DE69401813T2 - Enantioselektive oxazaborolidin-katalysatoren - Google Patents

Enantioselektive oxazaborolidin-katalysatoren

Info

Publication number
DE69401813T2
DE69401813T2 DE69401813T DE69401813T DE69401813T2 DE 69401813 T2 DE69401813 T2 DE 69401813T2 DE 69401813 T DE69401813 T DE 69401813T DE 69401813 T DE69401813 T DE 69401813T DE 69401813 T2 DE69401813 T2 DE 69401813T2
Authority
DE
Germany
Prior art keywords
formulas
compounds
oxazaborolidin
enantioselective
catalysts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69401813T
Other languages
English (en)
Other versions
DE69401813D1 (de
Inventor
George Quallich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of DE69401813D1 publication Critical patent/DE69401813D1/de
Application granted granted Critical
Publication of DE69401813T2 publication Critical patent/DE69401813T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/0201—Oxygen-containing compounds
    • B01J31/0211—Oxygen-containing compounds with a metal-oxygen link
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
    • B01J31/0235—Nitrogen containing compounds
    • B01J31/0252—Nitrogen containing compounds with a metal-nitrogen link, e.g. metal amides, metal guanidides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
    • B01J31/0271—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds also containing elements or functional groups covered by B01J31/0201 - B01J31/0231
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/12—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides
    • B01J31/14—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides of aluminium or boron
    • B01J31/146—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides of aluminium or boron of boron
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/022—Boron compounds without C-boron linkages
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/60—Reduction reactions, e.g. hydrogenation
    • B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69401813T 1993-05-14 1994-04-12 Enantioselektive oxazaborolidin-katalysatoren Expired - Fee Related DE69401813T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6189593A 1993-05-14 1993-05-14
PCT/IB1994/000066 WO1994026751A1 (en) 1993-05-14 1994-04-12 Enantioselective oxazaborolidine catalysts

Publications (2)

Publication Number Publication Date
DE69401813D1 DE69401813D1 (de) 1997-04-03
DE69401813T2 true DE69401813T2 (de) 1997-06-05

Family

ID=22038846

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69401813T Expired - Fee Related DE69401813T2 (de) 1993-05-14 1994-04-12 Enantioselektive oxazaborolidin-katalysatoren

Country Status (20)

Country Link
US (2) US6005133A (de)
EP (1) EP0698028B1 (de)
JP (1) JP2706851B2 (de)
KR (1) KR0180262B1 (de)
CN (1) CN1048498C (de)
AT (1) ATE149171T1 (de)
AU (1) AU674067B2 (de)
CA (1) CA2161969C (de)
DE (1) DE69401813T2 (de)
DK (1) DK0698028T3 (de)
ES (1) ES2098928T3 (de)
FI (1) FI108297B (de)
GR (1) GR3022924T3 (de)
IL (1) IL109563A (de)
MY (1) MY111215A (de)
NO (1) NO302822B1 (de)
NZ (1) NZ262945A (de)
TW (1) TW416958B (de)
WO (1) WO1994026751A1 (de)
ZA (1) ZA943295B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU659929B2 (en) * 1992-05-14 1995-06-01 Pfizer Inc. Enantioselective oxazaborolidine catalysts
GB9420616D0 (en) * 1994-10-12 1994-11-30 Merck Sharp & Dohme Method, compositions and use
US5840746A (en) * 1993-06-24 1998-11-24 Merck Frosst Canada, Inc. Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases
US5495054A (en) * 1994-05-31 1996-02-27 Sepracor, Inc. Tetrahydroindeno[1,2-D][1,3,2]oxazaboroles and their use as enantioselective catalysts
EP0713848B1 (de) * 1994-10-28 1999-09-08 SUMIKA FINE CHEMICALS Company, Limited Verfahren zur Herstellung von optisch aktiven Carbinolen
DE19506021C1 (de) * 1995-02-22 1996-06-27 Forschungszentrum Juelich Gmbh Verfahren zur enantioselektiven Reduktion von Ketonen mit chemischen Katalysatoren
DE19857765A1 (de) * 1998-12-15 2000-06-21 Clariant Gmbh Verfahren zur Herstellung von para-Oxadiazolyl-phenyl-boronsäuren
KR100375571B1 (ko) * 1999-11-25 2003-03-15 조병태 광학 활성 알파-술폰옥시알코올, 이의 제조 방법 및 이를이용한 광학 활성 에폭사이드 화합물의 제조 방법
US6509472B2 (en) * 2000-09-11 2003-01-21 Schering Corporation 4-Cyclohexyl-1,3,2-oxazaborolidine chiral accessories
US7109345B1 (en) 2003-02-07 2006-09-19 Margarita Ortiz-Marciales Efficient and convenient procedure for the synthesis of B-alkylated oxazaborolidines derived from ephedrine and norephedrine
FR2860795B1 (fr) * 2003-10-09 2006-04-07 Ppg Sipsy Procede de preparation in situ de composes chiraux derives de complexes d'oxazaborolidine-borane utiles dans les reactions de reduction asymetrique
FR2860794B1 (fr) 2003-10-09 2006-02-03 Ppg Sipsy Procede de preparation in situ de composes chiraux derives de complexes d'oxazaborolidine-borane utiles dans les reactions de reduction asymetrique
SG155231A1 (en) * 2005-06-13 2009-09-30 Basf Ag Process for synthesis of dialkoxyorganoboranes
US20080200672A1 (en) * 2005-08-30 2008-08-21 Margarita Ortiz-Marciales Highly enantioselective carbonyl reduction with borane catalyzed by chiral spiroborate esters derived from chiral beta-aminoalcohols
US20060223999A1 (en) * 2006-05-10 2006-10-05 Chemagis Ltd. Process for preparing montelukast and precursors thereof
RU2009102149A (ru) * 2006-06-26 2010-08-10 Басф Се (De) Комплексы боран-простой эфир
CN105061225B (zh) * 2015-08-07 2017-03-08 辽宁科技大学 一种双手性氨基醇化合物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3137723A (en) * 1961-09-25 1964-06-16 Olin Mathieson Boron containing heterocyclic compounds and process for producing them
JPS6118790A (ja) * 1984-07-05 1986-01-27 Sumitomo Chem Co Ltd 光学活性ボラン錯体およびその製造法
US4943635A (en) * 1987-08-27 1990-07-24 President & Fellows Of Harvard College Enantioselective reduction of ketones
AU660701B2 (en) * 1991-07-22 1995-07-06 Pfizer Inc. Process for the preparation of intermediates in the synthesis of chiral thiazolidine-2,4-dione derivatives
AU659929B2 (en) * 1992-05-14 1995-06-01 Pfizer Inc. Enantioselective oxazaborolidine catalysts

Also Published As

Publication number Publication date
DK0698028T3 (da) 1997-08-25
ES2098928T3 (es) 1997-05-01
DE69401813D1 (de) 1997-04-03
IL109563A0 (en) 1994-08-26
ZA943295B (en) 1995-11-13
EP0698028B1 (de) 1997-02-26
FI942240A0 (fi) 1994-05-13
KR0180262B1 (ko) 1999-05-15
US6037505A (en) 2000-03-14
TW416958B (en) 2001-01-01
GR3022924T3 (en) 1997-06-30
CN1124962A (zh) 1996-06-19
JPH08506345A (ja) 1996-07-09
IL109563A (en) 2000-02-29
NZ262945A (en) 1996-08-27
ATE149171T1 (de) 1997-03-15
NO954566D0 (no) 1995-11-13
NO954566L (no) 1995-11-13
US6005133A (en) 1999-12-21
CA2161969A1 (en) 1994-11-24
NO302822B1 (no) 1998-04-27
FI942240A (fi) 1994-11-15
MY111215A (en) 1999-09-30
AU6289694A (en) 1994-12-12
WO1994026751A1 (en) 1994-11-24
JP2706851B2 (ja) 1998-01-28
CA2161969C (en) 1998-11-03
EP0698028A1 (de) 1996-02-28
CN1048498C (zh) 2000-01-19
FI108297B (fi) 2001-12-31
AU674067B2 (en) 1996-12-05
KR960702468A (ko) 1996-04-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee