DE69506561T2 - Immunkonjugate die tyrosine kinase inhibitoren enthalten - Google Patents
Immunkonjugate die tyrosine kinase inhibitoren enthaltenInfo
- Publication number
- DE69506561T2 DE69506561T2 DE69506561T DE69506561T DE69506561T2 DE 69506561 T2 DE69506561 T2 DE 69506561T2 DE 69506561 T DE69506561 T DE 69506561T DE 69506561 T DE69506561 T DE 69506561T DE 69506561 T2 DE69506561 T2 DE 69506561T2
- Authority
- DE
- Germany
- Prior art keywords
- tyrosine kinase
- immuno
- kinase inhibitors
- conjugates contain
- contain tyrosine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/293,731 US5587459A (en) | 1994-08-19 | 1994-08-19 | Immunoconjugates comprising tyrosine kinase inhibitors |
PCT/US1995/010123 WO1996006116A1 (en) | 1994-08-19 | 1995-08-08 | Immunoconjugates comprising tyrosine kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69506561D1 DE69506561D1 (de) | 1999-01-21 |
DE69506561T2 true DE69506561T2 (de) | 1999-08-12 |
Family
ID=23130336
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69506561T Expired - Fee Related DE69506561T2 (de) | 1994-08-19 | 1995-08-08 | Immunkonjugate die tyrosine kinase inhibitoren enthalten |
Country Status (8)
Country | Link |
---|---|
US (2) | US5587459A (de) |
EP (1) | EP0776338B1 (de) |
JP (1) | JPH10505056A (de) |
AT (1) | ATE174345T1 (de) |
AU (1) | AU3216895A (de) |
CA (1) | CA2197577A1 (de) |
DE (1) | DE69506561T2 (de) |
WO (1) | WO1996006116A1 (de) |
Families Citing this family (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5911995A (en) * | 1994-08-19 | 1999-06-15 | Regents Of The University Of Minnesota | EGF-genistein conjugates for the treatment of cancer |
US5587459A (en) * | 1994-08-19 | 1996-12-24 | Regents Of The University Of Minnesota | Immunoconjugates comprising tyrosine kinase inhibitors |
JPH11506915A (ja) * | 1995-06-07 | 1999-06-22 | イノジェネティックス・ナムローゼ・フェンノートシャップ | Cd80およびcd86発現細胞に対して特異的なイムノトキシン |
FR2742156A1 (fr) * | 1995-12-06 | 1997-06-13 | Sanofi Sa | Polypeptide recepteur de l'il-13 |
IL116436A (en) | 1995-12-18 | 2006-12-31 | Yissum Res Dev Co | Fc?Á-PE CHIMERIC PROTEIN FOR TARGETED TREATMENT OF ALLERGY RESPONSES AND |
EP0946195A1 (de) * | 1996-10-01 | 1999-10-06 | Celltech Therapeutics Limited | Pharmazeutisches produkt, welches tyrosin kinase inhibitoren und anti-cd4antikörpern enthält |
US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
US6495579B1 (en) | 1996-12-02 | 2002-12-17 | Angiotech Pharmaceuticals, Inc. | Method for treating multiple sclerosis |
US20030157187A1 (en) * | 1996-12-02 | 2003-08-21 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for treating or preventing inflammatory diseases |
JP2001518935A (ja) | 1997-03-26 | 2001-10-16 | バイオソース テクノロジーズ,インコーポレイティド | 抗癌剤としてのジ―アリールエーテル類及びそれらの誘導体 |
AU7165798A (en) * | 1997-04-28 | 1998-11-24 | Anticancer, Inc. | Use of genistein and related compounds to treat certain sex hormone related conditions |
US6312941B1 (en) | 1997-11-26 | 2001-11-06 | The Regents Of The University Of Michigan | Compositions and methods for identifying signaling pathway agonists and antagonists |
AU760046B2 (en) | 1998-02-27 | 2003-05-08 | United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Disubstituted lavendustin a analogs and pharmaceutical compositions comprising the analogs |
US6645490B2 (en) * | 1998-03-02 | 2003-11-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Chimeric proteins with cell-targeting specificity and apoptosis-inducing activities |
US6051602A (en) * | 1998-03-16 | 2000-04-18 | The Procter & Gamble Company | Methods for regulating skin appearance |
WO1999050455A1 (en) * | 1998-03-27 | 1999-10-07 | Temple University - Of The Commonwealth System Of Higher Education | Methods for cancer prognosis and screening antiproliferative agents |
ATE350048T1 (de) * | 1998-04-16 | 2007-01-15 | Eurovita As | Neue synergistische zusammensetzungen, die aromatische verbindungen und in alpinia galanga vorhandene terpenoide enthalten |
WO1999055906A2 (en) * | 1998-04-27 | 1999-11-04 | University Health Network | Gene screening methods and related assays |
US6034053A (en) * | 1998-07-13 | 2000-03-07 | Wayne Hughes Institute | EGF-isoflavone conjugates for the prevention of restenosis |
AU771224B2 (en) | 1998-07-13 | 2004-03-18 | Board Of Regents, The University Of Texas System | Cancer treatment methods using antibodies to aminophospholipids |
EP1234585A3 (de) | 1998-09-04 | 2004-01-21 | The Regents Of The University Of Michigan | Zusammensetzungen zur Vorbeugung oder Behandlung von Krebs |
AU777970C (en) * | 1999-05-07 | 2006-08-17 | F. Hoffman-La Roche Ag | Treatment of autoimmune diseases with antagonists which bind to B cell surface markers |
JP2003528805A (ja) * | 1999-07-12 | 2003-09-30 | ジェネンテック・インコーポレーテッド | Cd20に結合するアンタゴニストを用いた異種抗原に対する免疫応答のブロッキング |
US6927203B1 (en) * | 1999-08-17 | 2005-08-09 | Purdue Research Foundation | Treatment of metastatic disease |
US7192698B1 (en) * | 1999-08-17 | 2007-03-20 | Purdue Research Foundation | EphA2 as a diagnostic target for metastatic cancer |
CA2380888A1 (en) | 1999-08-17 | 2001-02-22 | Purdue Research Foundation | Treatment of metastatic disease |
ITMI992711A1 (it) * | 1999-12-27 | 2001-06-27 | Novartis Ag | Composti organici |
GB2360771A (en) * | 2000-03-28 | 2001-10-03 | Antisoma Res Ltd | Compounds for targeting |
DE10024069A1 (de) * | 2000-05-17 | 2001-12-13 | Gluesenkamp Karl Heinz | Konjugat auf der Basis einer heterobifunktionalen Brückenverbindung, die mit einem Immunmodulator und einer zellerkennenden Einheit substituiert ist |
US7101976B1 (en) | 2000-09-12 | 2006-09-05 | Purdue Research Foundation | EphA2 monoclonal antibodies and methods of making and using same |
CA2422076A1 (en) * | 2000-09-18 | 2002-03-21 | Idec Pharmaceutical Corporation | Combination therapy for treatment of autoimmune diseases using b cell depleting/immunoregulatory antibody combination |
WO2002049672A2 (en) * | 2000-12-21 | 2002-06-27 | Mcgill University | Conjugates of antibodies and anticancer drugs |
AU2002322478A1 (en) * | 2001-03-02 | 2002-12-16 | Medimmune, Inc. | Methods of administering/dosing cd2 antagonists for the prevention and treatment of autoimmune disorders or inflammatory disorders |
US20040136908A1 (en) * | 2001-04-09 | 2004-07-15 | Olson William C. | Anti-cd19 immunotoxins |
US20020193569A1 (en) * | 2001-06-04 | 2002-12-19 | Idec Pharmaceuticals Corporation | Bispecific fusion protein and method of use for enhancing effector cell killing of target cells |
US20050152899A1 (en) * | 2002-05-10 | 2005-07-14 | Kinch Michael S. | EphA2 agonistic monoclonal antibodies and methods of use thereof |
WO2004014292A2 (en) * | 2002-05-10 | 2004-02-19 | Purdue Research Foundation | EphA2 AGONISTIC MONOCLONAL ANTIBODIES AND METHODS OF USE THEREOF |
EP1519956B1 (de) * | 2002-05-10 | 2011-09-21 | Medimmune, Inc. | Epha2 monoklonale antikörper und deren anwendungsverfahren |
US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
US7425618B2 (en) | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
EP2269656B1 (de) | 2002-07-15 | 2014-08-20 | Board Of Regents, The University Of Texas | Ausgewählte antikörper mit bindung an aminophospholipide und ihre verwendung bei der behandlung von krebs |
US20040265315A1 (en) * | 2002-09-05 | 2004-12-30 | Christine Dingivan | Methods of preventing or treating T cell malignancies by administering CD2 antagonists |
US7563810B2 (en) | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
US8034831B2 (en) | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
JP2006523240A (ja) * | 2003-04-11 | 2006-10-12 | メディミューン,インコーポレーテッド | EphA2、低増殖性細胞障害ならびに上皮および内皮の再構成 |
US20050059592A1 (en) * | 2003-04-11 | 2005-03-17 | Kiener Peter A. | EphA2 and hyperproliferative cell disorders |
EP2316487B1 (de) | 2003-04-11 | 2014-06-11 | MedImmune, LLC | Rekombinante IL-9 Antikörper und ihre Verwendung |
EP1660186B1 (de) | 2003-08-18 | 2013-12-25 | MedImmune, LLC | Humanisierung von antikörpern |
US20060228350A1 (en) * | 2003-08-18 | 2006-10-12 | Medimmune, Inc. | Framework-shuffling of antibodies |
KR20170102377A (ko) | 2004-01-22 | 2017-09-08 | 유니버시티 오브 마이애미 | 국소용 코-엔자임 큐10 제형 및 그의 사용 방법 |
WO2006047639A2 (en) | 2004-10-27 | 2006-05-04 | Medimmune, Inc. | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
AU2006227377B2 (en) | 2005-03-18 | 2013-01-31 | Medimmune, Llc | Framework-shuffling of antibodies |
EP1893647A2 (de) | 2005-06-23 | 2008-03-05 | MedImmune, Inc. | Antikörperformulierungen mit optimierten aggregations- und fragmentierungsprofilen |
JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
TW200808739A (en) | 2006-04-06 | 2008-02-16 | Novartis Vaccines & Diagnostic | Quinazolines for PDK1 inhibition |
ES2439994T3 (es) | 2006-08-28 | 2014-01-27 | Kyowa Hakko Kirin Co., Ltd. | Anticuerpos antagonistas monoclonales humanos específicos de LIGHT humano |
EP2136831B1 (de) | 2007-03-02 | 2012-09-12 | The Cleveland Clinic Foundation | Anti-angiogene peptide |
AU2008232902B2 (en) | 2007-03-30 | 2013-10-03 | Medlmmune, Llc | Antibody formulation |
DK2176298T3 (en) * | 2007-05-30 | 2018-02-12 | Xencor Inc | Methods and compositions for inhibiting CD32B-expressing cells |
WO2009060198A1 (en) | 2007-11-09 | 2009-05-14 | Peregrine Pharmaceuticals, Inc. | Anti-vegf antibody compositions and methods |
ES2437595T3 (es) | 2007-12-20 | 2014-01-13 | Novartis Ag | Derivados de tiazol usados como inhibidores de la PI 3 quinasa |
EP3470087A1 (de) | 2009-02-13 | 2019-04-17 | Immunomedics, Inc. | Lyophilisierte zusammensetzungen von immunkonjugaten mit einem intrazellulär spaltbaren linker |
US8293753B2 (en) | 2009-07-02 | 2012-10-23 | Novartis Ag | Substituted 2-carboxamide cycloamino ureas |
CA2774260C (en) | 2009-09-16 | 2018-10-09 | Immunomedics, Inc. | Class i anti-cea antibodies and uses thereof |
CA2782194C (en) | 2009-12-02 | 2018-01-16 | Immunomedics, Inc. | Combination of radiolabelled antibodies (rait) and antibody-drug conjugates (adc) for treatment of pancreatic cancer |
AR082418A1 (es) | 2010-08-02 | 2012-12-05 | Novartis Ag | Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico |
AR085091A1 (es) | 2011-01-26 | 2013-09-11 | Kolltan Pharmaceuticals Inc | Anticuerpos anti-kit y sus usos |
US8987257B2 (en) | 2011-01-31 | 2015-03-24 | Novartis Ag | Heterocyclic derivatives |
EP2670426B1 (de) | 2011-01-31 | 2017-05-10 | The General Hospital Corporation | Multimodale trail-moleküle und ihre verwendungen in zelltherapien |
WO2012151199A1 (en) | 2011-05-02 | 2012-11-08 | Immunomedics, Inc. | Ultrafiltration concentration of allotype selected antibodies for small-volume administration |
MX340452B (es) | 2011-10-28 | 2016-07-08 | Novartis Ag | Novedosos derivados de purina y su uso en el tratamiento de enfermedades. |
KR20150009540A (ko) | 2012-05-16 | 2015-01-26 | 노파르티스 아게 | Pi-3 키나제 억제제에 대한 투여 요법 |
US9862932B2 (en) | 2012-07-24 | 2018-01-09 | The General Hospital Corporation | Oncolytic virus therapy for resistant tumors |
EP4063391A1 (de) | 2012-07-25 | 2022-09-28 | Celldex Therapeutics, Inc. | Anti-kit-antikörper und verwendungen davon |
CA2874864C (en) | 2012-08-14 | 2023-02-21 | Ibc Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
WO2014035474A1 (en) * | 2012-08-30 | 2014-03-06 | The General Hospital Corporation | Compositions and methods for treating cancer |
CA2887129A1 (en) | 2012-10-09 | 2014-04-17 | Igenica, Inc. | Anti-c16orf54 antibodies and methods of use thereof |
KR20230078823A (ko) | 2012-12-13 | 2023-06-02 | 이뮤노메딕스, 인코오포레이티드 | 개선된 효능 및 감소된 독성을 위한 항체 및 sn-38의 면역컨쥬게이트의 투약 |
SG10201708143QA (en) | 2013-06-06 | 2017-11-29 | Pierre Fabre Médicament | Anti-c10orf54 antibodies and uses thereof |
PT3041507T (pt) | 2013-08-26 | 2021-07-26 | Biontech Res And Development Inc | Ácidos nucleicos que codificam anticorpos humanos para sialil-lewis |
CN105979947A (zh) | 2013-12-06 | 2016-09-28 | 诺华股份有限公司 | α-同工型选择性磷脂酰肌醇3-激酶抑制剂的剂量方案 |
AU2015219495B2 (en) | 2014-02-21 | 2019-11-21 | Ibc Pharmaceuticals, Inc. | Disease therapy by inducing immune response to Trop-2 expressing cells |
US9139649B2 (en) | 2014-02-25 | 2015-09-22 | Immunomedics, Inc. | Humanized anti-CD22 antibody |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
HUE055189T2 (hu) | 2014-06-04 | 2021-11-29 | Biontech Res And Development Inc | Humán monoklonális antitestek a GD2 ganglioziddal ellen |
US9580495B2 (en) | 2014-06-24 | 2017-02-28 | Immunomedics, Inc. | Anti-histone therapy for vascular necrosis in severe glomerulonephritis |
WO2016057398A1 (en) | 2014-10-07 | 2016-04-14 | Immunomedics, Inc. | Neoadjuvant use of antibody-drug conjugates |
PL3333191T3 (pl) | 2014-12-11 | 2021-05-04 | Pierre Fabre Médicament | Przeciwciała przeciwko c10orf54 i ich zastosowania |
FI3265123T3 (fi) | 2015-03-03 | 2023-01-31 | Vasta-aineita, käyttöjä & menetelmiä | |
CA2981543A1 (en) | 2015-04-22 | 2016-10-27 | Immunomedics, Inc. | Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells |
JP6980980B2 (ja) | 2015-06-25 | 2021-12-15 | イミューノメディクス、インコーポレイテッドImmunomedics, Inc. | 抗hla‐drまたは抗trop‐2抗体と微小管阻害剤、parp阻害剤、ブルトンキナーゼ阻害剤またはホスホイノシチド3‐キナーゼ阻害剤との併用は癌の治療効果を有意に改善する |
EP3316885B1 (de) | 2015-07-01 | 2021-06-23 | Immunomedics, Inc. | Antikörper-sn-38-immunkonjugate mit einem cl2a-linker |
RU2018119085A (ru) | 2015-11-02 | 2019-12-04 | Новартис Аг | Схема введения ингибитора фосфатидилинозитол-3-киназы |
CN108925136B (zh) | 2015-12-02 | 2022-02-01 | 斯特赛恩斯公司 | 特异于糖基化的btla(b和t淋巴细胞衰减因子)的抗体 |
WO2017096051A1 (en) | 2015-12-02 | 2017-06-08 | Stcube & Co., Inc. | Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof |
CA3026880A1 (en) | 2016-06-08 | 2017-12-14 | Paul Foster | Treatment of igg4-related diseases with anti-cd19 antibodies crossbinding to cd32b |
WO2018060833A1 (en) | 2016-09-27 | 2018-04-05 | Novartis Ag | Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib |
US11779604B2 (en) | 2016-11-03 | 2023-10-10 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses and methods |
KR20200015602A (ko) | 2017-05-31 | 2020-02-12 | 주식회사 에스티큐브앤컴퍼니 | Btn1a1에 면역특이적으로 결합하는 항체 및 분자 및 이의 치료적 용도 |
US20200131266A1 (en) | 2017-05-31 | 2020-04-30 | Stcube & Co., Inc. | Methods of treating cancer using antibodies and molecules that immunospecifically bind to btn1a1 |
CN110997724A (zh) | 2017-06-06 | 2020-04-10 | 斯特库伯株式会社 | 使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法 |
WO2019073069A1 (en) | 2017-10-13 | 2019-04-18 | Boehringer Ingelheim International Gmbh | HUMAN ANTIBODIES AGAINST THOMSEN-NEW ANTIGEN (TN) |
CN112740043A (zh) | 2018-07-20 | 2021-04-30 | 皮埃尔法布雷医药公司 | Vista受体 |
WO2022239720A1 (ja) | 2021-05-10 | 2022-11-17 | 公益財団法人川崎市産業振興財団 | 抗原への結合親和性を低減させた抗体 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61246124A (ja) * | 1985-04-24 | 1986-11-01 | Yamanouchi Pharmaceut Co Ltd | 制癌剤 |
JPS62201882A (ja) * | 1985-11-18 | 1987-09-05 | Yamanouchi Pharmaceut Co Ltd | イソフラボン誘導体 |
US4831117A (en) * | 1986-01-03 | 1989-05-16 | Uckun Fatih M | Monoclonal antibody specific for human B-cells |
US5239062A (en) * | 1986-03-20 | 1993-08-24 | Dana-Farber Cancer Institute, Inc. | Blocked lectins, methods and affinity support for making same using affinity ligands, and method of killing selected cell populations having reduced nonselective cytotoxicity |
IN165717B (de) * | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
JPH03275625A (ja) * | 1990-03-23 | 1991-12-06 | Nippon Oil & Fats Co Ltd | 制癌剤およびその製造法 |
US5151360A (en) * | 1990-12-31 | 1992-09-29 | Biomembrane Institute | Effect of n,n,n-trimethylsphingosine on protein kinase-c activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation |
AU3937693A (en) * | 1992-04-10 | 1993-11-18 | Brigham And Women's Hospital | Methods and compositions for oral delivery of therapeutic agents |
USRE40792E1 (en) * | 1992-05-19 | 2009-06-23 | Novogen Research Pty Ltd | Health supplements containing phyto-oestrogens, analogues or metabolites thereof |
WO1994018345A1 (en) * | 1993-02-05 | 1994-08-18 | Affymax Technologies N.V. | Receptor-binding antiproliferative peptides |
ES2150495T5 (es) * | 1993-05-19 | 2007-02-16 | Schering Corporation | Ligandos de flt3 purificados de mamifero y agonistas y antagonistas de los mismos. |
GB9314271D0 (en) * | 1993-07-09 | 1993-08-18 | Inst Of Cancer The Research | Cell growth factor receptors |
US5502037A (en) * | 1993-07-09 | 1996-03-26 | Neuromed Technologies, Inc. | Pro-cytotoxic drug conjugates for anticancer therapy |
EP0722489B1 (de) * | 1993-09-08 | 2002-04-03 | Imclone Systems, Inc. | Monoklonale antikörper, die flk-2-rezeptoren erkennen, und die isolierung primitiver hämatopoietischer stammzellpopulationen |
US5587459A (en) * | 1994-08-19 | 1996-12-24 | Regents Of The University Of Minnesota | Immunoconjugates comprising tyrosine kinase inhibitors |
-
1994
- 1994-08-19 US US08/293,731 patent/US5587459A/en not_active Expired - Lifetime
-
1995
- 1995-08-08 WO PCT/US1995/010123 patent/WO1996006116A1/en active IP Right Grant
- 1995-08-08 EP EP95928368A patent/EP0776338B1/de not_active Expired - Lifetime
- 1995-08-08 AT AT95928368T patent/ATE174345T1/de not_active IP Right Cessation
- 1995-08-08 AU AU32168/95A patent/AU3216895A/en not_active Abandoned
- 1995-08-08 DE DE69506561T patent/DE69506561T2/de not_active Expired - Fee Related
- 1995-08-08 CA CA002197577A patent/CA2197577A1/en not_active Abandoned
- 1995-08-08 JP JP8508124A patent/JPH10505056A/ja active Pending
-
1996
- 1996-11-22 US US08/755,462 patent/US5872223A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1996006116A1 (en) | 1996-02-29 |
JPH10505056A (ja) | 1998-05-19 |
AU3216895A (en) | 1996-03-14 |
EP0776338B1 (de) | 1998-12-09 |
DE69506561D1 (de) | 1999-01-21 |
US5872223A (en) | 1999-02-16 |
ATE174345T1 (de) | 1998-12-15 |
US5587459A (en) | 1996-12-24 |
CA2197577A1 (en) | 1996-02-29 |
EP0776338A1 (de) | 1997-06-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69506561D1 (de) | Immunkonjugate die tyrosine kinase inhibitoren enthalten | |
HUP0003194A3 (en) | Use of tyrosine kinase inhibitor in synergic pharmaceutical composition treating prostate cancer | |
MXPA00011248A (es) | Tratamientos de tumores humanos con radiacion e inhibidores de tirosina cinasas de recptor de factor de crecimiento. | |
MY130363A (en) | "pyrrole substituted 2-indolinone protein kinase inhibitors" | |
NZ514628A (en) | Use of inhibitors for inducing cancer cell death and tumor regression | |
WO1993021942A3 (en) | Use of mmp inhibitors | |
ZA987491B (en) | Naphthyridinones for inhibiting protein tyrosine kinase and cell cycle kinase mediated cellular proliferation | |
CY2006007I2 (el) | Χρηση αναστολεων cgmp-φωσφοδιεστερασης στην αγωγη της ανικανοτητας | |
MX9706529A (es) | Pirido (2,3-d)pirimidinas para inhibir la proliferacion celular mediada por la cinasa tirosina de proteinas. | |
AU7107496A (en) | Protein tyrosine kinase inhibitors for treating osteoarthritis | |
AP2000001996A0 (en) | Heterocyclic inhibitors of P38. | |
DK0971713T3 (da) | Anvendelse af cholinesteraseinhibitorer til behandling af opmærksomhedsforstyrrelser | |
DK0912192T3 (da) | Administration af GM-CSF til behandling af hjernetumorer og forebyggelse af sådanne tumorers tilbagevenden | |
ES2178157T3 (es) | Tratamiento de arritmias mediante la inhibicion de una proteina quinasa multifuncional dependiente de calcio/calmodulina. | |
ATE292121T1 (de) | Chinazolinderivate | |
IL136738A0 (en) | Inhibition of p38 kinase activity using substituted heterocyclic ureas | |
ATE296799T1 (de) | P38-inhibitoren | |
BG103575A (en) | SUBSTITUTED NITROGENCONTAINING HETEROCYCLES AS p38 PROTEINKINASE INHIBIRORS | |
NO984718L (no) | Irreversible inhibitorer for tyrosin-kinaser | |
MX9800921A (es) | Quinolonas y su uso terapeutico. | |
MX9800922A (es) | Quinolonas y su uso terapeutico. | |
NO985652D0 (no) | Anvendelse av naaladaseinhibitorer ved behandling av kreft | |
DK1272188T3 (da) | Anvendelse af EGFR-tyrosinkinaseinhibitorer til behandling af brystcancer | |
CA2238283A1 (en) | Method for identifying compounds for inhibition of neoplastic lesions, pharmaceutical compositions from such compounds and uses of such compounds and compositions for treating neoplastic lesions | |
ATE327973T1 (de) | Polyamin-analoge als cytotoxische wirkstoffe |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |