NZ514437A - A chimeric TIE-2-receptor ligand that binds to but does not activate TIE-2 - Google Patents
A chimeric TIE-2-receptor ligand that binds to but does not activate TIE-2Info
- Publication number
- NZ514437A NZ514437A NZ514437A NZ51443701A NZ514437A NZ 514437 A NZ514437 A NZ 514437A NZ 514437 A NZ514437 A NZ 514437A NZ 51443701 A NZ51443701 A NZ 51443701A NZ 514437 A NZ514437 A NZ 514437A
- Authority
- NZ
- New Zealand
- Prior art keywords
- tie
- binds
- activate
- ligand
- receptor ligand
- Prior art date
Links
Abstract
Described is a TIE-2 ligand that binds but does not activate TIE-2, wherein the N-terminal domain of the TIE-2 ligand is deleted. The ligand may be further modified by deletion of the coiled-coil domain and tagging with, for example, the Fc portion of human IgG-1. In addition, isolated nucleic acid molecules are provided that encode the TIE-2 ligands disclosed. Therapeutic compositions comprising the TIE-2 ligands are also disclosed.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2299996P | 1996-08-02 | 1996-08-02 | |
US08/740,223 US6265564B1 (en) | 1996-08-02 | 1996-10-25 | Expressed ligand-vascular intercellular signalling molecule |
NZ505684A NZ505684A (en) | 1996-08-02 | 1997-08-01 | Chimeric tie-2-receptor ligand 1 which binds and activates the tie-2 receptor |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ514437A true NZ514437A (en) | 2002-11-26 |
Family
ID=27353928
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ514437A NZ514437A (en) | 1996-08-02 | 2001-09-25 | A chimeric TIE-2-receptor ligand that binds to but does not activate TIE-2 |
Country Status (1)
Country | Link |
---|---|
NZ (1) | NZ514437A (en) |
-
2001
- 2001-09-25 NZ NZ514437A patent/NZ514437A/en not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
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PSEA | Patent sealed | ||
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EXPY | Patent expired |