element muni d'une couche de fibrine sa preparation et son utilisation. |
| EP1004427B1 (de) * | 1998-11-24 | 2003-05-02 | Nippon Shokubai Co., Ltd. | Verfahren zum Herstellen und zum Giessen eines Polysuccinimid-Polymers oder -Copolymers |
| US6147135A (en) * | 1998-12-31 | 2000-11-14 | Ethicon, Inc. | Fabrication of biocompatible polymeric composites |
| NZ543165A (en) * | 2000-11-01 | 2007-06-29 | Medi Physics Inc | Radioactive member for use in brachytherapy and method of making |
| US7776310B2 (en) | 2000-11-16 | 2010-08-17 | Microspherix Llc | Flexible and/or elastic brachytherapy seed or strand |
| US7074291B2 (en) * | 2001-11-02 | 2006-07-11 | Worldwide Medical Technologies, L.L.C. | Delivery system and method for interstitial radiation therapy using strands constructed with extruded strand housings |
| US7060020B2 (en) * | 2001-11-02 | 2006-06-13 | Ideamatrix, Inc. | Delivery system and method for interstitial radiation therapy |
| US7135027B2 (en) * | 2002-10-04 | 2006-11-14 | Baxter International, Inc. | Devices and methods for mixing and extruding medically useful compositions |
| US7322928B2 (en) | 2003-03-17 | 2008-01-29 | Medi-Physics, Inc. | Products and methods for brachytherapy |
| US6997862B2 (en) * | 2003-05-13 | 2006-02-14 | Ideamatrix, Inc. | Delivery system and method for interstitial radiation therapy using seed strands with custom end spacing |
| US7736293B2 (en) * | 2005-07-22 | 2010-06-15 | Biocompatibles Uk Limited | Implants for use in brachytherapy and other radiation therapy that resist migration and rotation |
| US8187159B2 (en) | 2005-07-22 | 2012-05-29 | Biocompatibles, UK | Therapeutic member including a rail used in brachytherapy and other radiation therapy |
| US7988611B2 (en) * | 2006-05-09 | 2011-08-02 | Biocompatibles Uk Limited | After-loader for positioning implants for needle delivery in brachytherapy and other radiation therapy |
| US20090216063A1 (en) * | 2008-01-29 | 2009-08-27 | Biocompatibles Uk Limited | Bio-absorbable brachytherapy strands |
| US7878964B1 (en) | 2006-09-07 | 2011-02-01 | Biocompatibles Uk Limited | Echogenic spacers and strands |
| US7874976B1 (en) | 2006-09-07 | 2011-01-25 | Biocompatibles Uk Limited | Echogenic strands and spacers therein |
| CN102675663B (zh) * | 2012-05-22 | 2013-11-13 | 太原理工大学 | 一种可生物降解的复合高吸水性树脂的制备方法 |
| CN112062929B (zh) * | 2020-09-16 | 2022-03-01 | 西南石油大学 | 一种暂堵材料及其制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4052988A (en) * | 1976-01-12 | 1977-10-11 | Ethicon, Inc. | Synthetic absorbable surgical devices of poly-dioxanone |
| FR2439003A1 (fr) * | 1978-10-20 | 1980-05-16 | Anvar | Nouvelles pieces d'osteosynthese, leur preparation et leur application |
| US4473670A (en) * | 1983-05-25 | 1984-09-25 | Ethicon, Inc. | Salt-filled absorbable polymers |
| US4612923A (en) * | 1983-12-01 | 1986-09-23 | Ethicon, Inc. | Glass-filled, absorbable surgical devices |
| DE3581471D1 (de) * | 1984-10-19 | 1991-02-28 | Battelle Memorial Institute | Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten. |
| US4646741A (en) * | 1984-11-09 | 1987-03-03 | Ethicon, Inc. | Surgical fastener made from polymeric blends |
| FI75493C (fi) * | 1985-05-08 | 1988-07-11 | Materials Consultants Oy | Sjaelvarmerat absorberbart osteosyntesmedel. |
| US4741337A (en) * | 1985-07-17 | 1988-05-03 | Ethicon, Inc. | Surgical fastener made from glycolide-rich polymer blends |
| US5152781A (en) * | 1987-12-17 | 1992-10-06 | Allied-Signal Inc. | Medical devices fabricated from homopolymers and copolymers having recurring carbonate units |
| US5274074A (en) * | 1987-12-17 | 1993-12-28 | United States Surgical Corporation | Medical devices fabricated from homopolymers and copolymers having recurring carbonate units |
| DE3921912A1 (de) * | 1989-07-04 | 1991-01-17 | Roehm Gmbh | Polyasparaginsaeurederivate als ueberzugsmittel fuer arzneiformen und lebensmittel |
| US5137928A (en) * | 1990-04-26 | 1992-08-11 | Hoechst Aktiengesellschaft | Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents |
| US5286810A (en) * | 1992-08-07 | 1994-02-15 | Srchem Incorporated | Salt of polymer from maleic acid, polyamind and ammonia |
-
1994
- 1994-03-08 US US08/208,391 patent/US5397816A/en not_active Expired - Lifetime
-
1995
- 1995-02-14 US US08/388,548 patent/US5521280A/en not_active Expired - Lifetime
- 1995-03-03 AU AU13626/95A patent/AU685567B2/en not_active Expired - Fee Related
- 1995-03-06 JP JP07240795A patent/JP3590665B2/ja not_active Expired - Fee Related
- 1995-03-06 CA CA002144024A patent/CA2144024A1/en not_active Abandoned
- 1995-03-07 DE DE69512291T patent/DE69512291T2/de not_active Expired - Fee Related
- 1995-03-07 BR BR9500840A patent/BR9500840A/pt not_active Application Discontinuation
- 1995-03-07 EP EP95301462A patent/EP0671177B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU685567B2 (en) | 1998-01-22 |
| US5521280A (en) | 1996-05-28 |
| US5397816A (en) | 1995-03-14 |
| CA2144024A1 (en) | 1995-09-09 |
| JP3590665B2 (ja) | 2004-11-17 |
| AU1362695A (en) | 1995-09-14 |
| JPH07268212A (ja) | 1995-10-17 |
| EP0671177B1 (de) | 1999-09-22 |
| BR9500840A (pt) | 1995-10-24 |
| DE69512291D1 (de) | 1999-10-28 |
| EP0671177A1 (de) | 1995-09-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69512291T2 (de) | Verstärkte absorbierbare Polymere | |
| DE69119919T2 (de) | Kristalline Copolyester aus amorphem (Laktid/Glykolid) und p-Dioxanon | |
| DE69617905T2 (de) | Schlagzähe modifizierte, schmelzstabile lactid-polymer-zusammensetzungen | |
| DE69414640T2 (de) | Hydroxyalkanoatpolymerzusammensetzungen | |
| DE69312312T2 (de) | Mit kautschuk modifizierte polylactid- und/oder glycolidzusammensetzung | |
| DE2827289C2 (de) | ||
| DE68914428T2 (de) | Absorbierbare Beschichtung und Mischung. | |
| DE69832617T2 (de) | Modifizierte polylactidzusammensetzungen, wasserempfindliche, biologisch abbaubare filme und faser aus polylactiden und polyvinylalkohol und ihre herstellungsverfahren | |
| EP0401844B1 (de) | Resorbierbare Formkörper und Verfahren zu ihrer Herstellung | |
| EP1907023B1 (de) | Resorbierbare polyetherester zur herstellung von medizinischen implantaten | |
| DE60119374T2 (de) | Methode zur herstellung von bioabbaubaren polyhydroxyalkanoat-copolymeren mit verbesserten kristallisationseigenschaften | |
| DE69916839T2 (de) | Mischung von bioresorbierbaren polymeren enthaltend ein pga-haltiges blockcopolymer und ein zweites makrophasengetrenntes polymer | |
| AU569296B2 (en) | Lactide/caprolactone polymer,method of making the same, composites thereof,and prostheses produced therefrom | |
| DE69821600T2 (de) | Von hydroxysäuren abgeleitete monomere und daraus hergestellte polymere | |
| DE69530363T2 (de) | Absorbierbare Polyetherestercarbonat-Blockcopolymere und daraus gefertigte chirurgische Artikel | |
| DE69831009T2 (de) | Polyhydroxyalkanoate enthaltende polymermischungen und zusammensetzungen mit guter beständigkeit der dehnung | |
| DE2917037C2 (de) | Parenteral arzneimittelhaltige partiell resorbierbare Mehrkomponentenmasse auf Basis von polymeren Stoffen | |
| EP0711567A1 (de) | Chirurgisches Nahtmaterial, seine Verwendung in der Chirurgie und Verfahren zu seiner Herstellung | |
| DE10248406A1 (de) | Laser-Sinter-Pulver mit Titandioxidpartikeln, Verfahren zu dessen Herstellung und Formkörper, hergestellt aus diesem Laser-Sinterpulver | |
| DE19753534A1 (de) | Schnell kristallisierende, biologisch abbaubare Polyesteramide | |
| DE60111567T2 (de) | Bioabbaubare polyhydroxyalkanoat-copolymere mit verbesserten kristallisationseigenschaften | |
| DE69732470T2 (de) | Abbaubares Monofilament und Verfahren zu seiner Herstellung | |
| EP0835895A2 (de) | Triblockterpolymer, seine Verwendung für chirurgisches Nahtmaterial und Verfahren zur Herstellung | |
| DE2525513A1 (de) | Stabilisierte polyalkylenharz- gemische | |
| DE69213529T2 (de) | Nylonzusammensetzung mit erhöhter Hydrolysierbarkeit und Verfahren zur Erhöhung der Hydrolysierbarkeit von Nylon |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: BOEHMERT & BOEHMERT, 28209 BREMEN |
|
| 8339 | Ceased/non-payment of the annual fee |