DE69421366T2 - Staurosporinderivate und Polyalkylenglykol-Glyceride enthaltende Arzneimittel - Google Patents
Staurosporinderivate und Polyalkylenglykol-Glyceride enthaltende ArzneimittelInfo
- Publication number
- DE69421366T2 DE69421366T2 DE69421366T DE69421366T DE69421366T2 DE 69421366 T2 DE69421366 T2 DE 69421366T2 DE 69421366 T DE69421366 T DE 69421366T DE 69421366 T DE69421366 T DE 69421366T DE 69421366 T2 DE69421366 T2 DE 69421366T2
- Authority
- DE
- Germany
- Prior art keywords
- polyalkylene glycol
- medicines containing
- staurosporine derivatives
- glycol glycerides
- containing staurosporine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 125000005456 glyceride group Chemical group 0.000 title abstract 2
- 229920001515 polyalkylene glycol Polymers 0.000 title abstract 2
- HKSZLNNOFSGOKW-FYTWVXJKSA-N staurosporine Chemical class C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1[C@H]1C[C@@H](NC)[C@@H](OC)[C@]4(C)O1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- 239000006185 dispersion Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- HKSZLNNOFSGOKW-UHFFFAOYSA-N ent-staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(C)O1 HKSZLNNOFSGOKW-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 235000003441 saturated fatty acids Nutrition 0.000 abstract 1
- 150000004671 saturated fatty acids Chemical class 0.000 abstract 1
- CGPUWJWCVCFERF-UHFFFAOYSA-N staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(OC)O1 CGPUWJWCVCFERF-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939325395A GB9325395D0 (en) | 1993-12-11 | 1993-12-11 | Compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69421366D1 DE69421366D1 (de) | 1999-12-02 |
| DE69421366T2 true DE69421366T2 (de) | 2000-03-23 |
Family
ID=10746475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69421366T Expired - Lifetime DE69421366T2 (de) | 1993-12-11 | 1994-12-02 | Staurosporinderivate und Polyalkylenglykol-Glyceride enthaltende Arzneimittel |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5736542A (de) |
| EP (1) | EP0657164B1 (de) |
| JP (1) | JPH07196512A (de) |
| KR (1) | KR100366176B1 (de) |
| AT (1) | ATE185970T1 (de) |
| AU (1) | AU692801B2 (de) |
| CA (1) | CA2137764C (de) |
| DE (1) | DE69421366T2 (de) |
| DK (1) | DK0657164T3 (de) |
| ES (1) | ES2140512T3 (de) |
| GB (1) | GB9325395D0 (de) |
| GR (1) | GR3032368T3 (de) |
| IL (1) | IL111872A (de) |
| NZ (1) | NZ270109A (de) |
| PH (1) | PH31454A (de) |
| PT (1) | PT657164E (de) |
| ZA (1) | ZA949824B (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7795246B2 (en) | 1998-08-06 | 2010-09-14 | Cephalon, Inc. | Particle-forming compositions containing fused pyrrolocarbazoles |
| US6200968B1 (en) * | 1998-08-06 | 2001-03-13 | Cephalon, Inc. | Particle-forming compositions containing fused pyrrolocarbazoles |
| US6242473B1 (en) * | 1999-01-08 | 2001-06-05 | Maxim Pharmaceuticals, Inc. | Treatment and prevention of reactive oxygen metabolite-mediated cellular damage |
| GB9903547D0 (en) | 1999-02-16 | 1999-04-07 | Novartis Ag | Organic compounds |
| DE19917990A1 (de) * | 1999-04-20 | 2000-11-02 | Florian Lang | Arzneimittel enthaltend Hemmstoffe der zellvolumenregulierten humanen Kinase h-sgk |
| EP1201668A4 (de) | 1999-07-13 | 2003-05-21 | Kyowa Hakko Kogyo Kk | Staurosporin-derivate |
| DE10042137A1 (de) * | 2000-08-28 | 2002-03-14 | Florian Lang | sgk2 und sgk3 als diagnostische und therapeutische Targets |
| CN100350911C (zh) * | 2001-03-26 | 2007-11-28 | 诺瓦提斯公司 | 含有水溶性差的活性成分、表面活性剂和水溶性聚合物的药物组合物 |
| BR0318166A (pt) * | 2003-03-03 | 2006-04-04 | Florian Lang | uso de uma substáncia para detectar sgk1, kit para essa detecção, bem como composição farmacêutica que inibe ou ativa a sua expressão e/ou função |
| US20040246627A1 (en) * | 2003-06-06 | 2004-12-09 | Durrum Thomas M. | Disc drive pivot bearing assembly |
| BRPI0413439A (pt) | 2003-08-08 | 2006-10-17 | Novartis Ag | combinações compreendendo estaurosporinas |
| PL1660047T3 (pl) | 2003-08-13 | 2014-05-30 | Biocon Ltd | Formulacje dawek stałych mikrocząsteczek soli kwasów tłuszczowych do środków terapeutycznych |
| WO2006082448A1 (en) * | 2005-02-07 | 2006-08-10 | Topotarget Uk Limited | Assays for agents with selective cytotoxicty to hdac resistant cell lines |
| US9994585B2 (en) * | 2007-12-31 | 2018-06-12 | Aphios Corporation | Transplantation therapies |
| US20100168219A1 (en) * | 2008-12-31 | 2010-07-01 | Jonathan Steven Alexander | Chronic inflammation and transplantation |
| US9034347B2 (en) | 2011-12-19 | 2015-05-19 | Arphios Corporation | Drug delivery system and method for the treatment of neuro-degenerative disease |
| US10828276B2 (en) | 2012-11-28 | 2020-11-10 | Aphios Corporation | Combination therapeutics and methods for the treatment of neurodegenerative and other diseases |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60185719A (ja) * | 1984-03-06 | 1985-09-21 | Ajinomoto Co Inc | 抗腫瘍剤 |
| JPH0699311B2 (ja) * | 1986-11-06 | 1994-12-07 | 旭化成工業株式会社 | 抗血管レン縮剤および血管弛緩剤 |
| US5093330A (en) * | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| IL86632A0 (en) * | 1987-06-15 | 1988-11-30 | Ciba Geigy Ag | Derivatives substituted at methyl-amino nitrogen |
| JPH01143877A (ja) * | 1987-11-30 | 1989-06-06 | Asahi Chem Ind Co Ltd | スタウロスポリン誘導体 |
| WO1989007105A1 (en) * | 1988-02-04 | 1989-08-10 | Kyowa Hakko Kogyo Co., Ltd. | Staurosporin derivatives |
| JPH0725786A (ja) * | 1990-05-16 | 1995-01-27 | Univ Rockefeller | アルツハイマー病を伴うアミロイドーシスの治療 |
| CA2107218A1 (en) * | 1991-03-29 | 1992-09-30 | Stuart H. Yuspa | Pharmaceutical compositions and methods for preventing skin tumor formation and causing regression of existing tumors |
| JPH0597708A (ja) * | 1991-10-02 | 1993-04-20 | Lion Corp | 歯周病治療剤 |
| AU2866992A (en) * | 1991-10-10 | 1993-05-03 | Schering Corporation | 4'-(n-substituted-n-oxide)staurosporine derivatives |
| JPH05247055A (ja) * | 1992-03-03 | 1993-09-24 | Meiji Seika Kaisha Ltd | スタウロスポリン誘導体及びそれを含有する抗腫瘍効果増強剤 |
-
1993
- 1993-12-11 GB GB939325395A patent/GB9325395D0/en active Pending
-
1994
- 1994-11-18 PH PH49409A patent/PH31454A/en unknown
- 1994-11-22 US US08/343,404 patent/US5736542A/en not_active Expired - Fee Related
- 1994-12-02 DE DE69421366T patent/DE69421366T2/de not_active Expired - Lifetime
- 1994-12-02 EP EP94308954A patent/EP0657164B1/de not_active Expired - Lifetime
- 1994-12-02 AT AT94308954T patent/ATE185970T1/de active
- 1994-12-02 DK DK94308954T patent/DK0657164T3/da active
- 1994-12-02 ES ES94308954T patent/ES2140512T3/es not_active Expired - Lifetime
- 1994-12-02 PT PT94308954T patent/PT657164E/pt unknown
- 1994-12-05 IL IL111872A patent/IL111872A/en not_active IP Right Cessation
- 1994-12-08 AU AU80308/94A patent/AU692801B2/en not_active Ceased
- 1994-12-09 CA CA002137764A patent/CA2137764C/en not_active Expired - Fee Related
- 1994-12-09 ZA ZA949824A patent/ZA949824B/xx unknown
- 1994-12-09 KR KR1019940033397A patent/KR100366176B1/ko not_active IP Right Cessation
- 1994-12-09 NZ NZ270109A patent/NZ270109A/en not_active IP Right Cessation
- 1994-12-12 JP JP6307534A patent/JPH07196512A/ja active Pending
-
2000
- 2000-01-14 GR GR20000400066T patent/GR3032368T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB9325395D0 (en) | 1994-02-16 |
| NZ270109A (en) | 1996-11-26 |
| ZA949824B (en) | 1995-07-13 |
| PH31454A (en) | 1998-11-03 |
| CA2137764A1 (en) | 1995-06-12 |
| US5736542A (en) | 1998-04-07 |
| IL111872A0 (en) | 1995-06-29 |
| ES2140512T3 (es) | 2000-03-01 |
| KR960021018A (ko) | 1996-07-18 |
| DK0657164T3 (da) | 2000-04-17 |
| JPH07196512A (ja) | 1995-08-01 |
| AU692801B2 (en) | 1998-06-18 |
| EP0657164A1 (de) | 1995-06-14 |
| KR100366176B1 (ko) | 2003-03-03 |
| PT657164E (pt) | 2000-04-28 |
| ATE185970T1 (de) | 1999-11-15 |
| CA2137764C (en) | 2006-02-07 |
| EP0657164B1 (de) | 1999-10-27 |
| AU8030894A (en) | 1995-06-22 |
| DE69421366D1 (de) | 1999-12-02 |
| GR3032368T3 (en) | 2000-04-27 |
| IL111872A (en) | 1998-02-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69421366D1 (de) | Staurosporinderivate und Polyalkylenglykol-Glyceride enthaltende Arzneimittel | |
| PT750495E (pt) | Utilizacao de um surfactante lipofilico numa composicao farmaceutica | |
| DE69506642D1 (de) | Pharmazeutische Zubereitungen enthaltend mehrfach ungesättigte Fettsäuren zusammen mit antioxydativen Vitaminen und Provitaminen | |
| SE8004938L (sv) | Farmaceutisk kompositon av fast lekemedel med fordrojd frigoring | |
| DE3780222T2 (de) | Pharmazeutische zusammensetzung mit kontrollierter wirkstofffreisetzung. | |
| ATE374602T1 (de) | Orale kapselformulierung mit verbesserter physikalischer stabilität | |
| ATE153854T1 (de) | Stabile pharmazeutische zubereitung mit fumagillolderivaten | |
| ES2101574T3 (es) | Composicion administrable por via oral apta para formar una microemulsion. | |
| DE60205633D1 (de) | Orale pharmazeutische zusammensetzung mit einem wirkstoff, der bei seiner ersten darmpassage starken wirkungen ausgesetzt werden kann | |
| KR950010875A (ko) | 피부외용제 | |
| RS49602B (sr) | Farmaceutske mikrosfere valproinske kiseline za oralnu upotrebu | |
| UY26303A1 (es) | Composiciones farmacéuticas para administración oral y tópica | |
| IT1263840B (it) | Formulazioni orali di ubidecarenone in forma di capsule | |
| ATE117200T1 (de) | Probucol enthaltendes arzneimittel mit gesteigerter bioverfügbarkeit. | |
| BE1002024A6 (fr) | Preparation medicamenteuse a base de derives d'esters d'hecogenine et leur utilisation pour le traitement de l'hyperplasie prostatique benigne. | |
| WO1999008666A3 (en) | Pharmaceutical composition comprising an azateroid | |
| SE8600496D0 (sv) | Pharmaceutical 9,10-dihydro ergot alkaloid containing compositions | |
| IT1292126B1 (it) | Esteri cerosi arricchiti in acidi grassi omega-3 insaturi,loro preparazione ed uso | |
| TH14737A (th) | สารผสมทางเภสัชศาสตร์ที่คงตัวของอนุพันธ์ฟิวแมจิลลอล | |
| IT1232963B (it) | Composizioni farmaceutiche topiche contenenti antiistaminici h2 | |
| IT1226144B (it) | Di estere fosforico dell'acido ursodeossicolico e suoi derivati, processo per la loro preparazione e composizioni terapeutiche che li contengono come principi attivi. | |
| CA2309033A1 (en) | Lacrimal gland specific emulsions for topical application to ocular tissue | |
| CA2572498A1 (en) | Biphasic capsule formulation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
|
| 8328 | Change in the person/name/address of the agent |
Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN |