NZ514437A - A chimeric TIE-2-receptor ligand that binds to but does not activate TIE-2 - Google Patents

A chimeric TIE-2-receptor ligand that binds to but does not activate TIE-2

Info

Publication number
NZ514437A
NZ514437A NZ514437A NZ51443701A NZ514437A NZ 514437 A NZ514437 A NZ 514437A NZ 514437 A NZ514437 A NZ 514437A NZ 51443701 A NZ51443701 A NZ 51443701A NZ 514437 A NZ514437 A NZ 514437A
Authority
NZ
New Zealand
Prior art keywords
tie
binds
activate
ligand
receptor ligand
Prior art date
Application number
NZ514437A
Inventor
Samuel Davis
George D Yancopoulos
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/740,223 external-priority patent/US6265564B1/en
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of NZ514437A publication Critical patent/NZ514437A/en

Links

Abstract

Described is a TIE-2 ligand that binds but does not activate TIE-2, wherein the N-terminal domain of the TIE-2 ligand is deleted. The ligand may be further modified by deletion of the coiled-coil domain and tagging with, for example, the Fc portion of human IgG-1. In addition, isolated nucleic acid molecules are provided that encode the TIE-2 ligands disclosed. Therapeutic compositions comprising the TIE-2 ligands are also disclosed.
NZ514437A 1996-08-02 2001-09-25 A chimeric TIE-2-receptor ligand that binds to but does not activate TIE-2 NZ514437A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2299996P 1996-08-02 1996-08-02
US08/740,223 US6265564B1 (en) 1996-08-02 1996-10-25 Expressed ligand-vascular intercellular signalling molecule
NZ505684A NZ505684A (en) 1996-08-02 1997-08-01 Chimeric tie-2-receptor ligand 1 which binds and activates the tie-2 receptor

Publications (1)

Publication Number Publication Date
NZ514437A true NZ514437A (en) 2002-11-26

Family

ID=27353928

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ514437A NZ514437A (en) 1996-08-02 2001-09-25 A chimeric TIE-2-receptor ligand that binds to but does not activate TIE-2

Country Status (1)

Country Link
NZ (1) NZ514437A (en)

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